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    Sik Fai Leung, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Pharmacy
    DepartmentPharmaceutical Chemistry
    Address600 16th Street
    San Francisco CA 94158

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25.
        View in: PubMed
      2. Leung SS, Mijalkovic J, Borrelli K, Jacobson MP. Testing physical models of passive membrane permeation. J Chem Inf Model. 2012 Jun 25; 52(6):1621-36.
        View in: PubMed
      3. Leung CS, Leung SS, Tirado-Rives J, Jorgensen WL. Methyl effects on protein-ligand binding. J Med Chem. 2012 May 10; 55(9):4489-500.
        View in: PubMed
      4. White TR, Renzelman CM, Rand AC, Rezai T, McEwen CM, Gelev VM, Turner RA, Linington RG, Leung SS, Kalgutkar AS, Bauman JN, Zhang Y, Liras S, Price DA, Mathiowetz AM, Jacobson MP, Lokey RS. On-resin N-methylation of cyclic peptides for discovery of orally bioavailable scaffolds. Nat Chem Biol. 2011 Nov; 7(11):810-7.
        View in: PubMed
      5. Crane CM, Pierce JG, Leung SS, Tirado-Rives J, Jorgensen WL, Boger DL. Synthesis and evaluation of selected key methyl ether derivatives of vancomycin aglycon. J Med Chem. 2010 Oct 14; 53(19):7229-35.
        View in: PubMed
      6. Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection. Antimicrob Agents Chemother. 2010 Jun; 54(6):2480-8.
        View in: PubMed
      7. Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM. Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole. PLoS Negl Trop Dis. 2010; 4(4):e651.
        View in: PubMed
      8. Leung SS, Tirado-Rives J, Jorgensen WL. Vancomycin analogs: Seeking improved binding of d-Ala-d-Ala and d-Ala-d-Lac peptides by side-chain and backbone modifications. Bioorg Med Chem. 2009 Aug 15; 17(16):5874-86.
        View in: PubMed
      9. Leung SS, Tirado-Rives J, Jorgensen WL. Vancomycin resistance: modeling backbone variants with D-Ala-D-Ala and D-Ala-D-Lac peptides. Bioorg Med Chem Lett. 2009 Feb 15; 19(4):1236-9.
        View in: PubMed
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