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    Stephen Massa, MD, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address4150 Clement St
    San Francisco CA 94121
    Phone415-221-4810
    vCardDownload vCard

      Collapse Biography 
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      University of California, San FranciscoResidency School of Medicine

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Simmons DA, Longo FM, Massa SM. Neurotrophin receptor signaling as a therapeutic target for Huntington's Disease. CNS Neurol Disord Drug Targets. 2016 Nov 06. PMID: 27823570.
        View in: PubMed
      2. Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D. The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking. J Neurosci. 2016 Sep 28; 36(39):10116-27. PMID: 27683907.
        View in: PubMed
      3. Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM. A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice. Hum Mol Genet. 2016 Sep 16. PMID: 27638888.
        View in: PubMed
      4. Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D. The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry. 2016 Mar 15; 79(6):463-73. PMID: 26204799.
        View in: PubMed
      5. Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q. Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR. Neurotoxicology. 2014 Dec; 45:81-90. PMID: 25277379; PMCID: PMC4268328 [Available on 12/01/15].
      6. Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One. 2014; 9(8):e102136. PMID: 25153701; PMCID: PMC4143160.
      7. Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice. J Alzheimers Dis. 2014; 42(2):459-83. PMID: 24898660; PMCID: PMC4278429.
      8. Shi J, Longo FM, Massa SM. A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury. Stem Cells. 2013 Nov; 31(11):2561-74. PMID: 23940017.
        View in: PubMed
      9. Longo FM, Massa SM. Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease. Nat Rev Drug Discov. 2013 Jul; 12(7):507-25. PMID: 23977697.
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      10. Lam TI, Bingham D, Chang TJ, Lee CC, Shi J, Wang D, Massa S, Swanson RA, Liu J. Beneficial effects of minocycline and botulinum toxin-induced constraint physical therapy following experimental traumatic brain injury. Neurorehabil Neural Repair. 2013 Nov-Dec; 27(9):889-99. PMID: 23778701.
        View in: PubMed
      11. Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM. Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiol Aging. 2013 Aug; 34(8):2052-63. PMID: 23545424.
        View in: PubMed
      12. Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO. Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J Neurosci. 2013 Jan 9; 33(2):397-410. PMID: 23303920; PMCID: PMC3710149.
      13. Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS. Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke. Stroke. 2012 Jul; 43(7):1918-24. PMID: 22535263; PMCID: PMC3383889.
      14. d'Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, Massa S, Liu J, Swanson RA. Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. J Neuroinflammation. 2012; 9:31. PMID: 22335939; PMCID: PMC3298794.
      15. Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J Neurosci. 2012 Feb 1; 32(5):1803-10. PMID: 22302819; PMCID: PMC3710112.
      16. Cherny RA, Ayton S, Finkelstein DI, Bush AI, McColl G, Massa SM. PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease. J Huntingtons Dis. 2012; 1(2):211-9. PMID: 25063332.
        View in: PubMed
      17. Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010 May; 120(5):1774-85. PMID: 20407211; PMCID: PMC2860903.
      18. Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM. The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci. 2009 Aug 26; 29(34):10627-37. PMID: 19710315; PMCID: PMC2771439.
      19. Lu Q, Longo FM, Zhou H, Massa SM, Chen YH. Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem. 2009; 16(11):1355-65. PMID: 19355891; PMCID: PMC3829470.
      20. Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM. Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. PLoS One. 2008; 3(11):e3604. PMID: 18978948; PMCID: PMC2575383.
      21. James SE, Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q. Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. Neurotoxicology. 2008 Jul; 29(4):605-12. PMID: 18539332; PMCID: PMC2615238.
      22. Longo FM, Massa SM. Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol Disord Drug Targets. 2008 Feb; 7(1):63-70. PMID: 18289033.
        View in: PubMed
      23. Longo FM, Yang T, Knowles JK, Xie Y, Moore LA, Massa SM. Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Curr Alzheimer Res. 2007 Dec; 4(5):503-6. PMID: 18220511.
        View in: PubMed
      24. Shi J, Miles DK, Orr BA, Massa SM, Kernie SG. Injury-induced neurogenesis in Bax-deficient mice: evidence for regulation by voltage-gated potassium channels. Eur J Neurosci. 2007 Jun; 25(12):3499-512. PMID: 17610570.
        View in: PubMed
      25. Yang T, Massa SM, Longo FM. LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways. J Neurobiol. 2006 Nov; 66(13):1420-36. PMID: 17013927.
        View in: PubMed
      26. Pehar M, Cassina P, Vargas MR, Xie Y, Beckman JS, Massa SM, Longo FM, Barbeito L. Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain. Eur J Neurosci. 2006 Sep; 24(6):1575-80. PMID: 17004921.
        View in: PubMed
      27. Massa SM, Xie Y, Yang T, Harrington AW, Kim ML, Yoon SO, Kraemer R, Moore LA, Hempstead BL, Longo FM. Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J Neurosci. 2006 May 17; 26(20):5288-300. PMID: 16707781.
        View in: PubMed
      28. Xie Y, Massa SM, Ensslen-Craig SE, Major DL, Yang T, Tisi MA, Derevyanny VD, Runge WO, Mehta BP, Moore LA, Brady-Kalnay SM, Longo FM. Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function. J Biol Chem. 2006 Jun 16; 281(24):16482-92. PMID: 16613844.
        View in: PubMed
      29. Longo FM, Yang T, Xie Y, Massa SM. Small molecule approaches for promoting neurogenesis. Curr Alzheimer Res. 2006 Feb; 3(1):5-10. PMID: 16472196.
        View in: PubMed
      30. Nguyen T, Hamby A, Massa SM. Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. Proc Natl Acad Sci U S A. 2005 Aug 16; 102(33):11840-5. PMID: 16087879; PMCID: PMC1187967.
      31. Longo FM, Massa SM. Neurotrophin receptor-based strategies for Alzheimer's disease. Curr Alzheimer Res. 2005 Apr; 2(2):167-9. PMID: 15974914.
        View in: PubMed
      32. Spano G, Beneduce L, Perrotta C, Massa S. Cloning and characterization of the hsp 18.55 gene, a new member of the small heat shock gene family isolated from wine Lactobacillus plantarum. Res Microbiol. 2005 Mar; 156(2):219-24. PMID: 15748987.
        View in: PubMed
      33. Longo FM, Massa SM. Neurotrophin-based strategies for neuroprotection. J Alzheimers Dis. 2004 Dec; 6(6 Suppl):S13-7. PMID: 15665408.
        View in: PubMed
      34. Longo FM, Massa SM. Neuroprotective strategies in Alzheimer's disease. NeuroRx. 2004 Jan; 1(1):117-27. PMID: 15717012; PMCID: PMC534917.
      35. Spano G, Chieppa G, Beneduce L, Massa S. Expression analysis of putative arcA, arcB and arcC genes partially cloned from Lactobacillus plantarum isolated from wine. J Appl Microbiol. 2004; 96(1):185-93. PMID: 14678173.
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      36. Zhang C, Xie Y, Martignetti JA, Yeo TT, Massa SM, Longo FM. A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs. DNA Cell Biol. 2003 May; 22(5):303-15. PMID: 12941158.
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      37. Yang T, Bernabeu R, Xie Y, Zhang JS, Massa SM, Rempel HC, Longo FM. Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. J Neurosci. 2003 Apr 15; 23(8):3353-63. PMID: 12716943.
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      38. Li Y, Yao XM, Hong-Brown L, Massa SM. Adaptable modification of adenoviral tropism using a bifunctional ligand protein. Virus Res. 2003 Feb; 91(2):223-30. PMID: 12573501.
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      39. Massa SM, Xie Y, Longo FM. Alzheimer's therapeutics: neurotrophin domain small molecule mimetics. J Mol Neurosci. 2003; 20(3):323-6. PMID: 14501015.
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      40. Massa SM, Xie Y, Longo FM. Alzheimer's therapeutics: neurotrophin small molecule mimetics. J Mol Neurosci. 2002 Aug-Oct; 19(1-2):107-11. PMID: 12212765.
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      41. Xie Y, Yeo TT, Zhang C, Yang T, Tisi MA, Massa SM, Longo FM. The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo. J Neurosci. 2001 Jul 15; 21(14):5130-8. PMID: 11438588.
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      42. Liu J, Ying W, Massa S, Duriez PJ, Swanson RA, Poirier GG, Sharp FR. Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains. Brain Res Mol Brain Res. 2000 Aug 14; 80(1):7-16. PMID: 11039724.
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      43. Yang T, Martignetti JA, Massa SM, Longo FM. Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma. Carcinogenesis. 2000 Feb; 21(2):125-31. PMID: 10657947.
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      44. Yang T, Zhang JS, Massa SM, Han X, Longo FM. Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue. Mol Carcinog. 1999 Jun; 25(2):139-49. PMID: 10365916.
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      45. Sharp FR, Massa SM, Swanson RA. Heat-shock protein protection. Trends Neurosci. 1999 Mar; 22(3):97-9. PMID: 10199631.
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      46. Biozzi G, Ribeiro OG, Saran A, Araujo ML, Maria DA, De Franco M, Cabrera WK, Sant'anna OA, Massa S, Covelli V, Mouton D, Neveu T, Siqueira M, Ibanez OM. Effect of genetic modification of acute inflammatory responsiveness on tumorigenesis in the mouse. Carcinogenesis. 1998 Feb; 19(2):337-46. PMID: 9498286.
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      47. Yeo TT, Yang T, Massa SM, Zhang JS, Honkaniemi J, Butcher LL, Longo FM. Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation. J Neurosci Res. 1997 Feb 1; 47(3):348-60. PMID: 9039657.
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      48. Honkaniemi J, Massa SM, Breckinridge M, Sharp FR. Global ischemia induces apoptosis-associated genes in hippocampus. Brain Res Mol Brain Res. 1996 Nov; 42(1):79-88. PMID: 8915583.
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      49. Matz PG, Massa SM, Weinstein PR, Turner C, Panter SS, Sharp FR. Focal hyperexpression of hemeoxygenase-1 protein and messenger RNA in rat brain caused by cellular stress following subarachnoid injections of lysed blood. J Neurosurg. 1996 Nov; 85(5):892-900. PMID: 8893729.
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      50. Artico M, Botta M, Corelli F, Mai A, Massa S, Ragno R. Investigation on QSAR and binding mode of a new class of human rhinovirus-14 inhibitors by CoMFA and docking experiments. Bioorg Med Chem. 1996 Oct; 4(10):1715-24. PMID: 8931942.
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      51. Sauvé MJ, Walker JA, Massa SM, Winkle RA, Scheinman MM. Patterns of cognitive recovery in sudden cardiac arrest survivors: the pilot study. Heart Lung. 1996 May-Jun; 25(3):172-81. PMID: 8635918.
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      52. Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR. Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia. Brain Res Mol Brain Res. 1996 Apr; 37(1-2):201-8. PMID: 8738152.
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      53. Matz P, Turner C, Weinstein PR, Massa SM, Panter SS, Sharp FR. Heme-oxygenase-1 induction in glia throughout rat brain following experimental subarachnoid hemorrhage. Brain Res. 1996 Mar 25; 713(1-2):211-22. PMID: 8724993.
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      54. Honkaniemi J, Massa SM, Sharp FR. Apoptosis associated genes are induced in gerbil hippocampus following global ischemia. Restor Neurol Neurosci. 1996 Jan 1; 9(4):227-30. PMID: 21551911.
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      55. Massa SM, Swanson RA, Sharp FR. The stress gene response in brain. Cerebrovasc Brain Metab Rev. 1996; 8(2):95-158. PMID: 8727184.
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      56. Massa SM, Longo FM, Zuo J, Wang S, Chen J, Sharp FR. Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain. J Neurosci Res. 1995 Apr 15; 40(6):807-19. PMID: 7629893.
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      57. Gitt MA, Wiser MF, Leffler H, Herrmann J, Xia YR, Massa SM, Cooper DN, Lusis AJ, Barondes SH. Sequence and mapping of galectin-5, a beta-galactoside-binding lectin, found in rat erythrocytes. J Biol Chem. 1995 Mar 10; 270(10):5032-8. PMID: 7890611.
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      58. Sharp FR, Butman M, Koistinaho J, Aardalen K, Nakki R, Massa SM, Swanson RA, Sagar SM. Phencyclidine induction of the hsp 70 stress gene in injured pyramidal neurons is mediated via multiple receptors and voltage gated calcium channels. Neuroscience. 1994 Oct; 62(4):1079-92. PMID: 7845588.
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      59. Sharp FR, Butman M, Aardalen K, Nickolenko J, Nakki R, Massa SM, Swanson RA, Sagar SM. Neuronal injury produced by NMDA antagonists can be detected using heat shock proteins and can be blocked with antipsychotics. Psychopharmacol Bull. 1994; 30(4):555-60. PMID: 7770620.
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      60. Longo FM, Wang S, Narasimhan P, Zhang JS, Chen J, Massa SM, Sharp FR. cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain. J Neurosci Res. 1993 Oct 15; 36(3):325-35. PMID: 8271311.
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      61. Massa SM, Cooper DN, Leffler H, Barondes SH. L-29, an endogenous lectin, binds to glycoconjugate ligands with positive cooperativity. Biochemistry. 1993 Jan 12; 32(1):260-7. PMID: 8418845.
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      62. Gitt MA, Massa SM, Leffler H, Barondes SH. Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin. J Biol Chem. 1992 May 25; 267(15):10601-6. PMID: 1375225.
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      63. Cooper DN, Massa SM, Barondes SH. Endogenous muscle lectin inhibits myoblast adhesion to laminin. J Cell Biol. 1991 Dec; 115(5):1437-48. PMID: 1955484; PMCID: PMC2289239.
      64. Lowenstein DH, Massa SM, Rowbotham MC, Collins SD, McKinney HE, Simon RP. Acute neurologic and psychiatric complications associated with cocaine abuse. Am J Med. 1987 Nov; 83(5):841-6. PMID: 3674091.
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      65. Massa S, Bosmann HB. Cellular adhesion: description, methodology and drug perturbation. Pharmacol Ther. 1983; 21(1):101-24. PMID: 6312467.
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