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    Todd Margolis, MD, PhD

    TitleProfessor
    SchoolUCSF Chancellor/EVC/FAS
    DepartmentProctor Foundation
    Address95 Kirkham St
    San Francisco CA 94122
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      Other Positions
      TitleDirector, Proctor Foundation


      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoPost-Doc Fellow/Scholar Medicine (Ophthalmology)1989
      University of California, San Francisco Residency School of Medicine
      University of California, San FranciscoM.D. Medicine1984
      University of California, San FranciscoPh.D. Graduate Division (Anatomy)1983

      Collapse Overview 
      Collapse Overview
      Margolis, a UCSF professor of ophthalmology, is the director of the Francis I. Proctor Foundation for Research in Ophthalmology at UCSF Medical Center. He is also president of the Association for Research in Vision and Ophthalmology, the world's largest eye and vision research organization, and serves on the National Advisory Eye Council of the National Eye Institute. He received his MD and his PhD degrees in neuroscience at UCSF.


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      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Liu Y, Chen AS, Kamphaengkham S, Leenasirimakul P, Jirawison C, Ausayakhun S, Margolis TP, Keenan JD. Diagnostic Utility of Ocular Symptoms and Vision for Cytomegalovirus Retinitis. PLoS One. 2016; 11(10):e0165564. PMID: 27788232.
        View in: PubMed
      2. Leenasirimakul P, Liu Y, Jirawison C, Khienprasit N, Kamphaengkham S, Ausayakhun S, Chen J, Yen M, Heiden D, Holland GN, Margolis TP, Keenan JD. Risk factors for CMV retinitis among individuals with HIV and low CD4 count in northern Thailand: importance of access to healthcare. Br J Ophthalmol. 2016 Aug; 100(8):1017-21. PMID: 27297217.
        View in: PubMed
      3. Delwig A, Keenan JD, Margolis TP. Topical Valganciclovir for the Treatment of Hypertensive Anterior Uveitis. Cornea. 2015 Nov; 34(11):1513-5. PMID: 26356754.
        View in: PubMed
      4. Van Gelder RN, Margolis TP. Ebola and the Ophthalmologist. Ophthalmology. 2015 Nov; 122(11):2152-4. PMID: 26498076.
        View in: PubMed
      5. Galor A, Batawi H, Felix ER, Margolis TP, Sarantopoulos KD, Martin ER, Levitt RC. Incomplete response to artificial tears is associated with features of neuropathic ocular pain. Br J Ophthalmol. 2016 Jun; 100(6):745-9. PMID: 26377416.
        View in: PubMed
      6. Lin MC, Asbell PA, Margolis T, McNamarra NA, Nichols KK, Nichols JJ, Polse KA. Dry Eye Disease. Optom Vis Sci. 2015 Sep; 92(9):922-4. PMID: 26301366.
        View in: PubMed
      7. Galor A, Felix ER, Feuer W, Shalabi N, Martin ER, Margolis TP, Sarantopoulos CD, Levitt RC. Dry eye symptoms align more closely to non-ocular conditions than to tear film parameters. Br J Ophthalmol. 2015 Aug; 99(8):1126-9. PMID: 25710726.
        View in: PubMed
      8. Tang S, Bosch-Marce M, Patel A, Margolis TP, Krause PR. Characterization of herpes simplex virus 2 primary microRNA Transcript regulation. J Virol. 2015 May; 89(9):4837-48. PMID: 25673716; PMCID: PMC4403459.
      9. Jirawison C, Yen M, Leenasirimakul P, Chen J, Guadanant S, Kunavisarut P, Patikulsila D, Watanachai N, Ausayakhun S, Heiden D, Holland GN, Margolis TP, Keenan JD. Telemedicine screening for cytomegalovirus retinitis at the point of care for human immunodeficiency virus infection. JAMA Ophthalmol. 2015 Feb; 133(2):198-205. PMID: 25412344.
        View in: PubMed
      10. Yen M, Chen J, Ausayakhun S, Kunavisarut P, Vichitvejpaisal P, Ausayakhun S, Jirawison C, Shantha J, Holland GN, Heiden D, Margolis TP, Keenan JD. Retinal detachment associated with AIDS-related cytomegalovirus retinitis: risk factors in a resource-limited setting. Am J Ophthalmol. 2015 Jan; 159(1):185-92. PMID: 25448999; PMCID: PMC4262697 [Available on 01/01/16].
      11. Galor A, Zlotcavitch L, Walter SD, Felix ER, Feuer W, Martin ER, Margolis TP, Sarantopoulos KD, Levitt RC. Dry eye symptom severity and persistence are associated with symptoms of neuropathic pain. Br J Ophthalmol. 2015 May; 99(5):665-8. PMID: 25336572.
        View in: PubMed
      12. Stanzel TP, Diaz JD, Mather R, Wong IG, Margolis TP, Gritz DC. The epidemiology of herpes simplex virus eye disease in Northern California. Ophthalmic Epidemiol. 2014 Dec; 21(6):370-7. PMID: 25299934.
        View in: PubMed
      13. Yen M, Ausayakhun S, Chen J, Ausayakhun S, Jirawison C, Heiden D, Holland GN, Margolis TP, Keenan JD. Telemedicine diagnosis of cytomegalovirus retinitis by nonophthalmologists. JAMA Ophthalmol. 2014 Sep; 132(9):1052-8. PMID: 24945306.
        View in: PubMed
      14. Vo RC, Stafeeva K, Aldave AJ, Stulting RD, Moore Q, Pflugfelder SC, Chungfat NC, Holsclaw DS, Margolis TP, Deng SX. Complications related to a cosmetic eye-whitening procedure. Am J Ophthalmol. 2014 Nov; 158(5):967-73. PMID: 25072832.
        View in: PubMed
      15. Maamari RN, Ausayakhun S, Margolis TP, Fletcher DA, Keenan JD. Novel telemedicine device for diagnosis of corneal abrasions and ulcers in resource-poor settings. JAMA Ophthalmol. 2014 Jul; 132(7):894-5. PMID: 25010172.
        View in: PubMed
      16. Culican SM, Rupp JD, Margolis TP. Retaining clinician-scientists: nature versus nurture. Invest Ophthalmol Vis Sci. 2014 May; 55(5):3219-22. PMID: 24867910.
        View in: PubMed
      17. Greene JB, Jeng BH, Fintelmann RE, Margolis TP. Oral azithromycin for the treatment of meibomitis. JAMA Ophthalmol. 2014 Jan; 132(1):121-2. PMID: 24201556.
        View in: PubMed
      18. Maamari RN, Keenan JD, Fletcher DA, Margolis TP. A mobile phone-based retinal camera for portable wide field imaging. Br J Ophthalmol. 2014 Apr; 98(4):438-41. PMID: 24344230.
        View in: PubMed
      19. Estopinal CB, Ausayakhun S, Ausayakhun S, Jirawison C, Joy Bhosai S, Margolis TP, Keenan JD. Access to ophthalmologic care in Thailand: a regional analysis. Ophthalmic Epidemiol. 2013 Oct; 20(5):267-73. PMID: 24070100.
        View in: PubMed
      20. Bertke AS, Ma A, Margolis MS, Margolis TP. Different mechanisms regulate productive herpes simplex virus 1 (HSV-1) and HSV-2 infections in adult trigeminal neurons. J Virol. 2013 Jun; 87(11):6512-6. PMID: 23514893; PMCID: PMC3648083.
      21. Heiden D, Margolis TP, Lowinger A, Saranchuk P. Eye exam with indirect ophthalmoscopy for diagnosis of disseminated tuberculosis in patients with HIV/AIDS. Br J Ophthalmol. 2013 May; 97(5):668-9. PMID: 23418196.
        View in: PubMed
      22. Bertke AS, Apakupakul K, Ma A, Imai Y, Gussow AM, Wang K, Cohen JI, Bloom DC, Margolis TP. LAT region factors mediating differential neuronal tropism of HSV-1 and HSV-2 do not act in trans. PLoS One. 2012; 7(12):e53281. PMID: 23300908; PMCID: PMC3534042.
      23. Fintelmann RE, Vastine DW, Bloomer MM, Margolis TP. Thygeson superficial punctate keratitis and scarring. Cornea. 2012 Dec; 31(12):1446-8. PMID: 22495026.
        View in: PubMed
      24. Gonzales JA, Levison AL, Stewart JM, Acharya NR, Margolis TP. Retinal necrosis following varicella-zoster vaccination. Arch Ophthalmol. 2012 Oct; 130(10):1355-6. PMID: 23044970.
        View in: PubMed
      25. Sy A, McLeod SD, Cohen EJ, Margolis TP, Mannis MJ, Lietman TM, Acharya NR. Practice patterns and opinions in the management of recurrent or chronic herpes zoster ophthalmicus. Cornea. 2012 Jul; 31(7):786-90. PMID: 22269677; PMCID: PMC3729033.
      26. Smits SL, Manandhar A, van Loenen FB, van Leeuwen M, Baarsma GS, Dorrestijn N, Osterhaus AD, Margolis TP, Verjans GM. High prevalence of anelloviruses in vitreous fluid of children with seasonal hyperacute panuveitis. J Infect Dis. 2012 Jun 15; 205(12):1877-84. PMID: 22492851.
        View in: PubMed
      27. Dalmon C, Porco TC, Lietman TM, Prajna NV, Prajna L, Das MR, Kumar JA, Mascarenhas J, Margolis TP, Whitcher JP, Jeng BH, Keenan JD, Chan MF, McLeod SD, Acharya NR. The clinical differentiation of bacterial and fungal keratitis: a photographic survey. Invest Ophthalmol Vis Sci. 2012 Apr; 53(4):1787-91. PMID: 22395880; PMCID: PMC3342793.
      28. Chen J, Ausayakhun S, Tangmonkongvoragul C, Ausayakhun S, Jirawison C, Margolis TP, Keenan JD. Incidence of cytomegalovirus retinitis in patients with human immunodeficiency virus following negative initial screening examination results. Arch Ophthalmol. 2012 Apr; 130(4):527-9. PMID: 22491928.
        View in: PubMed
      29. Ausayakhun S, Keenan JD, Ausayakhun S, Jirawison C, Khouri CM, Skalet AH, Heiden D, Holland GN, Margolis TP. Clinical features of newly diagnosed cytomegalovirus retinitis in northern Thailand. Am J Ophthalmol. 2012 May; 153(5):923-931.e1. PMID: 22265148; PMCID: PMC3331920.
      30. Chen J, Ausayakhun S, Ausayakhun S, Jirawison C, Khouri CM, Porco TC, Heiden D, Keenan JD, Margolis TP. Comparison of autophotomontage software programs in eyes with CMV retinitis. Invest Ophthalmol Vis Sci. 2011; 52(13):9339-44. PMID: 22064986; PMCID: PMC3250113.
      31. Ausayakhun S, Skalet AH, Jirawison C, Ausayakhun S, Keenan JD, Khouri C, Nguyen K, Kalyani PS, Heiden D, Holland GN, Margolis TP. Accuracy and reliability of telemedicine for diagnosis of cytomegalovirus retinitis. Am J Ophthalmol. 2011 Dec; 152(6):1053-1058.e1. PMID: 21861977.
        View in: PubMed
      32. Tun N, London N, Kyaw MK, Smithuis F, Ford N, Margolis T, Drew WL, Lewallen S, Heiden D. CMV retinitis screening and treatment in a resource-poor setting: three-year experience from a primary care HIV/AIDS programme in Myanmar. J Int AIDS Soc. 2011; 14:41. PMID: 21843351; PMCID: PMC3163508.
      33. Keenan JD, Mandel MR, Margolis TP. Peripheral ulcerative keratitis associated with vasculitis manifesting asymmetrically as fuchs superficial marginal keratitis and terrien marginal degeneration. Cornea. 2011 Jul; 30(7):825-7. PMID: 21150425.
        View in: PubMed
      34. Bertke AS, Swanson SM, Chen J, Imai Y, Kinchington PR, Margolis TP. A5-positive primary sensory neurons are nonpermissive for productive infection with herpes simplex virus 1 in vitro. J Virol. 2011 Jul; 85(13):6669-77. PMID: 21507969; PMCID: PMC3126511.
      35. Tang S, Bertke AS, Patel A, Margolis TP, Krause PR. Herpes simplex virus 2 microRNA miR-H6 is a novel latency-associated transcript-associated microRNA, but reduction of its expression does not influence the establishment of viral latency or the recurrence phenotype. J Virol. 2011 May; 85(9):4501-9. PMID: 21325410; PMCID: PMC3126258.
      36. Khalifa YM, Bloomer MM, Margolis TP. Secondary localized sectoral keratoconjunctival amyloidosis from ocular trauma. Cornea. 2010 Nov; 29(11):1328-9. PMID: 20697284.
        View in: PubMed
      37. Narkewicz MR, Rosenthal P, Schwarz KB, Drack A, Margolis T, Repka MX. Ophthalmologic complications in children with chronic hepatitis C treated with pegylated interferon. J Pediatr Gastroenterol Nutr. 2010 Aug; 51(2):183-6. PMID: 20512062; PMCID: PMC2910798.
      38. Khalifa YM, Jacoby RM, Margolis TP. Exacerbation of zoster interstitial keratitis after zoster vaccination in an adult. Arch Ophthalmol. 2010 Aug; 128(8):1079-80. PMID: 20697015.
        View in: PubMed
      39. Jeng BH, Gritz DC, Kumar AB, Holsclaw DS, Porco TC, Smith SD, Whitcher JP, Margolis TP, Wong IG. Epidemiology of ulcerative keratitis in Northern California. Arch Ophthalmol. 2010 Aug; 128(8):1022-8. PMID: 20697003.
        View in: PubMed
      40. Keenan JD, Fram NR, McLeod SD, Strauss EC, Margolis TP. Perifosine-related rapidly progressive corneal ring infiltrate. Cornea. 2010 May; 29(5):583-5. PMID: 20335808.
        View in: PubMed
      41. Cohen JI, Fahle G, Kemp MA, Apakupakul K, Margolis TP. Human herpesvirus 6-A, 6-B, and 7 in vitreous fluid samples. J Med Virol. 2010 May; 82(6):996-9. PMID: 20419813; PMCID: PMC2938775.
      42. Lin P, Loh AR, Margolis TP, Acharya NR. Cigarette smoking as a risk factor for uveitis. Ophthalmology. 2010 Mar; 117(3):585-90. PMID: 20036011; PMCID: PMC2830339.
      43. Hu AY, Strauss EC, Holland GN, Chan MF, Yu F, Margolis TP. Late varicella-zoster virus dendriform keratitis in patients with histories of herpes zoster ophthalmicus. Am J Ophthalmol. 2010 Feb; 149(2):214-220.e3. PMID: 19909942; PMCID: PMC4507370.
      44. Bertke AS, Patel A, Imai Y, Apakupakul K, Margolis TP, Krause PR. Latency-associated transcript (LAT) exon 1 controls herpes simplex virus species-specific phenotypes: reactivation in the guinea pig genital model and neuron subtype-specific latent expression of LAT. J Virol. 2009 Oct; 83(19):10007-15. PMID: 19641003; PMCID: PMC2748022.
      45. Imai Y, Apakupakul K, Krause PR, Halford WP, Margolis TP. Investigation of the mechanism by which herpes simplex virus type 1 LAT sequences modulate preferential establishment of latent infection in mouse trigeminal ganglia. J Virol. 2009 Aug; 83(16):7873-82. PMID: 19493993; PMCID: PMC2715745.
      46. Wang K, Mahalingam G, Imai Y, Pesnicak L, Margolis TP, Margolis TT, Straus SE, Cohen JI. Cell type specific accumulation of the major latency-associated transcript (LAT) of herpes simplex virus type 2 in LAT transgenic mice. Virology. 2009 Mar 30; 386(1):79-87. PMID: 19200567; PMCID: PMC2692716.
      47. Nagpal A, Vora R, Margolis TP, Acharya NR. Interstitial keratitis following varicella vaccination. Arch Ophthalmol. 2009 Feb; 127(2):222-3. PMID: 19204247.
        View in: PubMed
      48. Sansanayudh W, Cevallos V, Porco TC, Margolis TP, Lietman TM, Acharya NR. Fusarium and Acanthamoeba keratitis: can a single centre detect outbreaks? Br J Ophthalmol. 2008 May; 92(5):720-1. PMID: 18441185; PMCID: PMC2586076.
      49. Leigh JF, Acharya N, Cevallos V, Margolis TP. Does asymptomatic shedding of herpes simplex virus on the ocular surface lead to false-positive diagnostic PCR results? Br J Ophthalmol. 2008 Mar; 92(3):435-6. PMID: 18314406.
        View in: PubMed
      50. Heiden D, Ford N, Wilson D, Rodriguez WR, Margolis T, Janssens B, Bedelu M, Tun N, Goemaere E, Saranchuk P, Sabapathy K, Smithuis F, Luyirika E, Drew WL. Cytomegalovirus retinitis: the neglected disease of the AIDS pandemic. PLoS Med. 2007 Dec; 4(12):e334. PMID: 18052600; PMCID: PMC2100142.
      51. Margolis TP, Elfman FL, Leib D, Pakpour N, Apakupakul K, Imai Y, Voytek C. Spontaneous reactivation of herpes simplex virus type 1 in latently infected murine sensory ganglia. J Virol. 2007 Oct; 81(20):11069-74. PMID: 17686862; PMCID: PMC2045564.
      52. Freidlin J, Acharya N, Lietman TM, Cevallos V, Whitcher JP, Margolis TP. Spectrum of eye disease caused by methicillin-resistant Staphylococcus aureus. Am J Ophthalmol. 2007 Aug; 144(2):313-5. PMID: 17659970.
        View in: PubMed
      53. Acharya NR, Lietman TM, Margolis TP. Parasites on the rise: a new epidemic of Acanthamoeba keratitis. Am J Ophthalmol. 2007 Aug; 144(2):292-3. PMID: 17659960.
        View in: PubMed
      54. Margolis TP, Imai Y, Yang L, Vallas V, Krause PR. Herpes simplex virus type 2 (HSV-2) establishes latent infection in a different population of ganglionic neurons than HSV-1: role of latency-associated transcripts. J Virol. 2007 Feb; 81(4):1872-8. PMID: 17151134; PMCID: PMC1797553.
      55. Prabriputaloong T, Margolis TP, Lietman TM, Wong IG, Mather R, Gritz DC. Atopic disease and herpes simplex eye disease: a population-based case-control study. Am J Ophthalmol. 2006 Nov; 142(5):745-9. PMID: 17056358.
        View in: PubMed
      56. Stone DU, Char DH, Crawford JB, Margolis TP, Van Gelder RN, Strauss EC. Metaplastic squamous epithelial downgrowth after clear corneal cataract surgery. Am J Ophthalmol. 2006 Oct; 142(4):695-7. PMID: 17011874.
        View in: PubMed
      57. Gussow AM, Giordani NV, Tran RK, Imai Y, Kwiatkowski DL, Rall GF, Margolis TP, Bloom DC. Tissue-specific splicing of the herpes simplex virus type 1 latency-associated transcript (LAT) intron in LAT transgenic mice. J Virol. 2006 Oct; 80(19):9414-23. PMID: 16973547; PMCID: PMC1617271.
      58. Margolis TP, Whitcher JP. Fusarium--A new culprit in the contact lens case. JAMA. 2006 Aug 23; 296(8):985-7. PMID: 16929565.
        View in: PubMed
      59. Nikulina K, Bodeker M, Warren J, Matthews P, Margolis TP. A novel Krüppel related factor consisting of only a KRAB domain is expressed in the murine trigeminal ganglion. Biochem Biophys Res Commun. 2006 Sep 29; 348(3):839-49. PMID: 16904636.
        View in: PubMed
      60. Kim EC, Margolis TP. Hypertensive iridocyclitis. Br J Ophthalmol. 2006 Jul; 90(7):812-3. PMID: 16782945; PMCID: PMC1857144.
      61. Seitzman GD, Strauss EC, Margolis TP. "Steel wool keratopathy": a clinical sign of chronic inflammation. Cornea. 2006 Jul; 25(6):742-4. PMID: 17077672.
        View in: PubMed
      62. Halford WP, Weisend C, Grace J, Soboleski M, Carr DJ, Balliet JW, Imai Y, Margolis TP, Gebhardt BM. ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol J. 2006; 3:44. PMID: 16764725; PMCID: PMC1557838.
      63. Seitzman GD, Cevallos V, Margolis TP. Rose bengal and lissamine green inhibit detection of herpes simplex virus by PCR. Am J Ophthalmol. 2006 Apr; 141(4):756-8. PMID: 16564821.
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      64. Acharya N, Lietman T, Cevallos V, Whitcher JP, Saidel M, Stone D, Duncan J, Margolis TP. Correlation between clinical suspicion and polymerase chain reaction verification of infectious vitritis. Am J Ophthalmol. 2006 Mar; 141(3):584-5. PMID: 16490520.
        View in: PubMed
      65. Saidel MA, Berreen J, Margolis TP. Cytomegalovirus retinitis after intravitreous triamcinolone in an immunocompetent patient. Am J Ophthalmol. 2005 Dec; 140(6):1141-3. PMID: 16376669.
        View in: PubMed
      66. Magone MT, Seitzman GD, Nehls S, Margolis TP. Treatment of neurotrophic keratopathy with nasal dilator strips. Br J Ophthalmol. 2005 Nov; 89(11):1529-30. PMID: 16234466; PMCID: PMC1772934.
      67. McLeod SD, Mather R, Hwang DG, Margolis TP. Uveitis-associated flap edema and lamellar interface fluid collection after LASIK. Am J Ophthalmol. 2005 Jun; 139(6):1137-9. PMID: 15953462.
        View in: PubMed
      68. Magone MT, Nasser RE, Cevallos AV, Margolis TP. Chronic recurrent varicella-zoster virus keratitis confirmed by polymerase chain reaction testing. Am J Ophthalmol. 2005 Jun; 139(6):1135-6. PMID: 15953460.
        View in: PubMed
      69. Strauss EC, Aldave AJ, Spencer WH, Branco BC, Barsness DA, Calman AF, Margolis TP. Management of prominent iris vascular tufts causing recurrent spontaneous hyphema. Cornea. 2005 Mar; 24(2):224-6. PMID: 15725893.
        View in: PubMed
      70. Vagefi MR, Hollander DA, Seitzman GD, Margolis TP. Bilateral surgically induced necrotising scleritis with secondary superinfection. Br J Ophthalmol. 2005 Jan; 89(1):124-5. PMID: 15615764; PMCID: PMC1772468.
      71. Jeng BH, Margolis TP, Chandra NS, McCalmont TH. Ocular findings as a presenting sign of hydroa vacciniforme. Br J Ophthalmol. 2004 Nov; 88(11):1478-9. PMID: 15489499; PMCID: PMC1772374.
      72. Branco BC, Gaudio PA, Margolis TP. Epidemiology and molecular analysis of herpes simplex keratitis requiring primary penetrating keratoplasty. Br J Ophthalmol. 2004 Oct; 88(10):1285-8. PMID: 15377552; PMCID: PMC1772342.
      73. Margolis TP, Lietman T, Strauss E. Infectious agents and ARMD: a connection? Am J Ophthalmol. 2004 Sep; 138(3):468-70. PMID: 15364231.
        View in: PubMed
      74. Jeng BH, Whitcher JP, Margolis TP. Pseudogerontoxon. Clin Experiment Ophthalmol. 2004 Aug; 32(4):433-4. PMID: 15281982.
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      75. Yoon MK, Warren JF, Holsclaw DS, Gritz DC, Margolis TP. A novel arginine substitution mutation in 1A domain and a novel 27 bp insertion mutation in 2B domain of keratin 12 gene associated with Meesmann's corneal dystrophy. Br J Ophthalmol. 2004 Jun; 88(6):752-6. PMID: 15148206; PMCID: PMC1772161.
      76. Varaprasathan G, Miller K, Lietman T, Whitcher JP, Cevallos V, Okumoto M, Margolis TP, Yinghui M, Cunningham ET. Trends in the etiology of infectious corneal ulcers at the F. I. Proctor Foundation. Cornea. 2004 May; 23(4):360-4. PMID: 15097130.
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      77. Jeng BH, Whitcher JP, Margolis TP. Intracorneal graphite particles. Cornea. 2004 Apr; 23(3):319-20. PMID: 15084872.
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      78. Aldave AJ, Yellore VS, Thonar EJ, Udar N, Warren JF, Yoon MK, Cohen EJ, Rapuano CJ, Laibson PR, Margolis TP, Small K. Novel mutations in the carbohydrate sulfotransferase gene (CHST6) in American patients with macular corneal dystrophy. Am J Ophthalmol. 2004 Mar; 137(3):465-73. PMID: 15013869.
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      79. Imai Y, Shum C, Martin DF, Kuppermann BD, Drew WL, Margolis TP. Emergence of drug-resistant cytomegalovirus retinitis in the contralateral eyes of patients with AIDS treated with ganciclovir. J Infect Dis. 2004 Feb 15; 189(4):611-5. PMID: 14767813.
        View in: PubMed
      80. Warren JF, Abbott RL, Yoon MK, Crawford JB, Spencer WH, Margolis TP. A new mutation (Leu569Arg) within exon 13 of the TGFBI (BIGH3) gene causes lattice corneal dystrophy type I. Am J Ophthalmol. 2003 Nov; 136(5):872-8. PMID: 14597039.
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      81. Warren JF, Aldave AJ, Srinivasan M, Thonar EJ, Kumar AB, Cevallos V, Whitcher JP, Margolis TP. Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India. Arch Ophthalmol. 2003 Nov; 121(11):1608-12. PMID: 14609920.
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      82. Pepose JS, Margolis TP, LaRussa P, Pavan-Langston D. Ocular complications of smallpox vaccination. Am J Ophthalmol. 2003 Aug; 136(2):343-52. PMID: 12888060.
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      83. Strauss EC, Warren JF, Margolis TP, Holsclaw DS. Diagnosis of conjunctival B-cell lymphoma by polymerase chain reaction heteroduplex analysis. Am J Ophthalmol. 2003 Jul; 136(1):207-9. PMID: 12834702.
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      84. Ellison AR, Yang L, Cevallos AV, Margolis TP. Analysis of the herpes simplex virus type 1 UL6 gene in patients with stromal keratitis. Virology. 2003 May 25; 310(1):24-8. PMID: 12788627.
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      85. Kuo IC, Imai Y, Shum C, Martin DF, Kuppermann BD, Margolis TP. Genotypic analysis of cytomegalovirus retinitis poorly responsive to intravenous ganciclovir but responsive to the ganciclovir implant. Am J Ophthalmol. 2003 Jan; 135(1):20-5. PMID: 12504692.
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      86. Sherman MD, Feldman KA, Farahmand SM, Margolis TP. Treatment of conjunctival squamous cell carcinoma with topical cidofovir. Am J Ophthalmol. 2002 Sep; 134(3):432-3. PMID: 12208255.
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      87. Alrawi AM, Chern KC, Cevallos V, Lietman T, Whitcher JP, Margolis TP, Cunningham ET. Biotypes and serotypes of Haemophilus influenzae ocular isolates. Br J Ophthalmol. 2002 Mar; 86(3):276-7. PMID: 11864881; PMCID: PMC1771031.
      88. Feldman LT, Ellison AR, Voytek CC, Yang L, Krause P, Margolis TP. Spontaneous molecular reactivation of herpes simplex virus type 1 latency in mice. Proc Natl Acad Sci U S A. 2002 Jan 22; 99(2):978-83. PMID: 11773630; PMCID: PMC117416.
      89. Naseri A, Margolis TP. Varicella zoster virus immune recovery stromal keratitis in a patient with AIDS. Br J Ophthalmol. 2001 Nov; 85(11):1390-1. PMID: 11702739; PMCID: PMC1723762.
      90. Grigg ME, Ganatra J, Boothroyd JC, Margolis TP. Unusual abundance of atypical strains associated with human ocular toxoplasmosis. J Infect Dis. 2001 Sep 1; 184(5):633-9. PMID: 11474426.
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      91. Summers BC, Margolis TP, Leib DA. Herpes simplex virus type 1 corneal infection results in periocular disease by zosteriform spread. J Virol. 2001 Jun; 75(11):5069-75. PMID: 11333887; PMCID: PMC114911.
      92. Kuo IC, Margolis TP, Cevallos V, Hwang DG. Aspergillus fumigatus keratitis after laser in situ keratomileusis. Cornea. 2001 Apr; 20(3):342-4. PMID: 11322429.
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      93. Liu W, Shum C, Martin DF, Kuppermann BD, Hall AJ, Margolis TP. Prevalence of antiviral drug resistance in untreated patients with cytomegalovirus retinitis. J Infect Dis. 2000 Oct; 182(4):1234-8. PMID: 10979924.
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      94. Kuo IC, Rechdouni A, Rao NA, Johnston RH, Margolis TP, Cunningham ET. Subretinal fibrosis in patients with Vogt-Koyanagi-Harada disease. Ophthalmology. 2000 Sep; 107(9):1721-8. PMID: 10964836.
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      95. Berthomme H, Lokensgard J, Yang L, Margolis T, Feldman LT. Evidence for a bidirectional element located downstream from the herpes simplex virus type 1 latency-associated promoter that increases its activity during latency. J Virol. 2000 Apr; 74(8):3613-22. PMID: 10729137; PMCID: PMC111871.
      96. Margolis TP. Discontinuation of anticytomegalovirus therapy in patients with HIV infection and cytomegalovirus retinitis. Surv Ophthalmol. 2000 Mar-Apr; 44(5):455. PMID: 10809654.
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      97. Ellison AR, Yang L, Voytek C, Margolis TP. Establishment of latent herpes simplex virus type 1 infection in resistant, sensitive, and immunodeficient mouse strains. Virology. 2000 Mar 1; 268(1):17-28. PMID: 10683323.
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      98. Ganatra JB, Chandler D, Santos C, Kuppermann B, Margolis TP. Viral causes of the acute retinal necrosis syndrome. Am J Ophthalmol. 2000 Feb; 129(2):166-72. PMID: 10682968.
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      99. Yang L, Voytek CC, Margolis TP. Immunohistochemical analysis of primary sensory neurons latently infected with herpes simplex virus type 1. J Virol. 2000 Jan; 74(1):209-17. PMID: 10590108; PMCID: PMC111530.
      100. Gaynor BD, Margolis TP, Cunningham ET. Advances in diagnosis and management of herpetic uveitis. Int Ophthalmol Clin. 2000; 40(2):85-109. PMID: 10791259.
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      101. Jacobson MA, Stanley H, Holtzer C, Margolis TP, Cunningham ET. Natural history and outcome of new AIDS-related cytomegalovirus retinitis diagnosed in the era of highly active antiretroviral therapy. Clin Infect Dis. 2000 Jan; 30(1):231-3. PMID: 10619774.
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      102. Knox CM, Cevallos V, Margolis TP, Dean D. Identification of bacterial pathogens in patients with endophthalmitis by 16S ribosomal DNA typing. Am J Ophthalmol. 1999 Oct; 128(4):511-2. PMID: 10577597.
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      103. Zegans ME, Srinivasan M, McHugh T, Whitcher JP, Margolis TP, Lietman T, Jennette JC, Cunningham ET. Mooren ulcer in South India: serology and clinical risk factors. Am J Ophthalmol. 1999 Aug; 128(2):205-10. PMID: 10458177.
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      104. Holland GN, Van Horn SD, Margolis TP. Cataract surgery with ciliary sulcus fixation of intraocular lenses in patients with uveitis. Am J Ophthalmol. 1999 Jul; 128(1):21-30. PMID: 10482090.
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      105. Chern KC, Chandler DB, Martin DF, Kuppermann BD, Wolitz RA, Margolis TP. Glycoprotein B subtyping of cytomegalovirus (CMV) in the vitreous of patients with AIDS and CMV retinitis. J Infect Dis. 1998 Oct; 178(4):1149-53. PMID: 9806048.
        View in: PubMed
      106. Chern KC, Conrad D, Holland GN, Holsclaw DS, Schwartz LK, Margolis TP. Chronic varicella-zoster virus epithelial keratitis in patients with acquired immunodeficiency syndrome. Arch Ophthalmol. 1998 Aug; 116(8):1011-7. PMID: 9715680.
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      107. Cunningham ET, Margolis TP. Ocular manifestations of HIV infection. N Engl J Med. 1998 Jul 23; 339(4):236-44. PMID: 9673303.
        View in: PubMed
      108. Hodge WG, Seiff SR, Margolis TP. Ocular opportunistic infection incidences among patients who are HIV positive compared to patients who are HIV negative. Ophthalmology. 1998 May; 105(5):895-900. PMID: 9593394.
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      109. Liu W, Kuppermann BD, Martin DF, Wolitz RA, Margolis TP. Mutations in the cytomegalovirus UL97 gene associated with ganciclovir-resistant retinitis. J Infect Dis. 1998 May; 177(5):1176-81. PMID: 9593000.
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      110. Zegans ME, Walton RC, Holland GN, O'Donnell JJ, Jacobson MA, Margolis TP. Transient vitreous inflammatory reactions associated with combination antiretroviral therapy in patients with AIDS and cytomegalovirus retinitis. Am J Ophthalmol. 1998 Mar; 125(3):292-300. PMID: 9512145.
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      111. Margolis TP, Milner MS, Shama A, Hodge W, Seiff S. Herpes zoster ophthalmicus in patients with human immunodeficiency virus infection. Am J Ophthalmol. 1998 Mar; 125(3):285-91. PMID: 9512144.
        View in: PubMed
      112. Chern KC, Margolis TP. Varicella zoster virus ocular disease. Int Ophthalmol Clin. 1998; 38(4):149-60. PMID: 10081731.
        View in: PubMed
      113. Knox CM, Chandler D, Short GA, Margolis TP. Polymerase chain reaction-based assays of vitreous samples for the diagnosis of viral retinitis. Use in diagnostic dilemmas. Ophthalmology. 1998 Jan; 105(1):37-44; discussion 44-5. PMID: 9442777.
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      114. Silverstein BE, Cunningham ET, Margolis TP, Cevallos V, Wong IG. Microsporidial keratoconjunctivitis in a patient without human immunodeficiency virus infection. Am J Ophthalmol. 1997 Sep; 124(3):395-6. PMID: 9439367.
        View in: PubMed
      115. Gritz DC, Holsclaw DS, Neger RE, Whitcher JP, Margolis TP. Ocular and sinus microsporidial infection cured with systemic albendazole. Am J Ophthalmol. 1997 Aug; 124(2):241-3. PMID: 9262551.
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      116. Gritz DC, Scott TJ, Sedó SF, Cevallos AV, Margolis TP, Whitcher JP. Ocular flora of patients with AIDS compared with those of HIV-negative patients. Cornea. 1997 Jul; 16(4):400-5. PMID: 9220236.
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      117. Cunningham ET, Stalder AK, Sanna PP, Liu SS, Bloom FE, Howes EL, Campbell IL, Margolis TP. Distribution of tumor necrosis factor receptor messenger RNA in normal and herpes simplex virus infected trigeminal ganglia in the mouse. Brain Res. 1997 May 30; 758(1-2):99-106. PMID: 9203538.
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      118. Knox CM, Whitcher JP, Cevellos V, Margolis TP, Irvine AR. Nocardia scleritis. Am J Ophthalmol. 1997 May; 123(5):713-4. PMID: 9152089.
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      119. Silverstein BE, Conrad D, Margolis TP, Wong IG. Cytomegalovirus-associated acute retinal necrosis syndrome. Am J Ophthalmol. 1997 Feb; 123(2):257-8. PMID: 9186135.
        View in: PubMed
      120. Short GA, Margolis TP, Kuppermann BD, Irvine AR, Martin DF, Chandler D. A polymerase chain reaction-based assay for diagnosing varicella-zoster virus retinitis in patients with acquired immunodeficiency syndrome. Am J Ophthalmol. 1997 Feb; 123(2):157-64. PMID: 9186120.
        View in: PubMed
      121. Silverstein BE, Chandler D, Neger R, Margolis TP. Disciform keratitis: a case of herpes zoster sine herpete. Am J Ophthalmol. 1997 Feb; 123(2):254-5. PMID: 9186133.
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      122. Hodge WG, Margolis TP. Herpes simplex virus keratitis among patients who are positive or negative for human immunodeficiency virus: an epidemiologic study. Ophthalmology. 1997 Jan; 104(1):120-4. PMID: 9022115.
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      123. Cunningham ET, Stalder A, Sanna PP, Liu SS, Bloom FE, Howes EL, Campbell IL, Margolis TP. Localization of tumor necrosis factor receptor messenger RNA in normal and herpes simplex virus-infected mouse eyes. Invest Ophthalmol Vis Sci. 1997 Jan; 38(1):9-15. PMID: 9008625.
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      124. Cunningham ET, Short GA, Irvine AR, Duker JS, Margolis TP. Acquired immunodeficiency syndrome--associated herpes simplex virus retinitis. Clinical description and use of a polymerase chain reaction--based assay as a diagnostic tool. Arch Ophthalmol. 1996 Jul; 114(7):834-40. PMID: 8660167.
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      125. Holsclaw DS, Whitcher JP, Wong IG, Margolis TP. Supratarsal injection of corticosteroid in the treatment of refractory vernal keratoconjunctivitis. Am J Ophthalmol. 1996 Mar; 121(3):243-9. PMID: 8597266.
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      126. Wilkins J, Whitcher JP, Margolis TP. Penicillin-resistant Streptococcus pneumoniae keratitis. Cornea. 1996 Jan; 15(1):99-100. PMID: 8907389.
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      127. McCann JD, Margolis TP, Wong MG, Kuppermann BD, Luckie AP, Schwartz DM, Irvine AR, Ai E. A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis. Am J Ophthalmol. 1995 Aug; 120(2):219-26. PMID: 7639306.
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      128. Hodge W, Wohl T, Whitcher JP, Margolis TP. Corneal subepithelial infiltrate recurrence sine adenovirus. Cornea. 1995 May; 14(3):324-5. PMID: 7600819.
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      129. Dobson AT, Margolis TP, Gomes WA, Feldman LT. In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter. J Virol. 1995 Apr; 69(4):2264-70. PMID: 7884873; PMCID: PMC188896.
      130. Farrell MJ, Margolis TP, Gomes WA, Feldman LT. Effect of the transcription start region of the herpes simplex virus type 1 latency-associated transcript promoter on expression of productively infected neurons in vivo. J Virol. 1994 Sep; 68(9):5337-43. PMID: 8057417; PMCID: PMC236933.
      131. Engstrom RE, Holland GN, Margolis TP, Muccioli C, Lindley JI, Belfort R, Holland SP, Johnston WH, Wolitz RA, Kreiger AE. The progressive outer retinal necrosis syndrome. A variant of necrotizing herpetic retinopathy in patients with AIDS. Ophthalmology. 1994 Sep; 101(9):1488-502. PMID: 8090452.
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      132. Joshi N, Constable PH, Margolis TP, Hoyt CS, Leonard TJ. Bilateral angle closure glaucoma and accelerated cataract formation in a patient with AIDS. Br J Ophthalmol. 1994 Aug; 78(8):656-7. PMID: 7918297; PMCID: PMC504896.
      133. Wilkins JH, Joshi N, Margolis TP, Cevallos V, Dawson CR. Microsporidial keratoconjunctivitis treated successfully with a short course of fumagillin. Eye (Lond). 1994; 8 ( Pt 6):703-4. PMID: 7867837.
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      134. Margolis TP, Bloom DC, Dobson AT, Feldman LT, Stevens JG. Decreased reporter gene expression during latent infection with HSV LAT promoter constructs. Virology. 1993 Dec; 197(2):585-92. PMID: 8249281.
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      135. Farrell MJ, Hill JM, Margolis TP, Stevens JG, Wagner EK, Feldman LT. The herpes simplex virus type 1 reactivation function lies outside the latency-associated transcript open reading frame ORF-2. J Virol. 1993 Jun; 67(6):3653-5. PMID: 8388517; PMCID: PMC237719.
      136. Sedarati F, Margolis TP, Stevens JG. Latent infection can be established with drastically restricted transcription and replication of the HSV-1 genome. Virology. 1993 Feb; 192(2):687-91. PMID: 8380670.
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      137. Seiff SR, Margolis T. Readers comment on "Herpes zoster ophthalmicus". Surv Ophthalmol. 1992 Sep-Oct; 37(2):150; author reply 152-3. PMID: 1455299.
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      138. Margolis TP, Sedarati F, Dobson AT, Feldman LT, Stevens JG. Pathways of viral gene expression during acute neuronal infection with HSV-1. Virology. 1992 Jul; 189(1):150-60. PMID: 1604806.
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      139. Margolis TP, Dawson CR, LaVail JH. Herpes simplex viral infection of the mouse trigeminal ganglion. Immunohistochemical analysis of cell populations. Invest Ophthalmol Vis Sci. 1992 Feb; 33(2):259-67. PMID: 1371269.
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      140. Gardner BP, Margolis TP, Mondino BJ. Conjunctival lymphocytic nodule associated with the Epstein-Barr virus. Am J Ophthalmol. 1991 Nov 15; 112(5):567-71. PMID: 1659201.
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      141. Margolis TP, Lowder CY, Holland GN, Spaide RF, Logan AG, Weissman SS, Irvine AR, Josephberg R, Meisler DM, O'Donnell JJ. Varicella-zoster virus retinitis in patients with the acquired immunodeficiency syndrome. Am J Ophthalmol. 1991 Aug 15; 112(2):119-31. PMID: 1651054.
        View in: PubMed
      142. Margolis TP, Ostler HB. Treatment of ocular disease in eczema herpeticum. Am J Ophthalmol. 1990 Sep 15; 110(3):274-9. PMID: 2118723.
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      143. Dobson AT, Margolis TP, Sedarati F, Stevens JG, Feldman LT. A latent, nonpathogenic HSV-1-derived vector stably expresses beta-galactosidase in mouse neurons. Neuron. 1990 Sep; 5(3):353-60. PMID: 2169271.
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      144. LaVail JH, Zhan J, Margolis TP. HSV (type 1) infection of the trigeminal complex. Brain Res. 1990 Apr 30; 514(2):181-8. PMID: 2357535.
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      145. Margolis TP, LaVail JH, Setzer PY, Dawson CR. Selective spread of herpes simplex virus in the central nervous system after ocular inoculation. J Virol. 1989 Nov; 63(11):4756-61. PMID: 2552151; PMCID: PMC251112.
      146. Seiff SR, Margolis T, Graham SH, O'Donnell JJ. Use of intravenous acyclovir for treatment of herpes zoster ophthalmicus in patients at risk for AIDS. Ann Ophthalmol. 1988 Dec; 20(12):480-2. PMID: 3265292.
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      147. Margolis T, Irvine AR, Hoyt WF, Hyman R. Acute retinal necrosis syndrome presenting with papillitis and arcuate neuroretinitis. Ophthalmology. 1988 Jul; 95(7):937-40. PMID: 3174044.
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      148. Margolis T, Togni B, LaVail J, Dawson CR. Identifying HSV infected neurons after ocular inoculation. Curr Eye Res. 1987 Jan; 6(1):119-26. PMID: 3030634.
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      149. Margolis TP, LaVail JH. Further evidence in support of the selective uptake and anterograde transport of [125I]wheat germ agglutinin by chick retinal ganglion cells. Brain Res. 1984 Dec 17; 324(1):21-7. PMID: 6083824.
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      150. Margolis TP, LaVail JH. Rate of anterograde axonal transport of [125I]wheat germ agglutinin from retina to optic tectum in the chick. Brain Res. 1981 Dec 14; 229(1):218-23. PMID: 6171327.
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      151. Margolis TP, Marchand CM, Kistler HB, LaVail LH. Uptake and anterograde axonal transport of wheat germ agglutinin from retina to optic tectum in the chick. J Cell Biol. 1981 Apr; 89(1):152-6. PMID: 6164680; PMCID: PMC2111779.
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