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Timothy Acker, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address600 16th Street
San Francisco CA 94158
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    Collapse Research 
    Collapse Research Activities and Funding
    Development of Novel Human Herpes Virus Inhibitors
    NIH/NIGMS F32GM111012Apr 1, 2014 - Mar 31, 2017
    Role: Principal Investigator
    Rationally Designing Subunit Selective Antagonists for NR2C/D containing NMDA rec
    NIH/NINDS F31NS071802Jun 23, 2010 - Jun 22, 2013
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Selected Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gable JE, Lee GM, Acker T, Hulce KR, Gonzalez ER, Schweigler P, Melkko S, Farady CJ, Craik CS. Fragment-Based Protein-Protein Interaction Antagonists of a Viral Dimeric Protease. ChemMedChem. 2016 Apr 19; 11(8):862-9. PMID: 26822284.
      View in: PubMed
    2. Gable JE, Acker TM, Craik CS. Current and Potential Treatments for Ubiquitous but Neglected Herpesvirus Infections. Chem Rev. 2014 Nov 26; 114(22):11382-412. PMID: 25275644; PMCID: PMC4254030.
    3. Acker TM, Khatri A, Vance KM, Slabber C, Bacsa J, Snyder JP, Traynelis SF, Liotta DC. Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists. J Med Chem. 2013 Aug 22; 56(16):6434-56. PMID: 23909910; PMCID: PMC4643674.
    4. Santangelo RM, Acker TM, Zimmerman SS, Katzman BM, Strong KL, Traynelis SF, Liotta DC. Novel NMDA receptor modulators: an update. Expert Opin Ther Pat. 2012 Nov; 22(11):1337-52. PMID: 23009122; PMCID: PMC3677696.
    5. Acker TM, Yuan H, Hansen KB, Vance KM, Ogden KK, Jensen HS, Burger PB, Mullasseril P, Snyder JP, Liotta DC, Traynelis SF. Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol. 2011 Nov; 80(5):782-95. PMID: 21807990; PMCID: PMC3198917.
    6. Mosley CA, Acker TM, Hansen KB, Mullasseril P, Andersen KT, Le P, Vellano KM, Bräuner-Osborne H, Liotta DC, Traynelis SF. Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J Med Chem. 2010 Aug 12; 53(15):5476-90. PMID: 20684595; PMCID: PMC2920070.
    7. Raja SM, Chen S, Yue P, Acker TM, Lefkove B, Arbiser JL, Khuri FR, Sun SY. The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis. Mol Cancer Ther. 2008 Jul; 7(7):2212-23. PMID: 18645030; PMCID: PMC2756752.
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