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    Sarah Nelson, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address1700 4th Street
    San Francisco CA 94158
    Phone415-476-6383

       Biography 
       Awards and Honors
      Academy of Radiology Research 2014Distinguished Investigator
      ISMRM, Salt Lake City2013Outstanding Teacher Award
      Academy of Radiology Research2013Distinguished Investigator
      University of California, San Francisco Graduate Division Alumni Association2012Outstanding Faculty Mentorship Award
      San Francisco Business Times2012Most Influential Bay Area Women Award
      AACR2010Expert Speaker
      Surbeck Laboratory of Advanced Imaging2004Margaret Hart Surbeck Distinguished Professorship in Advanced Imaging
      International Society of Magnetic Resonance in Medicine1998Fellow

       Overview 
       Overview
      Sarah J. Nelson, PhD, is a Professor of Radiology and Biomedical Imaging with secondary appointment in the Department of Neurology. She is the Margaret Hart Surbeck Distinguished Professor of Advanced Imaging, Director of the Surbeck Laboratory, and Director of the Brain Research Interest Group at the University of California, San Francisco. She completed her BSc in Mathematics at the University of Manchester in England, and obtained her PhD in Biomathematics at the University of Heidelberg, Department of Mathematics in West Germany. She completed a postdoctoral fellowship in Biostatics at Fox Chase Institute for Cancer Research in Philadelphia, Pennsylvania.

      As Director of the Surbeck Laboratory, Dr. Nelson is responsible for managing the recharge operations for three research MR scanners, the 3T system at the Center of Molecular and Functional Imaging, and the 3T and 7T systems at the Institute for Quantitative Biosciences (QB3) at UCSF Byers Hall Mission Bay Campus. Her research program is focused on the development of techniques for acquisition, reconstruction, and quantitative analysis of magnetic resonance (MR) imaging and spectral data with the goal of improving the sensitivity and specificity of the data obtained for characterizing human diseases, selecting therapies, and monitoring novel treatment paradigms.

      Dr. Nelson has served as Principal Investigator and Co-Principal Investigator for numerous NIH grants, and she has published over 200 research articles.

      Expertise:
      Bioengineering, Mathematics

      Specialty:
      Magnetic resonance imaging and spectroscopy

      Professional Interests:
      Magnetic resonance imaging and spectroscopy, image reconstruction, signal processing, algorithm development, quantitative analysis, imaging biomarker discovery, neurological diseases, evaluation of therapy, brain cancer, prostate cancer, multiple sclerosis

      Education and Training:
      • Bachelor of Science: University of Manchester, England - Mathematics
      • Doctor of Philosophy: University of Heidelberg Department of Mathematics, West Germany - Biomathematics
      • Postdoctoral Fellowship: Fox Chase Institute for Cancer Research, Philadelphia, Pennsylvania - Biostatistics

       Interests
      Bioengineering, magnetic resonance imaging and spectroscopy, image reconstruction, signal processing, algorithm development, quantitative analysis, imaging biomarker discovery, neurological diseases, evaluation of therapy, brain cancer, prostate cancer, multiple sclerosis.

       ORNG Applications 
       Websites
       In The News
       Awarded Grants
       Global Health
       More Info

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. Metabolic imaging of patients with prostate cancer using hyperpolarized [1-¹³C]pyruvate. Sci Transl Med. 2013 Aug 14; 5(198):198ra108.
        View in: PubMed
      2. Barajas RF, Hess CP, Phillips JJ, Von Morze CJ, Yu JP, Chang SM, Nelson SJ, McDermott MW, Berger MS, Cha S. Super-resolution track density imaging of glioblastoma: histopathologic correlation. AJNR Am J Neuroradiol. 2013 Jul; 34(7):1319-25.
        View in: PubMed
      3. Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014 Jan; 71(1):1-11.
        View in: PubMed
      4. Nelson SJ, Ozhinsky E, Li Y, Park Iw, Crane J. Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging. J Magn Reson. 2013 Apr; 229:187-97.
        View in: PubMed
      5. Lupo JM, Essock-Burns E, Molinaro AM, Cha S, Chang SM, Butowski N, Nelson SJ. Using susceptibility-weighted imaging to determine response to combined anti-angiogenic, cytotoxic, and radiation therapy in patients with glioblastoma multiforme. Neuro Oncol. 2013 Apr; 15(4):480-9.
        View in: PubMed
      6. Li Y, Lupo JM, Parvataneni R, Lamborn KR, Cha S, Chang SM, Nelson SJ. Survival analysis in patients with newly diagnosed glioblastoma using pre- and postradiotherapy MR spectroscopic imaging. Neuro Oncol. 2013 May; 15(5):607-17.
        View in: PubMed
      7. Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013 Sep; 38(3):701-13.
        View in: PubMed
      8. Essock-Burns E, Phillips JJ, Molinaro AM, Lupo JM, Cha S, Chang SM, Nelson SJ. Comparison of DSC-MRI post-processing techniques in predicting microvascular histopathology in patients newly diagnosed with GBM. J Magn Reson Imaging. 2013 Aug; 38(2):388-400.
        View in: PubMed
      9. Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-¹³C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013 May; 31(4):490-6.
        View in: PubMed
      10. Park I, Hu S, Bok R, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ. Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Jul; 70(1):33-9.
        View in: PubMed
      11. Barajas RF, Phillips JJ, Parvataneni R, Molinaro A, Essock-Burns E, Bourne G, Parsa AT, Aghi MK, McDermott MW, Berger MS, Cha S, Chang SM, Nelson SJ. Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging. Neuro Oncol. 2012 Jul; 14(7):942-54.
        View in: PubMed
      12. Ozhinsky E, Vigneron DB, Chang SM, Nelson SJ. Automated prescription of oblique brain 3D magnetic resonance spectroscopic imaging. Magn Reson Med. 2013 Apr; 69(4):920-30.
        View in: PubMed
      13. Bian W, Harter K, Hammond-Rosenbluth KE, Lupo JM, Xu D, Kelley DA, Vigneron DB, Nelson SJ, Pelletier D. A serial in vivo 7T magnetic resonance phase imaging study of white matter lesions in multiple sclerosis. Mult Scler. 2013 Jan; 19(1):69-75.
        View in: PubMed
      14. Constantin A, Elkhaled A, Jalbert L, Srinivasan R, Cha S, Chang SM, Bajcsy R, Nelson SJ. Identifying malignant transformations in recurrent low grade gliomas using high resolution magic angle spinning spectroscopy. Artif Intell Med. 2012 May; 55(1):61-70.
        View in: PubMed
      15. Ozturk-Isik E, Pirzkall A, Lamborn KR, Cha S, Chang SM, Nelson SJ. Spatial characteristics of newly diagnosed grade 3 glioma assessed by magnetic resonance metabolic and diffusion tensor imaging. Transl Oncol. 2012 Feb; 5(1):10-8.
        View in: PubMed
      16. Wu B, Zhang X, Wang C, Li Y, Pang Y, Lu J, Xu D, Majumdar S, Nelson SJ, Vigneron DB. Flexible transceiver array for ultrahigh field human MR imaging. Magn Reson Med. 2012 Oct; 68(4):1332-8.
        View in: PubMed
      17. Elkhaled A, Jalbert LE, Phillips JJ, Yoshihara HA, Parvataneni R, Srinivasan R, Bourne G, Berger MS, Chang SM, Cha S, Nelson SJ. Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas. Sci Transl Med. 2012 Jan 11; 4(116):116ra5.
        View in: PubMed
      18. Lupo JM, Li Y, Hess CP, Nelson SJ. Advances in ultra-high field MRI for the clinical management of patients with brain tumors. Curr Opin Neurol. 2011 Dec; 24(6):605-15.
        View in: PubMed
      19. Pang Y, Xie Z, Xu D, Kelley DA, Nelson SJ, Vigneron DB, Zhang X. A dual-tuned quadrature volume coil with mixed ?/2 and ?/4 microstrip resonators for multinuclear MRSI at 7 T. Magn Reson Imaging. 2012 Feb; 30(2):290-8.
        View in: PubMed
      20. Wang C, Li Y, Wu B, Xu D, Nelson SJ, Vigneron DB, Zhang X. A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7 T. Magn Reson Imaging. 2012 Jan; 30(1):78-84.
        View in: PubMed
      21. Lupo JM, Chuang CF, Chang SM, Barani IJ, Jimenez B, Hess CP, Nelson SJ. 7-Tesla susceptibility-weighted imaging to assess the effects of radiotherapy on normal-appearing brain in patients with glioma. Int J Radiat Oncol Biol Phys. 2012 Mar 1; 82(3):e493-500.
        View in: PubMed
      22. Wu B, Wang C, Lu J, Pang Y, Nelson SJ, Vigneron DB, Zhang X. Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans. IEEE Trans Med Imaging. 2012 Feb; 31(2):183-91.
        View in: PubMed
      23. Khayal IS, Vandenberg SR, Smith KJ, Cloyd CP, Chang SM, Cha S, Nelson SJ, McKnight TR. MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas. Neuro Oncol. 2011 Nov; 13(11):1192-201.
        View in: PubMed
      24. Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM. Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage. 2012 Jan 2; 59(1):193-201.
        View in: PubMed
      25. Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression. Cell Metab. 2011 Jul 6; 14(1):131-42.
        View in: PubMed
      26. Nelson SJ. Assessment of therapeutic response and treatment planning for brain tumors using metabolic and physiological MRI. NMR Biomed. 2011 Jul; 24(6):734-49.
        View in: PubMed
      27. Ozhinsky E, Vigneron DB, Nelson SJ. Improved spatial coverage for brain 3D PRESS MRSI by automatic placement of outer-volume suppression saturation bands. J Magn Reson Imaging. 2011 Apr; 33(4):792-802.
        View in: PubMed
      28. Li Y, Lupo JM, Polley MY, Crane JC, Bian W, Cha S, Chang S, Nelson SJ. Serial analysis of imaging parameters in patients with newly diagnosed glioblastoma multiforme. Neuro Oncol. 2011 May; 13(5):546-57.
        View in: PubMed
      29. Essock-Burns E, Lupo JM, Cha S, Polley MY, Butowski NA, Chang SM, Nelson SJ. Assessment of perfusion MRI-derived parameters in evaluating and predicting response to antiangiogenic therapy in patients with newly diagnosed glioblastoma. Neuro Oncol. 2011 Jan; 13(1):119-31.
        View in: PubMed
      30. Kerchner GA, Hess CP, Hammond-Rosenbluth KE, Xu D, Rabinovici GD, Kelley DA, Vigneron DB, Nelson SJ, Miller BL. Hippocampal CA1 apical neuropil atrophy in mild Alzheimer disease visualized with 7-T MRI. Neurology. 2010 Oct 12; 75(15):1381-7.
        View in: PubMed
      31. Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011 Mar; 65(3):610-9.
        View in: PubMed
      32. Baranzini SE, Srinivasan R, Khankhanian P, Okuda DT, Nelson SJ, Matthews PM, Hauser SL, Oksenberg JR, Pelletier D. Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis. Brain. 2010 Sep; 133(9):2603-11.
        View in: PubMed
      33. Park I, Chen AP, Zierhut ML, Ozturk-Isik E, Vigneron DB, Nelson SJ. Implementation of 3 T lactate-edited 3D 1H MR spectroscopic imaging with flyback echo-planar readout for gliomas patients. Ann Biomed Eng. 2011 Jan; 39(1):193-204.
        View in: PubMed
      34. Srinivasan R, Phillips JJ, Vandenberg SR, Polley MY, Bourne G, Au A, Pirzkall A, Cha S, Chang SM, Nelson SJ. Ex vivo MR spectroscopic measure differentiates tumor from treatment effects in GBM. Neuro Oncol. 2010 Nov; 12(11):1152-61.
        View in: PubMed
      35. Khayal IS, Polley MY, Jalbert L, Elkhaled A, Chang SM, Cha S, Butowski NA, Nelson SJ. Evaluation of diffusion parameters as early biomarkers of disease progression in glioblastoma multiforme. Neuro Oncol. 2010 Sep; 12(9):908-16.
        View in: PubMed
      36. Wilson DM, Keshari KR, Larson PE, Chen AP, Hu S, Van Criekinge M, Bok R, Nelson SJ, Macdonald JM, Vigneron DB, Kurhanewicz J. Multi-compound polarization by DNP allows simultaneous assessment of multiple enzymatic activities in vivo. J Magn Reson. 2010 Jul; 205(1):141-7.
        View in: PubMed
      37. Larson PE, Bok R, Kerr AB, Lustig M, Hu S, Chen AP, Nelson SJ, Pauly JM, Kurhanewicz J, Vigneron DB. Investigation of tumor hyperpolarized [1-13C]-pyruvate dynamics using time-resolved multiband RF excitation echo-planar MRSI. Magn Reson Med. 2010 Mar; 63(3):582-91.
        View in: PubMed
      38. Ward CS, Venkatesh HS, Chaumeil MM, Brandes AH, Vancriekinge M, Dafni H, Sukumar S, Nelson SJ, Vigneron DB, Kurhanewicz J, James CD, Haas-Kogan DA, Ronen SM. Noninvasive detection of target modulation following phosphatidylinositol 3-kinase inhibition using hyperpolarized 13C magnetic resonance spectroscopy. Cancer Res. 2010 Feb 15; 70(4):1296-305.
        View in: PubMed
      39. Hu S, Lustig M, Balakrishnan A, Larson PE, Bok R, Kurhanewicz J, Nelson SJ, Goga A, Pauly JM, Vigneron DB. 3D compressed sensing for highly accelerated hyperpolarized (13)C MRSI with in vivo applications to transgenic mouse models of cancer. Magn Reson Med. 2010 Feb; 63(2):312-21.
        View in: PubMed
      40. Park I, Larson PE, Zierhut ML, Hu S, Bok R, Ozawa T, Kurhanewicz J, Vigneron DB, Vandenberg SR, James CD, Nelson SJ. Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors. Neuro Oncol. 2010 Feb; 12(2):133-44.
        View in: PubMed
      41. Xu D, Lee MC, Carballido-Gamio J, Barkovich M, Majumdar S, Vigneron DB, Nelson SJ. Quantitative analysis of spatial distortions of diffusion techniques at 3T. Magn Reson Imaging. 2010 Apr; 28(3):451-4.
        View in: PubMed
      42. Bian W, Khayal IS, Lupo JM, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson SJ. Multiparametric characterization of grade 2 glioma subtypes using magnetic resonance spectroscopic, perfusion, and diffusion imaging. Transl Oncol. 2009 Dec; 2(4):271-80.
        View in: PubMed
      43. Pirzkall A, McGue C, Saraswathy S, Cha S, Liu R, Vandenberg S, Lamborn KR, Berger MS, Chang SM, Nelson SJ. Tumor regrowth between surgery and initiation of adjuvant therapy in patients with newly diagnosed glioblastoma. Neuro Oncol. 2009 Dec; 11(6):842-52.
        View in: PubMed
      44. Zierhut ML, Yen YF, Chen AP, Bok R, Albers MJ, Zhang V, Tropp J, Park I, Vigneron DB, Kurhanewicz J, Hurd RE, Nelson SJ. Kinetic modeling of hyperpolarized 13C1-pyruvate metabolism in normal rats and TRAMP mice. J Magn Reson. 2010 Jan; 202(1):85-92.
        View in: PubMed
      45. Wu B, Wang C, Kelley DA, Xu D, Vigneron DB, Nelson SJ, Zhang X. Shielded microstrip array for 7T human MR imaging. IEEE Trans Med Imaging. 2010 Jan; 29(1):179-84.
        View in: PubMed
      46. Ozturk-Isik E, Chen AP, Crane JC, Bian W, Xu D, Han ET, Chang SM, Vigneron DB, Nelson SJ. 3D sensitivity encoded ellipsoidal MR spectroscopic imaging of gliomas at 3T. Magn Reson Imaging. 2009 Nov; 27(9):1249-57.
        View in: PubMed
      47. Zierhut ML, Ozturk-Isik E, Chen AP, Park I, Vigneron DB, Nelson SJ. (1)H spectroscopic imaging of human brain at 3 Tesla: comparison of fast three-dimensional magnetic resonance spectroscopic imaging techniques. J Magn Reson Imaging. 2009 Sep; 30(3):473-80.
        View in: PubMed
      48. Wu B, Wang C, Krug R, Kelley DA, Xu D, Pang Y, Banerjee S, Vigneron DB, Nelson SJ, Majumdar S, Zhang X. 7T human spine imaging arrays with adjustable inductive decoupling. IEEE Trans Biomed Eng. 2010 Feb; 57(2):397-403.
        View in: PubMed
      49. Srinivasan R, Ratiney H, Hammond-Rosenbluth KE, Pelletier D, Nelson SJ. MR spectroscopic imaging of glutathione in the white and gray matter at 7 T with an application to multiple sclerosis. Magn Reson Imaging. 2010 Feb; 28(2):163-70.
        View in: PubMed
      50. Lupo JM, Chen AP, Zierhut ML, Bok RA, Cunningham CH, Kurhanewicz J, Vigneron DB, Nelson SJ. Analysis of hyperpolarized dynamic 13C lactate imaging in a transgenic mouse model of prostate cancer. Magn Reson Imaging. 2010 Feb; 28(2):153-62.
        View in: PubMed
      51. Banerjee S, Ozturk-Isik E, Nelson SJ, Majumdar S. Elliptical magnetic resonance spectroscopic imaging with GRAPPA for imaging brain tumors at 3 T. Magn Reson Imaging. 2009 Dec; 27(10):1319-25.
        View in: PubMed
      52. Khayal IS, Nelson SJ. Characterization of low-grade gliomas using RGB color maps derived from ADC histograms. J Magn Reson Imaging. 2009 Jul; 30(1):209-13.
        View in: PubMed
      53. Yen YF, Kohler SJ, Chen AP, Tropp J, Bok R, Wolber J, Albers MJ, Gram KA, Zierhut ML, Park I, Zhang V, Hu S, Nelson SJ, Vigneron DB, Kurhanewicz J, Dirven HA, Hurd RE. Imaging considerations for in vivo 13C metabolic mapping using hyperpolarized 13C-pyruvate. Magn Reson Med. 2009 Jul; 62(1):1-10.
        View in: PubMed
      54. Hu S, Chen AP, Zierhut ML, Bok R, Yen YF, Schroeder MA, Hurd RE, Nelson SJ, Kurhanewicz J, Vigneron DB. In vivo carbon-13 dynamic MRS and MRSI of normal and fasted rat liver with hyperpolarized 13C-pyruvate. Mol Imaging Biol. 2009 Nov-Dec; 11(6):399-407.
        View in: PubMed
      55. Khayal IS, McKnight TR, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson SJ. Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas. NMR Biomed. 2009 May; 22(4):449-55.
        View in: PubMed
      56. Wilson DM, Hurd RE, Keshari K, Van Criekinge M, Chen AP, Nelson SJ, Vigneron DB, Kurhanewicz J. Generation of hyperpolarized substrates by secondary labeling with [1,1-13C] acetic anhydride. Proc Natl Acad Sci U S A. 2009 Apr 7; 106(14):5503-7.
        View in: PubMed
      57. Osorio JA, Xu D, Cunningham CH, Chen A, Kerr AB, Pauly JM, Vigneron DB, Nelson SJ. Design of cosine modulated very selective suppression pulses for MR spectroscopic imaging at 3T. Magn Reson Med. 2009 Mar; 61(3):533-40.
        View in: PubMed
      58. Metcalf M, Xu D, Okuda DT, Carvajal L, Srinivasan R, Kelley DA, Mukherjee P, Nelson SJ, Vigneron DB, Pelletier D. High-resolution phased-array MRI of the human brain at 7 tesla: initial experience in multiple sclerosis patients. J Neuroimaging. 2010 Apr; 20(2):141-7.
        View in: PubMed
      59. Hammond KE, Metcalf M, Carvajal L, Okuda DT, Srinivasan R, Vigneron D, Nelson SJ, Pelletier D. Quantitative in vivo magnetic resonance imaging of multiple sclerosis at 7 Tesla with sensitivity to iron. Ann Neurol. 2008 Dec; 64(6):707-13.
        View in: PubMed
      60. Okuda DT, Srinivasan R, Oksenberg JR, Goodin DS, Baranzini SE, Beheshtian A, Waubant E, Zamvil SS, Leppert D, Qualley P, Lincoln R, Gomez R, Caillier S, George M, Wang J, Nelson SJ, Cree BA, Hauser SL, Pelletier D. Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. Brain. 2009 Jan; 132(Pt 1):250-9.
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      61. Crawford FW, Khayal IS, McGue C, Saraswathy S, Pirzkall A, Cha S, Lamborn KR, Chang SM, Berger MS, Nelson SJ. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM. J Neurooncol. 2009 Feb; 91(3):337-51.
        View in: PubMed
      62. Albers MJ, Bok R, Chen AP, Cunningham CH, Zierhut ML, Zhang VY, Kohler SJ, Tropp J, Hurd RE, Yen YF, Nelson SJ, Vigneron DB, Kurhanewicz J. Hyperpolarized 13C lactate, pyruvate, and alanine: noninvasive biomarkers for prostate cancer detection and grading. Cancer Res. 2008 Oct 15; 68(20):8607-15.
        View in: PubMed
      63. Lupo JM, Banerjee S, Hammond KE, Kelley DA, Xu D, Chang SM, Vigneron DB, Majumdar S, Nelson SJ. GRAPPA-based susceptibility-weighted imaging of normal volunteers and patients with brain tumor at 7 T. Magn Reson Imaging. 2009 May; 27(4):480-8.
        View in: PubMed
      64. Saraswathy S, Crawford FW, Lamborn KR, Pirzkall A, Chang S, Cha S, Nelson SJ. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy. J Neurooncol. 2009 Jan; 91(1):69-81.
        View in: PubMed
      65. Tessem MB, Swanson MG, Keshari KR, Albers MJ, Joun D, Tabatabai ZL, Simko JP, Shinohara K, Nelson SJ, Vigneron DB, Gribbestad IS, Kurhanewicz J. Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Magn Reson Med. 2008 Sep; 60(3):510-6.
        View in: PubMed
      66. Li Y, Srinivasan R, Ratiney H, Lu Y, Chang SM, Nelson SJ. Comparison of T(1) and T(2) metabolite relaxation times in glioma and normal brain at 3T. J Magn Reson Imaging. 2008 Aug; 28(2):342-50.
        View in: PubMed
      67. Xu D, Cunningham CH, Chen AP, Li Y, Kelley DA, Mukherjee P, Pauly JM, Nelson SJ, Vigneron DB. Phased array 3D MR spectroscopic imaging of the brain at 7 T. Magn Reson Imaging. 2008 Nov; 26(9):1201-6.
        View in: PubMed
      68. Chen AP, Kurhanewicz J, Bok R, Xu D, Joun D, Zhang V, Nelson SJ, Hurd RE, Vigneron DB. Feasibility of using hyperpolarized [1-13C]lactate as a substrate for in vivo metabolic 13C MRSI studies. Magn Reson Imaging. 2008 Jul; 26(6):721-6.
        View in: PubMed
      69. Lee MC, Nelson SJ. Supervised pattern recognition for the prediction of contrast-enhancement appearance in brain tumors from multivariate magnetic resonance imaging and spectroscopy. Artif Intell Med. 2008 May; 43(1):61-74.
        View in: PubMed
      70. Khayal IS, Crawford FW, Saraswathy S, Lamborn KR, Chang SM, Cha S, McKnight TR, Nelson SJ. Relationship between choline and apparent diffusion coefficient in patients with gliomas. J Magn Reson Imaging. 2008 Apr; 27(4):718-25.
        View in: PubMed
      71. Cunningham CH, Chen AP, Lustig M, Hargreaves BA, Lupo J, Xu D, Kurhanewicz J, Hurd RE, Pauly JM, Nelson SJ, Vigneron DB. Pulse sequence for dynamic volumetric imaging of hyperpolarized metabolic products. J Magn Reson. 2008 Jul; 193(1):139-46.
        View in: PubMed
      72. Hu S, Lustig M, Chen AP, Crane J, Kerr A, Kelley DA, Hurd R, Kurhanewicz J, Nelson SJ, Pauly JM, Vigneron DB. Compressed sensing for resolution enhancement of hyperpolarized 13C flyback 3D-MRSI. J Magn Reson. 2008 Jun; 192(2):258-64.
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      73. Kurhanewicz J, Bok R, Nelson SJ, Vigneron DB. Current and potential applications of clinical 13C MR spectroscopy. J Nucl Med. 2008 Mar; 49(3):341-4.
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      74. Chen AP, Albers MJ, Cunningham CH, Kohler SJ, Yen YF, Hurd RE, Tropp J, Bok R, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Hyperpolarized C-13 spectroscopic imaging of the TRAMP mouse at 3T-initial experience. Magn Reson Med. 2007 Dec; 58(6):1099-106.
        View in: PubMed
      75. Hammond KE, Lupo JM, Xu D, Metcalf M, Kelley DA, Pelletier D, Chang SM, Mukherjee P, Vigneron DB, Nelson SJ. Development of a robust method for generating 7.0 T multichannel phase images of the brain with application to normal volunteers and patients with neurological diseases. Neuroimage. 2008 Feb 15; 39(4):1682-92.
        View in: PubMed
      76. Li Y, Chen AP, Crane JC, Chang SM, Vigneron DB, Nelson SJ. Three-dimensional J-resolved H-1 magnetic resonance spectroscopic imaging of volunteers and patients with brain tumors at 3T. Magn Reson Med. 2007 Nov; 58(5):886-92.
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      77. Chuang CF, Chan AA, Larson D, Verhey LJ, McDermott M, Nelson SJ, Pirzkall A. Potential value of MR spectroscopic imaging for the radiosurgical management of patients with recurrent high-grade gliomas. Technol Cancer Res Treat. 2007 Oct; 6(5):375-82.
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      78. Lupo JM, Cha S, Chang SM, Nelson SJ. Analysis of metabolic indices in regions of abnormal perfusion in patients with high-grade glioma. AJNR Am J Neuroradiol. 2007 Sep; 28(8):1455-61.
        View in: PubMed
      79. Osorio JA, Ozturk-Isik E, Xu D, Cha S, Chang S, Berger MS, Vigneron DB, Nelson SJ. 3D 1H MRSI of brain tumors at 3.0 Tesla using an eight-channel phased-array head coil. J Magn Reson Imaging. 2007 Jul; 26(1):23-30.
        View in: PubMed
      80. Ratiney H, Noworolski SM, Sdika M, Srinivasan R, Henry RG, Nelson SJ, Pelletier D. Estimation of metabolite T1 relaxation times using tissue specific analysis, signal averaging and bootstrapping from magnetic resonance spectroscopic imaging data. MAGMA. 2007 Jun; 20(3):143-55.
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      81. Cunningham CH, Chen AP, Albers MJ, Kurhanewicz J, Hurd RE, Yen YF, Pauly JM, Nelson SJ, Vigneron DB. Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C. J Magn Reson. 2007 Aug; 187(2):357-62.
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      82. Chen AP, Cunningham CH, Ozturk-Isik E, Xu D, Hurd RE, Kelley DA, Pauly JM, Kurhanewicz J, Nelson SJ, Vigneron DB. High-speed 3T MR spectroscopic imaging of prostate with flyback echo-planar encoding. J Magn Reson Imaging. 2007 Jun; 25(6):1288-92.
        View in: PubMed
      83. Cha S, Lupo JM, Chen MH, Lamborn KR, McDermott MW, Berger MS, Nelson SJ, Dillon WP. Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging. AJNR Am J Neuroradiol. 2007 Jun-Jul; 28(6):1078-84.
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      84. Park I, Tamai G, Lee MC, Chuang CF, Chang SM, Berger MS, Nelson SJ, Pirzkall A. Patterns of recurrence analysis in newly diagnosed glioblastoma multiforme after three-dimensional conformal radiation therapy with respect to pre-radiation therapy magnetic resonance spectroscopic findings. Int J Radiat Oncol Biol Phys. 2007 Oct 1; 69(2):381-9.
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      85. Catalaa I, Henry R, Dillon WP, Graves EE, McKnight TR, Lu Y, Vigneron DB, Nelson SJ. Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas. NMR Biomed. 2006 Jun; 19(4):463-75.
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      86. Banerjee S, Ozturk-Isik E, Nelson SJ, Majumdar S. Fast magnetic resonance spectroscopic imaging at 3 Tesla using autocalibrating parallel technique. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1866-9.
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