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    Todd McDevitt, PhD

    TitleProfessor
    SchoolUCSF School of Pharmacy
    DepartmentBioengineering
    Address1650 Owens Street
    San Francisco 94158
    Phone415-734-2875
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of WashingtonPh.D.Bioengineering2001
      Duke UniversityB.S.E.Biomedical & Electrical Engineering1997
      Collapse Awards and Honors
      California Institute for Regenerative Medicine2014 - 2019Research Leadership Award
      American Institute of Medical & Biological Engineering2014College of Fellows
      Georgia Trend magazine2013“40 Under 40”
      Georgia Institute of Technology2013 - 2014Carol Ann and David D. Flanagan Professorship
      Georgia Tech Biomedical Engineering Society2011“Above & Beyond” (Eagle) Award
      Society for Biomaterials2010Young Investigator Award
      Georgia Institute of Technology2010Junior Faculty Outstanding Undergraduate Research Mentor
      Petit Institute for Bioengineering and Bioscience (Georgia Tech)2009 - 2014Petit Faculty Fellow
      American Heart Association, Council on Basic Cardiovascular Sciences2004New Investigator Award

      Collapse Overview 
      Collapse Interests
      biomanufacturing, biomaterials, differentiation, morphogenesis, regenerative medicine, stem cells, tissue engineering

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Brewster L, Robinson S, Wang R, Griffiths S, Li H, Peister A, Copland I, McDevitt T. Expansion and angiogenic potential of mesenchymal stem cells from patients with critical limb ischemia. J Vasc Surg. 2016 Feb 24. PMID: 26921003.
        View in: PubMed
      2. Chi T, Park JS, Butts JC, Hookway TA, Su A, Zhu C, Styczynski MP, McDevitt TC, Wang H. A Multi-Modality CMOS Sensor Array for Cell-Based Assay and Drug Screening. IEEE Trans Biomed Circuits Syst. 2015 Dec; 9(6):801-14. PMID: 26812735.
        View in: PubMed
      3. Hookway TA, Butts JC, Lee E, Tang H, McDevitt TC. Aggregate formation and suspension culture of human pluripotent stem cells and differentiated progeny. Methods. 2016 May 15; 101:11-20. PMID: 26658353.
        View in: PubMed
      4. Wang Y, Yu X, Baker C, Murphy WL, McDevitt TC. Mineral particles modulate osteo-chondrogenic differentiation of embryonic stem cell aggregates. Acta Biomater. 2016 Jan 1; 29:42-51. PMID: 26597546.
        View in: PubMed
      5. Nguyen AH, Wang Y, White DE, Platt MO, McDevitt TC. MMP-mediated mesenchymal morphogenesis of pluripotent stem cell aggregates stimulated by gelatin methacrylate microparticle incorporation. Biomaterials. 2016 Jan; 76:66-75. PMID: 26519649.
        View in: PubMed
      6. Tellier LE, Miller T, McDevitt TC, Temenoff JS. Hydrolysis and Sulfation Pattern Effects on Release of Bioactive Bone Morphogenetic Protein-2 from Heparin-Based Microparticles. J Mater Chem B Mater Biol Med. 2015 Oct 28; 3(40):8001-8009. PMID: 27785363.
        View in: PubMed
      7. Sutha K, Schwartz Z, Wang Y, Hyzy S, Boyan BD, McDevitt TC. Osteogenic embryoid body-derived material induces bone formation in vivo. Sci Rep. 2015; 5:9960. PMID: 25961152; PMCID: PMC4426716.
      8. Fitzpatrick LE, McDevitt TC. Cell-derived matrices for tissue engineering and regenerative medicine applications. Biomater Sci. 2015 Jan; 3(1):12-24. PMID: 25530850; PMCID: PMC4270054 [Available on 01/01/16].
      9. Fridley KM, Nair R, McDevitt TC. Differential expression of extracellular matrix and growth factors by embryoid bodies in hydrodynamic and static cultures. Tissue Eng Part C Methods. 2014 Dec; 20(12):931-40. PMID: 25423310; PMCID: PMC4241877 [Available on 12/01/15].
      10. Nguyen AH, McKinney J, Miller T, Bongiorno T, McDevitt TC. Gelatin methacrylate microspheres for controlled growth factor release. Acta Biomater. 2015 Feb; 13:101-10. PMID: 25463489; PMCID: PMC4293288 [Available on 02/01/16].
      11. Goude MC, McDevitt TC, Temenoff JS. Chondroitin sulfate microparticles modulate transforming growth factor-ß1-induced chondrogenesis of human mesenchymal stem cell spheroids. Cells Tissues Organs. 2014; 199(2-3):117-30. PMID: 25413333; PMCID: PMC4268436 [Available on 11/18/15].
      12. Nguyen DC, Hookway TA, Wu Q, Jha R, Preininger MK, Chen X, Easley CA, Spearman P, Deshpande SR, Maher K, Wagner MB, McDevitt TC, Xu C. Microscale generation of cardiospheres promotes robust enrichment of cardiomyocytes derived from human pluripotent stem cells. Stem Cell Reports. 2014 Aug 12; 3(2):260-8. PMID: 25254340; PMCID: PMC4175548.
      13. Murphy WL, McDevitt TC, Engler AJ. Materials as stem cell regulators. Nat Mater. 2014 Jun; 13(6):547-57. PMID: 24845994; PMCID: PMC4163547.
      14. Hettiaratchi MH, Miller T, Temenoff JS, Guldberg RE, McDevitt TC. Heparin microparticle effects on presentation and bioactivity of bone morphogenetic protein-2. Biomaterials. 2014 Aug; 35(25):7228-38. PMID: 24881028; PMCID: PMC4093826.
      15. Kinney MA, Saeed R, McDevitt TC. Mesenchymal morphogenesis of embryonic stem cells dynamically modulates the biophysical microtissue niche. Sci Rep. 2014; 4:4290. PMID: 24598818; PMCID: PMC3944369.
      16. Loring JF, McDevitt TC, Palecek SP, Schaffer DV, Zandstra PW, Nerem RM. A global assessment of stem cell engineering. Tissue Eng Part A. 2014 Oct; 20(19-20):2575-89. PMID: 24428577; PMCID: PMC4195431.
      17. Ngangan AV, Waring JC, Cooke MT, Mandrycky CJ, McDevitt TC. Soluble factors secreted by differentiating embryonic stem cells stimulate exogenous cell proliferation and migration. Stem Cell Res Ther. 2014; 5(1):26. PMID: 24564947; PMCID: PMC4055104.
      18. Wilson JL, Suri S, Singh A, Rivet CA, Lu H, McDevitt TC. Single-cell analysis of embryoid body heterogeneity using microfluidic trapping array. Biomed Microdevices. 2014 Feb; 16(1):79-90. PMID: 24085533; PMCID: PMC3945678.
      19. Nsiah BA, Ahsan T, Griffiths S, Cooke M, Nerem RM, McDevitt TC. Fluid shear stress pre-conditioning promotes endothelial morphogenesis of embryonic stem cells within embryoid bodies. Tissue Eng Part A. 2014 Mar; 20(5-6):954-65. PMID: 24138406; PMCID: PMC3938916.
      20. McDevitt TC. Scalable culture of human pluripotent stem cells in 3D. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20852-3. PMID: 24327732; PMCID: PMC3876229.
      21. Suri S, Singh A, Nguyen AH, Bratt-Leal AM, McDevitt TC, Lu H. Microfluidic-based patterning of embryonic stem cells for in vitro development studies. Lab Chip. 2013 Dec 7; 13(23):4617-24. PMID: 24113509; PMCID: PMC3844158.
      22. Kinney MA, Hookway TA, Wang Y, McDevitt TC. Engineering three-dimensional stem cell morphogenesis for the development of tissue models and scalable regenerative therapeutics. Ann Biomed Eng. 2014 Feb; 42(2):352-67. PMID: 24297495; PMCID: PMC3939035.
      23. Bongiorno T, Kazlow J, Mezencev R, Griffiths S, Olivares-Navarrete R, McDonald JF, Schwartz Z, Boyan BD, McDevitt TC, Sulchek T. Mechanical stiffness as an improved single-cell indicator of osteoblastic human mesenchymal stem cell differentiation. J Biomech. 2014 Jun 27; 47(9):2197-204. PMID: 24296276; PMCID: PMC4024369.
      24. Zimmermann JA, McDevitt TC. Pre-conditioning mesenchymal stromal cell spheroids for immunomodulatory paracrine factor secretion. Cytotherapy. 2014 Mar; 16(3):331-45. PMID: 24219905.
        View in: PubMed
      25. Wilson JL, Najia MA, Saeed R, McDevitt TC. Alginate encapsulation parameters influence the differentiation of microencapsulated embryonic stem cell aggregates. Biotechnol Bioeng. 2014 Mar; 111(3):618-31. PMID: 24166004; PMCID: PMC4163549.
      26. Healy KE, McDevitt TC, Murphy WL, Nerem RM. Engineering the emergence of stem cell therapeutics. Sci Transl Med. 2013 Oct 16; 5(207):207ed17. PMID: 24132634.
        View in: PubMed
      27. Miller T, Goude MC, McDevitt TC, Temenoff JS. Molecular engineering of glycosaminoglycan chemistry for biomolecule delivery. Acta Biomater. 2014 Apr; 10(4):1705-19. PMID: 24121191; PMCID: PMC3960340.
      28. Griffiths S, Baraniak PR, Copland IB, Nerem RM, McDevitt TC. Human platelet lysate stimulates high-passage and senescent human multipotent mesenchymal stromal cell growth and rejuvenation in vitro. Cytotherapy. 2013 Dec; 15(12):1469-83. PMID: 23981539.
        View in: PubMed
      29. Bratt-Leal AM, Nguyen AH, Hammersmith KA, Singh A, McDevitt TC. A microparticle approach to morphogen delivery within pluripotent stem cell aggregates. Biomaterials. 2013 Oct; 34(30):7227-35. PMID: 23827184; PMCID: PMC3800695.
      30. Kinney MA, Sargent CY, McDevitt TC. Temporal modulation of ß-catenin signaling by multicellular aggregation kinetics impacts embryonic stem cell cardiomyogenesis. Stem Cells Dev. 2013 Oct 1; 22(19):2665-77. PMID: 23767804; PMCID: PMC3780328.
      31. Phillips-Cremins JE, Sauria ME, Sanyal A, Gerasimova TI, Lajoie BR, Bell JS, Ong CT, Hookway TA, Guo C, Sun Y, Bland MJ, Wagstaff W, Dalton S, McDevitt TC, Sen R, Dekker J, Taylor J, Corces VG. Architectural protein subclasses shape 3D organization of genomes during lineage commitment. Cell. 2013 Jun 6; 153(6):1281-95. PMID: 23706625; PMCID: PMC3712340.
      32. Singh A, Suri S, Lee T, Chilton JM, Cooke MT, Chen W, Fu J, Stice SL, Lu H, McDevitt TC, García AJ. Adhesion strength-based, label-free isolation of human pluripotent stem cells. Nat Methods. 2013 May; 10(5):438-44. PMID: 23563795; PMCID: PMC3641175.
      33. White DE, Kinney MA, McDevitt TC, Kemp ML. Spatial pattern dynamics of 3D stem cell loss of pluripotency via rules-based computational modeling. PLoS Comput Biol. 2013; 9(3):e1002952. PMID: 23516345; PMCID: PMC3597536.
      34. Wilson JL, McDevitt TC. Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation. Biotechnol Bioeng. 2013 Mar; 110(3):667-82. PMID: 23239279; PMCID: PMC4163548.
      35. Kinney MA, McDevitt TC. Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis. Trends Biotechnol. 2013 Feb; 31(2):78-84. PMID: 23219200; PMCID: PMC3557560.
      36. Fridley KM, Kinney MA, McDevitt TC. Hydrodynamic modulation of pluripotent stem cells. Stem Cell Res Ther. 2012; 3(6):45. PMID: 23168068; PMCID: PMC3580475.
      37. Nair R, Ngangan AV, Kemp ML, McDevitt TC. Gene expression signatures of extracellular matrix and growth factors during embryonic stem cell differentiation. PLoS One. 2012; 7(10):e42580. PMID: 23077480; PMCID: PMC3471908.
      38. Kinney MA, Saeed R, McDevitt TC. Systematic analysis of embryonic stem cell differentiation in hydrodynamic environments with controlled embryoid body size. Integr Biol (Camb). 2012 Jun; 4(6):641-50. PMID: 22609810; PMCID: PMC4459715.
      39. Zhang Y, Cooke M, Panjwani S, Cao K, Krauth B, Ho PY, Medrzycki M, Berhe DT, Pan C, McDevitt TC, Fan Y. Histone h1 depletion impairs embryonic stem cell differentiation. PLoS Genet. 2012; 8(5):e1002691. PMID: 22589736; PMCID: PMC3349736.
      40. Baraniak PR, Cooke MT, Saeed R, Kinney MA, Fridley KM, McDevitt TC. Stiffening of human mesenchymal stem cell spheroid microenvironments induced by incorporation of gelatin microparticles. J Mech Behav Biomed Mater. 2012 Jul; 11:63-71. PMID: 22658155; PMCID: PMC3528787.
      41. Olivares-Navarrete R, Sutha K, Hyzy SL, Hutton DL, Schwartz Z, McDevitt T, Boyan BD. Osteogenic differentiation of stem cells alters vitamin D receptor expression. Stem Cells Dev. 2012 Jul 1; 21(10):1726-35. PMID: 22034957; PMCID: PMC3376455.
      42. Purpura KA, Bratt-Leal AM, Hammersmith KA, McDevitt TC, Zandstra PW. Systematic engineering of 3D pluripotent stem cell niches to guide blood development. Biomaterials. 2012 Feb; 33(5):1271-80. PMID: 22079776; PMCID: PMC4280365.
      43. Bratt-Leal AM, Kepple KL, Carpenedo RL, Cooke MT, McDevitt TC. Magnetic manipulation and spatial patterning of multi-cellular stem cell aggregates. Integr Biol (Camb). 2011 Dec; 3(12):1224-32. PMID: 22076329; PMCID: PMC4633527.
      44. Baraniak PR, McDevitt TC. Scaffold-free culture of mesenchymal stem cell spheroids in suspension preserves multilineage potential. Cell Tissue Res. 2012 Mar; 347(3):701-11. PMID: 21833761; PMCID: PMC4149251.
      45. Kinney MA, Sargent CY, McDevitt TC. The multiparametric effects of hydrodynamic environments on stem cell culture. Tissue Eng Part B Rev. 2011 Aug; 17(4):249-62. PMID: 21491967; PMCID: PMC3142632.
      46. Lim JJ, Hammoudi TM, Bratt-Leal AM, Hamilton SK, Kepple KL, Bloodworth NC, McDevitt TC, Temenoff JS. Development of nano- and microscale chondroitin sulfate particles for controlled growth factor delivery. Acta Biomater. 2011 Mar; 7(3):986-95. PMID: 20965281; PMCID: PMC3032265.
      47. Bratt-Leal AM, Carpenedo RL, Ungrin MD, Zandstra PW, McDevitt TC. Incorporation of biomaterials in multicellular aggregates modulates pluripotent stem cell differentiation. Biomaterials. 2011 Jan; 32(1):48-56. PMID: 20864164; PMCID: PMC2987521.
      48. Carpenedo RL, Seaman SA, McDevitt TC. Microsphere size effects on embryoid body incorporation and embryonic stem cell differentiation. J Biomed Mater Res A. 2010 Aug; 94(2):466-75. PMID: 20213812.
        View in: PubMed
      49. Sargent CY, Berguig GY, Kinney MA, Hiatt LA, Carpenedo RL, Berson RE, McDevitt TC. Hydrodynamic modulation of embryonic stem cell differentiation by rotary orbital suspension culture. Biotechnol Bioeng. 2010 Feb 15; 105(3):611-26. PMID: 19816980.
        View in: PubMed
      50. Baraniak PR, McDevitt TC. Stem cell paracrine actions and tissue regeneration. Regen Med. 2010 Jan; 5(1):121-43. PMID: 20017699; PMCID: PMC2833273.
      51. Shukla S, Nair R, Rolle MW, Braun KR, Chan CK, Johnson PY, Wight TN, McDevitt TC. Synthesis and organization of hyaluronan and versican by embryonic stem cells undergoing embryoid body differentiation. J Histochem Cytochem. 2010 Apr; 58(4):345-58. PMID: 20026669; PMCID: PMC2842597.
      52. Sargent CY, Berguig GY, McDevitt TC. Cardiomyogenic differentiation of embryoid bodies is promoted by rotary orbital suspension culture. Tissue Eng Part A. 2009 Feb; 15(2):331-42. PMID: 19193130.
        View in: PubMed
      53. Carpenedo RL, Bratt-Leal AM, Marklein RA, Seaman SA, Bowen NJ, McDonald JF, McDevitt TC. Homogeneous and organized differentiation within embryoid bodies induced by microsphere-mediated delivery of small molecules. Biomaterials. 2009 May; 30(13):2507-15. PMID: 19162317; PMCID: PMC2921510.
      54. Bratt-Leal AM, Carpenedo RL, McDevitt TC. Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation. Biotechnol Prog. 2009 Jan-Feb; 25(1):43-51. PMID: 19198003; PMCID: PMC2693014.
      55. Nair R, Shukla S, McDevitt TC. Acellular matrices derived from differentiating embryonic stem cells. J Biomed Mater Res A. 2008 Dec 15; 87(4):1075-85. PMID: 18260134.
        View in: PubMed
      56. Ngangan AV, McDevitt TC. Acellularization of embryoid bodies via physical disruption methods. Biomaterials. 2009 Feb; 30(6):1143-9. PMID: 19042017; PMCID: PMC2655350.
      57. McDevitt TC, Palecek SP. Innovation in the culture and derivation of pluripotent human stem cells. Curr Opin Biotechnol. 2008 Oct; 19(5):527-33. PMID: 18760357; PMCID: PMC2585605.
      58. Nair R, Ngangan AV, McDevitt TC. Efficacy of solvent extraction methods for acellularization of embryoid bodies. J Biomater Sci Polym Ed. 2008; 19(6):801-19. PMID: 18534098.
        View in: PubMed
      59. McDevitt TC, Carpenedo RL, Sargent CY, Berguig GY, Marklein RA, Seaman S. Engineering the 3D microenvironment of embryonic stem cells undergoing differentiation. Biomed Mater Eng. 2008; 18(4-5):179-81. PMID: 19065018.
        View in: PubMed
      60. Carpenedo RL, Sargent CY, McDevitt TC. Rotary suspension culture enhances the efficiency, yield, and homogeneity of embryoid body differentiation. Stem Cells. 2007 Sep; 25(9):2224-34. PMID: 17585171.
        View in: PubMed
      61. McDevitt TC, Laflamme MA, Murry CE. Proliferation of cardiomyocytes derived from human embryonic stem cells is mediated via the IGF/PI 3-kinase/Akt signaling pathway. J Mol Cell Cardiol. 2005 Dec; 39(6):865-73. PMID: 16242146; PMCID: PMC3505759.
      62. McDevitt TC, Woodhouse KA, Hauschka SD, Murry CE, Stayton PS. Spatially organized layers of cardiomyocytes on biodegradable polyurethane films for myocardial repair. J Biomed Mater Res A. 2003 Sep 1; 66(3):586-95. PMID: 12918042.
        View in: PubMed
      63. Le Trong I, McDevitt TC, Nelson KE, Stayton PS, Stenkamp RE. Structural characterization and comparison of RGD cell-adhesion recognition sites engineered into streptavidin. Acta Crystallogr D Biol Crystallogr. 2003 May; 59(Pt 5):828-34. PMID: 12777798.
        View in: PubMed
      64. McDevitt TC, Angello JC, Whitney ML, Reinecke H, Hauschka SD, Murry CE, Stayton PS. In vitro generation of differentiated cardiac myofibers on micropatterned laminin surfaces. J Biomed Mater Res. 2002 Jun 5; 60(3):472-9. PMID: 11920672.
        View in: PubMed
      65. Garrison MD, McDevitt TC, Luginbühl R, Giachelli CM, Stayton P, Ratner BD. Quantitative interrogation of micropatterned biomolecules by surface force microscopy. Ultramicroscopy. 2000 Feb; 82(1-4):193-202. PMID: 10741670.
        View in: PubMed
      66. Stayton PS, Nelson KE, McDevitt TC, Bulmus V, Shimoboji T, Ding Z, Hoffman AS. Smart and biofunctional streptavidin. Biomol Eng. 1999 Dec 31; 16(1-4):93-9. PMID: 10796990.
        View in: PubMed
      67. McDevitt TC, Nelson KE, Stayton PS. Constrained cell recognition peptides engineered into streptavidin. Biotechnol Prog. 1999 May-Jun; 15(3):391-6. PMID: 10356256.
        View in: PubMed
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