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    Tippi Mackenzie, MD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentSurgery
    Address550 16th Street
    San Francisco CA 94158
    Phone415-476-2479

       Biography 
       Education and Training
      Stanford UniversityM.D.School of Medicine1997

       ORNG Applications 
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       Awarded Grants

       Bibliographic 
       Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. MacKenzie TC, David AL, Flake AW, Almeida-Porada G. Consensus statement from the first international conference for in utero stem cell transplantation and gene therapy. Front Pharmacol. 2015; 6:15.
        View in: PubMed
      2. Derderian SC, Jeanty C, Walters MC, Vichinsky E, MacKenzie TC. In utero hematopoietic cell transplantation for hemoglobinopathies. Front Pharmacol. 2014; 5:278.
        View in: PubMed
      3. Derderian SC, Jeanty C, Fleck SR, Cheng LS, Peyvandi S, Moon-Grady AJ, Farrell J, Hirose S, Gonzalez J, Keller RL, MacKenzie TC. The many faces of hydrops. J Pediatr Surg. 2015 Jan; 50(1):50-4.
        View in: PubMed
      4. Jeanty C, Kunisaki SM, MacKenzie TC. Novel non-surgical prenatal approaches to treating congenital diaphragmatic hernia. Semin Fetal Neonatal Med. 2014 Dec; 19(6):349-56.
        View in: PubMed
      5. Derderian SC, Coleman AM, Jeanty C, Lim FY, Shaaban AM, Farrell JA, Hirose S, MacKenzie TC, Lee H. Favorable outcomes in high-risk congenital pulmonary airway malformations treated with multiple courses of maternal betamethasone. J Pediatr Surg. 2015 Apr; 50(4):515-8.
        View in: PubMed
      6. Jeanty C, Derderian SC, Mackenzie TC. Maternal-fetal cellular trafficking: clinical implications and consequences. Curr Opin Pediatr. 2014 Jun; 26(3):377-82.
        View in: PubMed PMC4079801
      7. Derderian SC, Togarrati PP, King C, Moradi PW, Reynaud D, Czechowicz A, Weissman IL, MacKenzie TC. In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice. Blood. 2014 Aug 7; 124(6):973-80.
        View in: PubMed PMC4126335
      8. Sanchez Rodriguez R, Pauli ML, Neuhaus IM, Yu SS, Arron ST, Harris HW, Yang SH, Anthony BA, Sverdrup FM, Krow-Lucal E, MacKenzie TC, Johnson DS, Meyer EH, Löhr A, Hsu A, Koo J, Liao W, Gupta R, Debbaneh MG, Butler D, Huynh M, Levin EC, Leon A, Hoffman WY, McGrath MH, Alvarado MD, Ludwig CH, Truong HA, Maurano MM, Gratz IK, Abbas AK, Rosenblum MD. Memory regulatory T cells reside in human skin. J Clin Invest. 2014 Mar 3; 124(3):1027-36.
        View in: PubMed PMC3934172
      9. Derderian SC, Trivedi S, Farrell J, Keller RL, Rand L, Goldstein R, Feldstein VA, Hirose S, MacKenzie TC. Outcomes of fetal intervention for primary hydrothorax. J Pediatr Surg. 2014 Jun; 49(6):900-3; discussion 903-4.
        View in: PubMed
      10. Wegorzewska M, Nijagal A, Wong CM, Le T, Lescano N, Tang Q, MacKenzie TC. Fetal intervention increases maternal T cell awareness of the foreign conceptus and can lead to immune-mediated fetal demise. J Immunol. 2014 Feb 15; 192(4):1938-45.
        View in: PubMed
      11. Fleck S, Bautista G, Keating SM, Lee TH, Keller RL, Moon-Grady AJ, Gonzales K, Norris PJ, Busch MP, Kim CJ, Romero R, Lee H, Miniati D, MacKenzie TC. Fetal production of growth factors and inflammatory mediators predicts pulmonary hypertension in congenital diaphragmatic hernia. Pediatr Res. 2013 Sep; 74(3):290-8.
        View in: PubMed PMC4164304
      12. Nijagal A, Derderian C, Le T, Jarvis E, Nguyen L, Tang Q, Mackenzie TC. Direct and indirect antigen presentation lead to deletion of donor-specific T cells after in utero hematopoietic cell transplantation in mice. Blood. 2013 May 30; 121(22):4595-602.
        View in: PubMed PMC3668492
      13. Nijagal A, MacKenzie TC. Clinical implications of maternal-fetal cellular trafficking. Semin Pediatr Surg. 2013 Feb; 22(1):62-5.
        View in: PubMed
      14. Schecter SC, Courtier J, Cho SJ, Saadai P, Hirose S, Mackenzie TC, Miniati D. Hepatic portocholecystostomy for biliary atresia: a 25-year follow-up and review. J Pediatr Surg. 2013 Jan; 48(1):262-6.
        View in: PubMed
      15. Shue EH, Soares B, Courtier J, Hogue J, Shimotake T, MacKenzie TC. Type IV intestinal atresia, congenital bilateral perisylvian syndrome, and chronic pulmonary hypertension secondary to multiple vascular disruption syndrome in a monochorionic twin. J Pediatr Surg. 2012 Oct; 47(10):1938-42.
        View in: PubMed
      16. Nijagal A, Jelin E, Feldstein VA, Courtier J, Urisman A, Jones KD, Lee H, Hirose S, MacKenzie TC. The diagnosis and management of intradiaphragmatic extralobar pulmonary sequestrations: a report of 4 cases. J Pediatr Surg. 2012 Aug; 47(8):1501-5.
        View in: PubMed
      17. Saadai P, MacKenzie TC. Increased maternal microchimerism after open fetal surgery. Chimerism. 2012 Jul-Dec; 3(3):1-3.
        View in: PubMed PMC3545917
      18. Saadai P, Lee TH, Bautista G, Gonzales KD, Nijagal A, Busch MP, Kim CJ, Romero R, Lee H, Hirose S, Rand L, Miniati D, Farmer DL, MacKenzie TC. Alterations in maternal-fetal cellular trafficking after fetal surgery. J Pediatr Surg. 2012 Jun; 47(6):1089-94.
        View in: PubMed PMC3377979
      19. Saadai P, Jelin EB, Nijagal A, Schecter SC, Hirose S, MacKenzie TC, Rand L, Goldstein R, Farrell J, Harrison M, Lee H. Long-term outcomes after fetal therapy for congenital high airway obstructive syndrome. J Pediatr Surg. 2012 Jun; 47(6):1095-100.
        View in: PubMed
      20. Nijagal A, Flake AW, MacKenzie TC. In utero hematopoietic cell transplantation for the treatment of congenital anomalies. Clin Perinatol. 2012 Jun; 39(2):301-10.
        View in: PubMed
      21. Nijagal A, Fleck S, MacKenzie TC. Maternal microchimerism in patients with biliary atresia: Implications for allograft tolerance. Chimerism. 2012 Apr-Jun; 3(2):37-9.
        View in: PubMed PMC3442810
      22. Nijagal A, Fleck S, Hills NK, Feng S, Tang Q, Kang SM, Rosenthal P, MacKenzie TC. Decreased risk of graft failure with maternal liver transplantation in patients with biliary atresia. Am J Transplant. 2012 Feb; 12(2):409-19.
        View in: PubMed
      23. Landsman L, Nijagal A, Whitchurch TJ, Vanderlaan RL, Zimmer WE, Mackenzie TC, Hebrok M. Pancreatic mesenchyme regulates epithelial organogenesis throughout development. PLoS Biol. 2011 Sep; 9(9):e1001143.
        View in: PubMed PMC3167782
      24. Nijagal A, Le T, Wegorzewska M, Mackenzie TC. A mouse model of in utero transplantation. J Vis Exp. 2011; (47).
        View in: PubMed PMC3182662
      25. Nijagal A, Wegorzewska M, Jarvis E, Le T, Tang Q, MacKenzie TC. Maternal T cells limit engraftment after in utero hematopoietic cell transplantation in mice. J Clin Invest. 2011 Feb; 121(2):582-92.
        View in: PubMed PMC3026737
      26. Zaid HB, Rhee SJ, Hirose S, Mackenzie TC. Image of the month--quiz case. Gastric duplication cyst. Arch Surg. 2010 Oct; 145(10):1019, 1020.
        View in: PubMed
      27. Jancelewicz T, Vu LT, Keller RL, Bratton B, Lee H, Farmer D, Harrison M, Miniati D, Mackenzie T, Hirose S, Nobuhara K. Long-term surgical outcomes in congenital diaphragmatic hernia: observations from a single institution. J Pediatr Surg. 2010 Jan; 45(1):155-60; discussion 160.
        View in: PubMed
      28. Sabatino DE, Mackenzie TC, Peranteau W, Edmonson S, Campagnoli C, Liu YL, Flake AW, High KA. Persistent expression of hF.IX After tolerance induction by in utero or neonatal administration of AAV-1-F.IX in hemophilia B mice. Mol Ther. 2007 Sep; 15(9):1677-85.
        View in: PubMed
      29. Keswani SG, Crombleholme TM, Rychik J, Tian Z, Mackenzie TC, Johnson MP, Wilson RD, Flake AW, Hedrick HL, Howell LJ, Adzick NS. Impact of continuous intraoperative monitoring on outcomes in open fetal surgery. Fetal Diagn Ther. 2005 Jul-Aug; 20(4):316-20.
        View in: PubMed
      30. MacKenzie TC, Kobinger GP, Louboutin JP, Radu A, Javazon EH, Sena-Esteves M, Wilson JM, Flake AW. Transduction of satellite cells after prenatal intramuscular administration of lentiviral vectors. J Gene Med. 2005 Jan; 7(1):50-8.
        View in: PubMed
      31. Bouchard S, MacKenzie TC, Radu AP, Hayashi S, Peranteau WH, Chirmule N, Flake AW. Long-term transgene expression in cardiac and skeletal muscle following fetal administration of adenoviral or adeno-associated viral vectors in mice. J Gene Med. 2003 Nov; 5(11):941-50.
        View in: PubMed
      32. MacKenzie TC, Kobinger GP, Kootstra NA, Radu A, Sena-Esteves M, Bouchard S, Wilson JM, Verma IM, Flake AW. Efficient transduction of liver and muscle after in utero injection of lentiviral vectors with different pseudotypes. Mol Ther. 2002 Sep; 6(3):349-58.
        View in: PubMed
      33. MacKenzie TC, Crombleholme TM, Flake AW. The ex-utero intrapartum treatment. Curr Opin Pediatr. 2002 Aug; 14(4):453-8.
        View in: PubMed
      34. Mackenzie TC, Shaaban AF, Radu A, Flake AW. Engraftment of bone marrow and fetal liver cells after in utero transplantation in MDX mice. J Pediatr Surg. 2002 Jul; 37(7):1058-64.
        View in: PubMed
      35. Mackenzie TC, Crombleholme TM, Johnson MP, Schnaufer L, Flake AW, Hedrick HL, Howell LJ, Adzick NS. The natural history of prenatally diagnosed conjoined twins. J Pediatr Surg. 2002 Mar; 37(3):303-9.
        View in: PubMed
      36. MacKenzie TC, Flake AW. Human mesenchymal stem cells: insights from a surrogate in vivo assay system. Cells Tissues Organs. 2002; 171(1):90-5.
        View in: PubMed
      37. Gardner SC, Grunwald GK, Rumsfeld JS, Mackenzie T, Gao D, Perlin JB, McDonald G, Shroyer AL. Risk factors for intermediate-term survival after coronary artery bypass grafting. Ann Thorac Surg. 2001 Dec; 72(6):2033-7.
        View in: PubMed
      38. Kramer RE, Sokol RJ, Yerushalmi B, Liu E, MacKenzie T, Hoffenberg EJ, Narkewicz MR. Large-volume paracentesis in the management of ascites in children. J Pediatr Gastroenterol Nutr. 2001 Sep; 33(3):245-9.
        View in: PubMed
      39. Mackenzie TC, Howell LJ, Flake AW, Adzick NS. The management of prenatally diagnosed choledochal cysts. J Pediatr Surg. 2001 Aug; 36(8):1241-3.
        View in: PubMed
      40. Miga D, Sokol RJ, Mackenzie T, Narkewicz MR, Smith D, Karrer FM. Survival after first esophageal variceal hemorrhage in patients with biliary atresia. J Pediatr. 2001 Aug; 139(2):291-6.
        View in: PubMed
      41. MacKenzie TC, Guttenberg ME, Nisenbaum HL, Johnson MP, Adzick NS. A fetal lung lesion consisting of bronchogenic cyst, bronchopulmonary sequestration, and congenital cystic adenomatoid malformation: the missing link? Fetal Diagn Ther. 2001 Jul-Aug; 16(4):193-5.
        View in: PubMed
      42. Mackenzie TC, Flake AW. Human mesenchymal stem cells persist, demonstrate site-specific multipotential differentiation, and are present in sites of wound healing and tissue regeneration after transplantation into fetal sheep. Blood Cells Mol Dis. 2001 May-Jun; 27(3):601-4.
        View in: PubMed
      43. Mackenzie TC, Flake AW. Multilineage differentiation of human MSC after in utero transplantation. Cytotherapy. 2001; 3(5):403-5.
        View in: PubMed
      44. Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R, Marshak DR, Flake AW. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med. 2000 Nov; 6(11):1282-6.
        View in: PubMed
      45. Zawada ET, Johnson M, McClung D, TerWee J, MacKenzie T. Systemic and renal hemodynamic consequences of manipulation of serum calcium and/or parathyroid hormone in the intact conscious mongrel dog. J Am Coll Nutr. 1987 Apr; 6(2):131-8.
        View in: PubMed
      46. Zawada ET, Johnson M, Mackenzie T, Sica DA, Muakkassa W, Green SJ, Goldman M. Hemoglobin A1 in renal transplant recipients. Arch Intern Med. 1985 Jan; 145(1):82-4.
        View in: PubMed
      47. Green S, Zawada ET, Muakkassa W, Johnson M, Mackenzie T, McClanahan M, Graybill A, Goldman M. Effect of clonidine therapy on renal hemodynamics in renal transplant hypertension. Arch Intern Med. 1984 Jun; 144(6):1205-8.
        View in: PubMed
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