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    Stephen Lazarus, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address505 Parnassus Avenue
    San Francisco CA 94117
    Phone415-476-2091
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoResidency School of Medicine

      Collapse Overview 
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      Dr. Lazarus is an inbred product of the University of California, having received his A.B. from Berkeley, his M.D. from Irvine, and training in Internal Medicine and Pulmonary & Critical Care Medicine at UCSF. Drafted into military service during the Viet Nam era, he spent 2 years as Chief of Pulmonary Medicine and Co-Director of the ICU at Andrews Air Force Base in Washington, D.C. before returning to UCSF for additional research training in the Cardiovascular Research Institute. Since joining the faculty at UCSF in 1983, Dr. Lazarus has directed basic and clinical research on the mechanisms and treatment of asthma, COPD, and other airway diseases. He is an Attending Physician on the Pulmonary Consult Service, the Adult Pulmonary Function Laboratory, and the Chest Faculty Practice at UCSF-Moffitt-Long Hospital, and has been Director of the Chest Faculty Practice, Director of the Medical Specialty Practices, and Interim Chief of the Division of Pulmonary and Critical Care Medicine. Currently he is Director of the Training Program in Pulmonary and Critical Care Medicine and Associate Director of the Adult Pulmonary Laboratory.

      Research Interests:
      Dr. Lazarus' research has focused on the role of inflammatory cells and mediators in regulating function of the lung and airways in obstructive lung diseases. After working in whole animals and organ systems, he developed continuous mastocytoma cell lines that share many important features of normal human mast cells. These cells served as a unique model system for mast cell biology as well as a source of mast cell-derived mediators to examine the role of these mediators in important biological processes.

      Studies of mast cell mediators led to a series of investigator-initiated clinical research projects to examine the role of leukotrienes in chronic asthma and in mediating the bronchoconstrictor response to inhaled sulfur dioxide; the role of tachykinins in mediating the airway hyperresponsiveness, airway inflammation, and symptoms of chronic asthma; and the correlation between elastase and elastolytic activity in the sputum of patients with chronic bronchitis and physiological measures of lung function. In collaboration with Drs John Fahy, George Caughey, and Jay Nadel, Dr. Lazarus examined the effect of sputum proteases on airway inflammation, and the effect of inflammatory mediators on regulation of airway mucin gene expression and mucin secretion (via the EGF-receptor).

      These studies provided the infrastructure for several successful competitive applications to the NIH to participate in Clinical Research Networks. In 1993, Drs. Boushey, Lazarus, and Fahy were awarded one of 6 Asthma Clinical Research Network (ACRN) Centers in the US, and their application was again successful in an open competition in 2003. This network conducts multicenter clinical trials to examine important mechanisms in the treatment and pathogenesis of asthma. In addition to serving on the Steering Committee of the Network, responsible for the design and implementation of all studies, Dr. Lazarus was the Lead Investigator on 2 major ACRN projects: one, a study that examined clinical outcomes and inflammatory biomarkers in subjects treated with inhaled corticosteroids or a long-acting ß-agonist, was published in JAMA, and was responsible for a change in asthma management guidelines. Dr. Lazarus also led a study that demonstrated that asthmatics who smoke have a blunted response to inhaled corticosteroids – apparently because smoking regulates transcription factors related to airway inflammation.

      In 2003, Dr. Lazarus built upon studies of mucus hypersecretion and airway function to prepare a successful application to the NIH/NHLBI to participate as one of 7 sites in the COPD Clinical Research Network (CCRN). As Principal Investigator of this award, Dr. Lazarus led studies to examine biomarkers as predictors of COPD exacerbations, and to explore the role of arachidonic acid metabolites in the pathogenesis of COPD exacerbations. Dr. Lazarus Chairs the Steering Committee of this Network.

      Dr. Lazarus is also Co-PI of the new (in 2009) AsthmaNet, an NHLBI network funded for 7 years to examine clinical outcomes and mechanisms of asthma. He is the lead investigator of a study of TH2 high vs TH2 low asthma phenotypes, to be launched in 2012.

      Finally, in collaboration with Prescott Woodruff, Dr. Lazarus is a Co-Investigator of the new SPIROMICS network, an NHLBI-sponsored project to identify subpopulations of COPD patients that are similar with respect to molecular mechanisms of disease.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Durack J, Lynch SV, Nariya S, Bhakta NR, Beigelman A, Castro M, Dyer AM, Israel E, Kraft M, Martin RJ, Mauger DT, Rosenberg SR, Sharp-King T, White SR, Woodruff PG, Avila PC, Denlinger LC, Holguin F, Lazarus SC, Lugogo N, Moore WC, Peters SP, Que L, Smith LJ, Sorkness CA, Wechsler M, Wenzel SE, Boushey HA, Huang YJ. Features of the bronchial bacterial microbiome associated with atopy, asthma and responsiveness to inhaled corticosteroid treatment. J Allergy Clin Immunol. 2016 Nov 9. PMID: 27838347.
        View in: PubMed
      2. Sadatsafavi M, Sin DD, Zafari Z, Criner G, Connett JE, Lazarus S, Han M, Martinez F, Albert R. The Association Between Rate and Severity of Exacerbations in Chronic Obstructive Pulmonary Disease: An Application of a Joint Frailty-Logistic Model. Am J Epidemiol. 2016 Nov 1; 184(9):681-689. PMID: 27737842.
        View in: PubMed
      3. Leung JM, Chen V, Hollander Z, Dai D, Tebbutt SJ, Aaron SD, Vandemheen KL, Rennard SI, FitzGerald JM, Woodruff PG, Lazarus SC, Connett JE, Coxson HO, Miller B, Borchers C, McManus BM, Ng RT, Sin DD. COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry. PLoS One. 2016; 11(8):e0161129. PMID: 27525416.
        View in: PubMed
      4. Bhatt SP, Connett JE, Voelker H, Lindberg SM, Westfall E, Wells JM, Lazarus SC, Criner GJ, Dransfield MT. ß-Blockers for the prevention of acute exacerbations of chronic obstructive pulmonary disease (ßLOCK COPD): a randomised controlled study protocol. BMJ Open. 2016; 6(6):e012292. PMID: 27267111.
        View in: PubMed
      5. Woodruff PG, Barr RG, Bleecker E, Christenson SA, Couper D, Curtis JL, Gouskova NA, Hansel NN, Hoffman EA, Kanner RE, Kleerup E, Lazarus SC, Martinez FJ, Paine R, Rennard S, Tashkin DP, Han MK. Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function. N Engl J Med. 2016 May 12; 374(19):1811-21. PMID: 27168432.
        View in: PubMed
      6. Bacharier LB, Guilbert TW, Mauger DT, Boehmer S, Beigelman A, Fitzpatrick AM, Jackson DJ, Baxi SN, Benson M, Burnham CA, Cabana M, Castro M, Chmiel JF, Covar R, Daines M, Gaffin JM, Gentile DA, Holguin F, Israel E, Kelly HW, Lazarus SC, Lemanske RF, Ly N, Meade K, Morgan W, Moy J, Olin T, Peters SP, Phipatanakul W, Pongracic JA, Raissy HH, Ross K, Sheehan WJ, Sorkness C, Szefler SJ, Teague WG, Thyne S, Martinez FD. Early Administration of Azithromycin and Prevention of Severe Lower Respiratory Tract Illnesses in Preschool Children With a History of Such Illnesses: A Randomized Clinical Trial. JAMA. 2015 Nov 17; 314(19):2034-44. PMID: 26575060.
        View in: PubMed
      7. Dunn RM, Lehman E, Chinchilli VM, Martin RJ, Boushey HA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo NL, Peters SP, Sorkness CA, Szefler S, Wechsler ME. Impact of Age and Sex on Response to Asthma Therapy. Am J Respir Crit Care Med. 2015 Sep 1; 192(5):551-8. PMID: 26068329; PMCID: PMC4595693 [Available on 09/01/16].
      8. Wang Y, Tong C, Wang Z, Wang Z, Mauger D, Tantisira KG, Israel E, Szefler SJ, Chinchilli VM, Boushey HA, Lazarus SC, Lemanske RF, Wu R. Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma. Pharmacogenomics J. 2015 Oct; 15(5):422-9. PMID: 25601762.
        View in: PubMed
      9. Ono E, Dutile S, Kazani S, Wechsler ME, Yang J, Hammock BD, Douda DN, Tabet Y, Khaddaj-Mallat R, Sirois M, Sirois C, Rizcallah E, Rousseau E, Martin R, Sutherland ER, Castro M, Jarjour NN, Israel E, Levy BD. Lipoxin generation is related to soluble epoxide hydrolase activity in severe asthma. Am J Respir Crit Care Med. 2014 Oct 15; 190(8):886-97. PMID: 25162465; PMCID: PMC4299578.
      10. Han MK, Tayob N, Murray S, Dransfield MT, Washko G, Scanlon PD, Criner GJ, Casaburi R, Connett J, Lazarus SC, Albert R, Woodruff P, Martinez FJ. Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy. Am J Respir Crit Care Med. 2014 Jun 15; 189(12):1503-8. PMID: 24779680; PMCID: PMC4226018.
      11. Criner GJ, Connett JE, Aaron SD, Albert RK, Bailey WC, Casaburi R, Cooper JA, Curtis JL, Dransfield MT, Han MK, Make B, Marchetti N, Martinez FJ, Niewoehner DE, Scanlon PD, Sciurba FC, Scharf SM, Sin DD, Voelker H, Washko GR, Woodruff PG, Lazarus SC. Simvastatin for the prevention of exacerbations in moderate-to-severe COPD. N Engl J Med. 2014 Jun 5; 370(23):2201-10. PMID: 24836125; PMCID: PMC4375247.
      12. Castro M, King TS, Kunselman SJ, Cabana MD, Denlinger L, Holguin F, Kazani SD, Moore WC, Moy J, Sorkness CA, Avila P, Bacharier LB, Bleecker E, Boushey HA, Chmiel J, Fitzpatrick AM, Gentile D, Hundal M, Israel E, Kraft M, Krishnan JA, LaForce C, Lazarus SC, Lemanske R, Lugogo N, Martin RJ, Mauger DT, Naureckas E, Peters SP, Phipatanakul W, Que LG, Sheshadri A, Smith L, Solway J, Sullivan-Vedder L, Sumino K, Wechsler ME, Wenzel S, White SR, Sutherland ER. Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. JAMA. 2014 May; 311(20):2083-91. PMID: 24838406; PMCID: PMC4217655.
      13. Woodruff PG, Chatila W, Connett JE, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Marchetti N, Rogers TJ, Scanlon PD, Sin DD, Voelker H, Wendt C, Albert RK. Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial. Eur Respir J. 2014 Jan; 43(1):295-8. PMID: 24136332; PMCID: PMC4326242.
      14. Peters SP, Bleecker ER, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger LC, Engle LL, Dimango EA, Israel E, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Szefler SJ. Predictors of response to tiotropium versus salmeterol in asthmatic adults. J Allergy Clin Immunol. 2013 Nov; 132(5):1068-1074.e1. PMID: 24084072; PMCID: PMC3826080.
      15. Couper D, LaVange LM, Han M, Barr RG, Bleecker E, Hoffman EA, Kanner R, Kleerup E, Martinez FJ, Woodruff PG, Rennard S. Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS). Thorax. 2014 May; 69(5):491-4. PMID: 24029743; PMCID: PMC3954445.
      16. Albert RK, Connett J, Curtis JL, Martinez FJ, Han MK, Lazarus SC, Woodruff PG. Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2012; 7:767-77. PMID: 23226013; PMCID: PMC3514010.
      17. Denlinger LC, Manthei DM, Seibold MA, Ahn K, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Chinchili VM, Fahy JV, Hawkins GA, Icitovic N, Israel E, Jarjour NN, King T, Kraft M, Lazarus SC, Lehman E, Martin RJ, Meyers DA, Peters SP, Sheerar D, Shi L, Sutherland ER, Szefler SJ, Wechsler ME, Sorkness CA, Lemanske RF. P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy. Am J Respir Crit Care Med. 2013 Jan 1; 187(1):28-33. PMID: 23144325; PMCID: PMC3570642.
      18. Brozek JL, Kraft M, Krishnan JA, Cloutier MM, Lazarus SC, Li JT, Santesso N, Strunk RC, Casale TB. Long-acting ß2-agonist step-off in patients with controlled asthma. Arch Intern Med. 2012 Oct 8; 172(18):1365-75. PMID: 22928176.
        View in: PubMed
      19. Calhoun WJ, Ameredes BT, King TS, Icitovic N, Bleecker ER, Castro M, Cherniack RM, Chinchilli VM, Craig T, Denlinger L, DiMango EA, Engle LL, Fahy JV, Grant JA, Israel E, Jarjour N, Kazani SD, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Moore WC, Pascual R, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Boushey HA. Comparison of physician-, biomarker-, and symptom-based strategies for adjustment of inhaled corticosteroid therapy in adults with asthma: the BASALT randomized controlled trial. JAMA. 2012 Sep 12; 308(10):987-97. PMID: 22968888; PMCID: PMC3697088.
      20. Dransfield MT, Harnden S, Burton RL, Albert RK, Bailey WC, Casaburi R, Connett J, Cooper JA, Criner GJ, Curtis JL, Han MK, Make B, Marchetti N, Martinez FJ, McEvoy C, Nahm MH, Niewoehner DE, Porszasz J, Reilly J, Scanlon PD, Scharf SM, Sciurba FC, Washko GR, Woodruff PG, Lazarus SC. Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease. Clin Infect Dis. 2012 Sep; 55(5):e35-44. PMID: 22652582; PMCID: PMC3491850.
      21. Casaburi R, Porszasz J, Hecht A, Tiep B, Albert RK, Anthonisen NR, Bailey WC, Connett JE, Cooper JA, Criner GJ, Curtis J, Dransfield M, Lazarus SC, Make B, Martinez FJ, McEvoy C, Niewoehner DE, Reilly JJ, Scanlon P, Scharf SM, Sciurba FC, Woodruff P. Influence of lightweight ambulatory oxygen on oxygen use and activity patterns of COPD patients receiving long-term oxygen therapy. COPD. 2012 Feb; 9(1):3-11. PMID: 22292592.
        View in: PubMed
      22. Holbrook JT, Wise RA, Gold BD, Blake K, Brown ED, Castro M, Dozor AJ, Lima JJ, Mastronarde JG, Sockrider MM, Teague WG. Lansoprazole for children with poorly controlled asthma: a randomized controlled trial. JAMA. 2012 Jan 25; 307(4):373-81. PMID: 22274684; PMCID: PMC4153372.
      23. McGrath KW, Icitovic N, Boushey HA, Lazarus SC, Sutherland ER, Chinchilli VM, Fahy JV. A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. Am J Respir Crit Care Med. 2012 Mar 15; 185(6):612-9. PMID: 22268133; PMCID: PMC3326288.
      24. Kunisaki KM, Niewoehner DE, Connett JE. Vitamin D levels and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study. Am J Respir Crit Care Med. 2012 Feb 1; 185(3):286-90. PMID: 22077070; PMCID: PMC3297108.
      25. Tantisira KG, Lasky-Su J, Harada M, Murphy A, Litonjua AA, Himes BE, Lange C, Lazarus R, Sylvia J, Klanderman B, Duan QL, Qiu W, Hirota T, Martinez FD, Mauger D, Sorkness C, Szefler S, Lazarus SC, Lemanske RF, Peters SP, Lima JJ, Nakamura Y, Tamari M, Weiss ST. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011 Sep 29; 365(13):1173-83. PMID: 21991891; PMCID: PMC3667396.
      26. Wechsler ME, Castro M, Lehman E, Chinchilli VM, Sutherland ER, Denlinger L, Lazarus SC, Peters SP, Israel E. Impact of race on asthma treatment failures in the asthma clinical research network. Am J Respir Crit Care Med. 2011 Dec 1; 184(11):1247-53. PMID: 21885625; PMCID: PMC3361331.
      27. Albert RK, Connett J, Bailey WC, Casaburi R, Cooper JA, Criner GJ, Curtis JL, Dransfield MT, Han MK, Lazarus SC, Make B, Marchetti N, Martinez FJ, Madinger NE, McEvoy C, Niewoehner DE, Porsasz J, Price CS, Reilly J, Scanlon PD, Sciurba FC, Scharf SM, Washko GR, Woodruff PG, Anthonisen NR. Azithromycin for prevention of exacerbations of COPD. N Engl J Med. 2011 Aug 25; 365(8):689-98. PMID: 21864166; PMCID: PMC3220999.
      28. Woodruff PG, Albert RK, Bailey WC, Casaburi R, Connett JE, Cooper JA, Criner GJ, Curtis JL, Dransfield MT, Han MK, Harnden SM, Kim V, Marchetti N, Martinez FJ, McEvoy CE, Niewoehner DE, Reilly JJ, Rice K, Scanlon PD, Scharf SM, Sciurba FC, Washko GR, Lazarus SC. Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization. COPD. 2011 Feb; 8(1):21-9. PMID: 21299475; PMCID: PMC3775706.
      29. Huang YJ, Nelson CE, Brodie EL, Desantis TZ, Baek MS, Liu J, Woyke T, Allgaier M, Bristow J, Wiener-Kronish JP, Sutherland ER, King TS, Icitovic N, Martin RJ, Calhoun WJ, Castro M, Denlinger LC, Dimango E, Kraft M, Peters SP, Wasserman SI, Wechsler ME, Boushey HA, Lynch SV. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol. 2011 Feb; 127(2):372-381.e1-3. PMID: 21194740; PMCID: PMC3037020.
      30. Sutherland ER, King TS, Icitovic N, Ameredes BT, Bleecker E, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Chinchilli VM, Craig TJ, Denlinger L, DiMango EA, Fahy JV, Israel E, Jarjour N, Kraft M, Lazarus SC, Lemanske RF, Peters SP, Ramsdell J, Sorkness CA, Szefler SJ, Walter MJ, Wasserman SI, Wechsler ME, Chu HW, Martin RJ. A trial of clarithromycin for the treatment of suboptimally controlled asthma. J Allergy Clin Immunol. 2010 Oct; 126(4):747-53. PMID: 20920764; PMCID: PMC2950827.
      31. Peters SP, Kunselman SJ, Icitovic N, Moore WC, Pascual R, Ameredes BT, Boushey HA, Calhoun WJ, Castro M, Cherniack RM, Craig T, Denlinger L, Engle LL, DiMango EA, Fahy JV, Israel E, Jarjour N, Kazani SD, Kraft M, Lazarus SC, Lemanske RF, Lugogo N, Martin RJ, Meyers DA, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Walter MJ, Wechsler ME, Chinchilli VM, Bleecker ER. Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010 Oct 28; 363(18):1715-26. PMID: 20979471; PMCID: PMC3011177.
      32. Lazarus SC. Clinical practice. Emergency treatment of asthma. N Engl J Med. 2010 Aug 19; 363(8):755-64. PMID: 20818877.
        View in: PubMed
      33. Janson SL, McGrath KW, Covington JK, Baron RB, Lazarus SC. Objective airway monitoring improves asthma control in the cold and flu season: a cluster randomized trial. Chest. 2010 Nov; 138(5):1148-55. PMID: 20538819; PMCID: PMC2972622.
      34. Newcomb PA, McGrath KW, Covington JK, Lazarus SC, Janson SL. Barriers to patient-clinician collaboration in asthma management: the patient experience. J Asthma. 2010 Mar; 47(2):192-7. PMID: 20170328.
        View in: PubMed
      35. Wechsler ME, Kunselman SJ, Chinchilli VM, Bleecker E, Boushey HA, Calhoun WJ, Ameredes BT, Castro M, Craig TJ, Denlinger L, Fahy JV, Jarjour N, Kazani S, Kim S, Kraft M, Lazarus SC, Lemanske RF, Markezich A, Martin RJ, Permaul P, Peters SP, Ramsdell J, Sorkness CA, Sutherland ER, Szefler SJ, Walter MJ, Wasserman SI, Israel E. Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial. Lancet. 2009 Nov 21; 374(9703):1754-64. PMID: 19932356; PMCID: PMC2914569.
      36. Gordon E, Lazarus SC. Management of chronic obstructive pulmonary disease: moving beyond the asthma algorithm. J Allergy Clin Immunol. 2009 Nov; 124(5):873-80; quiz 881-2. PMID: 19895979.
        View in: PubMed
      37. Reddel HK, Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, Chanez P, Enright PL, Gibson PG, de Jongste JC, Kerstjens HA, Lazarus SC, Levy ML, O'Byrne PM, Partridge MR, Pavord ID, Sears MR, Sterk PJ, Stoloff SW, Sullivan SD, Szefler SJ, Thomas MD, Wenzel SE. An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009 Jul 1; 180(1):59-99. PMID: 19535666.
        View in: PubMed
      38. Qian Z, Lin HM, Chinchilli VM, Lehman EB, Duan Y, Craig TJ, Wilson WE, Liao D, Lazarus SC, Bascom R. Interaction of ambient air pollution with asthma medication on exhaled nitric oxide among asthmatics. Arch Environ Occup Health. 2009; 64(3):168-76. PMID: 19864219; PMCID: PMC3713465.
      39. Qian Z, Lin HM, Chinchilli VM, Lehman EB, Stewart WF, Shah N, Duan Y, Craig TJ, Wilson WE, Liao D, Lazarus SC, Bascom R. Associations between air pollution and peak expiratory flow among patients with persistent asthma. J Toxicol Environ Health A. 2009; 72(1):39-46. PMID: 18979353; PMCID: PMC2848818.
      40. Walter MJ, Castro M, Kunselman SJ, Chinchilli VM, Reno M, Ramkumar TP, Avila PC, Boushey HA, Ameredes BT, Bleecker ER, Calhoun WJ, Cherniack RM, Craig TJ, Denlinger LC, Israel E, Fahy JV, Jarjour NN, Kraft M, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Ramsdell JW, Sorkness CA, Sutherland ER, Szefler SJ, Wasserman SI, Wechsler ME. Predicting worsening asthma control following the common cold. Eur Respir J. 2008 Dec; 32(6):1548-54. PMID: 18768579; PMCID: PMC2592508.
      41. Taylor DR, Bateman ED, Boulet LP, Boushey HA, Busse WW, Casale TB, Chanez P, Enright PL, Gibson PG, de Jongste JC, Kerstjens HA, Lazarus SC, Levy ML, O'Byrne PM, Partridge MR, Pavord ID, Sears MR, Sterk PJ, Stoloff SW, Szefler SJ, Sullivan SD, Thomas MD, Wenzel SE, Reddel HK. A new perspective on concepts of asthma severity and control. Eur Respir J. 2008 Sep; 32(3):545-54. PMID: 18757695.
        View in: PubMed
      42. Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lemanske RF, Leone FT, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Wechsler ME, Fahy JV. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med. 2007 Apr 15; 175(8):783-90. PMID: 17204725; PMCID: PMC1899291.
      43. Martin RJ, Szefler SJ, King TS, Kraft M, Boushey HA, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fahy JV, Israel E, Lazarus SC, Lemanske RF, Leone FT, Pesola GR, Peters SP, Sorkness CA, Szwejbka LA, Wechsler ME. The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial. J Allergy Clin Immunol. 2007 Jan; 119(1):73-80. PMID: 17208587; PMCID: PMC2872157.
      44. Lazarus SC. Mild persistent asthma: is any treatment needed? J Allergy Clin Immunol. 2006 Oct; 118(4):805-8. PMID: 17030230.
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      45. Innes AL, Woodruff PG, Ferrando RE, Donnelly S, Dolganov GM, Lazarus SC, Fahy JV. Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction. Chest. 2006 Oct; 130(4):1102-8. PMID: 17035444.
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      46. Deykin A, Wechsler ME, Boushey HA, Chinchilli VM, Kunselman SJ, Craig TJ, DiMango E, Fahy JV, Kraft M, Leone F, Lazarus SC, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E. Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma. Am J Respir Crit Care Med. 2007 Feb 1; 175(3):228-34. PMID: 16973987; PMCID: PMC1899264.
      47. Wechsler ME, Lehman E, Lazarus SC, Lemanske RF, Boushey HA, Deykin A, Fahy JV, Sorkness CA, Chinchilli VM, Craig TJ, DiMango E, Kraft M, Leone F, Martin RJ, Peters SP, Szefler SJ, Liu W, Israel E. beta-Adrenergic receptor polymorphisms and response to salmeterol. Am J Respir Crit Care Med. 2006 Mar 1; 173(5):519-26. PMID: 16322642; PMCID: PMC2662935.
      48. Boushey HA, Sorkness CA, King TS, Sullivan SD, Fahy JV, Lazarus SC, Chinchilli VM, Craig TJ, Dimango EA, Deykin A, Fagan JK, Fish JE, Ford JG, Kraft M, Lemanske RF, Leone FT, Martin RJ, Mauger EA, Pesola GR, Peters SP, Rollings NJ, Szefler SJ, Wechsler ME, Israel E. Daily versus as-needed corticosteroids for mild persistent asthma. N Engl J Med. 2005 Apr 14; 352(15):1519-28. PMID: 15829533.
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      49. Fabbri L, Peters SP, Pavord I, Wenzel SE, Lazarus SC, Macnee W, Lemaire F, Abraham E. Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004. Am J Respir Crit Care Med. 2005 Apr 1; 171(7):686-98. PMID: 15790866.
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      50. Deykin A, Lazarus SC, Fahy JV, Wechsler ME, Boushey HA, Chinchilli VM, Craig TJ, Dimango E, Kraft M, Leone F, Lemanske RF, Martin RJ, Pesola GR, Peters SP, Sorkness CA, Szefler SJ, Israel E. Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids. J Allergy Clin Immunol. 2005 Apr; 115(4):720-7. PMID: 15805990.
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      51. Bush A, Accurso F, Macnee W, Lazarus SC, Abraham E. Cystic fibrosis, pediatrics, control of breathing, pulmonary physiology and anatomy, and surfactant biology in AJRCCM in 2004. Am J Respir Crit Care Med. 2005 Mar 15; 171(6):545-53. PMID: 15753484.
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      52. Israel E, Chinchilli VM, Ford JG, Boushey HA, Cherniack R, Craig TJ, Deykin A, Fagan JK, Fahy JV, Fish J, Kraft M, Kunselman SJ, Lazarus SC, Lemanske RF, Liggett SB, Martin RJ, Mitra N, Peters SP, Silverman E, Sorkness CA, Szefler SJ, Wechsler ME, Weiss ST, Drazen JM. Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial. Lancet. 2004 Oct 23-29; 364(9444):1505-12. PMID: 15500895.
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      53. Kraft M, Martin RJ, Lazarus SC, Fahy JV, Boushey HA, Lemanske RF, Szefler SJ. Airway tissue mast cells in persistent asthma: predictor of treatment failure when patients discontinue inhaled corticosteroids. Chest. 2003 Jul; 124(1):42-50. PMID: 12853500.
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      54. Martin RJ, Szefler SJ, Chinchilli VM, Kraft M, Dolovich M, Boushey HA, Cherniack RM, Craig TJ, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kunselman SJ, Lazarus SC, Lemanske RF, Peters SP, Sorkness CA. Systemic effect comparisons of six inhaled corticosteroid preparations. Am J Respir Crit Care Med. 2002 May 15; 165(10):1377-83. PMID: 12016099.
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      56. Szefler SJ, Martin RJ, King TS, Boushey HA, Cherniack RM, Chinchilli VM, Craig TJ, Dolovich M, Drazen JM, Fagan JK, Fahy JV, Fish JE, Ford JG, Israel E, Kiley J, Kraft M, Lazarus SC, Lemanske RF, Mauger E, Peters SP, Sorkness CA. Significant variability in response to inhaled corticosteroids for persistent asthma. J Allergy Clin Immunol. 2002 Mar; 109(3):410-8. PMID: 11897984.
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      57. Chinchilli VM, Drazen JM, Fish JE, Lemanske RF, Lazarus SC, Martin RJ. The clinical trials in the initial five-year award period of the Asthma Clinical Research Network. Control Clin Trials. 2001 Dec; 22(6 Suppl):126S-34S. PMID: 11728619.
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      58. Burgel PR, Lazarus SC, Tam DC, Ueki IF, Atabai K, Birch M, Nadel JA. Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation. J Immunol. 2001 Nov 15; 167(10):5948-54. PMID: 11698473.
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      59. Woodruff PG, Khashayar R, Lazarus SC, Janson S, Avila P, Boushey HA, Segal M, Fahy JV. Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma. J Allergy Clin Immunol. 2001 Nov; 108(5):753-8. PMID: 11692100.
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      60. Fahy JV, Boushey HA, Lazarus SC, Mauger EA, Cherniack RM, Chinchilli VM, Craig TJ, Drazen JM, Ford JG, Fish JE, Israel E, Kraft M, Lemanske RF, Martin RJ, McLean D, Peters SP, Sorkness C, Szefler SJ. Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study. Am J Respir Crit Care Med. 2001 May; 163(6):1470-5. PMID: 11371420.
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      61. Lazarus SC, Boushey HA, Fahy JV, Chinchilli VM, Lemanske RF, Sorkness CA, Kraft M, Fish JE, Peters SP, Craig T, Drazen JM, Ford JG, Israel E, Martin RJ, Mauger EA, Nachman SA, Spahn JD, Szefler SJ. Long-acting beta2-agonist monotherapy vs continued therapy with inhaled corticosteroids in patients with persistent asthma: a randomized controlled trial. JAMA. 2001 May 23-30; 285(20):2583-93. PMID: 11368732.
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      62. Lemanske RF, Sorkness CA, Mauger EA, Lazarus SC, Boushey HA, Fahy JV, Drazen JM, Chinchilli VM, Craig T, Fish JE, Ford JG, Israel E, Kraft M, Martin RJ, Nachman SA, Peters SP, Spahn JD, Szefler SJ. Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. JAMA. 2001 May 23-30; 285(20):2594-603. PMID: 11368733.
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      63. Leone FT, Mauger EA, Peters SP, Chinchilli VM, Fish JE, Boushey HA, Cherniack RM, Drazen JM, Fahy JV, Ford J, Israel E, Lazarus SC, Lemanske RF, Martin RJ, McGeady SJ, Sorkness C, Szefler SJ. The utility of peak flow, symptom scores, and beta-agonist use as outcome measures in asthma clinical research. Chest. 2001 Apr; 119(4):1027-33. PMID: 11296165.
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      64. Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma. Int Arch Allergy Immunol. 2001 Jan-Mar; 124(1-3):183-6. PMID: 11306963.
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      65. Israel E, Drazen JM, Liggett SB, Boushey HA, Cherniack RM, Chinchilli VM, Cooper DM, Fahy JV, Fish JE, Ford JG, Kraft M, Kunselman S, Lazarus SC, Lemanske RF, Martin RJ, McLean DE, Peters SP, Silverman EK, Sorkness CA, Szefler SJ, Weiss ST, Yandava CN. The effect of polymorphisms of the beta(2)-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med. 2000 Jul; 162(1):75-80. PMID: 10903223.
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      66. Lazarus SC. Antileukotrienes and laboratory models of asthma. Clin Rev Allergy Immunol. 1999 Spring-Summer; 17(1-2):223-33. PMID: 10436868.
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      67. Liu H, Lazarus SC, Caughey GH, Fahy JV. Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro. Am J Physiol. 1999 Jan; 276(1 Pt 1):L28-34. PMID: 9887052.
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      68. Lazarus SC. Inflammation, inflammatory mediators, and mediator antagonists in asthma. J Clin Pharmacol. 1998 Jul; 38(7):577-82. PMID: 9702841.
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      69. Lazarus SC, Lee T, Kemp JP, Wenzel S, Dubé LM, Ochs RF, Carpentier PJ, Lancaster JF. Safety and clinical efficacy of zileuton in patients with chronic asthma. Am J Manag Care. 1998 Jun; 4(6):841-8. PMID: 10181070.
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      70. Lazarus SC, Wong HH, Watts MJ, Boushey HA, Lavins BJ, Minkwitz MC. The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide-induced bronchoconstriction in patients with asthma. Am J Respir Crit Care Med. 1997 Dec; 156(6):1725-30. PMID: 9412547.
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      71. Fish JE, Peters SP, Chambers CV, McGeady SJ, Epstein KR, Boushey HA, Cherniack RM, Chinchilli VM, Drazen JM, Fahy JV, Hurd SS, Israel E, Lazarus SC, Lemanske RF, Martin RJ, Mauger EA, Sorkness C, Szefler SJ. An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network. Am J Respir Crit Care Med. 1997 Oct; 156(4 Pt 1):1165-71. PMID: 9351617.
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      72. Drazen JM, Israel E, Boushey HA, Chinchilli VM, Fahy JV, Fish JE, Lazarus SC, Lemanske RF, Martin RJ, Peters SP, Sorkness C, Szefler SJ. Comparison of regularly scheduled with as-needed use of albuterol in mild asthma. Asthma Clinical Research Network. N Engl J Med. 1996 Sep 19; 335(12):841-7. PMID: 8778601.
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      73. Kamada AK, Szefler SJ, Martin RJ, Boushey HA, Chinchilli VM, Drazen JM, Fish JE, Israel E, Lazarus SC, Lemanske RF. Issues in the use of inhaled glucocorticoids. The Asthma Clinical Research Network. Am J Respir Crit Care Med. 1996 Jun; 153(6 Pt 1):1739-48. PMID: 8665030.
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      74. Thomas PS, Pennington DW, Schreck RE, Levine TM, Lazarus SC. Authentic 17 kDa tumour necrosis factor alpha is synthesized and released by canine mast cells and up-regulated by stem cell factor. Clin Exp Allergy. 1996 Jun; 26(6):710-8. PMID: 8809429.
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      75. Fang KC, Raymond WW, Lazarus SC, Caughey GH. Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase. J Clin Invest. 1996 Apr 1; 97(7):1589-96. PMID: 8601622; PMCID: PMC507221.
      76. Inase N, Levine TM, Lazarus SC. Mitogen-inducible prostaglandin G/H synthase is expressed in canine mastocytoma cells. Am J Respir Cell Mol Biol. 1993 Nov; 9(5):526-32. PMID: 8217194.
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      77. Inase N, Schreck RE, Lazarus SC. Heparin inhibits histamine release from canine mast cells. Am J Physiol. 1993 Apr; 264(4 Pt 1):L387-90. PMID: 7682786.
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      78. Baxter AB, Lazarus SC, Brasch RC. In vitro histamine release induced by magnetic resonance imaging and iodinated contrast media. Invest Radiol. 1993 Apr; 28(4):308-12. PMID: 7683008.
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      79. Thomas PS, Wilson AN, Schreck RE, Lazarus SC. Prostaglandin D2 production and identification of prostaglandin H synthase within canine mast cell granule. Am J Physiol. 1992 Aug; 263(2 Pt 1):L168-76. PMID: 1514641.
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      80. Thomas PS, Schreck RE, Lazarus SC. Tobacco smoke releases performed mediators from canine mast cells and modulates prostaglandin production. Am J Physiol. 1992 Jul; 263(1 Pt 1):L67-72. PMID: 1636731.
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      81. Gold WM, Lazarus SC. Mast cells and cell-to-cell interactions in airways. Am Rev Respir Dis. 1991 Mar; 143(3 Pt 2):S61-3. PMID: 1900681.
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      82. Thomas PS, Schreck RE, Ruoss SJ, Lazarus SC. Heterogeneity of intact granules purified from canine mastocytoma cell lines. Am J Physiol. 1991 Feb; 260(2 Pt 1):L153-60. PMID: 1899974.
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      83. Sommerhoff CP, Osborne ML, Lazarus SC. Effect of inhibitors on histamine release from mast cells recovered by bronchoalveolar lavage in basenji-greyhound and mongrel dogs. Agents Actions. 1990 Nov; 31(3-4):183-9. PMID: 1707583.
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      84. Bernstein MS, Lazarus SC. Diagnosis and management of asthma. Compr Ther. 1989 Dec; 15(12):53-60. PMID: 2514067.
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      85. Lazarus SC. Rational therapy of acute asthma. Ann Allergy. 1989 Dec; 63(6 Pt 2):585-90. PMID: 2688497.
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      86. Sommerhoff CP, Caughey GH, Finkbeiner WE, Lazarus SC, Basbaum CB, Nadel JA. Mast cell chymase. A potent secretagogue for airway gland serous cells. J Immunol. 1989 Apr 1; 142(7):2450-6. PMID: 2494259.
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      87. Franconi GM, Graf PD, Lazarus SC, Nadel JA, Caughey GH. Mast cell tryptase and chymase reverse airway smooth muscle relaxation induced by vasoactive intestinal peptide in the ferret. J Pharmacol Exp Ther. 1989 Mar; 248(3):947-51. PMID: 2495355.
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      88. Sommerhoff CP, Osborne ML, Gold WM, Lazarus SC. Functional and morphologic characterization of mast cells recovered by bronchoalveolar lavage from Basenji greyhound and mongrel dogs. J Allergy Clin Immunol. 1989 Feb; 83(2 Pt 1):441-9. PMID: 2465334.
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      89. Sekizawa K, Caughey GH, Lazarus SC, Gold WM, Nadel JA. Mast cell tryptase causes airway smooth muscle hyperresponsiveness in dogs. J Clin Invest. 1989 Jan; 83(1):175-9. PMID: 2642918; PMCID: PMC303658.
      90. Forsberg LS, Lazarus SC, Seno N, DeVinney R, Caughey GH, Gold WM. Dog mastocytoma proteoglycans: occurrence of heparin and oversulfated chondroitin sulfates, containing trisulfated disaccharides, in three cell lines. Biochim Biophys Acta. 1988 Dec 15; 967(3):416-28. PMID: 3143422.
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      91. Barnett K, Jacoby DB, Nadel JA, Lazarus SC. The effects of epithelial cell supernatant on contractions of isolated canine tracheal smooth muscle. Am Rev Respir Dis. 1988 Oct; 138(4):780-3. PMID: 3202451.
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      92. Caughey GH, Viro NF, Calonico LD, McDonald DM, Lazarus SC, Gold WM. Chymase and tryptase in dog mastocytoma cells: asynchronous expression as revealed by enzyme cytochemical staining. J Histochem Cytochem. 1988 Aug; 36(8):1053-60. PMID: 3134486.
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      93. Varsano S, Lazarus SC, Gold WM, Nadel JA. Selective adhesion of mast cells to tracheal epithelial cells in vitro. J Immunol. 1988 Apr 1; 140(7):2184-92. PMID: 2450914.
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      94. Caughey GH, Lazarus SC, Viro NF, Gold WM, Nadel JA. Tryptase and chymase: comparison of extraction and release in two dog mastocytoma lines. Immunology. 1988 Feb; 63(2):339-44. PMID: 3127330; PMCID: PMC1454507.
      95. Caughey GH, Viro NF, Lazarus SC, Nadel JA. Purification and characterization of dog mastocytoma chymase: identification of an octapeptide conserved in chymotryptic leukocyte proteinases. Biochim Biophys Acta. 1988 Jan 29; 952(2):142-9. PMID: 3122835.
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      96. Caughey GH, Viro NF, Ramachandran J, Lazarus SC, Borson DB, Nadel JA. Dog mastocytoma tryptase: affinity purification, characterization, and amino-terminal sequence. Arch Biochem Biophys. 1987 Nov 1; 258(2):555-63. PMID: 3118812.
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      97. Lazarus SC. The role of mast cell-derived mediators in airway function. Am Rev Respir Dis. 1987 Jun; 135(6 Pt 2):S35-8. PMID: 3296896.
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      98. Lazarus SC, Borson DB, Gold WM, Nadel JA. Inflammatory mediators, tachykinins and enkephalinase in airways. Int Arch Allergy Appl Immunol. 1987; 82(3-4):372-6. PMID: 2437051.
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      99. Ducolone A, Vandevenne A, Fraisse P, Yapi A, Chaix C, Lazarus S, Burghard G. [Characteristics and evolutive data of chronic respiratory diseases after respiratory intensive care. Evaluation of the Pneumology Department of the Pavillon Saint-François in Strasbourg between 1980 and 1985]. Rev Pneumol Clin. 1987; 43(6):306-11. PMID: 3441722.
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      100. Lazarus SC, DeVinney R, McCabe LJ, Finkbeiner WE, Elias DJ, Gold WM. Isolated canine mastocytoma cells: propagation and characterization of two cell lines. Am J Physiol. 1986 Dec; 251(6 Pt 1):C935-44. PMID: 2431625.
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      101. Lazarus SC. Role of inflammation and inflammatory mediators in airways disease. Am J Med. 1986 Nov 14; 81(5A):2-7. PMID: 3538864.
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      102. Becker AB, Chung KF, McDonald DM, Lazarus SC, Frick OL, Gold WM. Cutaneous mast cell heterogeneity: response to antigen in atopic dogs. J Allergy Clin Immunol. 1986 Nov; 78(5 Pt 1):937-42. PMID: 3782660.
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      103. Lazarus SC, McCabe LJ, Nadel JA, Gold WM, Leikauf GD. Effects of mast cell-derived mediators on epithelial cells in canine trachea. Am J Physiol. 1986 Sep; 251(3 Pt 1):C387-94. PMID: 3092676.
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      104. Lazarus SC, Basbaum CB, Barnes PJ, Gold WM. cAMP immunocytochemistry provides evidence for functional VIP receptors in trachea. Am J Physiol. 1986 Jul; 251(1 Pt 1):C115-9. PMID: 2425626.
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      105. Lazarus SC. Mast cell-derived mediators and their role in cell-to-cell interactions in the lung. Respiration. 1986; 50 Suppl 2:17-21. PMID: 3563113.
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      106. Becker AB, Chung KF, McDonald DM, Lazarus SC, Frick OL, Gold WM. Mast cell heterogeneity in dog skin. Anat Rec. 1985 Dec; 213(4):477-80, 530-1. PMID: 4083528.
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      107. Chung KF, Becker AB, Lazarus SC, Frick OL, Nadel JA, Gold WM. Antigen-induced airway hyperresponsiveness and pulmonary inflammation in allergic dogs. J Appl Physiol (1985). 1985 Apr; 58(4):1347-53. PMID: 3988688.
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      108. Lazarus SC, Basbaum CB, Gold WM. Localization of cAMP in dog and cat trachea: effects of beta-adrenergic agonists. Am J Physiol. 1984 Nov; 247(5 Pt 1):C327-34. PMID: 6093565.
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      109. Lazarus SC, Basbaum CB, Gold WM. Prostaglandins and intracellular cyclic AMP in respiratory secretory cells. Am Rev Respir Dis. 1984 Aug; 130(2):262-6. PMID: 6087701.
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      110. Mjörndal TO, Chesrown SE, Frey MJ, Reed BR, Lazarus SC, Gold WM. Effect of beta-adrenergic stimulation on experimental canine anaphylaxis in vivo. J Allergy Clin Immunol. 1983 Jan; 71(1 Pt 1):62-70. PMID: 6185556.
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      111. Brown JK, Leff AR, Frey MJ, Reed BR, Lazarus SC, Shields R, Gold WM. Characterization of tracheal mast cell reactions in vivo. Inhibition by a beta-adrenergic agonist. Am Rev Respir Dis. 1982 Nov; 126(5):842-8. PMID: 6183998.
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      112. Lazarus SC, Chesrown SE, Frey MJ, Reed BR, Mjörndal TO, Gold WM. Experimental canine anaphylaxis: cyclic nucleotides, histamine, and lung function. J Appl Physiol Respir Environ Exerc Physiol. 1979 May; 46(5):919-26. PMID: 224010.
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      113. Adams RA, Foley GE, Uzman BG, Farber S, Lazarus S, Kleinman L. Leukemia: serial transplantation of human leukemic lymphoblasts in the newborn Syrian hamster. Cancer Res. 1967 Apr; 27(4):772-83. PMID: 4295047.
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