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    Tien Peng, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address513 Parnassus Ave.
    San Francisco CA 94117
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      Collapse Biography 
      Collapse Education and Training
      University of VirginiaB.A.2000
      Johns Hopkins UniversityM.D.School of Medicine2006
      Collapse Awards and Honors
      National Institutes of Health2003 - 2004Clinical Research Training Program Scholar
      University of Pennsylvania2013 - 2014Willam Maul Measey Senior Research Fellow
      University of Pennsylvania2013Stanley E. Bradley Award for Bench Research
      Federation of American Societies for Experimental Biology2014Jo Rae Wright Award
      American Society for Clinical Investigation2016Young Physician Scientist Award

      Collapse Overview 
      Collapse Overview
      Our laboratory is interested in studying how key developmental pathways continue to persist in adulthood to maintain normal homeostatic organ function. We are particularly focused on the mesenchymal cell types (e.g. fibroblasts, pericytes, and etc.) that are poorly understood and lack precise anatomical definition, but are integral to the structural integrity and function of adult organs such as the lung. Previous work focused on how the Hedgehog pathway directed mesenchymal progenitor differentiation during embryonic development, and much to our surprise, how Hedgehog continues to maintain normal mesenchymal homeostasis during adulthood. We found that cellular quiescence in the adult lung is not a default state, but rather actively maintained by epithelial-mesenchymal crosstalk coordinated by Hedgehog. This suggests that cellular quiescence is tightly regulated by the state of Hedgehog activation within the mesenchyme to regulate cellular turnover during homeostasis and injury, and that dysregulated Hedgehog signaling could lead to maladaptive remodeling and lung diseases. Our projects utilizes sophisticated murine genetic models to manipulate and characterize cellular populations in a temporally/spatially specific manner, dissecting the role of key developmental pathways in regulating adult organ structural integrity, immune homeostasis, and aging.


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      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 2015 Oct 22; 526(7574):578-82. PMID: 26436454.
        View in: PubMed
      2. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014 Jun 15; 28(12):1363-79. PMID: 24939938; PMCID: PMC4066405.
      3. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/ß-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 5; 13(6):720-33. PMID: 24315444; PMCID: PMC3900235.
      4. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92. PMID: 23873040; PMCID: PMC3758448.
      5. Peng T, Morrisey EE. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulm Circ. 2013 Jan; 3(1):176-8. PMID: 23662197; PMCID: PMC3641728.
      6. Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60. PMID: 19399660; PMCID: PMC2819481.
      7. Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. Am J Clin Oncol. 2007 Dec; 30(6):664-5. PMID: 18091066; PMCID: PMC3991117.
      8. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52. PMID: 17440165.
        View in: PubMed
      9. Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158. PMID: 16526403.
        View in: PubMed
      10. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 2003 Jun; 7(6):827-38. PMID: 12788657.
        View in: PubMed
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