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    Simone Mayer, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    DepartmentRegeneration Medicine
    Address35 Medical Center Way
    San Francisco CA 94143
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      Collapse Biography 
      Collapse Education and Training
      Max Planck Institute of Experimental MedicinePhDMolecular Neurobiology2014
      Georg August University GoettingenMaster of ScienceMolecular Biology2011
      University of CambridgeBA (hons)Physiology, Development, Neuroscience2009

      Collapse Overview 
      Collapse Overview
      I received my BA in Natural Sciences from the University of Cambridge, UK. I went on to study Molecular Biology at the International Max Planck Research School and received my MSc and PhD degrees from the University of Goettingen in Germany. During my graduate studies I performed a research project at Yale University in the lab of Dr. Nenad Sestan, where I showed that ANKRD32 is differentially expressed in human and mouse cortical development. My PhD work focused on the intracellular mechanisms that allow clustering of inhibitory neurotransmitter receptors at synapses. I found that the small GTPase TC10 triggers the recruitment of the scaffold protein gephyrin to synapses by activating the guanine nucleotide exchange factor collybistin. This work was guided by Dr. Theofilos Papadopoulos in the lab of Dr. Nils Brose at the Max Planck Institute of Experimental Medicine. I joined the lab of Dr. Arnold Kriegstein at UCSF as a postdoctoral researcher in 2015. My current research interest is in brain development and evolution. I am exploring the role of activated gene networks and cellular signaling in the germinal zones of the developing neocortex. Relating brain development to the evolutionary expansion of the neocortex has the potential to provide insights into the molecular mechanisms underlying the diverse brain disorders, for example brain tumors, that may have emerged as the cost of the expansion of the neocortex.

      Collapse Interests
      brain evolution, neural stem cells, neurotransmission, neocortical development, cell biology, signaling pathways

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      Collapse Featured Publications

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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mayer S, Kumar R, Jaiswal M, Soykan T, Ahmadian MR, Brose N, Betz H, Rhee JS, Papadopoulos T. Collybistin activation by GTP-TC10 enhances postsynaptic gephyrin clustering and hippocampal GABAergic neurotransmission. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):20795-800. PMID: 24297911; PMCID: PMC3870750.
      2. Kang HJ, Kawasawa YI, Cheng F, Zhu Y, Xu X, Li M, Sousa AM, Pletikos M, Meyer KA, Sedmak G, Guennel T, Shin Y, Johnson MB, Krsnik Z, Mayer S, Fertuzinhos S, Umlauf S, Lisgo SN, Vortmeyer A, Weinberger DR, Mane S, Hyde TM, Huttner A, Reimers M, Kleinman JE, Sestan N. Spatio-temporal transcriptome of the human brain. Nature. 2011 Oct 27; 478(7370):483-9. PMID: 22031440; PMCID: PMC3566780.
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