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    Shenheng Guan, PhD

    TitleProfessor
    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    Address600 16th Street
    San Francisco CA 94158
    Phone415-476-0245
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB, et al. Optimization of aryl amides that extend survival in prion-infected mice. J Pharmacol Exp Ther. 2016 Jun 17. PMID: 27317802.
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      2. Kim EJ, Youn JH, Park CH, Kim TW, Guan S, Xu S, Burlingame AL, Kim YP, Kim SK, Wang ZY, Kim TW. Oligomerization between BSU1 Family Members Potentiates Brassinosteroid Signaling in Arabidopsis. Mol Plant. 2016 Jan 4; 9(1):178-81. PMID: 26432287.
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      3. Lu J, Trnka MJ, Roh SH, Robinson PJ, Shiau C, Fujimori DG, Chiu W, Burlingame AL, Guan S. Improved Peak Detection and Deconvolution of Native Electrospray Mass Spectra from Large Protein Complexes. J Am Soc Mass Spectrom. 2015 Dec; 26(12):2141-51. PMID: 26323614.
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      4. Watts JC, Giles K, Serban A, Patel S, Oehler A, Bhardwaj S, Guan S, Greicius MD, Miller BL, DeArmond SJ, Geschwind MD, Prusiner SB. Modulation of Creutzfeldt-Jakob disease prion propagation by the A224V mutation. Ann Neurol. 2015 Oct; 78(4):540-53. PMID: 26094969.
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      5. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. PMID: 26224882; PMCID: PMC4576665 [Available on 10/01/16].
      6. Guan S, Trnka MJ, Bushnell DA, Robinson PJ, Gestwicki JE, Burlingame AL. Deconvolution method for specific and nonspecific binding of ligand to multiprotein complex by native mass spectrometry. Anal Chem. 2015 Aug 18; 87(16):8541-6. PMID: 26189511.
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      7. Kaake RM, Wang X, Burke A, Yu C, Kandur W, Yang Y, Novtisky EJ, Second T, Duan J, Kao A, Guan S, Vellucci D, Rychnovsky SD, Huang L. A new in vivo cross-linking mass spectrometry platform to define protein-protein interactions in living cells. Mol Cell Proteomics. 2014 Dec; 13(12):3533-43. PMID: 25253489; PMCID: PMC4256503 [Available on 12/01/15].
      8. Cho Y, Di Liberto V, Carlin D, Abe N, Li KH, Burlingame AL, Guan S, Michaelevski I, Cavalli V. Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration. J Biol Chem. 2014 May 30; 289(22):15820-32. PMID: 24737317; PMCID: PMC4140936.
      9. Correia MA, Wang Y, Kim SM, Guan S. Hepatic cytochrome P450 ubiquitination: conformational phosphodegrons for E2/E3 recognition? IUBMB Life. 2014 Feb; 66(2):78-88. PMID: 24488826; PMCID: PMC3959620.
      10. Ni W, Xu SL, Chalkley RJ, Pham TN, Guan S, Maltby DA, Burlingame AL, Wang ZY, Quail PH. Multisite light-induced phosphorylation of the transcription factor PIF3 is necessary for both its rapid degradation and concomitant negative feedback modulation of photoreceptor phyB levels in Arabidopsis. Plant Cell. 2013 Jul; 25(7):2679-98. PMID: 23903316; PMCID: PMC3753391.
      11. Ouellet H, Chow ED, Guan S, Cox JS, Burlingame AL, de Montellano PR. Genetic and mass spectrometric tools for elucidating the physiological function(s) of cytochrome P450 enzymes from Mycobacterium tuberculosis. Methods Mol Biol. 2013; 987:79-94. PMID: 23475669.
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      12. Watson C, Zhu L, Guan S, Machen TE, Forte JG. Reaction of proton pump inhibitors with model peptides results in novel products. J Pharmacol Sci. 2013; 122(3):213-22. PMID: 23877017.
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      13. Zhuang M, Guan S, Wang H, Burlingame AL, Wells JA. Substrates of IAP ubiquitin ligases identified with a designed orthogonal E3 ligase, the NEDDylator. Mol Cell. 2013 Jan 24; 49(2):273-82. PMID: 23201124; PMCID: PMC3557559.
      14. Kao A, Randall A, Yang Y, Patel VR, Kandur W, Guan S, Rychnovsky SD, Baldi P, Huang L. Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling. Mol Cell Proteomics. 2012 Dec; 11(12):1566-77. PMID: 22550050; PMCID: PMC3518129.
      15. Guan S, Price JC, Ghaemmaghami S, Prusiner SB, Burlingame AL. Compartment modeling for mammalian protein turnover studies by stable isotope metabolic labeling. Anal Chem. 2012 May 1; 84(9):4014-21. PMID: 22444387; PMCID: PMC3923578.
      16. Sivaramakrishnan S, Ouellet H, Matsumura H, Guan S, Mo├źnne-Loccoz P, Burlingame AL, Ortiz de Montellano PR. Proximal ligand electron donation and reactivity of the cytochrome P450 ferric-peroxo anion. J Am Chem Soc. 2012 Apr 18; 134(15):6673-84. PMID: 22444582; PMCID: PMC3329582.
      17. Wang Y, Guan S, Acharya P, Liu Y, Thirumaran RK, Brandman R, Schuetz EG, Burlingame AL, Correia MA. Multisite phosphorylation of human liver cytochrome P450 3A4 enhances Its gp78- and CHIP-mediated ubiquitination: a pivotal role of its Ser-478 residue in the gp78-catalyzed reaction. Mol Cell Proteomics. 2012 Feb; 11(2):M111.010132. PMID: 22101235; PMCID: PMC3277751.
      18. Guan S, Price JC, Prusiner SB, Ghaemmaghami S, Burlingame AL. A data processing pipeline for mammalian proteome dynamics studies using stable isotope metabolic labeling. Mol Cell Proteomics. 2011 Dec; 10(12):M111.010728. PMID: 21937731; PMCID: PMC3237081.
      19. Kim TW, Guan S, Burlingame AL, Wang ZY. The CDG1 kinase mediates brassinosteroid signal transduction from BRI1 receptor kinase to BSU1 phosphatase and GSK3-like kinase BIN2. Mol Cell. 2011 Aug 19; 43(4):561-71. PMID: 21855796; PMCID: PMC3206214.
      20. Wang Y, Guan S, Acharya P, Koop DR, Liu Y, Liao M, Burlingame AL, Correia MA. Ubiquitin-dependent proteasomal degradation of human liver cytochrome P450 2E1: identification of sites targeted for phosphorylation and ubiquitination. J Biol Chem. 2011 Mar 18; 286(11):9443-56. PMID: 21209460; PMCID: PMC3058980.
      21. Kao A, Chiu CL, Vellucci D, Yang Y, Patel VR, Guan S, Randall A, Baldi P, Rychnovsky SD, Huang L. Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexes. Mol Cell Proteomics. 2011 Jan; 10(1):M110.002212. PMID: 20736410; PMCID: PMC3013449.
      22. Price JC, Guan S, Burlingame A, Prusiner SB, Ghaemmaghami S. Analysis of proteome dynamics in the mouse brain. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14508-13. PMID: 20699386; PMCID: PMC2922600.
      23. Ouellet H, Guan S, Johnston JB, Chow ED, Kells PM, Burlingame AL, Cox JS, Podust LM, de Montellano PR. Mycobacterium tuberculosis CYP125A1, a steroid C27 monooxygenase that detoxifies intracellularly generated cholest-4-en-3-one. Mol Microbiol. 2010 Aug; 77(3):730-42. PMID: 20545858; PMCID: PMC2909382.
      24. Guan S, Burlingame AL. High mass selectivity for top-down proteomics by application of SWIFT technology. J Am Soc Mass Spectrom. 2010 Mar; 21(3):455-9. PMID: 20060315; PMCID: PMC3384707.
      25. Guan S, Burlingame AL. Data processing algorithms for analysis of high resolution MSMS spectra of peptides with complex patterns of posttranslational modifications. Mol Cell Proteomics. 2010 May; 9(5):804-10. PMID: 19955076; PMCID: PMC2871415.
      26. Kim TW, Guan S, Sun Y, Deng Z, Tang W, Shang JX, Sun Y, Burlingame AL, Wang ZY. Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors. Nat Cell Biol. 2009 Oct; 11(10):1254-60. PMID: 19734888; PMCID: PMC2910619.
      27. McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY). 2009 Jan; 1(1):109-21. PMID: 20157594; PMCID: PMC2815768.
      28. Casati P, Campi M, Chu F, Suzuki N, Maltby D, Guan S, Burlingame AL, Walbot V. Histone acetylation and chromatin remodeling are required for UV-B-dependent transcriptional activation of regulated genes in maize. Plant Cell. 2008 Apr; 20(4):827-42. PMID: 18398050; PMCID: PMC2390752.
      29. Deng Z, Zhang X, Tang W, Oses-Prieto JA, Suzuki N, Gendron JM, Chen H, Guan S, Chalkley RJ, Peterman TK, Burlingame AL, Wang ZY. A proteomics study of brassinosteroid response in Arabidopsis. Mol Cell Proteomics. 2007 Dec; 6(12):2058-71. PMID: 17848588; PMCID: PMC2966871.
      30. Gampala SS, Kim TW, He JX, Tang W, Deng Z, Bai MY, Guan S, Lalonde S, Sun Y, Gendron JM, Chen H, Shibagaki N, Ferl RJ, Ehrhardt D, Chong K, Burlingame AL, Wang ZY. An essential role for 14-3-3 proteins in brassinosteroid signal transduction in Arabidopsis. Dev Cell. 2007 Aug; 13(2):177-89. PMID: 17681130; PMCID: PMC2000337.
      31. Medzihradszky KF, Guan S, Maltby DA, Burlingame AL. Sulfopeptide fragmentation in electron-capture and electron-transfer dissociation. J Am Soc Mass Spectrom. 2007 Sep; 18(9):1617-24. PMID: 17629708.
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      32. Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JO, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL. O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Mol Cell Proteomics. 2006 May; 5(5):923-34. PMID: 16452088.
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      33. Medzihradszky KF, Zhang X, Chalkley RJ, Guan S, McFarland MA, Chalmers MJ, Marshall AG, Diaz RL, Allis CD, Burlingame AL. Characterization of Tetrahymena histone H2B variants and posttranslational populations by electron capture dissociation (ECD) Fourier transform ion cyclotron mass spectrometry (FT-ICR MS). Mol Cell Proteomics. 2004 Sep; 3(9):872-86. PMID: 15199121.
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      34. Guan S. Frequency encoding of resonant mass sensors for chemical vapor detection. Anal Chem. 2003 Sep 1; 75(17):4551-7. PMID: 14632063.
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      35. Shenheng Guan and Ralph B. Nielsen. . Rapid scan Fourier transform detection of quartz crystal microbalance array. Review of Scientific Instruments. 2003; 74(12):5241-5248.
      36. Bergh, Sam; Guan, Shenheng; Hagemeyer, Alfred; Lugmair, Claus; Turner, Howard; Volpe, Anthony F.; Weinberg, W. Henry; Mott, Graham. . Gas phase oxidation of ethane to acetic acid using high-throughput screening in a massively parallel microfluidic reactor system. Applied Catalysis, A: General. 2003; 254(1):67-76.
      37. Liu, Yumin; Cong, Peijun; Doolen, Robert D.; Guan, Shenheng; Markov, Victor; Woo, Lenny; Zeyss, Sabine; Dingerdissen, Uwe. . Discovery from combinatorial heterogeneous catalysis. A new class of catalyst for ethane oxidative dehydrogenation at low temperatures. Applied Catalysis, A: General. 2003; 254(1):59-66.
      38. Bergh, Sam; Cong, Peijun; Ehnebuske, Bren; Guan, Shenheng; Hagemeyer, Alfred; Lin, Hong; Liu, Yumin; Lugmair, Claus G.; Turner, Howard W.; Volpe, Anthony F., Jr.; Weinberg, W. Henry; Woo, Lenny; Zysk, Jessica. . Combinatorial Heterogeneous Catalysis: Oxidative Dehydrogenation of Ethane to Ethylene, Selective Oxidation of Ethane to Acetic Acid, and Selective Ammoxidation of Propane to Acrylonitrile. Topics in Catalysis. 2003; 23(1-4):65-79.
      39. Desrosiers, Peter; Guan, Shenheng; Hagemeyer, Alfred; Lowe, David M.; Lugmair, Claus; Poojary, Damodara M.; Turner, Howard; Weinberg, Henry; Zhou, Xiaoping; Armbrust, Ralph; Fengler, Gerd; Notheis, Ulrich. . Application of combinatorial catalysis for the direct amination of benzene to aniline. Catalysis Today. 2003; 81(3):319-328.
      40. Alfred Hagemeyer, Ramesh Borade, Peter Desrosiers, Shenheng Guan, David M. Lowe, Damodara M. Poojary, Howard Turner, Henry Weinberg, Xiaoping Zhou, Ralph Armbrust, Gerd Fengler, Ulrich Notheis. . Application of combinatorial catalysis for the direct ammination of benzene to aniline. Applied Catalysis A: General. 2002; 227:43-61.
      41. Cong P, Dehestani A, Doolen R, Giaquinta DM, Guan S, Markov V, Poojary D, Self K, Turner H, Weinberg WH. Combinatorial discovery of oxidative dehydrogenation catalysts within the Mo-V-Nb-O system. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):11077-80. PMID: 10500131; PMCID: PMC17988.
      42. Cong, Peijun; Doolen, Robert D.; Fan, Qun; Giaquinta, Daniel M.; Guan, Shenheng; McFarland, Eric W.; Poojary, Damodara M.; Self, Kyle; Turner, Howard W.; Weinberg, W. Henry. . High-throughput synthesis and screening of combinatorial heterogeneous catalyst libraries. Angew. Chem., Int. Ed. 1999; 38(4):484-488.
      43. George S. Jackson, Forest M. White, Shenheng Guan, and Alan G. Marshall. . Matrix-shimmed ion cyclotron resonance ion trap simultaneously optimized for excitation, detection, quadrupolar axialization, and trapping. J. Am. Soc. Mass Spectrom. 1999; 10:759-769.
      44. Korsmeyer KK, Guan S, Yang ZC, Falick AM, Ziegler DM, Cashman JR. N-Glycosylation of pig flavin-containing monooxygenase form 1: determination of the site of protein modification by mass spectrometry. Chem Res Toxicol. 1998 Oct; 11(10):1145-53. PMID: 9778310.
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      45. Solouki T, Reinhold BB, Costello CE, O'Malley M, Guan S, Marshall AG. Electrospray ionization and matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry of permethylated oligosaccharides. Anal Chem. 1998 Mar 1; 70(5):857-64. PMID: 9511464.
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      46. Guan S, Marshall AG. Linear prediction Cholesky decomposition vs Fourier transform spectral analysis for ion cyclotron resonance mass spectrometry. Anal Chem. 1997 Mar 15; 69(6):1156-62. PMID: 9075405.
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      47. Solouki T, Emmett MR, Guan S, Marshall AG. Detection, number, and sequence location of sulfur-containing amino acids and disulfide bridges in peptides by ultrahigh-resolution MALDI FTICR mass spectrometry. Anal Chem. 1997 Mar 15; 69(6):1163-8. PMID: 9075406.
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      48. Guan S, Marshall AG. Two-way conversation with a mass spectrometer: nondestructive interactive mass spectrometry. Anal Chem. 1997 Jan 1; 69(1):1-4. PMID: 8990977.
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      49. Solouki T, Pasa-Tolic L, Jackson GS, Guan S, Marshall AG. High-resolution multistage MS, MS2, and MS3 matrix-assisted laser desorption/ionization FT-ICR mass spectra of peptides from a single laser shot. Anal Chem. 1996 Nov 1; 68(21):3718-25. PMID: 8914481.
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      50. Senko MW, Hendrickson CL, Pasa-Tolic L, Marto JA, White FM, Guan S, Marshall AG. Electrospray ionization Fourier transform ion cyclotron resonance at 9.4 T. Rapid Commun Mass Spectrom. 1996; 10(14):1824-8. PMID: 8953784.
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      51. Hendrickson CL, Drader JJ, Laude DA, Guan S, Marshall AG. Fourier transform ion cyclotron resonance mass spectrometry in a 20 T resistive magnet. Rapid Commun Mass Spectrom. 1996; 10(14):1829-32. PMID: 8953785.
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      52. Senko MW, Canterbury JD, Guan S, Marshall AG. A high-performance modular data system for Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 1996; 10(14):1839-44. PMID: 8953786.
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      53. Li GZ, Vining BA, Guan S, Marshall AG. Laser-induced fluorescence of Ba+ ions trapped and mass-selected in a Fourier transform ion cyclotron resonance mass spectrometer. Rapid Commun Mass Spectrom. 1996; 10(14):1850-4. PMID: 8953788.
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      54. Guan S, Huang Y, Xin T, Marshall AG. Determination of ion magnetron radial distribution in Fourier transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 1996; 10(14):1855-9. PMID: 8953789.
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      55. Guan S, Marshall AG, Scheppele SE. Resolution and chemical formula identification of aromatic hydrocarbons and aromatic compounds containing sulfur, nitrogen, or oxygen in petroleum distillates and refinery streams. Anal Chem. 1996 Jan 1; 68(1):46-71. PMID: 21619221.
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      56. Guan S, Marshall AG. Stacked-ring electrostatic ion guide. J Am Soc Mass Spectrom. 1996 Jan; 7(1):101-6. PMID: 24202800.
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      57. Solouki T, Marto JA, White FM, Guan S, Marshall AG. Attomole biomolecule mass analysis by matrix-assisted laser desorption/ionization Fourier transform ion cyclotron resonance. Anal Chem. 1995 Nov 15; 67(22):4139-44. PMID: 8633766.
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      58. Huang Y, Pasa-Tolic L, Guan S, Marshall AG. Collision-induced dissociation for mass spectrometric analysis of biopolymers: high-resolution Fourier transform ion cyclotron resonance MS4. Anal Chem. 1994 Dec 15; 66(24):4385-9. PMID: 7847634.
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      59. Marto JA, Guan S, Marshall AG. Wide-mass-range axialization for high-resolution Fourier-transform ion cyclotron resonance mass spectrometry of externally generated ions. Rapid Commun Mass Spectrom. 1994 Aug; 8(8):615-20. PMID: 7949329.
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      60. Guan S, Marshall AG, Wahl MC. MS/MS with high detection efficiency and mass resolving power for product ions in Fourier transform ion cyclotron resonance mass spectrometry. Anal Chem. 1994 Apr 15; 66(8):1363-7. PMID: 7516123.
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      61. Xiang X, Guan S, Marshal AG. Simulated ion trajectory and induced signal in ion cyclotron resonance ion traps. J Am Soc Mass Spectrom. 1994 Apr; 5(4):238-49. PMID: 24222561.
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      62. Guan S, Marshall AG. Equilibrium space charge distribution in a quadrupole ion trap. J Am Soc Mass Spectrom. 1994 Feb; 5(2):64-71. PMID: 24222517.
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      63. Wahl MC, Kim HS, Wood TD, Guan S, Marshall AG. Thin gold film-assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry of biomolecules. Anal Chem. 1993 Dec 15; 65(24):3669-76. PMID: 7508694.
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      64. Guan S, Wahl MC, Marshall AG. Elimination of frequency drift from Fourier transform ion cyclotron resonance mass spectra by digital quadrature heterodyning: ultrahigh mass resolving power for laser-desorbed molecules. Anal Chem. 1993 Dec 15; 65(24):3647-53. PMID: 8311249.
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      65. Guan S, Marshall AG. Multiply pulsed collision gas for ion axialization in Fourier-transform ion cyclotron resonance mass spectrometry. Rapid Commun Mass Spectrom. 1993 Sep; 7(9):857-60. PMID: 8219324.
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      66. Guan S, Wahl MC, Wood TD, Marshall AG. Enhanced mass resolving power, sensitivity, and selectivity in laser desorption Fourier transform ion cyclotron resonance mass spectrometry by ion axialization and cooling. Anal Chem. 1993 Jul 1; 65(13):1753-7. PMID: 8368527.
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      67. Guan S, Marshall AG. Stored waveform inverse Fourier transform axial excitation/ejection for quadrupole ion trap mass spectrometry. Anal Chem. 1993 May 1; 65(9):1288-94. PMID: 8503506.
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      68. Guan S, Gorshkov MV, Alber GM, Marshall AG. Resonant excitation of relativistic-ion cyclotron orbital motion. Phys Rev A. 1993 Apr; 47(4):2730-2737. PMID: 9909244.
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      69. Guan S. Linear response theory of ion excitation for Fourier transform mass spectrometry. J Am Soc Mass Spectrom. 1991 Dec; 2(6):483-6. PMID: 24242770.
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      70. Guan SH, Falick AM, Williams DE, Cashman JR. Evidence for complex formation between rabbit lung flavin-containing monooxygenase and calreticulin. Biochemistry. 1991 Oct 15; 30(41):9892-900. PMID: 1911780.
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      71. Guan SH, Falick AM, Cashman JR. N-terminus determination: FAD and NADP binding domain mapping of hog liver flavin-containing monooxygenase by tandem mass spectrometry. Biochem Biophys Res Commun. 1990 Jul 31; 170(2):937-43. PMID: 2383273.
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