Shingo Kajimura, PhD

TitleAssociate Professor
SchoolUCSF School of Dentistry
DepartmentCell and Tissue Biology
Address35 Medical Center Way
San Francisco CA 94143
vCardDownload vCard

    Collapse Biography 
    Collapse Awards and Honors
    Helmholtz Zentrum München and Nature Medicine2014The Helmholtz Young Investigator in Diabetes Award
    Baker IDI 2014Baker IDI Metabolism & Inflammation Distinguished Lecture
    The White House2013The Presidential Early Career Awards for Scientists and Engineers (PECASE)
    The Pew Charitable Trusts2013Pew Scholar
    NIDDK2010NIH Pathway to Independence K99/R00
    American Heart Association2009Scientist Development Award

    Collapse Overview 
    Collapse overview
    Obesity is a major risk factor for metabolic disorders such as type-2 diabetes and cardiovascular disease. A fundamental concept in understanding obesity is energy balance; obesity develops when energy intake (i.e., feeding) chronically exceeds total energy expenditure.

    Adipose tissue serves as a central regulator of energy balance. Two types of adipose tissue, white and brown, are found in mammals: white adipose tissue (WAT) functions exclusively in the storage of excess energy, while brown adipose tissue (BAT) is specialized to dissipate chemical energy in the form of heat through a process called non-shivering thermogenesis. Due to its remarkable oxidative capacity to dissipate excess chemical energy, brown fat function is tightly linked to the development of obesity and metabolic disorders in rodents and humans. The main focus of our lab is to uncover the molecular circuits that control brown and white fat cell development and their roles in energy metabolism.

    Over the last several years, we have been studying the transcriptional regulation of brown fat development. As an example, we have defined key transcriptional regulators, such as PRDM16 (PR-domain containing 16), C/EBPß, and EHMT1 that determine the cellular fate of brown and beige adipocytes. By employing a wide range of molecular biology, developmental biology, and biochemical/pharmacological approaches, we aim to engineer adipose cell fate and generate energy-burning brown/beige adipocytes in vivo. We hope these studies lead to the development of novel therapeutic interventions for obesity and obesity-related metabolic diseases, such as type 2 diabetes.

    Collapse Research 
    Collapse Research Activities and Funding
    Biological roles and developmental pathway of burn-induced beige fat in humans
    NIH/NIDDK R01DK112268Sep 20, 2016 - Jun 30, 2018
    Role: Principal Investigator
    BAT-mediated inter-organ communication in energy homeostasis
    NIH/NIDDK R01DK108822Apr 1, 2016 - Feb 29, 2020
    Role: Principal Investigator
    Molecular Control of Brown Adipose Cell Fate and Energy Metabolism
    NIH/NIDDK R01DK097441Sep 10, 2012 - Jun 30, 2018
    Role: Principal Investigator
    Engineering Functional Brown Fat with Anti-Obesity Potential
    NIH/NIDDK R00DK087853May 1, 2011 - Apr 30, 2014
    Role: Principal Investigator
    Engineering Functional Brown Fat with Anti-Obesity Potential
    NIH/NIDDK K99DK087853Apr 1, 2010 - Mar 31, 2012
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Websites
    Collapse In The News

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Kajimura S. Adipose tissue in 2016: Advances in the understanding of adipose tissue biology. Nat Rev Endocrinol. 2017 Feb; 13(2):69-70. PMID: 28051117.
      View in: PubMed
    2. Kajimura S. PDGFA Makes Thin Skin Thicker: Molecular Regulation of Adipose Progenitor Maintenance. Cell Stem Cell. 2016 Dec 01; 19(6):675-676. PMID: 27912085.
      View in: PubMed
    3. Altshuler-Keylin S, Shinoda K, Hasegawa Y, Ikeda K, Hong H, Kang Q, Yang Y, Perera RM, Debnath J, Kajimura S, et al. Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance. Cell Metab. 2016 Aug 24. PMID: 27568548.
      View in: PubMed
    4. Inagaki T, Sakai J, Kajimura S. Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol. 2016 Aug; 17(8):480-95. PMID: 27251423.
      View in: PubMed
    5. Chondronikola M, Volpi E, Børsheim E, Porter C, Saraf MK, Annamalai P, Yfanti C, Chao T, Wong D, Shinoda K, Labbe SM, Hurren NM, Cesani F, Kajimura S, Sidossis LS. Brown Adipose Tissue Activation Is Linked to Distinct Systemic Effects on Lipid Metabolism in Humans. Cell Metab. 2016 Jun 14; 23(6):1200-6. PMID: 27238638.
      View in: PubMed
    6. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016 Apr; 22(4):427-32. PMID: 26950360.
      View in: PubMed
    7. Ohyama K, Nogusa Y, Shinoda K, Suzuki K, Bannai M, Kajimura S. A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. Diabetes. 2016 May; 65(5):1410-23. PMID: 26936964.
      View in: PubMed
    8. Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metab. 2016 Mar 8; 23(3):454-66. PMID: 26876562.
      View in: PubMed
    9. Shinoda K, Ohyama K, Hasegawa Y, Chang HY, Ogura M, Sato A, Hong H, Hosono T, Sharp LZ, Scheel DW, Graham M, Ishihama Y, Kajimura S. Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. Cell Metab. 2015 Dec 1; 22(6):997-1008. PMID: 26525534; PMCID: PMC4670581 [Available on 12/01/16].
    10. Güller I, McNaughton S, Crowley T, Gilsanz V, Kajimura S, Watt M, Russell AP. Comparative analysis of microRNA expression in mouse and human brown adipose tissue. BMC Genomics. 2015; 16(1):820. PMID: 26482036; PMCID: PMC4617708.
    11. Kajimura S. Promoting brown and beige adipocyte biogenesis through the PRDM16 pathway. Int J Obes Suppl. 2015 Aug; 5(Suppl 1):S11-4. PMID: 27152168.
      View in: PubMed
    12. Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015 Apr; 21(4):389-94. PMID: 25774848; PMCID: PMC4427356.
    13. Sidossis L, Kajimura S. Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. J Clin Invest. 2015 Feb; 125(2):478-86. PMID: 25642708; PMCID: PMC4319444 [Available on 02/02/16].
    14. Kajimura S. Engineering Fat Cell Fate to Fight Obesity and Metabolic Diseases. Keio J Med. 2015; 64(4):65. PMID: 26727580.
      View in: PubMed
    15. Ohyama K, Nogusa Y, Suzuki K, Shinoda K, Kajimura S, Bannai M. A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E315-23. PMID: 25516550.
      View in: PubMed
    16. Galmozzi A, Sonne SB, Altshuler-Keylin S, Hasegawa Y, Shinoda K, Luijten IH, Chang JW, Sharp LZ, Cravatt BF, Saez E, Kajimura S. ThermoMouse: an in vivo model to identify modulators of UCP1 expression in brown adipose tissue. Cell Rep. 2014 Dec 11; 9(5):1584-93. PMID: 25466254; PMCID: PMC4268417 [Available on 12/11/15].
    17. Gridley T, Kajimura S. Lightening up a notch: Notch regulation of energy metabolism. Nat Med. 2014 Aug; 20(8):811-2. PMID: 25100522; PMCID: PMC4431689.
    18. Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, Kajimura S, Piston DW, Mathis D, Cinti S, Shulman GI, Seale P, Spiegelman BM. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 2014 Jan 16; 156(1-2):304-16. PMID: 24439384; PMCID: PMC3922400.
    19. Ohno H, Shinoda K, Ohyama K, Sharp LZ, Kajimura S. EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex. Nature. 2013 Dec 5; 504(7478):163-7. PMID: 24196706; PMCID: PMC3855638.
    20. Kajimura S, Saito M. A new era in brown adipose tissue biology: molecular control of brown fat development and energy homeostasis. Annu Rev Physiol. 2014; 76:225-49. PMID: 24188710; PMCID: PMC4090362.
    21. Aune UL, Ruiz L, Kajimura S. Isolation and differentiation of stromal vascular cells to beige/brite cells. J Vis Exp. 2013; (73). PMID: 23568137; PMCID: PMC3641667.
    22. Sharp LZ, Shinoda K, Ohno H, Scheel DW, Tomoda E, Ruiz L, Hu H, Wang L, Pavlova Z, Gilsanz V, Kajimura S. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One. 2012; 7(11):e49452. PMID: 23166672; PMCID: PMC3500293.
    23. Gilsanz V, Hu HH, Kajimura S. Relevance of brown adipose tissue in infancy and adolescence. Pediatr Res. 2013 Jan; 73(1):3-9. PMID: 23090604; PMCID: PMC3614088.
    24. Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. A novel therapeutic approach to treating obesity through modulation of TGFß signaling. Endocrinology. 2012 Jul; 153(7):3133-46. PMID: 22549226; PMCID: PMC3791434.
    25. Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPAR? agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metab. 2012 Mar 7; 15(3):395-404. PMID: 22405074; PMCID: PMC3410936.
    26. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM. A PGC1-a-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012 Jan 26; 481(7382):463-8. PMID: 22237023; PMCID: PMC3522098.
    27. Kamei H, Ding Y, Kajimura S, Wells M, Chiang P, Duan C. Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability. Development. 2011 Feb; 138(4):777-86. PMID: 21266413.
      View in: PubMed
    28. Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest. 2011 Jan; 121(1):96-105. PMID: 21123942; PMCID: PMC3007155.
    29. Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 2010 Jul 22; 466(7305):451-6. PMID: 20651683; PMCID: PMC2987584.
    30. Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metab. 2010 Apr 7; 11(4):257-62. PMID: 20374957; PMCID: PMC2857670.
    31. Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 2009 Aug 27; 460(7259):1154-8. PMID: 19641492; PMCID: PMC2754867.
    32. Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes Dev. 2009 Apr 1; 23(7):788-97. PMID: 19339685; PMCID: PMC2763499.
    33. Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7. PMID: 18728005; PMCID: PMC2581541.
    34. Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 2008 Aug 21; 454(7207):961-7. PMID: 18719582; PMCID: PMC2583329.
    35. Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15; 22(10):1397-409. PMID: 18483224; PMCID: PMC2377193.
    36. Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metab. 2007 Jul; 6(1):38-54. PMID: 17618855; PMCID: PMC2564846.
    37. Takahashi H, Prunet P, Kitahashi T, Kajimura S, Hirano T, Grau EG, Sakamoto T. Prolactin receptor and proliferating/apoptotic cells in esophagus of the Mozambique tilapia (Oreochromis mossambicus) in fresh water and in seawater. Gen Comp Endocrinol. 2007 Jun-Jul; 152(2-3):326-31. PMID: 17418192.
      View in: PubMed
    38. Kajimura S, Aida K, Duan C. Understanding hypoxia-induced gene expression in early development: in vitro and in vivo analysis of hypoxia-inducible factor 1-regulated zebra fish insulin-like growth factor binding protein 1 gene expression. Mol Cell Biol. 2006 Feb; 26(3):1142-55. PMID: 16428465; PMCID: PMC1347021.
    39. Kajimura S, Seale AP, Hirano T, Cooke IM, Grau EG. Physiological concentrations of ouabain rapidly inhibit prolactin release from the tilapia pituitary. Gen Comp Endocrinol. 2005 Sep 15; 143(3):240-50. PMID: 15922343.
      View in: PubMed
    40. Kajimura S, Aida K, Duan C. Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1240-5. PMID: 15644436; PMCID: PMC545835.
    41. Kajimura S, Kawaguchi N, Kaneko T, Kawazoe I, Hirano T, Visitacion N, Grau EG, Aida K. Identification of the growth hormone receptor in an advanced teleost, the tilapia (Oreochromis mossambicus) with special reference to its distinct expression pattern in the ovary. J Endocrinol. 2004 Apr; 181(1):65-76. PMID: 15072567.
      View in: PubMed
    42. Uchida K, Yoshikawa-Ebesu JS, Kajimura S, Yada T, Hirano T, Gordon Grau E. In vitro effects of cortisol on the release and gene expression of prolactin and growth hormone in the tilapia, Oreochromis mossambicus. Gen Comp Endocrinol. 2004 Jan 1; 135(1):116-25. PMID: 14644651.
      View in: PubMed
    43. Kajimura S, Hirano T, Moriyama S, Vakkuri O, Leppäluoto J, Grau EG. Changes in plasma concentrations of immunoreactive ouabain in the tilapia in response to changing salinity: is ouabain a hormone in fish? Gen Comp Endocrinol. 2004 Jan 1; 135(1):90-9. PMID: 14644648.
      View in: PubMed
    44. Kajimura S, Hirano T, Visitacion N, Moriyama S, Aida K, Grau EG. Dual mode of cortisol action on GH/IGF-I/IGF binding proteins in the tilapia, Oreochromis mossambicus. J Endocrinol. 2003 Jul; 178(1):91-9. PMID: 12844340.
      View in: PubMed
    45. Uchida K, Kajimura S, Riley LG, Hirano T, Aida K, Grau EG. Effects of fasting on growth hormone/insulin-like growth factor I axis in the tilapia, Oreochromis mossambicus. Comp Biochem Physiol A Mol Integr Physiol. 2003 Feb; 134(2):429-39. PMID: 12547273.
      View in: PubMed
    46. Seale AP, Riley LG, Leedom TA, Kajimura S, Dores RM, Hirano T, Grau EG. Effects of environmental osmolality on release of prolactin, growth hormone and ACTH from the tilapia pituitary. Gen Comp Endocrinol. 2002 Sep; 128(2):91-101. PMID: 12392682.
      View in: PubMed
    47. Kajimura S, Uchida K, Yada T, Hirano T, Aida K, Gordon Grau E. Effects of insulin-like growth factors (IGF-I and -II) on growth hormone and prolactin release and gene expression in euryhaline tilapia, Oreochromis mossambicus. Gen Comp Endocrinol. 2002 Jul; 127(3):223-31. PMID: 12225763.
      View in: PubMed
    48. Yada T, Uchida K, Kajimura S, Azuma T, Hirano T, Grau EG. Immunomodulatory effects of prolactin and growth hormone in the tilapia, Oreochromis mossambicus. J Endocrinol. 2002 Jun; 173(3):483-92. PMID: 12065238.
      View in: PubMed
    49. Kajimura S, Yoshiura Y, Suzuki M, Aida K. cDNA cloning of two gonadotropin beta subunits (GTH-Ibeta and -IIbeta) and their expression profiles during gametogenesis in the Japanese flounder (Paralichthys olivaceus). Gen Comp Endocrinol. 2001 May; 122(2):117-29. PMID: 11316417.
      View in: PubMed
    Shingo's Networks
    Derived automatically from this person's publications.
    People in Profiles who have published with this person.
    Related Authors
    People who share related concepts with this person.
    Back to TOP