Tomoki Hashimoto, MD

SchoolUCSF School of Medicine
Address1001 Potrero Ave, SFGH 1
San Francisco CA 94110
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    My research program focuses on basic and translational research of vascular diseases including, intracranial aneurysms, aortic aneurysms, and brain arteriovenous malformations. These vascular lesions usually remain asymptomatic until they rupture. In case of intracranial aneurysms, rupture results in subarachnoid hemorrhage that can potentially cause severe mortality and morbidity.

    Prevention of rupture of these vascular lesions is critical. We are working to identify new therapeutic targets that induce stabilization and regression of vascular lesions so that they remain unruptured and asymptomatic. We utilize novel animal models and human specimens to achieve these goals.

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    The Role of Mast Cells in the Pathophysiology of Intracranial Aneurysm
    NIH/NINDS R01NS082280Sep 1, 2013 - May 31, 2018
    Role: Principal Investigator
    Intracranial aneurysm pathogenesis-roles of vascular remodeling and inflammation
    NIH/NINDS R01NS055876Jul 1, 2006 - Feb 29, 2016
    Role: Principal Investigator
    Integrative Study of Brain Vascular Malformations
    NIH/NINDS P01NS044155Jul 1, 2002 - Mar 31, 2014
    Role: Principal Investigator

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