Shaun Fontaine, PhD

TitleProLynx, Inc.-Scientist
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1700 4th Street
San Francisco CA 94158
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    1. Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. J Med Chem. 2016 Dec 22; 59(24):11161-11170. PMID: 27936709.
      View in: PubMed
    2. Schneider EL, Hearn BR, Pfaff SJ, Fontaine SD, Reid R, Ashley GW, Grabulovski S, Strassberger V, Vogt L, Jung T, Santi DV. Approach for Half-Life Extension of Small Antibody Fragments That Does Not Affect Tissue Uptake. Bioconjug Chem. 2016 Oct 7. PMID: 27657443.
      View in: PubMed
    3. Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol. 2016 Sep; 12(9):680-5. PMID: 27376690.
      View in: PubMed
    4. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. PMID: 26789650.
      View in: PubMed
    5. Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine S, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. Sci Rep. 2015; 5:13891. PMID: 26403635; PMCID: PMC4585899.
    6. Fontaine S, Reid R, Robinson L, Ashley GW, Santi DV. Long-term stabilization of maleimide-thiol conjugates. Bioconjug Chem. 2015 Jan 21; 26(1):145-52. PMID: 25494821.
      View in: PubMed
    7. Fontaine S, DiPasquale AG, Renslo AR. Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery. Org Lett. 2014 Nov 7; 16(21):5776-9. PMID: 25331549; PMCID: PMC4227544.
    8. Fontaine S, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51. PMID: 25314098; PMCID: PMC4420023 [Available on 01/01/16].
    9. Ko KS, Alexander MD, Fontaine S, Biggs-Houck JE, La Clair JJ, Burkart MD. Synthetic studies on the mycolactone core. Org Biomol Chem. 2010 Nov 21; 8(22):5159-65. PMID: 20844795.
      View in: PubMed
    10. Alexander MD, Fontaine S, La Clair JJ, Dipasquale AG, Rheingold AL, Burkart MD. Synthesis of the mycolactone core by ring-closing metathesis. Chem Commun (Camb). 2006 Nov 28; (44):4602-4. PMID: 17082856.
      View in: PubMed
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