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Stephen Rothman, PhD

TitleProfessor Emeritus
SchoolUCSF School of Dentistry
DepartmentCell and Tissue Biology
Address1001 Potrero Ave, SFGH 30
San Francisco CA 94110
Phone510-527-6379
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Rothman S. How is the balance between protein synthesis and degradation achieved? Theor Biol Med Model. 2010; 7:25. PMID: 20573219; PMCID: PMC2909984.
    2. Rothman S. The incoherence of the vesicle theory of protein secretion. J Theor Biol. 2007 Mar 7; 245(1):150-60. PMID: 17101153.
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    3. Rothman S. The constancy of the internal environment: proteins in plasma. FASEB J. 2005 Sep; 19(11):1383-8. PMID: 16126905.
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    4. Rothman S, Tseng H, Goldfine I. Oral gene therapy: a novel method for the manufacture and delivery of protein drugs. Diabetes Technol Ther. 2005 Jun; 7(3):549-57. PMID: 15929688.
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    5. Sheu E, Rothman S, German M, Wang X, Finer M, McMahon BM. The Gene Pill and its therapeutic applications. Curr Opin Mol Ther. 2003 Aug; 5(4):420-7. PMID: 14513686.
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    6. Rothman S, Liebow C, Isenman L. Conservation of digestive enzymes. Physiol Rev. 2002 Jan; 82(1):1-18. PMID: 11773607.
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    7. Loo BW, Sauerwald IM, Hitchcock AP, Rothman SS. A new sample preparation method for biological soft X-ray microscopy: nitrogen-based contrast and radiation tolerance properties of glycol methacrylate-embedded and sectioned tissue. J Microsc. 2001 Oct; 204(Pt 1):69-86. PMID: 11580815.
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    8. Loo BW, Meyer-Ilse W, Rothman SS. Automatic image acquisition, calibration and montage assembly for biological X-ray microscopy. J Microsc. 2000 Feb; 197(Pt 2):185-201. PMID: 10652011.
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    9. Goldfine ID, German MS, Tseng HC, Wang J, Bolaffi JL, Chen JW, Olson DC, Rothman SS. The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract. Nat Biotechnol. 1997 Dec; 15(13):1378-82. PMID: 9415890.
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    10. Young MK, Tseng HC, Fang H, Liang W, Rothman SS. Comparison of stored and secreted rat pancreatic digestive enzymes by mass spectrometry: alpha-amylase. Biochim Biophys Acta. 1996 Mar 7; 1293(1):63-71. PMID: 8652629.
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    11. Goncz KK, Rothman SS. A trans-membrane pore can account for protein movement across zymogen granule membranes. Biochim Biophys Acta. 1995 Aug 23; 1238(1):91-3. PMID: 7654756.
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    12. Goncz KK, Behrsing R, Rothman SS. The protein content and morphogenesis of zymogen granules. Cell Tissue Res. 1995 Jun; 280(3):519-30. PMID: 7606766.
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    13. Goncz KK, Rothman S. Protein flux across the membrane of single secretion granules. Biochim Biophys Acta. 1992 Aug 10; 1109(1):7-16. PMID: 1504082.
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    14. Loo BW, Williams S, Meizel S, Rothman S. X-ray stereomicroscopy: high resolution 3-D imaging of human spermatozoa in aqueous suspension with natural contrast. J Microsc. 1992 May; 166(Pt 2):Rp5-6. PMID: 1625335.
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    15. Rothman SS, Iskander N, Attwood D, Vladimirsky Y, McQuaid K, Grendell J, Kirz J, Ade H, McNulty I, Kern D. The interior of a whole and unmodified biological object--the zymogen granule--viewed with a high-resolution X-ray microscope. Biochim Biophys Acta. 1989 Jun 27; 991(3):484-6. PMID: 2730924.
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    16. Rothman S, Melese T. "Leaky" cells of glandular epithelia. Int Rev Cytol. 1988; 112:225-44. PMID: 3045045.
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    17. Niederau C, Grendell JH, Rothman S. Characteristics of rat pancreatic zymogen granules prepared by different methods. Am J Physiol. 1986 Sep; 251(3 Pt 1):G421-9. PMID: 2428256.
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    18. Niederau C, Grendell JH, Rothman S. Digestive end products release pancreatic enzymes from particulate cellular pools, particularly zymogen granules. Biochim Biophys Acta. 1986 Apr 11; 881(2):281-91. PMID: 2420368.
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    19. Ermak TH, Rothman SS. Zymogen granule size in pancreas of nursing rats. J Morphol. 1986 Mar; 187(3):289-99. PMID: 3701872.
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    20. Niederau C, Grendell JH, Rothman S. Effects of proglumide on ductal and basolateral secretion of pancreatic digestive enzymes. Am J Physiol. 1985 Jul; 249(1 Pt 1):G100-7. PMID: 2409815.
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    21. Rothman S, Liebow C. Permeability of zymogen granule membrane to protein. Am J Physiol. 1985 Apr; 248(4 Pt 1):G385-92. PMID: 2580444.
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    22. Rothman SS, Grendell JH. On the endocrine secretion of pancreatic digestive enzymes. Gastroenterology. 1984 Oct; 87(4):986-7. PMID: 6205937.
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    23. Grendell JH, Tseng HC, Rothman SS. Regulation of digestion. I. Effects of glucose and lysine on pancreatic secretion. Am J Physiol. 1984 Apr; 246(4 Pt 1):G445-50. PMID: 6426308.
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    24. Tseng HC, Grendell JH, Rothman SS. Regulation of digestion. II. Effects of insulin and glucagon on pancreatic secretion. Am J Physiol. 1984 Apr; 246(4 Pt 1):G451-6. PMID: 6372508.
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    25. Rothman SS, Grendell JH. The case of the disappearing pancreatic digestive enzymes. Gastroenterology. 1983 Dec; 85(6):1438-42. PMID: 6628935.
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    26. Ermak TH, Rothman SS. Increase in zymogen granule volume accounts for increase in volume density during prenatal development of pancreas. Anat Rec. 1983 Nov; 207(3):487-501. PMID: 6650878.
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    27. Mélèse T, Rothman SS. Distribution of three hexose derivatives across the pancreatic epithelium: paracellular shunts or cellular passage? Biochim Biophys Acta. 1983 Sep 22; 763(2):212-9. PMID: 6412763.
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    28. Mélèse T, Rothman SS. Pancreatic epithelium is permeable to sucrose and inulin across secretory cells. Proc Natl Acad Sci U S A. 1983 Aug; 80(15):4870-4. PMID: 6348774; PMCID: PMC384147.
    29. Melese T, Rothman SS. Increased phosphate efflux from acinar cell during protein secretion. Am J Physiol. 1983 Jul; 245(1):C121-4. PMID: 6135348.
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    30. Ho JJ, Rothman SS. Protein concentration in the pancreatic zymogen granule. Biochim Biophys Acta. 1983 Feb 22; 755(3):457-66. PMID: 6186292.
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    31. Tseng HC, Grendell JH, Rothman SS. Food, duodenal extracts, and enzyme secretion by the pancreas. Am J Physiol. 1982 Oct; 243(4):G304-12. PMID: 6181696.
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    32. Miyasaka K, Rothman SS. Redistribution of amylase activity accompanying its secretion by the pancreas. Proc Natl Acad Sci U S A. 1982 Sep; 79(17):5438-42. PMID: 6182564; PMCID: PMC346913.
    33. Grendell JH, Rothman SS. Effect of changes in circulating amylase levels on amylase output in bile. Am J Physiol. 1982 Jul; 243(1):G54-9. PMID: 6178302.
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    34. Ho JJ, Rothman SS. Nature of flow dependence of protein secretion by the exocrine pancreas. Am J Physiol. 1982 Jan; 242(1):G32-9. PMID: 7058896.
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    35. Grendell JH, Rothman SS. Digestive end products mobilize secretory proteins from subcellular stores in the pancreas. Am J Physiol. 1981 Jul; 241(1):G67-73. PMID: 6166207.
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    36. Ermak TH, Rothman SS. Zymogen granules of pancreas decrease in size in response to feeding. Cell Tissue Res. 1981; 214(1):51-66. PMID: 7471176.
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    37. Rothman SS, Isenman LD, Ho JJ. Protein secretion by the pancreas. Science. 1980 Sep 26; 209(4464):1554. PMID: 17745970.
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    38. Rothman SS. Passage of proteins through membranes--old assumptions and new perspectives. Am J Physiol. 1980 May; 238(5):G391-402. PMID: 6155081.
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    39. Ermak TH, Rothman SS. Large decrease in zymogen granule size in the postnatal rat pancreas. J Ultrastruct Res. 1980 Feb; 70(2):242-56. PMID: 7359624.
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    40. Isenman LD, Rothman S. Transpancreatic transport of digestive enzyme. Biochim Biophys Acta. 1979 Jul 4; 585(3):321-32. PMID: 314819.
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    41. Isenman LD, Rothman S. Diffusion-like process can account for protein secretion by the pancreas. Science. 1979 Jun 15; 204(4398):1212-5. PMID: 451566.
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    42. Götze H, Rothman S. Amylase transport across ileal epithelium in vitro. Biochim Biophys Acta. 1978 Sep 11; 512(1):214-20. PMID: 308817.
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    43. Ermak TH, Rothman S. Internal organization of the zymogen granule: formation of reticular structures in vitro. J Ultrastruct Res. 1978 Jul; 64(1):98-113. PMID: 29972.
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    44. Rothman S. Chymotrypsinogen . inositol phosphatide complexes and the transport of digestive enzyme across membranes. Biochim Biophys Acta. 1978 May 18; 509(2):374-83. PMID: 26403.
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    45. Isenman LD, Rothman S. Transport of alpha-amylase across the basolateral membrane of the pancreatic acinar cell. Proc Natl Acad Sci U S A. 1977 Sep; 74(9):4068-72. PMID: 302947; PMCID: PMC431848.
    46. Rothman S. The digestive enzymes of the pancreas: a mixture of inconstant proportions. Annu Rev Physiol. 1977; 39:373-89. PMID: 322600.
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    47. Liebow C, Rothman S. Equilibration of pancratic digestive enzymes across zymogen granule membranes. Biochim Biophys Acta. 1976 Nov 11; 455(1):241-53. PMID: 990328.
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    48. Rothman S. Protein transport by the pancreas. Science. 1975 Nov 21; 190(4216):747-53. PMID: 1105785.
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    49. Rothman S. Enzyme secretion in the absense of zymogen granules. Am J Physiol. 1975 Jun; 228(6):1828-34. PMID: 1155612.
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    50. Liebow C, Rothman SS. Transport of bovine chymotrypsinogen into rabbit pancreatic cells. Am J Physiol. 1974 May; 226(5):1077-81. PMID: 4824859.
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    51. Rothman SS, Isenman LD. Secretion of digestive enzyme derived from two parallel intracellular pools. Am J Physiol. 1974 May; 226(5):1082-7. PMID: 4824860.
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    52. Rothman SS, Burwen S, Liebow C. The zymogen granule: intragranular organization and its functional significance. Adv Cytopharmacol. 1974; 2:341-8. PMID: 4613156.
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    53. Rothman SS. Molecular regulation of digestion: short term and bond specific. Am J Physiol. 1974 Jan; 226(1):77-83. PMID: 4809890.
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    54. Liebow C, Rothman SS. Distribution of zymogen granule size. Am J Physiol. 1973 Jul; 225(1):258-62. PMID: 4714407.
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    55. Liebow C, Rothman SS. Membrane transport of proteins. Nat New Biol. 1972 Dec 6; 240(101):176-8. PMID: 4508302.
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    56. Burwen SJ, Rothman SS. Zymogen granules: osmotic properties, interactions with ions, and some structural implications. Am J Physiol. 1972 May; 222(5):1177-81. PMID: 5022376.
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    57. Rothman SS. Association of bovine alpha-chymotrypsinogen and trypsinogen with rat zymogen granules. Am J Physiol. 1972 May; 222(5):1299-302. PMID: 5063240.
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    58. Rothman SS. The behavior of isolated zymogen granules: pH-dependent release and reassociation of protein. Biochim Biophys Acta. 1971 Aug 13; 241(2):567-77. PMID: 4334149.
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    59. Rothman SS. Intracellular storage of exportable protein in functionally hypertrophied pancreas. Am J Physiol. 1970 Dec; 219(6):1652-7. PMID: 5485682.
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    60. Rothman SS, Wells H. Enhancement of pancreatic enzyme synthesis by pancreozymin. Am J Physiol. 1967 Jul; 213(1):215-8. PMID: 6028957.
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    61. Rothman SS. "Non-parallel transport" of enzyme protein by the pancreas. Nature. 1967 Feb 4; 213(5075):460-2. PMID: 6032225.
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