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    Timothy Campbell, MD, PhD

    Address400 Parnassus Ave, 4th floor
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      UCSFHematology and Oncology FellowshipMedicine - Hematology and Oncology2015
      UCSFInternal Medicine ResidencyMedicine2012
      Indiana University School of MedicineM.D.Medicine2010
      Indiana University School of MedicinePh.D.Microbiology and Immunology2010
      Purdue UniversityB.S. and B.A.Biology and Philosophy2002
      Collapse Awards and Honors
      American Society of Hematology2016 - 2018ASH Scholar in Basic Science
      UCSF2015 - 2016Eli and Edythe Broad Regeneration Medicine and Stem Cell Fellowship

      Collapse Overview 
      Collapse Overview
      I am currently completing my postdoctoral research in Emmanuelle Passegué’s laboratory at UCSF. My focus in the laboratory is to understand the mechanism of bone marrow stromal remodeling in models of myeloproliferative neoplasms (MPN) such as those driven by BCR/ABL translocation, Jak2 and MPL mutations. We know that stroma remodeling such as fibrosis is important in disease progression in MPN and we feel it is an attractive novel target for therapy development. We use both mouse models and human primary tissue to model the interaction between malignant, transformed hematopoietic cells and stroma populations including mesenchymal stem cells. In addition to basic research, I am involved in clinical patient care, and I spend about 20% of my time seeing patients with both non-malignant and malignant hematologic conditions at UCSF.

      Collapse Interests
      Hematopoietic stem cells, bone marrow stroma, myeloproliferative neoplasms, leukemia, multiple myeloma, mouse models, human tissue

      Collapse ORNG Applications 
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      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Broxmeyer HE, Capitano M, Campbell TB, Hangoc G, Cooper S. Modulation of Hematopoietic Chemokine Effects In Vitro and In Vivo by DPP-4/CD26. Stem Cells Dev. 2016 Apr 15; 25(8):575-85. PMID: 26943017.
        View in: PubMed
      2. Schepers K, Campbell TB, Passegué E. Normal and leukemic stem cell niches: insights and therapeutic opportunities. Cell Stem Cell. 2015 Mar 5; 16(3):254-67. PMID: 25748932; PMCID: PMC4391962 [Available on 03/05/16].
      3. Broxmeyer HE, Hoggatt J, O'Leary HA, Mantel C, Chitteti BR, Cooper S, Messina-Graham S, Hangoc G, Farag S, Rohrabaugh SL, Ou X, Speth J, Pelus LM, Srour EF, Campbell TB. Dipeptidylpeptidase 4 negatively regulates colony-stimulating factor activity and stress hematopoiesis. Nat Med. 2012 Dec; 18(12):1786-96. PMID: 23160239; PMCID: PMC3742313.
      4. Rohrabaugh SL, Campbell TB, Hangoc G, Broxmeyer HE. Ex vivo rapamycin treatment of human cord blood CD34+ cells enhances their engraftment of NSG mice. Blood Cells Mol Dis. 2011 Apr 15; 46(4):318-20. PMID: 21411351; PMCID: PMC3075341.
      5. Campbell TB, Basu S, Hangoc G, Tao W, Broxmeyer HE. Overexpression of Rheb2 enhances mouse hematopoietic progenitor cell growth while impairing stem cell repopulation. Blood. 2009 Oct 15; 114(16):3392-401. PMID: 19690340; PMCID: PMC2765676.
      6. Liu Y, Hangoc G, Campbell TB, Goodman M, Tao W, Pollok K, Srour EF, Broxmeyer HE. Identification of parameters required for efficient lentiviral vector transduction and engraftment of human cord blood CD34(+) NOD/SCID-repopulating cells. Exp Hematol. 2008 Aug; 36(8):947-56. PMID: 18640494; PMCID: PMC2586287.
      7. Campbell TB, Broxmeyer HE. CD26 inhibition and hematopoiesis: a novel approach to enhance transplantation. Front Biosci. 2008; 13:1795-805. PMID: 17981668.
        View in: PubMed
      8. Li G, Abediankenari S, Kim YJ, Campbell TB, Ito S, Graham-Evans B, Cooper S, Broxmeyer HE. TGF-beta combined with M-CSF and IL-4 induces generation of immune inhibitory cord blood dendritic cells capable of enhancing cytokine-induced ex vivo expansion of myeloid progenitors. Blood. 2007 Oct 15; 110(8):2872-9. PMID: 17585053; PMCID: PMC2018669.
      9. Campbell TB, Hangoc G, Liu Y, Pollok K, Broxmeyer HE. Inhibition of CD26 in human cord blood CD34+ cells enhances their engraftment of nonobese diabetic/severe combined immunodeficiency mice. Stem Cells Dev. 2007 Jun; 16(3):347-54. PMID: 17610364.
        View in: PubMed
      10. Broxmeyer HE, Orschell CM, Clapp DW, Hangoc G, Cooper S, Plett PA, Liles WC, Li X, Graham-Evans B, Campbell TB, Calandra G, Bridger G, Dale DC, Srour EF. Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. J Exp Med. 2005 Apr 18; 201(8):1307-18. PMID: 15837815; PMCID: PMC2213145.
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