Tien Peng, MD

Title(s)Associate Professor, Medicine
SchoolSchool of Medicine
Phone--
ORCID ORCID Icon0000-0002-2226-4635 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of VirginiaB.A.2000
    Johns Hopkins UniversityM.D.2006School of Medicine
    Columbia University Medical CenterInternal Medicine Residency2009
    University of PennsylvaniaClinical/Postdoctoral Fellowship2015Pulmonary Medicine/Cell and Developmental Biology
    Collapse Awards and Honors
    Federation of American Societies for Experimental Biology2014Jo Rae Wright Award
    American Society for Clinical Investigation2016Young Physician Scientist Award
    National Institutes of Health2016  - 2021NIH New Innovator Award

    Collapse Overview 
    Collapse Overview
    The Peng Lab is interested in how fibroblasts integrate extracellular cues to modify the tissue niche, with a particular focus on fibroblasts that support tissue-resident stem cells and immune cells. We utilize complex murine genetic models and human specimen to interrogate how fibroblasts maintain organ homeostasis, initiate disease, and drive tissue aging. Tien is a pulmonologist by training and the lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.

    Collapse Research 
    Collapse Research Activities and Funding
    Mesenchymal modulation of epithelial metaplasia in lung fibrosis
    NIH R01HL155622Feb 1, 2021 - Dec 31, 2024
    Role: Principal Investigator
    Maintenance of the alveolar niche in emphysema
    NIH R01HL142552Aug 22, 2018 - Jun 30, 2022
    Role: Principal Investigator
    Defining the resident mesenchymal stem cell niche and function in vivo
    NIH DP2AG056034Sep 30, 2016 - Jun 30, 2021
    Role: Principal Investigator
    The roles of Hedgehog signaling in pulmonary vascular development and remodeling
    NIH K08HL121146Sep 1, 2014 - Jun 30, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Collaboration Interests

    Collapse Featured Content 
    Collapse Twitter

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis. J Clin Invest. 2024 Mar 07. Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T. PMID: 38451724.
      View in: PubMed   Mentions:    Fields:    
    2. In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Sci Adv. 2023 Dec 08; 9(49):eadj4884. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH. PMID: 38064566; PMCID: PMC10708181.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Bad Neighbors or Bad Neighborhoods: Pathogenic Residency of T Cells in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2023 12 01; 208(11):1148-1150. Peng T. PMID: 37855741; PMCID: PMC10868362.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    4. Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19. Elife. 2023 10 13; 12. COVID Tissue Atlas Consortium, Granados AA, Bucher S, Song H, Agrawal A, Chen AT, Peng T, Neff N, Pisco AO, Huang F, Wang B. PMID: 37830426; PMCID: PMC10575628.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv. 2023 Apr 28. Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. PMID: 37163060; PMCID: PMC10168323.
      View in: PubMed   Mentions:
    6. Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir. Immunity. 2023 03 14; 56(3):576-591.e10. Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T. PMID: 36822205; PMCID: PMC10578134.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    7. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science. 2022 10 14; 378(6616):192-201. Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. PMID: 36227993; PMCID: PMC10621323.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    8. Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche. Front Cell Dev Biol. 2022; 10:932723. Allen NC, Reyes NS, Lee JY, Peng T. PMID: 35912114; PMCID: PMC9325971.
      View in: PubMed   Mentions: 2  
    9. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol. 2022 01; 24(1):10-23. Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. PMID: 34969962; PMCID: PMC8761168.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    10. An inflammatory switch for stem cell plasticity. Nat Cell Biol. 2021 09; 23(9):928-929. Kathiriya JJ, Peng T. PMID: 34475536; PMCID: PMC8440424.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    11. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020 11; 22(11):1295-1306. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. PMID: 33046884; PMCID: PMC7642162.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    12. The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance. J Dev Biol. 2019 Jul 09; 7(3). Wang C, Cassandras M, Peng T. PMID: 31323955; PMCID: PMC6787692.
      View in: PubMed   Mentions: 15  
    13. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 03 19; 50(3):707-722.e6. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. PMID: 30824323; PMCID: PMC6553479.
      View in: PubMed   Mentions: 135     Fields:    Translation:AnimalsCells
    14. Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging Cell. 2019 06; 18(3):e12914. Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. PMID: 30790400; PMCID: PMC6516428.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    15. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. J Clin Invest. 2018 10 01; 128(10):4343-4358. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. PMID: 29999500; PMCID: PMC6159975.
      View in: PubMed   Mentions: 37     Fields:    Translation:HumansAnimalsCells
    16. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep. 2016 11 22; 17(9):2312-2325. Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. PMID: 27880906; PMCID: PMC5214982.
      View in: PubMed   Mentions: 153     Fields:    Translation:AnimalsCells
    17. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature. 2015 Oct 22; 526(7574):578-82. Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. PMID: 26436454; PMCID: PMC4713039.
      View in: PubMed   Mentions: 107     Fields:    Translation:AnimalsCells
    18. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes Dev. 2014 Jun 15; 28(12):1363-79. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. PMID: 24939938; PMCID: PMC4066405.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimalsCells
    19. Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell. 2013 Dec 05; 13(6):720-33. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. PMID: 24315444; PMCID: PMC3900235.
      View in: PubMed   Mentions: 152     Fields:    Translation:AnimalsCells
    20. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature. 2013 Aug 29; 500(7464):589-92. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. PMID: 23873040; PMCID: PMC3758448.
      View in: PubMed   Mentions: 116     Fields:    Translation:AnimalsCells
    21. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulm Circ. 2013 Jan; 3(1):176-8. Peng T, Morrisey EE. PMID: 23662197; PMCID: PMC3641728.
      View in: PubMed   Mentions: 16  
    22. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers. 2009 May; 14(3):156-60. Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM, Pulmonary Vascular Complications of Liver Disease Study Group. PMID: 19399660; PMCID: PMC2819481.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. Am J Clin Oncol. 2007 Dec; 30(6):664-5. Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. PMID: 18091066; PMCID: PMC3991117.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    24. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. J Natl Cancer Inst. 2007 Apr 18; 99(8):639-52. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. PMID: 17440165.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansCells
    25. Short hairpin RNA loop design for the facilitation of sequence verification. Biotechniques. 2006 Feb; 40(2):154, 156, 158. Akeju O, Peng T, Park JK. PMID: 16526403.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    26. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Mol Ther. 2003 Jun; 7(6):827-38. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. PMID: 12788657.
      View in: PubMed   Mentions: 64     Fields:    Translation:HumansAnimalsCells
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