 Takashi Mikawa, PhD
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| Title | Professor in Residence |
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| School | UCSF School of Medicine |
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| Department | Cardiovascular Research Institute |
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| Address | 555 Mission Bay Blvd South
San Francisco CA 94158
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| Phone | 415-476-3230 |
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 Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Venters SJ, Mikawa T, Hyer J. Central and Peripheral Retina Arise through Distinct Developmental Paths. PLoS One. 2013; 8(4):e61422.
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Bressan M, Liu G, Mikawa T. Early mesodermal cues assign avian cardiac pacemaker fate potential in a tertiary heart field. Science. 2013 May 10; 340(6133):744-8.
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An KD, Degawa Y, Fujihara E, Mikawa T, Ohkuma M, Okada G. Molecular phylogenetic analyses based on the nuclear rRNA genes and the intron-exon structures of the nuSSU rRNA gene in Dictyocatenulata alba (anamorphic Ascomycota). Fungal Biol. 2012 Nov; 116(11):1134-45.
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Garriock RJ, Mikawa T. Early arterial differentiation and patterning in the avian embryo model. Semin Cell Dev Biol. 2011 Dec; 22(9):985-92.
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Garriock RJ, Czeisler C, Ishii Y, Navetta AM, Mikawa T. An anteroposterior wave of vascular inhibitor downregulation signals aortae fusion along the embryonic midline axis. Development. 2010 Nov; 137(21):3697-706.
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Liu J, Bressan M, Hassel D, Huisken J, Staudt D, Kikuchi K, Poss KD, Mikawa T, Stainier DY. A dual role for ErbB2 signaling in cardiac trabeculation. Development. 2010 Nov; 137(22):3867-75.
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Oda-Ishii I, Ishii Y, Mikawa T. Eph regulates dorsoventral asymmetry of the notochord plate and convergent extension-mediated notochord formation. PLoS One. 2010; 5(10):e13689.
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Ishii Y, Garriock RJ, Navetta AM, Coughlin LE, Mikawa T. BMP signals promote proepicardial protrusion necessary for recruitment of coronary vessel and epicardial progenitors to the heart. Dev Cell. 2010 Aug 17; 19(2):307-16.
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Ishii Y, Weinberg K, Oda-Ishii I, Coughlin L, Mikawa T. Morphogenesis and cytodifferentiation of the avian retinal pigmented epithelium require downregulation of Group B1 Sox genes. Development. 2009 Aug; 136(15):2579-89.
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Pennisi DJ, Mikawa T. FGFR-1 is required by epicardium-derived cells for myocardial invasion and correct coronary vascular lineage differentiation. Dev Biol. 2009 Apr 1; 328(1):148-59.
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Bressan M, Davis P, Timmer J, Herzlinger D, Mikawa T. Notochord-derived BMP antagonists inhibit endothelial cell generation and network formation. Dev Biol. 2009 Feb 1; 326(1):101-11.
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Ishii Y, Langberg J, Rosborough K, Mikawa T. Endothelial cell lineages of the heart. Cell Tissue Res. 2009 Jan; 335(1):67-73.
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Ikeda F, Saika T, Sato Y, Suzuki M, Hasegawa M, Mikawa T, Kobayashi I, Tsuji A. Antifungal activity of micafungin against Candida and Aspergillus spp. isolated from pediatric patients in Japan. Med Mycol. 2009 Mar; 47(2):145-8.
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Ishii Y, Langberg JD, Hurtado R, Lee S, Mikawa T. Induction of proepicardial marker gene expression by the liver bud. Development. 2007 Oct; 134(20):3627-37.
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Mikawa T, Hurtado R. Development of the cardiac conduction system. Semin Cell Dev Biol. 2007 Feb; 18(1):90-100.
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Dias da Silva MR, Tiffin N, Mima T, Mikawa T, Hyer J. FGF-mediated induction of ciliary body tissue in the chick eye. Dev Biol. 2007 Apr 1; 304(1):272-85.
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Pallante BA, Duignan I, Okin D, Chin A, Bressan MC, Mikawa T, Edelberg JM. Bone marrow Oct3/4+ cells differentiate into cardiac myocytes via age-dependent paracrine mechanisms. Circ Res. 2007 Jan 5; 100(1):e1-11.
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Hurtado R, Mikawa T. Enhanced sensitivity and stability in two-color in situ hybridization by means of a novel chromagenic substrate combination. Dev Dyn. 2006 Oct; 235(10):2811-6.
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Turner BA, Sparrow J, Cai B, Monroe J, Mikawa T, Hempstead BL. TrkB/BDNF signaling regulates photoreceptor progenitor cell fate decisions. Dev Biol. 2006 Nov 15; 299(2):455-65.
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Tomanek RJ, Ishii Y, Holifield JS, Sjogren CL, Hansen HK, Mikawa T. VEGF family members regulate myocardial tubulogenesis and coronary artery formation in the embryo. Circ Res. 2006 Apr 14; 98(7):947-53.
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Pennisi DJ, Mikawa T. Normal patterning of the coronary capillary plexus is dependent on the correct transmural gradient of FGF expression in the myocardium. Dev Biol. 2005 Mar 15; 279(2):378-90.
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Ishii Y, Mikawa T. Somatic transgenesis in the avian model system. Birth Defects Res C Embryo Today. 2005 Mar; 75(1):19-27.
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Sedmera D, Reckova M, Bigelow MR, Dealmeida A, Stanley CP, Mikawa T, Gourdie RG, Thompson RP. Developmental transitions in electrical activation patterns in chick embryonic heart. Anat Rec A Discov Mol Cell Evol Biol. 2004 Oct; 280(2):1001-9.
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Hatcher CJ, Diman NY, Kim MS, Pennisi D, Song Y, Goldstein MM, Mikawa T, Basson CT. A role for Tbx5 in proepicardial cell migration during cardiogenesis. Physiol Genomics. 2004 Jul 8; 18(2):129-40.
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Reese DE, Hall CE, Mikawa T. Negative regulation of midline vascular development by the notochord. Dev Cell. 2004 May; 6(5):699-708.
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Mima T, Mikawa T. Folding of the tectal cortex by local remodeling of neural differentiation. Dev Dyn. 2004 Mar; 229(3):475-9.
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Mikawa T, Poh AM, Kelly KA, Ishii Y, Reese DE. Induction and patterning of the primitive streak, an organizing center of gastrulation in the amniote. Dev Dyn. 2004 Mar; 229(3):422-32.
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Ishii Y, Reese DE, Mikawa T. Somatic transgenesis using retroviral vectors in the chicken embryo. Dev Dyn. 2004 Mar; 229(3):630-42.
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Xaymardan M, Tang L, Zagreda L, Pallante B, Zheng J, Chazen JL, Chin A, Duignan I, Nahirney P, Rafii S, Mikawa T, Edelberg JM. Platelet-derived growth factor-AB promotes the generation of adult bone marrow-derived cardiac myocytes. Circ Res. 2004 Mar 19; 94(5):E39-45.
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Hall CE, Hurtado R, Hewett KW, Shulimovich M, Poma CP, Reckova M, Justus C, Pennisi DJ, Tobita K, Sedmera D, Gourdie RG, Mikawa T. Hemodynamic-dependent patterning of endothelin converting enzyme 1 expression and differentiation of impulse-conducting Purkinje fibers in the embryonic heart. Development. 2004 Feb; 131(3):581-92.
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Pennisi DJ, Ballard VL, Mikawa T. Epicardium is required for the full rate of myocyte proliferation and levels of expression of myocyte mitogenic factors FGF2 and its receptor, FGFR-1, but not for transmural myocardial patterning in the embryonic chick heart. Dev Dyn. 2003 Oct; 228(2):161-72.
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Nahirney PC, Mikawa T, Fischman DA. Evidence for an extracellular matrix bridge guiding proepicardial cell migration to the myocardium of chick embryos. Dev Dyn. 2003 Aug; 227(4):511-23.
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Hyer J, Kuhlman J, Afif E, Mikawa T. Optic cup morphogenesis requires pre-lens ectoderm but not lens differentiation. Dev Biol. 2003 Jul 15; 259(2):351-63.
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Kumazawa S, Kanda M, Utagawa M, Chiba N, Ohtani H, Mikawa T. MK7924, a novel metabolite with nematocidal activity from Coronophora gregaria. J Antibiot (Tokyo). 2003 Jul; 56(7):652-4.
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Sugi Y, Ito N, Szebenyi G, Myers K, Fallon JF, Mikawa T, Markwald RR. Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation. Dev Biol. 2003 Jun 15; 258(2):252-63.
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Mikawa T, Gourdie RG, Takebayashi-Suzuki K, Kanzawa N, Hyer J, Pennisi DJ, Poma CP, Shulimovich M, Diaz KG, Layliev J, Prasad A. Induction and patterning of the Purkinje fibre network. Novartis Found Symp. 2003; 250:142-53; discussion 153-6, 276-9.
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Gourdie RG, Harris BS, Bond J, Edmondson AM, Cheng G, Sedmera D, O'Brien TX, Mikawa T, Thompson RP. His-Purkinje lineages and development. Novartis Found Symp. 2003; 250:110-22; discussion 122-4, 276-9.
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Ballard VL, Mikawa T. Constitutive expression of preproendothelin in the cardiac neural crest selectively promotes expansion of the adventitia of the great vessels in vivo. Dev Biol. 2002 Nov 1; 251(1):167-77.
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Reese DE, Mikawa T, Bader DM. Development of the coronary vessel system. Circ Res. 2002 Nov 1; 91(9):761-8.
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Pennisi DJ, Rentschler S, Gourdie RG, Fishman GI, Mikawa T. Induction and patterning of the cardiac conduction system. Int J Dev Biol. 2002 Sep; 46(6):765-75.
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Kanzawa N, Poma CP, Takebayashi-Suzuki K, Diaz KG, Layliev J, Mikawa T. Competency of embryonic cardiomyocytes to undergo Purkinje fiber differentiation is regulated by endothelin receptor expression. Development. 2002 Jul; 129(13):3185-94.
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Kelly KA, Wei Y, Mikawa T. Cell death along the embryo midline regulates left-right sidedness. Dev Dyn. 2002 Jun; 224(2):238-44.
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Shibata T, Nishinaka T, Mikawa T, Aihara H, Kurumizaka H, Yokoyama S, Ito Y. Homologous genetic recombination as an intrinsic dynamic property of a DNA structure induced by RecA/Rad51-family proteins: a possible advantage of DNA over RNA as genomic material. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8425-32.
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Takebayashi-Suzuki K, Pauliks LB, Eltsefon Y, Mikawa T. Purkinje fibers of the avian heart express a myogenic transcription factor program distinct from cardiac and skeletal muscle. Dev Biol. 2001 Jun 15; 234(2):390-401.
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Hatcher CJ, Kim MS, Mah CS, Goldstein MM, Wong B, Mikawa T, Basson CT. TBX5 transcription factor regulates cell proliferation during cardiogenesis. Dev Biol. 2001 Feb 15; 230(2):177-88.
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Wei Y, Mikawa T. Fate diversity of primitive streak cells during heart field formation in ovo. Dev Dyn. 2000 Dec; 219(4):505-13.
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Lin MI, Das I, Schwartz GM, Tsoulfas P, Mikawa T, Hempstead BL. Trk C receptor signaling regulates cardiac myocyte proliferation during early heart development in vivo. Dev Biol. 2000 Oct 15; 226(2):180-91.
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Fujii T, Funahashi J, Matsuura R, Izaki T, Nakamura H, Mikawa T, Tanaka H. Axonal growth of the spinal cord interneurons expressing a homophilic adhesion molecule SC1 ectopically. Neurosci Res. 2000 Oct; 38(2):175-81.
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Takebayashi-Suzuki K, Yanagisawa M, Gourdie RG, Kanzawa N, Mikawa T. In vivo induction of cardiac Purkinje fiber differentiation by coexpression of preproendothelin-1 and endothelin converting enzyme-1. Development. 2000 Aug; 127(16):3523-32.
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Das I, Sparrow JR, Lin MI, Shih E, Mikawa T, Hempstead BL. Trk C signaling is required for retinal progenitor cell proliferation. J Neurosci. 2000 Apr 15; 20(8):2887-95.
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Wei Y, Mikawa T. Formation of the avian primitive streak from spatially restricted blastoderm: evidence for polarized cell division in the elongating streak. Development. 2000 Jan; 127(1):87-96.
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Gourdie RG, Cheng G, Thompson RP, Mikawa T. Retroviral cell lineage analysis in the developing chick heart. Methods Mol Biol. 2000; 135:297-304.
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Hyer J, Johansen M, Prasad A, Wessels A, Kirby ML, Gourdie RG, Mikawa T. Induction of Purkinje fiber differentiation by coronary arterialization. Proc Natl Acad Sci U S A. 1999 Nov 9; 96(23):13214-8.
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Cheng G, Litchenberg WH, Cole GJ, Mikawa T, Thompson RP, Gourdie RG. Development of the cardiac conduction system involves recruitment within a multipotent cardiomyogenic lineage. Development. 1999 Nov; 126(22):5041-9.
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Ohuchi H, Tomonari S, Itoh H, Mikawa T, Noji S. Identification of chick rax/rx genes with overlapping patterns of expression during early eye and brain development. Mech Dev. 1999 Jul; 85(1-2):193-5.
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Sakurai T, Cheeptham N, Mikawa T, Yokota A, Tomita F. A novel screen for the detection of chitin acting antifungal compounds. J Antibiot (Tokyo). 1999 May; 52(5):508-11.
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Saiki M, Mima T, Takahashi JC, Tani S, Yukawa H, Ueno H, Mikawa T, Itoh N, Kikuchi H, Hashimoto N, Miyatake S. Adenovirus-mediated gene transfer of a truncated form of fibroblast growth factor receptor inhibits growth of glioma cells both in vitro and in vivo. J Neurooncol. 1999; 44(3):195-203.
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Gourdie RG, Kubalak S, Mikawa T. Conducting the embryonic heart: orchestrating development of specialized cardiac tissues. Trends Cardiovasc Med. 1999 Jan-Feb; 9(1-2):18-26.
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Poelmann RE, Mikawa T, Gittenberger-de Groot AC. Neural crest cells in outflow tract septation of the embryonic chicken heart: differentiation and apoptosis. Dev Dyn. 1998 Jul; 212(3):373-84.
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Gourdie RG, Wei Y, Kim D, Klatt SC, Mikawa T. Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers. Proc Natl Acad Sci U S A. 1998 Jun 9; 95(12):6815-8.
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Hyer J, Mima T, Mikawa T. FGF1 patterns the optic vesicle by directing the placement of the neural retina domain. Development. 1998 Mar; 125(5):869-77.
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Ong LL, Kim N, Mima T, Cohen-Gould L, Mikawa T. Trabecular myocytes of the embryonic heart require N-cadherin for migratory unit identity. Dev Biol. 1998 Jan 1; 193(1):1-9.
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Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA. Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain. J Biol Chem. 1997 Aug 15; 272(33):20866-72.
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Hyer J, Mikawa T. Retroviral techniques for studying organogenesis with a focus on heart development. Mol Cell Biochem. 1997 Jul; 172(1-2):23-35.
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Alyonycheva T, Cohen-Gould L, Siewert C, Fischman DA, Mikawa T. Skeletal muscle-specific myosin binding protein-H is expressed in Purkinje fibers of the cardiac conduction system. Circ Res. 1997 May; 80(5):665-72.
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Fischman DA, Mikawa T. The use of replication-defective retroviruses for cell lineage studies of myogenic cells. Methods Cell Biol. 1997; 52:215-27.
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Goldman SA, Zukhar A, Barami K, Mikawa T, Niedzwiecki D. Ependymal/subependymal zone cells of postnatal and adult songbird brain generate both neurons and nonneuronal siblings in vitro and in vivo. J Neurobiol. 1996 Aug; 30(4):505-20.
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Cohen-Gould L, Mikawa T. The fate diversity of mesodermal cells within the heart field during chicken early embryogenesis. Dev Biol. 1996 Jul 10; 177(1):265-73.
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Magome E, Harimaya K, Gomi S, Koyama M, Chiba N, Ota K, Mikawa T. Structure of furanocandin, a new antifungal antibiotic from Tricothecium sp. J Antibiot (Tokyo). 1996 Jun; 49(6):599-602.
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Mishima N, Mikawa T, Kirby ML. Smooth muscle alpha-actin downregulation in cultured chick aortic smooth muscle and neural crest cells is associated with altered cell shape. Exp Cell Res. 1996 Apr 10; 224(1):204-7.
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Mikawa T, Hyer J, Itoh N, Wei Y. Retroviral vectors to study cardiovascular development. Trends Cardiovasc Med. 1996 Apr; 6(3):79-86.
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Mikawa T, Gourdie RG. Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev Biol. 1996 Mar 15; 174(2):221-32.
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Mikawa T, Fischman DA. The polyclonal origin of myocyte lineages. Annu Rev Physiol. 1996; 58:509-21.
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Itoh N, Mima T, Mikawa T. Loss of fibroblast growth factor receptors is necessary for terminal differentiation of embryonic limb muscle. Development. 1996 Jan; 122(1):291-300.
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Gilbert R, Kelly MG, Mikawa T, Fischman DA. The carboxyl terminus of myosin binding protein C (MyBP-C, C-protein) specifies incorporation into the A-band of striated muscle. J Cell Sci. 1996 Jan; 109 ( Pt 1):101-11.
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Gourdie RG, Mima T, Thompson RP, Mikawa T. Terminal diversification of the myocyte lineage generates Purkinje fibers of the cardiac conduction system. Development. 1995 May; 121(5):1423-31.
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Ohuchi H, Nakagawa T, Yamauchi M, Ohata T, Yoshioka H, Kuwana T, Mima T, Mikawa T, Nohno T, Noji S. An additional limb can be induced from the flank of the chick embryo by FGF4. Biochem Biophys Res Commun. 1995 Apr 26; 209(3):809-16.
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Mikawa T. Retroviral targeting of FGF and FGFR in cardiomyocytes and coronary vascular cells during heart development. Ann N Y Acad Sci. 1995 Mar 27; 752:506-16.
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Nawrotzki R, Fischman DA, Mikawa T. Antisense suppression of skeletal muscle myosin light chain-1 biosynthesis impairs myofibrillogenesis in cultured myotubes. J Muscle Res Cell Motil. 1995 Feb; 16(1):45-56.
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Mima T, Ohuchi H, Noji S, Mikawa T. FGF can induce outgrowth of somatic mesoderm both inside and outside of limb-forming regions. Dev Biol. 1995 Feb; 167(2):617-20.
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Mima T, Ueno H, Fischman DA, Williams LT, Mikawa T. Fibroblast growth factor receptor is required for in vivo cardiac myocyte proliferation at early embryonic stages of heart development. Proc Natl Acad Sci U S A. 1995 Jan 17; 92(2):467-71.
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Kumazawa S, Kanda M, Aoyama H, Utagawa M, Ohtani H, Chiga I, Mikawa T, Hayase T, Hino T. Nuclear magnetic resonance study and secondary structure determination of the antibiotic peptide, aibellin. Biosci Biotechnol Biochem. 1994 Dec; 58(12):2188-92.
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Epstein ML, Mikawa T, Brown AM, McFarlin DR. Mapping the origin of the avian enteric nervous system with a retroviral marker. Dev Dyn. 1994 Nov; 201(3):236-44.
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Kumazawa S, Kanda M, Aoyama H, Utagawa M, Kondo J, Sakamoto S, Ohtani H, Mikawa T, Chiga I, Hayase T, et al. Structural elucidation of aibellin, a new peptide antibiotic with efficiency enhancing activity on rumen fermentation. J Antibiot (Tokyo). 1994 Oct; 47(10):1136-44.
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Kumazawa S, Asami Y, Awane K, Ohtani H, Fukuchi C, Mikawa T, Hayase T. Structural studies of new macrolide antibiotics, shurimycins A and B. J Antibiot (Tokyo). 1994 Jun; 47(6):688-96.
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Ogawara H, Higashi K, Machida T, Takashima J, Chiba N, Mikawa T. Inhibitors of diacylglycerol kinase from Drechslera sacchari. J Antibiot (Tokyo). 1994 Apr; 47(4):499-501.
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Okagaki T, Weber FE, Fischman DA, Vaughan KT, Mikawa T, Reinach FC. The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. J Cell Biol. 1993 Nov; 123(3):619-26.
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Xiao JZ, Kumazawa S, Tomita H, Yoshikawa N, Kimura C, Mikawa T. Rousselianone A, novel antibiotic related to phenalenone produced by Phaeosphaeria rousseliana. J Antibiot (Tokyo). 1993 Oct; 46(10):1570-4.
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Xaio J, Kumazawa S, Yoshikawa N, Mikawa T, Sato Y. Dactylfungins, novel antifungal antibiotics produced by Dactylaria parvispora. J Antibiot (Tokyo). 1993 Jan; 46(1):48-55.
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Mikawa T, Fischman DA. Retroviral analysis of cardiac morphogenesis: discontinuous formation of coronary vessels. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9504-8.
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Mikawa T, Cohen-Gould L, Fischman DA. Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus. III: Polyclonal origin of adjacent ventricular myocytes. Dev Dyn. 1992 Oct; 195(2):133-41.
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Herzlinger D, Koseki C, Mikawa T, al-Awqati Q. Metanephric mesenchyme contains multipotent stem cells whose fate is restricted after induction. Development. 1992 Mar; 114(3):565-72.
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Mikawa T, Borisov A, Brown AM, Fischman DA. Clonal analysis of cardiac morphogenesis in the chicken embryo using a replication-defective retrovirus: I. Formation of the ventricular myocardium. Dev Dyn. 1992 Jan; 193(1):11-23.
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Mikawa T, Fischman DA, Dougherty JP, Brown AM. In vivo analysis of a new lacZ retrovirus vector suitable for cell lineage marking in avian and other species. Exp Cell Res. 1991 Aug; 195(2):516-23.
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Itoh J, Takeuchi Y, Gomi S, Inouye S, Mikawa T, Yoshikawa N, Ohkishi H. MK4588, a new antibiotic related to xanthocillin. J Antibiot (Tokyo). 1990 May; 43(5):456-61.
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Kobayashi K, Nishino C, Ohya J, Sato S, Mikawa T, Shiobara Y, Kodama M. Actinoplanones C, D, E, F and G, new cytotoxic polycyclic xanthones from Actinoplanes sp. J Antibiot (Tokyo). 1988 Jun; 41(6):741-50.
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Kobayashi K, Nishino C, Ohya J, Sato S, Mikawa T, Shiobara Y, Kodama M. Actinoplanones A and B, new cytotoxic polycyclic xanthones from Actinoplanes sp. J Antibiot (Tokyo). 1988 Apr; 41(4):502-11.
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Kobayashi K, Nishino C, Ohya J, Sato S, Mikawa T, Shiobara Y, Kodama M, Nishimoto N. Oligomycin E, a new antitumor antibiotic produced by Streptomyces sp. MCI-2225. J Antibiot (Tokyo). 1987 Jul; 40(7):1053-7.
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Ebashi S, Mikawa T, Kuwayama H, Suzuki M, Ikemoto H, Ishizaki Y, Koga R. Ca2+ regulation in smooth muscle; dissociation of myosin light chain kinase activity from activation of actin-myosin interaction. Prog Clin Biol Res. 1987; 245:109-17.
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