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    Suzaynn Schick, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    Address1001 Potrero Ave, SFGH 1
    San Francisco CA 94110
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      University of California, San Francisco Postdoctoral StudiesGraduate Division
      University of California, San FranciscoPh.D. Graduate Division (Biomedical Sciences)2001

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      I study the health effects of air pollution in human subjects. I focus on the chemistry and toxicity of smoke and on how smoking and using electronic cigarettes can cause heart and lung disease. My analysis of tobacco industry research showed that sidestream cigarette smoke (the primary constituent of secondhand cigarette smoke) is more toxic than the smoke that smokers inhale and that secondhand smoke becomes more toxic as it ages.

      I have published three controlled human exposure studies on the health effects of secondhand cigarette smoke which show that:
      1. A single 30-minute exposure to fresh sidestream cigarette smoke, at 350 micrograms of particles per cubic meter, decreases flow-mediated dilation of the brachial artery and increases plasma VEGF and endothelial progenitor cell motility. (These changes can increase the risk of heart attack.)
      2. For each increase in SHS exposure by 100 µg/m3 particles, the absolute maximal percent brachial artery flow-mediated dilation was reduced by 0.67%. (Even a little smoke can increase the risk of heart disease.)
      3. A single 30-minute exposure to aged cigarette smoke, at 1000 µg/m3 particles, increases nasal congestion in healthy human subjects. (Nasal congestion can lead to sinus infections.)

      My research on the chemistry and toxicity of cigarette smoke has helped define a new health risk from smoking: thirdhand cigarette smoke. Thirdhand smoke is the tiny droplets of oils and waxes (tar) that stick to surfaces, like walls, furniture, clothing and hair. Thirdhand smoke cannot be removed by ventilation. Many of the toxins and carcinogens in smoke linger for days, months and years after the cigarettes are gone. My laboratory is funded by the California Tobacco-Related Disease Research Program to study how humans absorb thirdhand smoke from the environment. My laboratory is also funded by the FDA and the NIH to study the cardiovascular effects of tobacco and nicotine delivery products. I am member of the California Thirdhand Smoke Consortium, the UCSF Helen Diller Family Comprehensive Cancer Center and the UCSF Center for Tobacco Control Research and Education. My goals are to understand how smoke causes heart attacks and respiratory disease and to educate society on the true impact that air pollution has on human health.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Wang X, Derakhshandeh R, Liu J, Narayan S, Nabavizadeh P, Le S, Danforth OM, Pinnamaneni K, Rodriguez HJ, Luu E, Sievers RE, Schick SF, Glantz SA, Springer ML. One Minute of Marijuana Secondhand Smoke Exposure Substantially Impairs Vascular Endothelial Function. J Am Heart Assoc. 2016; 5(8). PMID: 27464788.
        View in: PubMed
      2. Bahl V, Johnson K, Phandthong R, Zahedi A, Schick SF, Talbot P, et al. Thirdhand Cigarette Smoke Causes Stress-Induced Mitochondrial Hyperfusion and Alters the Transcriptional Profile of Stem Cells. Toxicol Sci. 2016 Jun 2. PMID: 27255386.
        View in: PubMed
      3. Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y. Corrigendum: Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2016; 6:23849. PMID: 27072199.
        View in: PubMed
      4. Bahl V, Weng NJ, Schick SF, Sleiman M, Whitehead J, Ibarra A, Talbot P. Cytotoxicity of Thirdhand Smoke and Identification of Acrolein as a Volatile Thirdhand Smoke Chemical That Inhibits Cell Proliferation. Toxicol Sci. 2016 Mar; 150(1):234-46. PMID: 26719373.
        View in: PubMed
      5. Bahl V, Shim HJ, Jacob P, Dias K, Schick SF, Talbot P. Thirdhand smoke: Chemical dynamics, cytotoxicity, and genotoxicity in outdoor and indoor environments. Toxicol In Vitro. 2016 Apr; 32:220-31. PMID: 26689327.
        View in: PubMed
      6. Xu B, Chen M, Yao M, Ji X, Mao Z, Tang W, Qiao S, Schick SF, Mao JH, Hang B, Xia Y. Metabolomics reveals metabolic changes in male reproductive cells exposed to thirdhand smoke. Sci Rep. 2015; 5:15512. PMID: 26489853; PMCID: PMC4614949.
      7. Waldo SW, Brenner DA, McCabe JM, Cruz MD, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. Correction: A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(5):e0126062. PMID: 25938419; PMCID: PMC4418848.
      8. Waldo SW, Brenner DA, McCabe JM, Dela Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. A novel minimally-invasive method to sample human endothelial cells for molecular profiling. PLoS One. 2015; 10(2):e0118081. PMID: 25679506; PMCID: PMC4332500.
      9. Waldo SW, Brenner DA, McCabe JM, Dela Cruz M, Long B, Narla VA, Park J, Kulkarni A, Sinclair E, Chan SY, Schick SF, Malik N, Ganz P, Hsue PY. A Novel Minimally-Invasive Method to Sample Human Endothelial Cells for Molecular Profiling. PLoS One. 2015 Feb 13; 10(2):e0126062. PMID: 26859004.
        View in: PubMed
      10. Bahl V, Jacob P, Havel C, Schick SF, Talbot P. Thirdhand cigarette smoke: factors affecting exposure and remediation. PLoS One. 2014; 9(10):e108258. PMID: 25286392; PMCID: PMC4186756.
      11. Pinnamaneni K, Sievers RE, Sharma R, Selchau AM, Gutierrez G, Nordsieck EJ, Su R, An S, Chen Q, Wang X, Derakhshandeh R, Aschbacher K, Heiss C, Glantz SA, Schick SF, Springer ML. Brief exposure to secondhand smoke reversibly impairs endothelial vasodilatory function. Nicotine Tob Res. 2014 May; 16(5):584-90. PMID: 24302638; PMCID: PMC3977486.
      12. Jacob P, Goniewicz ML, Havel CM, Schick SF, Benowitz NL. Nicotelline: a proposed biomarker and environmental tracer for particulate matter derived from tobacco smoke. Chem Res Toxicol. 2013 Nov 18; 26(11):1615-31. PMID: 24125094; PMCID: PMC3929594.
      13. Schick SF, Farraro KF, Perrino C, Sleiman M, van de Vossenberg G, Trinh MP, Hammond SK, Jenkins BM, Balmes J. Thirdhand cigarette smoke in an experimental chamber: evidence of surface deposition of nicotine, nitrosamines and polycyclic aromatic hydrocarbons and de novo formation of NNK. Tob Control. 2014 Mar; 23(2):152-9. PMID: 23716171.
        View in: PubMed
      14. Hang B, Sarker AH, Havel C, Saha S, Hazra TK, Schick S, Jacob P, Rehan VK, Chenna A, Sharan D, Sleiman M, Destaillats H, Gundel LA. Thirdhand smoke causes DNA damage in human cells. Mutagenesis. 2013 Jul; 28(4):381-91. PMID: 23462851; PMCID: PMC3681537.
      15. Schick SF, van den Vossenberg G, Luo A, Whitlatch A, Jacob P, Balmes J, Shusterman D. Thirty minute-exposure to aged cigarette smoke increases nasal congestion in nonsmokers. J Toxicol Environ Health A. 2013; 76(10):601-13. PMID: 23859154.
        View in: PubMed
      16. Suzaynn F. Schick, Kathryn F. Farraro, Jiaxi Fang, Sarah Nasir, Justin Kim, Donald Lucas, Hofer Wong, John Balmes, D. Ken Giles, and Bryan Jenkins. . Aerosol Science and Technology. An Apparatus for Generating Aged Cigarette Smoke for Controlled Human Exposure Studies. 2012; (46):1246-1255.
      17. Frey PF, Ganz P, Hsue PY, Benowitz NL, Glantz SA, Balmes JR, Schick SF. The exposure-dependent effects of aged secondhand smoke on endothelial function. J Am Coll Cardiol. 2012 May 22; 59(21):1908-13. PMID: 22595411.
        View in: PubMed
      18. Shusterman DJ, Weaver EM, Goldberg AN, Schick SF, Wong HH, Balmes JR. Pilot evaluation of the nasal nitric oxide response to humming as an index of osteomeatal patency. Am J Rhinol Allergy. 2012 Mar-Apr; 26(2):123-6. PMID: 22487289.
        View in: PubMed
      19. Matt GE, Quintana PJ, Destaillats H, Gundel LA, Sleiman M, Singer BC, Jacob P, Benowitz N, Winickoff JP, Rehan V, Talbot P, Schick S, Samet J, Wang Y, Hang B, Martins-Green M, Pankow JF, Hovell MF. Thirdhand tobacco smoke: emerging evidence and arguments for a multidisciplinary research agenda. Environ Health Perspect. 2011 Sep; 119(9):1218-26. PMID: 21628107; PMCID: PMC3230406.
      20. Schick SF, Schick S. Thirdhand smoke: here to stay. Tob Control. 2011 Jan; 20(1):1-3. PMID: 21172855.
        View in: PubMed
      21. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol. 2008 May 6; 51(18):1760-71. PMID: 18452782.
        View in: PubMed
      22. Schick S, Gvinianidze K, Tsereteli D, Novotny T, Hammond K. Pilot study of compliance with healthcare facility smoking laws in Georgia. Georgian Med News. 2008 Jan; (154):47-52. PMID: 18323594.
        View in: PubMed
      23. Schick SF, Bero LA, Cook DM. The tobacco industry and the Data Quality Act. Science. 2007 Aug 17; 317(5840):898. PMID: 17702925.
        View in: PubMed
      24. Schick SF, Glantz S. Concentrations of the carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in sidestream cigarette smoke increase after release into indoor air: results from unpublished tobacco industry research. Cancer Epidemiol Biomarkers Prev. 2007 Aug; 16(8):1547-53. PMID: 17684127.
        View in: PubMed
      25. Schick SF, Glantz SA. Old ways, new means: tobacco industry funding of academic and private sector scientists since the Master Settlement Agreement. Tob Control. 2007 Jun; 16(3):157-64. PMID: 17565125; PMCID: PMC2598497.
      26. Schick SF, Schick S, Glantz SA. Sidestream cigarette smoke toxicity increases with aging and exposure duration. Tob Control. 2006 Dec; 15(6):424-9. PMID: 17130369; PMCID: PMC2563675.
      27. Schick S, Glantz S. Philip Morris toxicological experiments with fresh sidestream smoke: more toxic than mainstream smoke. Tob Control. 2005 Dec; 14(6):396-404. PMID: 16319363; PMCID: PMC1748121.
      28. Schick S, Glantz S. Scientific analysis of second-hand smoke by the tobacco industry, 1929-1972. Nicotine Tob Res. 2005 Aug; 7(4):591-612. PMID: 16085530.
        View in: PubMed
      29. Glantz, Stanton A Schick, Suzaynn F. . Implications of ASHRAE's guidelines for ventilation in smoking permitted areas. ASHRAE Journal. 2004; 3(46):54-61.
      30. Damsky Ch, Schick SF, Klimanskaya I, Stephens L, Zhou Y, Fisher S. Adhesive interactions in peri-implantation morphogenesis and placentation. Reprod Toxicol. 1997 Mar-Jun; 11(2-3):367-75. PMID: 9100312.
        View in: PubMed
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