Rosaura Esteve-Puig, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Medicine
Address2340 Sutter Street
San Francisco CA 94115
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    University of California San FranciscoPostdoctoral Researcher2012Helen Diller Family Comprehensive Cancer Center. Dermatology Department
    University of BarcelonaPhD in Biomedicine. Thesis title: New evasion mechanism to metabolic stress in melanoma2011University of Barcelona- Faculty of Biology
    University of BarcelonaMaster's Degree, Biological and Biomedical Sciences2007University of Barcelona. Faculty of Biology -Department of Biochemistry and Molecular Biology
    Vall d'Hebron Institute of ResearchPhD student2006University of Barcelona/Vall d'Hebron Institute of Research- Animal Model and Cancer Research
    Vall d'Hebron Institute of OncologyPostgraduate Researcher2005Growth Factors Laboratory
    University of BarcelonaBachelor of Science in Biology Degree2004University of Barcelona. Faculty of Biology
    University of BarcelonaGraduate Student Researcher2002University of Barcelona. Faculty of Biology -Department of Cell Biology

    Collapse Overview 
    Collapse Overview
    Postdoctoral researcher specializing in cancer biology since 2005.

    Pursuing an understanding of tumor molecular mechanisms with the aim of revealing novel clinical therapies.

    Expert in signal transduction pathways, protein post translational modifications, long noncoding RNAs and the molecular and cell biology of cancer with a broad range of technical experience including the recently emerged CRISPR/CAS9 system, RNA-protein interaction methods, esiRNA/shRNA technology and molecular cloning.

    Contributed missing pieces to the UV-induced DNA damage response pathway, revealed a novel mechanism for the modulation of the ERK pathway signaling by methylation, proposed a new metabolic clinical approach in cancer, and identified and characterized new kinase fusions in spitzoid melanomas.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Posch C, Sanlorenzo M, Vujic I, Oses-Prieto JA, Cholewa BD, Kim ST, Ma J, Lai K, Zekhtser M, Esteve-Puig R, Green G, Chand S, Burlingame AL, Panzer-Grümayer R, Rappersberger K, Ortiz-Urda S, et al. Phosphoproteomic Analyses of NRAS(G12) and NRAS(Q61) Mutant Melanocytes Reveal Increased CK2a Kinase Levels in NRAS(Q61) Mutant Cells. J Invest Dermatol. 2016 May 29. PMID: 27251789.
      View in: PubMed
    2. Vujic I, Sanlorenzo M, Esteve-Puig R, Vujic M, Kwong A, Tsumura A, Murphy R, Moy A, Posch C, Monshi B, Rappersberger K, Ortiz-Urda S. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9; 7(6):7297-306. PMID: 26771141.
      View in: PubMed
    3. Vujic I, Sanlorenzo M, Posch C, Esteve-Puig R, Yen AJ, Kwong A, Tsumura A, Murphy R, Rappersberger K, Ortiz-Urda S. Metformin and trametinib have synergistic effects on cell viability and tumor growth in NRAS mutant cancer. Oncotarget. 2015 Jan 20; 6(2):969-78. PMID: 25504439; PMCID: PMC4359268.
    4. Esteve-Puig R, Gil R, González-Sánchez E, Bech-Serra JJ, Grueso J, Hernández-Losa J, Moliné T, Canals F, Ferrer B, Cortés J, Bastian B, Ramón Y Cajal S, Martín-Caballero J, Flores JM, Vivancos A, García-Patos V, Recio JÁ. A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation. PLoS Genet. 2014 Oct; 10(10):e1004721. PMID: 25329316; PMCID: PMC4199501.
    5. Wiesner T, He J, Yelensky R, Esteve-Puig R, Botton T, Yeh I, Lipson D, Otto G, Brennan K, Murali R, Garrido M, Miller VA, Ross JS, Berger MF, Sparatta A, Palmedo G, Cerroni L, Busam KJ, Kutzner H, Cronin MT, Stephens PJ, Bastian BC. Kinase fusions are frequent in Spitz tumours and spitzoid melanomas. Nat Commun. 2014; 5:3116. PMID: 24445538; PMCID: PMC4084638.
    6. Bastian BC, Esteve-Puig R. Targeting activated KIT signaling for melanoma therapy. J Clin Oncol. 2013 Sep 10; 31(26):3288-90. PMID: 23940224.
      View in: PubMed
    7. Andreu-Pérez P, Esteve-Puig R, de Torre-Minguela C, López-Fauqued M, Bech-Serra JJ, Tenbaum S, García-Trevijano ER, Canals F, Merlino G, Avila MA, Recio JA. Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. Sci Signal. 2011 Sep 13; 4(190):ra58. PMID: 21917714.
      View in: PubMed
    8. Esteve-Puig R, Canals F, Colomé N, Merlino G, Recio JA. Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF. PLoS One. 2009; 4(3):e4771. PMID: 19274086; PMCID: PMC2651576.
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