Ruby Ghadially • UCSF Profiles

Ruby Ghadially, MD

Title(s)	Professor, Dermatology
School	School of Medicine
Address	4150 Clement Street, #001 San Francisco CA 94121
Phone	415-750-2091 ext. 3373
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Biography

Education and Training

University of Sheffield England		1982
University of Toronto	Residency	1988	Dermatology

Overview

Websites

Clinical Profile at UCSF Medical Center

Research

Research Activities and Funding

The role of IL17A and keratinocyte stem cells in human psoriasis.
NIH I01CX001816Oct 1, 2020 - Sep 30, 2024
Role: Principal Investigator

The role of IL17A and keratinocyte stem cells in human psoriasis
Merit Review 1 I01 CX001816-01A2Oct 1, 2020 - Sep 2, 2024
Role: Principal Investigator
Description: We will study the abnormal stem cell behavior underlying psoriasis

Characterization of Human Epidermal Stem Cells
NIH I01BX000794Oct 1, 2010 - Sep 30, 2014
Role: Principal Investigator

Reversing Epidermal Stem Cell Aging: Role of Bmi-1 and the Stem Cell Niche
NIH R21AR060651Sep 10, 2010 - May 31, 2013
Role: Principal Investigator

Characterization of Epidermal Stem Cells
NIH R01AR053765Sep 1, 2005 - May 31, 2011
Role: Principal Investigator

Epidermal Stem Cells: Age-Related Changes
NIH R03AR048667Sep 15, 2002 - Aug 31, 2005
Role: Principal Investigator

Age-Related Changes in Epidermal Stem Cells
NIH R03AG020372Sep 30, 2001 - Aug 31, 2003
Role: Principal Investigator

CYTOKINE EXPRESSION AND SIGNALLING IN AGED EPIDERMIS
NIH K08AR001973Jul 20, 1996 - May 31, 2002
Role: Principal Investigator

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

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Short cell cycle duration is a phenotype of human epidermal stem cells. Stem Cell Res Ther. 2024 Mar 13; 15(1):76. Xiao T, Eze UC, Charruyer-Reinwald A, Weisenberger T, Khalifa A, Abegaze B, Schwab GK, Elsabagh RH, Parenteau TR, Kochanowski K, Piper M, Xia Y, Cheng JB, Cho RJ, Ghadially R. PMID: 38475896; PMCID: PMC10935907.

View in: PubMed Mentions: Fields:
Cel Cell Biology The Therapeutics
Translation:Humans Cells
Classification of human chronic inflammatory skin disease based on single-cell immune profiling. Sci Immunol. 2022 04 15; 7(70):eabl9165. Liu Y, Wang H, Taylor M, Cook C, Martínez-Berdeja A, North JP, Harirchian P, Hailer AA, Zhao Z, Ghadially R, Ricardo-Gonzalez RR, Grekin RC, Mauro TM, Kim E, Choi J, Purdom E, Cho RJ, Cheng JB. PMID: 35427179; PMCID: PMC9301819.

View in: PubMed Mentions: 24 Fields:
All Allergy and Immunology
Translation:Humans
Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness. Proc Natl Acad Sci U S A. 2021 02 23; 118(8). Braz JM, Dembo T, Charruyer A, Ghadially R, Fassett MS, Basbaum AI. PMID: 33602818; PMCID: PMC7923356.

View in: PubMed Mentions: 9 Fields:
Sci Science
Translation:Animals Cells
Decreased p53 is associated with a decline in asymmetric stem cell self-renewal in aged human epidermis. Aging Cell. 2021 02; 20(2):e13310. Charruyer A, Weisenberger T, Li H, Khalifa A, Schroeder AW, Belzer A, Ghadially R. PMID: 33524216; PMCID: PMC7884041.

View in: PubMed Mentions: 4 Fields:
Cel Cell Biology
Translation:Humans
Facial psoriasis in a mask-like distribution. JAAD Case Rep. 2021 Jan; 7:128-130. Zachary CMB, Belzer A, Fackler NP, Shiu J, Smith J, Ghadially R. PMID: 33426251; PMCID: PMC7777451.

View in: PubMed Mentions:
Single-Cell Profiling Reveals Divergent, Globally Patterned Immune Responses in Murine Skin Inflammation. iScience. 2020 Oct 23; 23(10):101582. Liu Y, Cook C, Sedgewick AJ, Zhang S, Fassett MS, Ricardo-Gonzalez RR, Harirchian P, Kashem SW, Hanakawa S, Leistico JR, North JP, Taylor MA, Zhang W, Man MQ, Charruyer A, Beliakova-Bethell N, Benz SC, Ghadially R, Mauro TM, Kaplan DH, Kabashima K, Choi J, Song JS, Cho RJ, Cheng JB. PMID: 33205009; PMCID: PMC7648132.

View in: PubMed Mentions: 17
IL-1α, IL-6, and GM-CSF Are Downstream Mediators of IL-17A that Promote Asymmetric Stem Cell Self-Renewal in Human Keratinocytes. J Invest Dermatol. 2021 02; 141(2):458-462.e3. Li H, Charruyer A, Weisenberger T, Khalifa A, Nguyen R, Ghadially R. PMID: 32621824.

View in: PubMed Mentions: 2 Fields:
Der Dermatology
Translation:Humans Cells
Proderm technology: a water- based lipid delivery system for dermatitis that penetrates viable epidermis and has antibacterial effects. BMC Dermatol. 2019 01 22; 19(1):2. Charruyer A, Silvander M, Caputo-Janhager M, Raymond I, Ghadially R. PMID: 30670022; PMCID: PMC6343233.

View in: PubMed Mentions: Fields:
Der Dermatology
Translation:Humans Cells CTClinical Trials
Transcriptional Programming of Normal and Inflamed Human Epidermis at Single-Cell Resolution. Cell Rep. 2018 10 23; 25(4):871-883. Cheng JB, Sedgewick AJ, Finnegan AI, Harirchian P, Lee J, Kwon S, Fassett MS, Golovato J, Gray M, Ghadially R, Liao W, Perez White BE, Mauro TM, Mully T, Kim EA, Sbitany H, Neuhaus IM, Grekin RC, Yu SS, Gray JW, Purdom E, Paus R, Vaske CJ, Benz SC, Song JS, Cho RJ. PMID: 30355494; PMCID: PMC6367716.

View in: PubMed Mentions: 115 Fields:
Cel Cell Biology Mol Molecular Biology
Translation:Humans Cells
Influence of pH on Skin Stem Cells and Their Differentiation. Curr Probl Dermatol. 2018; 54:71-78. Charruyer A, Ghadially R. PMID: 30130775.

View in: PubMed Mentions: 7 Fields:
Der Dermatology
Translation:Humans Animals Cells
Brief Report: Interleukin-17A-Dependent Asymmetric Stem Cell Divisions Are Increased in Human Psoriasis: A Mechanism Underlying Benign Hyperproliferation. Stem Cells. 2017 08; 35(8):2001-2007. Charruyer A, Fong S, Vitcov GG, Sklar S, Tabernik L, Taneja M, Caputo M, Soeung C, Yue L, Uchida Y, Arron ST, Horton KM, Foster RD, Sano S, North JP, Ghadially R. PMID: 28600817.

View in: PubMed Mentions: 4 Fields:
Cel Cell Biology Emb Embryology
Translation:Humans Animals
Phycosaccharide AI, a mixture of alginate polysaccharides, increases stem cell proliferation in aged keratinocytes. Exp Dermatol. 2016 09; 25(9):738-40. Charruyer A, Fong S, Yue L, Arron ST, Ghadially R. PMID: 27095184.

View in: PubMed Mentions: 2 Fields:
Der Dermatology
Translation:Humans Cells
Targeting ALDH1 to decrease tumorigenicity, growth and metastasis of human melanoma. Melanoma Res. 2015 Apr; 25(2):138-48. Yue L, Huang ZM, Fong S, Leong S, Jakowatz JG, Charruyer-Reinwald A, Wei M, Ghadially R. PMID: 25643237.

View in: PubMed Mentions: 35 Fields:
Neo Neoplasms
Translation:Humans Animals Cells
The CD44+ ALDH+ population of human keratinocytes is enriched for epidermal stem cells with long-term repopulating ability. Stem Cells. 2013 Apr; 31(4):786-99. Szabo AZ, Fong S, Yue L, Zhang K, Strachan LR, Scalapino K, Mancianti ML, Ghadially R. PMID: 23335266; PMCID: PMC4104573.

View in: PubMed Mentions: 16 Fields:
Cel Cell Biology Emb Embryology
Translation:Humans Animals Cells
CD133 is a marker for long-term repopulating murine epidermal stem cells. J Invest Dermatol. 2012 Nov; 132(11):2522-33. Charruyer A, Strachan LR, Yue L, Toth AS, Cecchini G, Mancianti ML, Ghadially R. PMID: 22763787; PMCID: PMC3997791.

View in: PubMed Mentions: 11 Fields:
Der Dermatology
Translation:Animals Cells
25 years of epidermal stem cell research. J Invest Dermatol. 2012 Mar; 132(3 Pt 2):797-810. Ghadially R. PMID: 22205306; PMCID: PMC3998762.

View in: PubMed Mentions: 31 Fields:
Der Dermatology
Translation:Cells
The role of stem and circulating cells in cancer metastasis. J Surg Oncol. 2011 May 01; 103(6):555-7. Ghadially R. PMID: 21480249.

View in: PubMed Mentions: 8 Fields:
Gen General Surgery Neo Neoplasms
Translation:Humans Cells
What's new in dermatology: epidermal stem cells. G Ital Dermatol Venereol. 2011 Feb; 146(1):57-67. Charruyer A, Ghadially R. PMID: 21317858.

View in: PubMed Mentions: 3 Fields:
Der Dermatology Sex Sexually Transmitted Diseases
Translation:Humans Animals Cells
Selection of tumorigenic melanoma cells using ALDH. J Invest Dermatol. 2010 Dec; 130(12):2799-808. Boonyaratanakornkit JB, Yue L, Strachan LR, Scalapino KJ, LeBoit PE, Lu Y, Leong SP, Smith JE, Ghadially R. PMID: 20739950; PMCID: PMC5621840.

View in: PubMed Mentions: 56 Fields:
Der Dermatology
Translation:Humans Animals Cells
Limiting dilution analysis of murine epidermal stem cells using an in vivo regeneration assay. Methods Mol Biol. 2010; 585:421-32. Strachan LR, Ghadially R. PMID: 19908020; PMCID: PMC2783164.

View in: PubMed Mentions: 2 Fields:
Mol Molecular Biology
Translation:Animals Cells
Transit-amplifying cell frequency and cell cycle kinetics are altered in aged epidermis. J Invest Dermatol. 2009 Nov; 129(11):2574-83. Charruyer A, Barland CO, Yue L, Wessendorf HB, Lu Y, Lawrence HJ, Mancianti ML, Ghadially R. PMID: 19458632.

View in: PubMed Mentions: 18 Fields:
Der Dermatology
Translation:Animals Cells
Stem cells and tissue-engineered skin. Skin Pharmacol Physiol. 2009; 22(2):55-62. Charruyer A, Ghadially R. PMID: 19188753; PMCID: PMC2709994.

View in: PubMed Mentions: 10 Fields:
Der Dermatology Pha Pharmacology Phy Physiology
Translation:Humans Animals Cells
Tiers of clonal organization in the epidermis: the epidermal proliferation unit revisited. Stem Cell Rev. 2008 Sep; 4(3):149-57. Strachan LR, Ghadially R. PMID: 18574734.

View in: PubMed Mentions: 11 Fields:
Cel Cell Biology
Translation:Humans Animals Cells
Rapid adhesion to collagen isolates murine keratinocytes with limited long-term repopulating ability in vivo despite high clonogenicity in vitro. Stem Cells. 2008 Jan; 26(1):235-43. Strachan LR, Scalapino KJ, Lawrence HJ, Ghadially R. PMID: 17932419.

View in: PubMed Mentions: 11 Fields:
Cel Cell Biology Emb Embryology
Translation:Animals Cells
A new water-based topical carrier with polar skin-lipids. Lipids Health Dis. 2006 May 03; 5:12. Silvander M, Ringstad L, Ghadially R, Sköld T. PMID: 16672068; PMCID: PMC1464131.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Met Metabolism
Translation:Animals Cells
Epidermal stem cells. Adv Dermatol. 2005; 21:335-55. Ghadially R. PMID: 16350449.

View in: PubMed Mentions: Fields:
Der Dermatology
Translation:Humans Cells
In search of the elusive epidermal stem cell. Ernst Schering Res Found Workshop. 2005; (54):45-62. Ghadially R. PMID: 16080286.

View in: PubMed Mentions: 2 Fields:
Med Medicine (General)
Translation:Humans Cells
Imiquimod-induced interleukin-1 alpha stimulation improves barrier homeostasis in aged murine epidermis. J Invest Dermatol. 2004 Feb; 122(2):330-6. Barland CO, Zettersten E, Brown BS, Ye J, Elias PM, Ghadially R. PMID: 15009713.

View in: PubMed Mentions: 30 Fields:
Der Dermatology
Translation:Humans Animals Cells
Measuring stem cell frequency in epidermis: a quantitative in vivo functional assay for long-term repopulating cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11412-7. Schneider TE, Barland C, Alex AM, Mancianti ML, Lu Y, Cleaver JE, Lawrence HJ, Ghadially R. PMID: 13679571; PMCID: PMC208771.

View in: PubMed Mentions: 20 Fields:
Sci Science
Translation:Animals Cells
Alterations in cytokine regulation in aged epidermis: implications for permeability barrier homeostasis and inflammation. I. IL-1 gene family. Exp Dermatol. 2002 Jun; 11(3):209-16. Ye J, Garg A, Calhoun C, Feingold KR, Elias PM, Ghadially R. PMID: 12102659.

View in: PubMed Mentions: 26 Fields:
Der Dermatology
Translation:Animals
The aged epidermal permeability barrier: basis for functional abnormalities. Clin Geriatr Med. 2002 Feb; 18(1):103-20, vii. Elias PM, Ghadially R. PMID: 11913735.

View in: PubMed Mentions: 16 Fields:
Ger Geriatrics
Translation:Humans
Testosterone perturbs epidermal permeability barrier homeostasis. J Invest Dermatol. 2001 Mar; 116(3):443-51. Kao JS, Garg A, Mao-Qiang M, Crumrine D, Ghadially R, Feingold KR, Elias PM. PMID: 11231319.

View in: PubMed Mentions: 11 Fields:
Der Dermatology
Translation:Humans Animals
Recessive x-linked ichthyosis: role of cholesterol-sulfate accumulation in the barrier abnormality. J Invest Dermatol. 1998 Nov; 111(5):784-90. Zettersten E, Man MQ, Sato J, Denda M, Farrell A, Ghadially R, Williams ML, Feingold KR, Elias PM. PMID: 9804339.

View in: PubMed Mentions: 13 Fields:
Der Dermatology
Translation:Humans Animals Cells
Aging and the epidermal permeability barrier: implications for contact dermatitis. Am J Contact Dermat. 1998 Sep; 9(3):162-9. Ghadially R. PMID: 9744909.

View in: PubMed Mentions: 6 Fields:
Der Dermatology
Translation:Humans Cells
Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol. 1997 Sep; 37(3 Pt 1):403-8. Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. PMID: 9308554.

View in: PubMed Mentions: 14 Fields:
Der Dermatology
Translation:Humans Animals
Stratum corneum structure and function correlates with phenotype in psoriasis. J Invest Dermatol. 1996 Oct; 107(4):558-64. Ghadially R, Reed JT, Elias PM. PMID: 8823361.

View in: PubMed Mentions: 43 Fields:
Der Dermatology
Translation:Humans
Decreased epidermal lipid synthesis accounts for altered barrier function in aged mice. J Invest Dermatol. 1996 May; 106(5):1064-9. Ghadially R, Brown BE, Hanley K, Reed JT, Feingold KR, Elias PM. PMID: 8618040.

View in: PubMed Mentions: 16 Fields:
Der Dermatology
Translation:Animals
Tumours of the skin. IARC Sci Publ. 1996; (126):1-43. Ghadially FN, Ghadially R. PMID: 8875259.

View in: PubMed Mentions: Fields:
Neo Neoplasms
Translation:Animals
Skin type, but neither race nor gender, influence epidermal permeability barrier function. Arch Dermatol. 1995 Oct; 131(10):1134-8. Reed JT, Ghadially R, Elias PM. PMID: 7574829.

View in: PubMed Mentions: 38 Fields:
Der Dermatology
Translation:Humans
The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model. J Clin Invest. 1995 May; 95(5):2281-90. Ghadially R, Brown BE, Sequeira-Martin SM, Feingold KR, Elias PM. PMID: 7738193; PMCID: PMC295841.

View in: PubMed Mentions: 85 Fields:
Med Medicine (General)
Translation:Humans Animals
Membrane structural abnormalities in the stratum corneum of the autosomal recessive ichthyoses. J Invest Dermatol. 1992 Dec; 99(6):755-63. Ghadially R, Williams ML, Hou SY, Elias PM. PMID: 1469289.

View in: PubMed Mentions: 12 Fields:
Der Dermatology
Translation:Humans Cells
Exogenous origin of n-alkanes in pathologic scale. Arch Dermatol. 1992 Aug; 128(8):1065-71. Williams ML, Vogel JS, Ghadially R, Brown BE, Elias PM. PMID: 1497360.

View in: PubMed Mentions: 3 Fields:
Der Dermatology
Translation:Humans Animals
Ichthyoses and hyperkeratotic disorders. Dermatol Clin. 1992 Jul; 10(3):597-607. Ghadially R, Chong LP. PMID: 1617817.

View in: PubMed Mentions: Fields:
Der Dermatology
Translation:Humans
Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation. Br J Dermatol. 1992 Apr; 126(4):337-45. Menon GK, Ghadially R, Williams ML, Elias PM. PMID: 1571254.

View in: PubMed Mentions: 18 Fields:
Der Dermatology
Translation:Humans Animals Cells
Effects of petrolatum on stratum corneum structure and function. J Am Acad Dermatol. 1992 Mar; 26(3 Pt 2):387-96. Ghadially R, Halkier-Sorensen L, Elias PM. PMID: 1564142.

View in: PubMed Mentions: 29 Fields:
Der Dermatology
Translation:Humans Animals CTClinical Trials
Membrane structures in normal and essential fatty acid-deficient stratum corneum: characterization by ruthenium tetroxide staining and x-ray diffraction. J Invest Dermatol. 1991 Feb; 96(2):215-23. Hou SY, Mitra AK, White SH, Menon GK, Ghadially R, Elias PM. PMID: 1991982.

View in: PubMed Mentions: 65 Fields:
Der Dermatology
Translation:Animals Cells
Anchoring fibrils in a spindle cell squamous carcinoma. J Submicrosc Cytol Pathol. 1989 Apr; 21(2):249-57. Ghadially R, Ghadially FN. PMID: 2752358.

View in: PubMed Mentions: 2 Fields:
Cel Cell Biology Pat Pathology
Translation:Humans Cells
Simple method for purification of phospholipase A from cobra venom. Toxicon. 1969 Sep; 7(2):151-7. Braganca BM, Sambray YM, Ghadially RC. PMID: 5387831.

View in: PubMed Mentions: 1 Fields:
Tox Toxicology
Translation:Animals Cells
Myo-Inositol activity of oxidtion products derived from myo-inositol. Arch Biochem Biophys. 1962 Dec; 99:537-8. JOHNSTON JA, GHADIALLY RC, ROBERTS RN, FUHR BW. PMID: 13957897.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry Bio Biophysics