Tiffany Ho, PhD

TitleAssociate Researcher
SchoolUCSF School of Medicine
Address401 Parnassus Ave.
San Francisco CA 94143
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyB.A.2006Cognitive Science
    University of California, San DiegoPh.D.2012Psychology
    Collapse Awards and Honors
    Society for Neuroscience2014Postdoctoral Fellow Travel Award
    American Foundation for Suicide Prevention2014 - 2016Postdoctoral Research Fellowship
    Society of Biological Psychiatry2015Travel Award
    Career Development Institute for Psychiatry2016 - 2018Trainee
    American College of Neuropsychopharmacology2016Travel Award
    Klingenstein Third Generation Foundation2017 - 2019Fellow in Child and Adolescent Depression

    Collapse Overview 
    Collapse Overview
    My research utilizes a multimethodological approach (task-based fMRI, resting-state fMRI, DTI, VBM, quantitative modeling of behavior) to examine cognitive and neural differences between adolescents with depression and typically developing youth. I am currently funded by the American Foundation for Suicide Prevention and am leading a project on identifying functional and structural patterns between depressed adolescents with and without a history of suicidal attempt. My longstanding goal is to use cognitive and computational neuroscience tools to probe basic dimensions of functioning transdiagnostically and longitudinally so that we can begin (1) basing classification of mental illness beyond DSM criteria and rely more on objective biomarkers, (2) identifying neural risk factors and predictors of negative psychiatric behaviors (e.g., mood symptoms, suicidal ideation, self-harm), and (3) develop more comprehensive models in psychiatry that will lead to improved intervention strategies and successful treatment outcomes. I am particularly interested in adolescence as it is a sensitive period of development where the incidence of mood disorders rises dramatically and as such, may also be a window where well-designed interventions can lead to significant improvements.

    My prior research experience includes fMRI studies of perceptual decision making, psychophysical studies of visual attention, pharmacological studies of ion channels, pharmacological and behavioral studies on rodent models of alcoholism, and PSG studies on sleep in normal, insomniac, and bipolar populations. Each experience has offered me something unique and interesting about neuroscience, and has informed both my current research and teaching.

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Henje Blom E, Tymofiyeva O, Chesney MA, Ho TC, Moran P, Connolly CG, Duncan LG, Baldini L, Weng HY, Acree M, Goldman V, Hecht FM, Yang TT. Feasibility and Preliminary Efficacy of a Novel RDoC-Based Treatment Program for Adolescent Depression: "Training for Awareness Resilience and Action" (TARA)-A Pilot Study. Front Psychiatry. 2016; 7:208. PMID: 28138319.
      View in: PubMed
    2. Connolly CG, Ho T, Blom EH, LeWinn KZ, Sacchet MD, Tymofiyeva O, Simmons AN, Yang TT. Resting-state functional connectivity of the amygdala and longitudinal changes in depression severity in adolescent depression. J Affect Disord. 2016 Sep 23; 207:86-94. PMID: 27716542.
      View in: PubMed
    3. Tymofiyeva O, Connolly CG, Ho T, Sacchet MD, Henje Blom E, LeWinn KZ, Xu D, Yang TT, et al. DTI-based connectome analysis of adolescents with major depressive disorder reveals hypoconnectivity of the right caudate. J Affect Disord. 2016 Sep 19; 207:18-25. PMID: 27673479.
      View in: PubMed
    4. Colich NL, Ho T, Foland-Ross LC, Eggleston C, Ordaz SJ, Singh MK, Gotlib IH. Hyperactivation in Cognitive Control and Visual Attention Brain Regions During Emotional Interference in Adolescent Depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2016.
    5. Ho T, Sanders SJ, Gotlib IH, Hoeft F, et al. Intergenerational Neuroimaging of Human Brain Circuitry. Trends Neurosci. 2016 Sep 9. PMID: 27623194.
      View in: PubMed
    6. Sacchet MD, Ho T, Connolly CG, Tymofiyeva O, Lewinn KZ, Han LK, Blom EH, Tapert SF, Max JE, Frank GK, Paulus MP, Simmons AN, Gotlib IH, Yang TT, et al. Large-Scale Hypoconnectivity between Resting-State Functional Networks in Unmedicated Adolescent Major Depressive Disorder. Neuropsychopharmacology. 2016 May 26. PMID: 27238621.
      View in: PubMed
    7. Ho TC, Zhang S, Sacchet MD, Weng H, Connolly CG, Henje Blom E, Han LK, Mobayed NO, Yang TT. Fusiform Gyrus Dysfunction is Associated with Perceptual Processing Efficiency to Emotional Faces in Adolescent Depression: A Model-Based Approach. Front Psychol. 2016; 7:40. PMID: 26869950.
      View in: PubMed
    8. Henje-Blom E, Ho T, Connolly CG, LeWinn KZ, Sacchet MD, Tymofiyeva O, Weng HY, Yang TT. The neuroscience and context of adolescent depression. Acta Paediatr. 2016 Apr; 105(4):358-65. PMID: 26663379.
      View in: PubMed
    9. Henje Blom E, Han LK, Connolly CG, Ho TC, Lin J, LeWinn KZ, Simmons AN, Sacchet MD, Mobayed N, Luna ME, Paulus M, Epel ES, Blackburn EH, Wolkowitz OM, Yang TT. Peripheral telomere length and hippocampal volume in adolescents with major depressive disorder. Transl Psychiatry. 2015; 5:e676. PMID: 26556285.
      View in: PubMed
    10. Henje Blom E, Connolly CG, Ho TC, LeWinn KZ, Mobayed N, Han L, Paulus MP, Wu J, Simmons AN, Yang TT. Altered insular activation and increased insular functional connectivity during sad and happy face processing in adolescent major depressive disorder. J Affect Disord. 2015 Jun 1; 178:215-23. PMID: 25827506; PMCID: PMC4412607 [Available on 06/01/16].
    11. Ho TC, Connolly CG, Henje Blom E, LeWinn KZ, Strigo IA, Paulus MP, Frank G, Max JE, Wu J, Chan M, Tapert SF, Simmons AN, Yang TT. Emotion-Dependent Functional Connectivity of the Default Mode Network in Adolescent Depression. Biol Psychiatry. 2015 Nov 1; 78(9):635-46. PMID: 25483399; PMCID: PMC4362932 [Available on 11/01/16].
    12. Henje Blom E, Duncan LG, Ho TC, Connolly CG, LeWinn KZ, Chesney M, Hecht FM, Yang TT. The development of an RDoC-based treatment program for adolescent depression: "Training for Awareness, Resilience, and Action" (TARA). Front Hum Neurosci. 2014; 8:630. PMID: 25191250; PMCID: PMC4137278.
    13. LeWinn KZ, Connolly CG, Wu J, Drahos M, Hoeft F, Ho TC, Simmons AN, Yang TT. White matter correlates of adolescent depression: structural evidence for frontolimbic disconnectivity. J Am Acad Child Adolesc Psychiatry. 2014 Aug; 53(8):899-909, 909.e1-7. PMID: 25062597; PMCID: PMC4112055.
    14. Ester EF, Ho TC, Brown SD, Serences JT. Variability in visual working memory ability limits the efficiency of perceptual decision making. J Vis. 2014; 14(4). PMID: 24695991; PMCID: PMC3974583.
    15. Ho TC, Yang G, Wu J, Cassey P, Brown SD, Hoang N, Chan M, Connolly CG, Henje-Blom E, Duncan LG, Chesney MA, Paulus MP, Max JE, Patel R, Simmons AN, Yang TT. Functional connectivity of negative emotional processing in adolescent depression. J Affect Disord. 2014 Feb; 155:65-74. PMID: 24268546.
      View in: PubMed
    16. Connolly CG, Wu J, Ho TC, Hoeft F, Wolkowitz O, Eisendrath S, Frank G, Hendren R, Max JE, Paulus MP, Tapert SF, Banerjee D, Simmons AN, Yang TT. Resting-state functional connectivity of subgenual anterior cingulate cortex in depressed adolescents. Biol Psychiatry. 2013 Dec 15; 74(12):898-907. PMID: 23910949; PMCID: PMC4103629.
    17. Ho TC, Wu J, Shin DD, Liu TT, Tapert SF, Yang G, Connolly CG, Frank GK, Max JE, Wolkowitz O, Eisendrath S, Hoeft F, Banerjee D, Hood K, Hendren RL, Paulus MP, Simmons AN, Yang TT. Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression. J Am Acad Child Adolesc Psychiatry. 2013 Oct; 52(10):1076-1091.e2. PMID: 24074474; PMCID: PMC3825460.
    18. Ho TC, Ester EF. Target enhancement and distractor suppression in naturalistic visual search. J Neurosci. 2012 Nov 21; 32(47):16539-40. PMID: 23175809; PMCID: PMC3535462.
    19. Ho TC, Brown S, Abuyo NA, Ku EH, Serences JT. Perceptual consequences of feature-based attentional enhancement and suppression. J Vis. 2012; 12(8):15. PMID: 22923726; PMCID: PMC4503215.
    20. Ho TC, Horn NA, Huynh T, Kelava L, Lansman JB. Evidence TRPV4 contributes to mechanosensitive ion channels in mouse skeletal muscle fibers. Channels (Austin). 2012 Jul-Aug; 6(4):246-54. PMID: 22785252; PMCID: PMC3508903.
    21. Ho T, Brown S, van Maanen L, Forstmann BU, Wagenmakers EJ, Serences JT. The optimality of sensory processing during the speed-accuracy tradeoff. J Neurosci. 2012 Jun 6; 32(23):7992-8003. PMID: 22674274; PMCID: PMC3388609.
    22. van Maanen L, Brown SD, Eichele T, Wagenmakers EJ, Ho T, Serences J, Forstmann BU. Neural correlates of trial-to-trial fluctuations in response caution. J Neurosci. 2011 Nov 30; 31(48):17488-95. PMID: 22131410.
      View in: PubMed
    23. Ho TC, Brown S, Serences JT. Domain general mechanisms of perceptual decision making in human cortex. J Neurosci. 2009 Jul 8; 29(27):8675-87. PMID: 19587274; PMCID: PMC2719543.
    24. Serences JT, Saproo S, Scolari M, Ho T, Muftuler LT. Estimating the influence of attention on population codes in human visual cortex using voxel-based tuning functions. Neuroimage. 2009 Jan 1; 44(1):223-31. PMID: 18721888.
      View in: PubMed
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