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Hypoimmune islets achieve insulin independence after allogeneic transplantation in a fully immunocompetent non-human primate. Cell Stem Cell. 2024 03 07; 31(3):334-340.e5.
Hu X, White K, Young C, Olroyd AG, Kievit P, Connolly AJ, Deuse T, Schrepfer S. PMID: 38335966.
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PubMed Mentions: Fields:
Translation:
HumansAnimals
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Synthetic immune checkpoint engagers protect HLA-deficient iPSCs and derivatives from innate immune cell cytotoxicity. Cell Stem Cell. 2023 11 02; 30(11):1538-1548.e4.
Gravina A, Tediashvili G, Zheng Y, Iwabuchi KA, Peyrot SM, Roodsari SZ, Gargiulo L, Kaneko S, Osawa M, Schrepfer S, Deuse T. PMID: 37922880.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques. Nat Biotechnol. 2024 Mar; 42(3):413-423.
Hu X, White K, Olroyd AG, DeJesus R, Dominguez AA, Dowdle WE, Friera AM, Young C, Wells F, Chu EY, Ito CE, Krishnapura H, Jain S, Ankala R, McGill TJ, Lin A, Egenberger K, Gagnon A, Michael Rukstalis J, Hogrebe NJ, Gattis C, Basco R, Millman JR, Kievit P, Davis MM, Lanier LL, Connolly AJ, Deuse T, Schrepfer S. PMID: 37156915; PMCID: PMC10940156.
View in:
PubMed Mentions:
9 Fields:
Translation:
AnimalsCells
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Human hypoimmune primary pancreatic islets avoid rejection and autoimmunity and alleviate diabetes in allogeneic humanized mice. Sci Transl Med. 2023 04 12; 15(691):eadg5794.
Hu X, Gattis C, Olroyd AG, Friera AM, White K, Young C, Basco R, Lamba M, Wells F, Ankala R, Dowdle WE, Lin A, Egenberger K, Rukstalis JM, Millman JR, Connolly AJ, Deuse T, Schrepfer S. PMID: 37043559.
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PubMed Mentions:
10 Fields:
Translation:
HumansAnimals
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Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice. Nat Commun. 2023 04 10; 14(1):2020.
Hu X, Manner K, DeJesus R, White K, Gattis C, Ngo P, Bandoro C, Tham E, Chu EY, Young C, Wells F, Basco R, Friera A, Kangeyan D, Beauchesne P, Dowdle WE, Deuse T, Fry TJ, Foster AE, Schrepfer S. PMID: 37037829; PMCID: PMC10086027.
View in:
PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Protection of cell therapeutics from antibody-mediated killing by CD64 overexpression. Nat Biotechnol. 2023 05; 41(5):717-727.
Gravina A, Tediashvili G, Rajalingam R, Quandt Z, Deisenroth C, Schrepfer S, Deuse T. PMID: 36593395; PMCID: PMC10188358.
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PubMed Mentions:
6 Fields:
Translation:
HumansAnimalsCells
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Author Correction: Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2022 Nov; 40(11):1690.
Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S. PMID: 36114291.
View in:
PubMed Mentions:
1 Fields:
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Hypoimmune induced pluripotent stem cell-derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice. Proc Natl Acad Sci U S A. 2021 07 13; 118(28).
Deuse T, Tediashvili G, Hu X, Gravina A, Tamenang A, Wang D, Connolly A, Mueller C, Mallavia B, Looney MR, Alawi M, Lanier LL, Schrepfer S. PMID: 34244428; PMCID: PMC8285900.
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PubMed Mentions:
14 Fields:
Translation:
AnimalsCells
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Immunomodulation Therapy Using Tolerogenic Macrophages in a Rodent Model of Pulmonary Hypertension. Stem Cells Dev. 2021 05 15; 30(10):515-525.
Guihaire J, Deuse T, Wang D, Spin JM, Blankenberg FG, Fadel E, Reichenspurner H, Schrepfer S. PMID: 33726521.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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The SIRPα-CD47 immune checkpoint in NK cells. J Exp Med. 2021 03 01; 218(3).
Deuse T, Hu X, Agbor-Enoh S, Jang MK, Alawi M, Saygi C, Gravina A, Tediashvili G, Nguyen VQ, Liu Y, Valantine H, Lanier LL, Schrepfer S. PMID: 33416832; PMCID: PMC7802363.
View in:
PubMed Mentions:
60 Fields:
Translation:
HumansAnimalsCells
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Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact. Cell. 2020 11 25; 183(5):1185-1201.e20.
da Silveira WA, Fazelinia H, Rosenthal SB, Laiakis EC, Kim MS, Meydan C, Kidane Y, Rathi KS, Smith SM, Stear B, Ying Y, Zhang Y, Foox J, Zanello S, Crucian B, Wang D, Nugent A, Costa HA, Zwart SR, Schrepfer S, Elworth RAL, Sapoval N, Treangen T, MacKay M, Gokhale NS, Horner SM, Singh LN, Wallace DC, Willey JS, Schisler JC, Meller R, McDonald JT, Fisch KM, Hardiman G, Taylor D, Mason CE, Costes SV, Beheshti A. PMID: 33242417; PMCID: PMC7870178.
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PubMed Mentions:
87 Fields:
Translation:
HumansAnimalsCells
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The H-Y Antigen in Embryonic Stem Cells Causes Rejection in Syngeneic Female Recipients. Stem Cells Dev. 2020 09 15; 29(18):1179-1189.
Hu X, Kueppers ST, Kooreman NG, Gravina A, Wang D, Tediashvili G, Schlickeiser S, Frentsch M, Nikolaou C, Thiel A, Marcus S, Fuchs S, Velden J, Reichenspurner H, Volk HD, Deuse T, Schrepfer S. PMID: 32723003; PMCID: PMC7482111.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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A Cryoinjury Model to Study Myocardial Infarction in the Mouse. J Vis Exp. 2019 09 19; (151).
Wang D, Tediashvili G, Hu X, Gravina A, Marcus SG, Zhang H, Olgin JE, Deuse T, Schrepfer S. PMID: 31609308.
View in:
PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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De novo mutations in mitochondrial DNA of iPSCs produce immunogenic neoepitopes in mice and humans. Nat Biotechnol. 2019 10; 37(10):1137-1144.
Deuse T, Hu X, Agbor-Enoh S, Koch M, Spitzer MH, Gravina A, Alawi M, Marishta A, Peters B, Kosaloglu-Yalcin Z, Yang Y, Rajalingam R, Wang D, Nashan B, Kiefmann R, Reichenspurner H, Valantine H, Weissman IL, Schrepfer S. PMID: 31427818.
View in:
PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients. Nat Biotechnol. 2019 03; 37(3):252-258.
Deuse T, Hu X, Gravina A, Wang D, Tediashvili G, De C, Thayer WO, Wahl A, Garcia JV, Reichenspurner H, Davis MM, Lanier LL, Schrepfer S. PMID: 30778232; PMCID: PMC6419516.
View in:
PubMed Mentions:
269 Fields:
Translation:
HumansAnimalsCells
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Dead space ventilation promotes alveolar hypocapnia reducing surfactant secretion by altering mitochondrial function. Thorax. 2019 03; 74(3):219-228.
Kiefmann M, Tank S, Tritt MO, Keller P, Heckel K, Schulte-Uentrop L, Olotu C, Schrepfer S, Goetz AE, Kiefmann R. PMID: 30636196.
View in:
PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Exosomal profiling in cardiac allograft rejection: Best basic science article in 2018. J Heart Lung Transplant. 2019 03; 38(3):334-336.
Kulkarni HS, Diamond JM, Schrepfer S, Cantu E. PMID: 30642798; PMCID: PMC6379143.
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PubMed Mentions: Fields:
Translation:
HumansCells
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No effect of thymosin beta-4 on the expression of the transcription factor Islet-1 in the adult murine heart. Pharmacol Res Perspect. 2018 06; 6(3):e00407.
Weinberger F, Nicol P, Starbatty J, Stubbendorff M, Becher PM, Schrepfer S, Eschenhagen T. PMID: 29864245; PMCID: PMC5986028.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Sphingosine-1-phosphate receptor 1 regulates neointimal growth in a humanized model for restenosis. J Vasc Surg. 2018 12; 68(6S):201S-207S.
Braetz J, Becker A, Geissen M, Larena-Avellaneda A, Schrepfer S, Daum G. PMID: 29804740.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimalsCells
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Optimization of oxygenation during ex vivo lung perfusion-Best basic science article in 2017. J Heart Lung Transplant. 2018 06; 37(6):800-802.
Shaver CM, Diamond JM, Schrepfer S, Cantu E. PMID: 29525103.
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PubMed Mentions: Fields:
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Balloon-based Injury to Induce Myointimal Hyperplasia in the Mouse Abdominal Aorta. J Vis Exp. 2018 02 07; (132).
Tediashvili G, Wang D, Reichenspurner H, Deuse T, Schrepfer S. PMID: 29443065; PMCID: PMC5912362.
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PubMed Mentions: Fields:
Translation:
Animals
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Opportunities for Lung Repair and Regeneration: An Overview. Ann Am Thorac Soc. 2017 09; 14(Suppl_3):S247-S250.
Schrepfer S. PMID: 28945474.
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PubMed Mentions: Fields:
Translation:
Humans
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Thalidomide treatment prevents chronic graft rejection after aortic transplantation in rats - an experimental study. Transpl Int. 2017 Nov; 30(11):1181-1189.
Miller KK, Wang D, Hu X, Hua X, Deuse T, Neofytou E, Renne T, Velden J, Reichenspurner H, Schrepfer S, Bernstein D. PMID: 28672061; PMCID: PMC5643223.
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PubMed Mentions: Fields:
Translation:
AnimalsCells
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Differences in Vascular Response between Balloon Overstretch and Stent Overexpansion in Nonatherosclerotic Porcine Coronary Arteries. Comp Med. 2017 Aug 01; 67(4):350-355.
Mitsutake Y, Reifart J, Pyun WB, Lyons JK, Deuse T, Schrepfer S, Ikeno F. PMID: 28830582; PMCID: PMC5557207.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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The ubiquitin-proteasome system: A potential therapeutic target for heart failure. J Heart Lung Transplant. 2017 Jul; 36(7):708-714.
Barac YD, Emrich F, Krutzwakd-Josefson E, Schrepfer S, Sampaio LC, Willerson JT, Robbins RC, Ciechanover A, Mohr FW, Aravot D, Taylor DA. PMID: 28341100.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
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Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency. J Vis Exp. 2017 01 15; (119).
Wang D, Tediashvili G, Pecha S, Reichenspurner H, Deuse T, Schrepfer S. PMID: 28117809; PMCID: PMC5352261.
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PubMed Mentions:
2 Fields:
Translation:
Animals
-
Orthotopic tracheal transplantation using human bronchus: an original xenotransplant model of obliterative airway disorder. Transpl Int. 2016 Dec; 29(12):1337-1348.
Guihaire J, Itagaki R, Stubbendorff M, Hua X, Deuse T, Ullrich S, Fadel E, Dorfmüller P, Robbins RC, Reichenspurner H, Schumacher U, Schrepfer S. PMID: 27614085.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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miR-126: a potential new key player in hypoxia and reperfusion? Ann Transl Med. 2016 Oct; 4(19):377.
Guenther SP, Schrepfer S. PMID: 27826580; PMCID: PMC5075839.
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PubMed Mentions:
6
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The Selective JAK1/3-Inhibitor R507 Mitigates Obliterative Airway Disease Both With Systemic Administration and Aerosol Inhalation. Transplantation. 2016 05; 100(5):1022-31.
Deuse T, Hua X, Stubbendorff M, Spin JM, Neofytou E, Taylor V, Chen Y, Park G, Fink JB, Renne T, Kiefmann M, Kiefmann R, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 26910327.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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"Bioengineered lungs" Best science paper in JHLT 2014-2015. J Heart Lung Transplant. 2016 Apr; 35(4):544-6.
Schrepfer S, Cantu E, Gandy K, Baan CC, West LJ. PMID: 27044534.
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PubMed Mentions: Fields:
Translation:
Humans
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miR-21 promotes fibrosis in an acute cardiac allograft transplantation model. Cardiovasc Res. 2016 May 15; 110(2):215-26.
Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T. PMID: 26865549.
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PubMed Mentions:
29 Fields:
Translation:
Animals
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Sex Differences in Immunology: More Severe Development of Experimental Pulmonary Hypertension in Male Rats Exposed to Vascular Endothelial Growth Factor Receptor Blockade. Biomed Res Int. 2015; 2015:765292.
Guihaire J, Deuse T, Wang D, Fadel E, Reichenspurner H, Schrepfer S. PMID: 26421302; PMCID: PMC4569774.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. Am J Physiol Heart Circ Physiol. 2015 Oct; 309(7):H1130-40.
Wang H, Weihrauch D, Kersten JR, Toth JM, Passerini AG, Rajamani A, Schrepfer S, LaDisa JF. PMID: 26254329; PMCID: PMC4865061.
View in:
PubMed Mentions:
3 Fields:
Translation:
Animals
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Distal Airway Stem Cells are Essential for Lung Regeneration. Transplantation. 2015 Aug; 99(8):1540-1.
Deuse T, Schrepfer S. PMID: 26308298.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Local MicroRNA Modulation Using a Novel Anti-miR-21-Eluting Stent Effectively Prevents Experimental In-Stent Restenosis. Arterioscler Thromb Vasc Biol. 2015 Sep; 35(9):1945-53.
Wang D, Deuse T, Stubbendorff M, Chernogubova E, Erben RG, Eken SM, Jin H, Li Y, Busch A, Heeger CH, Behnisch B, Reichenspurner H, Robbins RC, Spin JM, Tsao PS, Schrepfer S, Maegdefessel L. PMID: 26183619; PMCID: PMC4552606.
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PubMed Mentions:
63 Fields:
Translation:
HumansAnimals
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Effective Apical Infection of Differentiated Human Bronchial Epithelial Cells and Induction of Proinflammatory Chemokines by the Highly Pneumotropic Human Adenovirus Type 14p1. PLoS One. 2015; 10(7):e0131201.
Lam E, Ramke M, Warnecke G, Schrepfer S, Kopfnagel V, Dobner T, Heim A. PMID: 26168049; PMCID: PMC4500402.
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PubMed Mentions:
9 Fields:
Translation:
HumansCells
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Advancing knowledge of right ventricular pathophysiology in chronic pressure overload: Insights from experimental studies. Arch Cardiovasc Dis. 2015 Oct; 108(10):519-29.
Guihaire J, Noly PE, Schrepfer S, Mercier O. PMID: 26184869.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimals
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Mesenchymal stromal cell therapy: different sources exhibit different immunobiological properties. Transplantation. 2015 Jun; 99(6):1113-8.
Neofytou E, Deuse T, Beygui RE, Schrepfer S. PMID: 26035274.
View in:
PubMed Mentions:
5 Fields:
Translation:
HumansCells
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Immunobiology of fibrin-based engineered heart tissue. Stem Cells Transl Med. 2015 Jun; 4(6):625-31.
Conradi L, Schmidt S, Neofytou E, Deuse T, Peters L, Eder A, Hua X, Hansen A, Robbins RC, Beygui RE, Reichenspurner H, Eschenhagen T, Schrepfer S. PMID: 25947338; PMCID: PMC4449088.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Impaired Endothelial Regeneration Through Human Parvovirus B19-Infected Circulating Angiogenic Cells in Patients With Cardiomyopathy. J Infect Dis. 2015 Oct 01; 212(7):1070-81.
Schmidt-Lucke C, Zobel T, Schrepfer S, Kuhl U, Wang D, Klingel K, Becher PM, Fechner H, Pozzuto T, Van Linthout S, Lassner D, Spillmann F, Escher F, Holinski S, Volk HD, Schultheiss HP, Tschope C. PMID: 25805750.
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PubMed Mentions:
18 Fields:
Translation:
HumansAnimalsCells
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Erratum: miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun. 2015 Feb 26; 6:6506.
Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Heymann HM, Chernogubova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS. PMID: 25716653; PMCID: PMC4349130.
View in:
PubMed Mentions:
1 Fields:
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SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts. Cell Stem Cell. 2015 Jan 08; 16(1):33-8.
Deuse T, Wang D, Stubbendorff M, Itagaki R, Grabosch A, Greaves LC, Alawi M, Grünewald A, Hu X, Hua X, Velden J, Reichenspurner H, Robbins RC, Jaenisch R, Weissman IL, Schrepfer S. PMID: 25465116.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development. Nat Commun. 2014 Oct 31; 5:5214.
Maegdefessel L, Spin JM, Raaz U, Eken SM, Toh R, Azuma J, Adam M, Nakagami F, Nagakami F, Heymann HM, Chernogubova E, Chernugobova E, Jin H, Roy J, Hultgren R, Caidahl K, Schrepfer S, Hamsten A, Eriksson P, McConnell MV, Dalman RL, Tsao PS. PMID: 25358394; PMCID: PMC4217126.
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PubMed Mentions:
108 Fields:
Translation:
HumansAnimalsCells
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Inducing myointimal hyperplasia versus atherosclerosis in mice: an introduction of two valid models. J Vis Exp. 2014 May 14; (87).
Stubbendorff M, Hua X, Deuse T, Ali Z, Reichenspurner H, Maegdefessel L, Robbins RC, Schrepfer S. PMID: 24893977; PMCID: PMC4186352.
View in:
PubMed Mentions:
5 Fields:
Translation:
Animals
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Dichloroacetate prevents restenosis in preclinical animal models of vessel injury. Nature. 2014 May 29; 509(7502):641-4.
Deuse T, Hua X, Wang D, Maegdefessel L, Heeren J, Scheja L, Bolaños JP, Rakovic A, Spin JM, Stubbendorff M, Ikeno F, Länger F, Zeller T, Schulte-Uentrop L, Stoehr A, Itagaki R, Haddad F, Eschenhagen T, Blankenberg S, Kiefmann R, Reichenspurner H, Velden J, Klein C, Yeung A, Robbins RC, Tsao PS, Schrepfer S. PMID: 24747400; PMCID: PMC4323184.
View in:
PubMed Mentions:
34 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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The Ca²⁺-activated K⁺ channel KCa3.1 as a potential new target for the prevention of allograft vasculopathy. PLoS One. 2013; 8(11):e81006.
Chen YJ, Lam J, Gregory CR, Schrepfer S, Wulff H. PMID: 24312257; PMCID: PMC3843675.
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PubMed Mentions:
13 Fields:
Translation:
HumansAnimals
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Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue. Stem Cells Dev. 2013 Oct 01; 22(19):2619-29.
Stubbendorff M, Deuse T, Hua X, Phan TT, Bieback K, Atkinson K, Eiermann TH, Velden J, Schröder C, Reichenspurner H, Robbins RC, Volk HD, Schrepfer S. PMID: 23711207.
View in:
PubMed Mentions:
29 Fields:
Translation:
HumansAnimalsCells
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Small animal models of experimental obliterative bronchiolitis. Am J Respir Cell Mol Biol. 2013 Jun; 48(6):675-84.
Jungraithmayr W, Jang JH, Schrepfer S, Inci I, Weder W. PMID: 23392572.
View in:
PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease. Transplantation. 2013 Jan 27; 95(2):285-92.
Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Köhler R, Miura H, Länger F, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 23325003; PMCID: PMC3777777.
View in:
PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
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Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545. Transplantation. 2012 Oct 15; 94(7):695-702.
Deuse T, Hua X, Taylor V, Stubbendorff M, Baluom M, Chen Y, Park G, Velden J, Streichert T, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 22971540.
View in:
PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up. Circ Res. 2013 Jan 04; 112(1):165-73.
Vrtovec B, Poglajen G, Lezaic L, Sever M, Domanovic D, Cernelc P, Socan A, Schrepfer S, Torre-Amione G, Haddad F, Wu JC. PMID: 23065358.
View in:
PubMed Mentions:
106 Fields:
Translation:
HumansCells
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Human internal mammary artery (IMA) transplantation and stenting: a human model to study the development of in-stent restenosis. J Vis Exp. 2012 May 09; (63):e3663.
Hua X, Deuse T, Michelakis ED, Haromy A, Tsao PS, Maegdefessel L, Erben RG, Bergow C, Behnisch BB, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 22617624; PMCID: PMC3466952.
View in:
PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
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Localization of Islet-1-positive cells in the healthy and infarcted adult murine heart. Circ Res. 2012 May 11; 110(10):1303-10.
Weinberger F, Mehrkens D, Friedrich FW, Stubbendorff M, Hua X, Müller JC, Schrepfer S, Evans SM, Carrier L, Eschenhagen T. PMID: 22427341; PMCID: PMC5559221.
View in:
PubMed Mentions:
38 Fields:
Translation:
Animals
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Human leukocyte antigen I knockdown human embryonic stem cells induce host ignorance and achieve prolonged xenogeneic survival. Circulation. 2011 Sep 13; 124(11 Suppl):S3-9.
Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 21911816.
View in:
PubMed Mentions:
10 Fields:
Translation:
HumansAnimalsCells
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Immunobiology of naïve and genetically modified HLA-class-I-knockdown human embryonic stem cells. J Cell Sci. 2011 Sep 01; 124(Pt 17):3029-37.
Deuse T, Seifert M, Phillips N, Fire A, Tyan D, Kay M, Tsao PS, Hua X, Velden J, Eiermann T, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 21878509.
View in:
PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Assessment of physiologic natural killer cell cytotoxicity in vitro. Hum Immunol. 2011 Nov; 72(11):1007-12.
Duske H, Sputtek A, Binder T, Kröger N, Schrepfer S, Eiermann T. PMID: 21924314.
View in:
PubMed Mentions:
8 Fields:
Translation:
HumansCells
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Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo. PLoS One. 2011; 6(8):e23101.
Michelfelder S, Varadi K, Raupp C, Hunger A, Körbelin J, Pahrmann C, Schrepfer S, Müller OJ, Kleinschmidt JA, Trepel M. PMID: 21850255; PMCID: PMC3151269.
View in:
PubMed Mentions:
26 Fields:
Translation:
HumansAnimalsCells
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Bioluminescence imaging for assessment of immune responses following implantation of engineered heart tissue (EHT). J Vis Exp. 2011 Jun 01; (52).
Conradi L, Pahrmann C, Schmidt S, Deuse T, Hansen A, Eder A, Reichenspurner H, Robbins RC, Eschenhagen T, Schrepfer S. PMID: 21673633; PMCID: PMC3197032.
View in:
PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Prevention of transplant coronary artery disease by prenylation inhibitors. J Heart Lung Transplant. 2011 Jul; 30(7):761-9.
Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP. PMID: 21458297.
View in:
PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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Orthotopic aortic transplantation: a rat model to study the development of chronic vasculopathy. J Vis Exp. 2010 Dec 04; (46).
Stubbendorff M, Deuse T, Hammel A, Robbins RC, Reichenspurner H, Schrepfer S. PMID: 21178963; PMCID: PMC3278333.
View in:
PubMed Mentions:
4 Fields:
Translation:
Animals
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Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Transplant. 2011; 20(5):655-67.
Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, Schrepfer S. PMID: 21054940.
View in:
PubMed Mentions:
121 Fields:
Translation:
HumansAnimalsCells
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Sustained inhibition of epsilon protein kinase C inhibits vascular restenosis after balloon injury and stenting. Circulation. 2010 Sep 14; 122(11 Suppl):S170-8.
Deuse T, Koyanagi T, Erben RG, Hua X, Velden J, Ikeno F, Reichenspurner H, Robbins RC, Mochly-Rosen D, Schrepfer S. PMID: 20837910.
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PubMed Mentions:
11 Fields:
Translation:
HumansAnimalsCells
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Non-volume-loaded heart provides a more relevant heterotopic transplantation model. Transpl Immunol. 2010 May; 23(1-2):65-70.
Tang-Quan KR, Bartos J, Deuse T, Churchill E, Schäfer H, Reichenspurner H, Mochly-Rosen D, Robbins RC, Schrepfer S. PMID: 20403439.
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PubMed Mentions:
2 Fields:
Translation:
Animals
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Heterotopic and orthotopic tracheal transplantation in mice used as models to study the development of obliterative airway disease. J Vis Exp. 2010 Jan 20; (35).
Hua X, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. PMID: 20090665; PMCID: PMC2841570.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Mechanisms behind local immunosuppression using inhaled tacrolimus in preclinical models of lung transplantation. Am J Respir Cell Mol Biol. 2010 Oct; 43(4):403-12.
Deuse T, Blankenberg F, Haddad M, Reichenspurner H, Phillips N, Robbins RC, Schrepfer S. PMID: 19880819.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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LAD-ligation: a murine model of myocardial infarction. J Vis Exp. 2009 Oct 14; (32).
Kolk MV, Meyberg D, Deuse T, Tang-Quan KR, Robbins RC, Reichenspurner H, Schrepfer S. PMID: 19829290; PMCID: PMC3164062.
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PubMed Mentions:
47 Fields:
Translation:
Animals
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Poor functional recovery after transplantation of diabetic bone marrow stem cells in ischemic myocardium. J Heart Lung Transplant. 2009 Nov; 28(11):1158-1165.e1.
Govaert JA, Swijnenburg RJ, Schrepfer S, Xie X, van der Bogt KE, Hoyt G, Stein W, Ransohoff KJ, Robbins RC, Wu JC. PMID: 19782602; PMCID: PMC3163601.
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PubMed Mentions:
12 Fields:
Translation:
HumansAnimals
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Hepatocyte growth factor or vascular endothelial growth factor gene transfer maximizes mesenchymal stem cell-based myocardial salvage after acute myocardial infarction. Circulation. 2009 Sep 15; 120(11 Suppl):S247-54.
Deuse T, Peter C, Fedak PW, Doyle T, Reichenspurner H, Zimmermann WH, Eschenhagen T, Stein W, Wu JC, Robbins RC, Schrepfer S. PMID: 19752375.
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PubMed Mentions:
98 Fields:
Translation:
Animals
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Imaging in-stent restenosis: an inexpensive, reliable, and rapid preclinical model. J Vis Exp. 2009 Sep 14; (31).
Deuse T, Ikeno F, Robbins RC, Schrepfer S. PMID: 19752856; PMCID: PMC3129662.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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A novel JAK3 inhibitor, R348, attenuates chronic airway allograft rejection. Transplantation. 2009 Mar 15; 87(5):653-9.
Velotta JB, Deuse T, Haddad M, Masuda E, Park G, Carroll D, Taylor V, Robbins RC, Schrepfer S. PMID: 19295308.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Comparison of transplantation of adipose tissue- and bone marrow-derived mesenchymal stem cells in the infarcted heart. Transplantation. 2009 Mar 15; 87(5):642-52.
van der Bogt KE, Schrepfer S, Yu J, Sheikh AY, Hoyt G, Govaert JA, Velotta JB, Contag CH, Robbins RC, Wu JC. PMID: 19295307; PMCID: PMC2866004.
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PubMed Mentions:
60 Fields:
Translation:
AnimalsCells
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In vivo imaging of embryonic stem cells reveals patterns of survival and immune rejection following transplantation. Stem Cells Dev. 2008 Dec; 17(6):1023-9.
Swijnenburg RJ, Schrepfer S, Cao F, Pearl JI, Xie X, Connolly AJ, Robbins RC, Wu JC. PMID: 18491958; PMCID: PMC2657199.
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PubMed Mentions:
58 Fields:
Translation:
AnimalsCells
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Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation. 2008 Sep 30; 118(14 Suppl):S121-9.
van der Bogt KE, Sheikh AY, Schrepfer S, Hoyt G, Cao F, Ransohoff KJ, Swijnenburg RJ, Pearl J, Lee A, Fischbein M, Contag CH, Robbins RC, Wu JC. PMID: 18824743; PMCID: PMC3657517.
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PubMed Mentions:
112 Fields:
Translation:
AnimalsCells
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Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci U S A. 2008 Sep 02; 105(35):12991-6.
Swijnenburg RJ, Schrepfer S, Govaert JA, Cao F, Ransohoff K, Sheikh AY, Haddad M, Connolly AJ, Davis MM, Robbins RC, Wu JC. PMID: 18728188; PMCID: PMC2529073.
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PubMed Mentions:
133 Fields:
Translation:
HumansAnimalsCells
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Novel immunosuppression: R348, a JAK3- and Syk-inhibitor attenuates acute cardiac allograft rejection. Transplantation. 2008 Mar 27; 85(6):885-92.
Deuse T, Velotta JB, Hoyt G, Govaert JA, Taylor V, Masuda E, Herlaar E, Park G, Carroll D, Pelletier MP, Robbins RC, Schrepfer S. PMID: 18360272.
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PubMed Mentions:
9 Fields:
Translation:
Animals
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Prevention and inhibition but not reversion of chronic allograft vasculopathy by FK778. Transplantation. 2008 Mar 27; 85(6):870-7.
Deuse T, Hoyt G, Koyanagi T, Robbins RC, Schrepfer S. PMID: 18360270.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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Introducing the first polymer-free leflunomide eluting stent. Atherosclerosis. 2008 Sep; 200(1):126-34.
Deuse T, Erben RG, Ikeno F, Behnisch B, Boeger R, Connolly AJ, Reichenspurner H, Bergow C, Pelletier MP, Robbins RC, Schrepfer S. PMID: 18295768.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimalsCells
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Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. FASEB J. 2008 Jul; 22(7):2561-8.
Huellner MW, Schrepfer S, Weyand M, Weiner H, Wimplinger I, Eschenhagen T, Rau T. PMID: 18272654.
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PubMed Mentions:
12 Fields:
Translation:
HumansCells
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Failed induction of heme oxygenase 1 in endothelial cells exposed to the hemoglobin based oxygen carrier Oxyglobin. Artif Cells Blood Substit Immobil Biotechnol. 2008; 36(1):34-44.
Rempf C, Ritter A, Schrepfer S, Freitag M, Standl T, Gottschalk A. PMID: 18293159.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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Right atrial mass after primary repair of an atrial septal defect: thrombus masquerading as a myxoma. Ann Thorac Surg. 2007 Nov; 84(5):1742-4.
Sheikh AY, Schrepfer S, Stein W, West J, Lombard J, Burdon T, Pinsker B, Pelletier MP. PMID: 17954102.
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PubMed Mentions:
6 Fields:
Translation:
Humans
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Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model? Transpl Immunol. 2007 Jun; 17(4):255-61.
Deuse T, Schrepfer S, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP. PMID: 17493528.
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PubMed Mentions:
5 Fields:
Translation:
AnimalsCells
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Coincidence of aortic valve stenosis and regurgitation and multiple cardiac papillary fibroelastomas in a young male adult. J Thorac Cardiovasc Surg. 2007 Feb; 133(2):564-5.
Sydow K, Schrepfer S, Franzen O, Detter C, Willems S, Meinertz T, Reichenspurner H. PMID: 17258602.
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PubMed Mentions: Fields:
Translation:
Humans
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Simplified protocol to isolate, purify, and culture expand mesenchymal stem cells. Stem Cells Dev. 2007 Feb; 16(1):105-7.
Schrepfer S, Deuse T, Lange C, Katzenberg R, Reichenspurner H, Robbins RC, Pelletier MP. PMID: 17348808.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy. J Heart Lung Transplant. 2007 Jan; 26(1):70-7.
Schrepfer S, Deuse T, Koch-Nolte F, Krieger T, Haddad M, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H. PMID: 17234520.
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PubMed Mentions:
1 Fields:
Translation:
HumansAnimalsCells
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Experimental orthotopic tracheal transplantation: The Stanford technique. Microsurgery. 2007; 27(3):187-9.
Schrepfer S, Deuse T, Hoyt G, Sheikh AY, Hoffmann J, Reichenspurner H, Robbins RC, Pelletier MP. PMID: 17326196.
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PubMed Mentions:
6 Fields:
Translation:
Animals
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Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides? Cardiology. 2007; 108(2):128-37.
Schrepfer S, Deuse T, Sultan KR, Haddad M, Böger R, Münzel T, Schäfer H, Pelletier MP, Robbins RC, Reichenspurner H. PMID: 17028423.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity. Menopause. 2006 May-Jun; 13(3):489-99.
Schrepfer S, Deuse T, Münzel T, Schäfer H, Braendle W, Reichenspurner H. PMID: 16735947.
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PubMed Mentions:
10 Fields:
Translation:
Animals
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Heparins increase endothelial nitric oxide bioavailability by liberating vessel-immobilized myeloperoxidase. Circulation. 2006 Apr 18; 113(15):1871-8.
Baldus S, Rudolph V, Roiss M, Ito WD, Rudolph TK, Eiserich JP, Sydow K, Lau D, Szöcs K, Klinke A, Kubala L, Berglund L, Schrepfer S, Deuse T, Haddad M, Risius T, Klemm H, Reichenspurner HC, Meinertz T, Heitzer T. PMID: 16606792.
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PubMed Mentions:
62 Fields:
Translation:
HumansCells
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Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease. Transpl Int. 2006 Apr; 19(4):310-8.
Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schäfer H, Detter C, Reichenspurner H. PMID: 16573547.
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PubMed Mentions:
2 Fields:
Translation:
AnimalsCells
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The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system. Transpl Immunol. 2005 Oct; 15(1):45-53.
Schrepfer S, Deuse T, Schäfer H, Koch-Nolte F, Braendle W, Reichenspurner H. PMID: 16223672.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation. J Heart Lung Transplant. 2005 Nov; 24(11):1844-54.
Deuse T, Schrepfer S, Koch-Nolte F, Haddad M, Schwedhelm E, Böger R, Schäfer H, Detter C, Reichenspurner H. PMID: 16297791.
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PubMed Mentions:
1 Fields:
Translation:
Animals
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FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival. Transpl Int. 2005 Feb; 18(2):215-20.
Schrepfer S, Deuse T, Schäfer H, Reichenspurner H. PMID: 15691275.
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PubMed Mentions:
3 Fields:
Translation:
AnimalsCells
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FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies. Transplantation. 2004 Jul 15; 78(1):71-7.
Deuse T, Schrepfer S, Schäfer H, Koch-Nolte F, Schwedhelm E, Böger RH, Reichenspurner H. PMID: 15257041.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells
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The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent. Transplantation. 2004 Feb 27; 77(4):509-13.
Deuse T, Schrepfer S, Reichenspurner H. PMID: 15084926.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model. Transplantation. 2003 Dec 15; 76(11):1627-9.
Deuse T, Schrepfer S, Reichenspurner H. PMID: 14702537.
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PubMed Mentions:
3 Fields:
Translation:
Animals
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Successful resection of a symptomatic right ventricular lipoma. Ann Thorac Surg. 2003 Oct; 76(4):1305-7.
Schrepfer S, Deuse T, Detter C, Treede H, Koops A, Boehm DH, Willems S, Lacour-Gayet F, Reichenspurner H. PMID: 14530040.
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PubMed Mentions:
20 Fields:
Translation:
Humans
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New technique for chest opening in mice: U-sternotomy. Microsurgery. 2003; 23(3):274-5.
Schrepfer S, Deuse T, Reichenspurner H. PMID: 12833331.
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Translation:
AnimalsCells
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Myoblasts survive intracardiac transfer and divide further after transplantation. Heart Surg Forum. 2002; 5(4):340-4.
Gulbins H, Schrepfer S, Uhlig A, Goldemund A, Oberhoffer M, Reichenspurner H, Meiser B, Reichart B. PMID: 12538115.
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PubMed Mentions:
1 Fields:
Translation:
AnimalsCells