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    Tracy McKnight, PhD

    TitleAssoc. Professor in Residence
    SchoolUCSF School of Medicine
    DepartmentRadiology
    Address185 Berry Street
    San Francisco CA 94143
    Phone415-353-9467
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      Collapse Biography 
      Collapse Awards and Honors
      American Society of Neuroradiology2007Outstanding Presentation Award
      Alliance for Graduate Education and the Professoriate (AGEP) Colloquium, San Francisco2006Keynote Address
      American Society of Neuroradiology2001Outstanding Presentation Award
      National Institutes of Health Diagnostic Oncology1998Training Fellowship
      National Institutes of Health Cardiovascular and Neurophysiology1994Training Fellowship
      University of California, Davis1991Patricia Roberts Harris Fellowship

      Collapse Overview 
      Collapse Overview
      Tracy R. McKnight, PhD, is an Associate Professor in Residence, Director of the Center for Molecular and Functional Imaging Tissue Lab, and Co-Chair of the Safety and Compliance Committee in the Department of Radiology. Also, she is the Director of the UCSF – Tuskegee Summer Internship in Bioengineering and she is Co-Director of the UCSF Tumor Microenvironment Network Imaging and Tissue Procurement Core in Neurosurgery. Dr. McKnight received her BS in Physics from Spelman College in Atlanta, Georgia, in 1988, and she obtained her MS in Physics from Polytechnic University in Brooklyn, New York, in 1990. She completed her PhD in Biomedical Engineering from the University of California, Davis in 1998, followed by a visiting postdoctoral scholar at UCSF.

      Dr. McKnight’s research program is focused on improving the monitoring and treatment of patients with brain tumors through the use of advanced imaging technologies. A primary goal of her research is to investigate the biomedical mechanisms associated with the malignant progression of brain tumors using techniques that can be incorporated into patient management tools. Dr. McKnight’s recent research program is the study of cell and animal models of glioma. The purpose of this study is to probe the relationship between MR signals and subcellular mechanisms involved in tumor progression, and to characterize the structural and fluid mobility properties of tumors.

      Dr. McKnight is a member of the International Society of Magnetic Resonance in Medicine, the American Association for Cancer Research, and the American Society of Neuroradiology. Dr. McKnight is a member of several UCSF committees and departmental committees, and she is a reviewer for five scientific journals. She has 27 published articles and she has written 26 peer-reviewed articles, 45 abstracts, and 5 significant publications.

      Expertise:
      Neuroradiology and Neurosurgery

      Specialty:
      Neurosurgery, brain tumors, MRS

      Professional Interests:
      Cancer, magnetic resonance imaging, magnetic resonance spectroscopy, brain tumor, tumor biology, cancer progression, metabolism

      Education and Training:
      • Bachelor of Science: Spelman College, Atlanta, Georgia - Physics
      • Masters of Science: Polytechnic University, Brooklyn, New York - Physics
      • Doctor of Philosophy: University of California, Davis - Biomedical Engineering
      • Visiting Postdoctoral Scholar: University of California, San Francisco Department of Radiology

      Collapse Interests
      Cancer, magnetic resonance imaging, magnetic resonance spectroscopy, brain tumor, tumor biology, cancer progression, metabolism.

      Collapse ORNG Applications 
      Collapse Websites
      Collapse Awarded Grants

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Miroshnikova YA, Mouw JK, Barnes JM, Pickup MW, Lakins JN, Kim Y, Lobo K, Persson AI, Reis GF, McKnight TR, Holland EC, Phillips JJ, Weaver VM. Tissue mechanics promote IDH1-dependent HIF1a-tenascin C feedback to regulate glioblastoma aggression. Nat Cell Biol. 2016 Nov 07. PMID: 27820599.
        View in: PubMed
      2. McKnight TR, Yoshihara HA, Sitole LJ, Martin JN, Steffens F, Meyer D. A combined chemometric and quantitative NMR analysis of HIV/AIDS serum discloses metabolic alterations associated with disease status. Mol Biosyst. 2014 Nov; 10(11):2889-97. PMID: 25105420; PMCID: PMC4492936.
      3. Hashizume R, Smirnov I, Liu S, Phillips JJ, Hyer J, McKnight TR, Wendland M, Prados M, Banerjee A, Nicolaides T, Mueller S, James CD, Gupta N. Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatment. J Neurooncol. 2012 Dec; 110(3):305-13. PMID: 22983601.
        View in: PubMed
      4. Khayal IS, Vandenberg SR, Smith KJ, Cloyd CP, Chang SM, Cha S, Nelson SJ, McKnight TR. MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas. Neuro Oncol. 2011 Nov; 13(11):1192-201. PMID: 21865401; PMCID: PMC3199150.
      5. McKnight TR, Smith KJ, Chu PW, Chiu KS, Cloyd CP, Chang SM, Phillips JJ, Berger MS. Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytoma. J Magn Reson Imaging. 2011 Apr; 33(4):808-16. PMID: 21448944; PMCID: PMC3076678.
      6. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82. PMID: 21156288; PMCID: PMC3031116.
      7. Khayal IS, McKnight TR, McGue C, Vandenberg S, Lamborn KR, Chang SM, Cha S, Nelson SJ. Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomas. NMR Biomed. 2009 May; 22(4):449-55. PMID: 19125391; PMCID: PMC3772178.
      8. Fiandaca MS, Varenika V, Eberling J, McKnight T, Bringas J, Pivirotto P, Beyer J, Hadaczek P, Bowers W, Park J, Federoff H, Forsayeth J, Bankiewicz KS. Real-time MR imaging of adeno-associated viral vector delivery to the primate brain. Neuroimage. 2009 Aug; 47 Suppl 2:T27-35. PMID: 19095069; PMCID: PMC2730220.
      9. Haas-Kogan DA, Banerjee A, Kocak M, Prados MD, Geyer JR, Fouladi M, McKnight T, Poussaint TY, Broniscer A, Blaney SM, Boyett JM, Kun LE. Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma. Neuro Oncol. 2008 Jun; 10(3):341-7. PMID: 18417739; PMCID: PMC2563056.
      10. Khayal IS, Crawford FW, Saraswathy S, Lamborn KR, Chang SM, Cha S, McKnight TR, Nelson SJ. Relationship between choline and apparent diffusion coefficient in patients with gliomas. J Magn Reson Imaging. 2008 Apr; 27(4):718-25. PMID: 18383265; PMCID: PMC3030277.
      11. Laprie A, Catalaa I, Cassol E, McKnight TR, Berchery D, Marre D, Bachaud JM, Berry I, Moyal EC. Proton magnetic resonance spectroscopic imaging in newly diagnosed glioblastoma: predictive value for the site of postradiotherapy relapse in a prospective longitudinal study. Int J Radiat Oncol Biol Phys. 2008 Mar 1; 70(3):773-81. PMID: 18262090.
        View in: PubMed
      12. McKnight TR, Lamborn KR, Love TD, Berger MS, Chang S, Dillon WP, Bollen A, Nelson SJ. Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas. J Neurosurg. 2007 Apr; 106(4):660-6. PMID: 17432719.
        View in: PubMed
      13. Catalaa I, Henry R, Dillon WP, Graves EE, McKnight TR, Lu Y, Vigneron DB, Nelson SJ. Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral gliomas. NMR Biomed. 2006 Jun; 19(4):463-75. PMID: 16763973.
        View in: PubMed
      14. Saito R, Krauze MT, Bringas JR, Noble C, McKnight TR, Jackson P, Wendland MF, Mamot C, Drummond DC, Kirpotin DB, Hong K, Berger MS, Park JW, Bankiewicz KS. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol. 2005 Dec; 196(2):381-9. PMID: 16197944.
        View in: PubMed
      15. Krauze MT, Mcknight TR, Yamashita Y, Bringas J, Noble CO, Saito R, Geletneky K, Forsayeth J, Berger MS, Jackson P, Park JW, Bankiewicz KS. Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging. Brain Res Brain Res Protoc. 2005 Dec; 16(1-3):20-6. PMID: 16181805.
        View in: PubMed
      16. Krauze MT, Saito R, Noble C, Bringas J, Forsayeth J, McKnight TR, Park J, Bankiewicz KS. Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen. Exp Neurol. 2005 Nov; 196(1):104-11. PMID: 16109410.
        View in: PubMed
      17. Laprie A, Pirzkall A, Haas-Kogan DA, Cha S, Banerjee A, Le TP, Lu Y, Nelson S, McKnight TR. Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):20-31. PMID: 15850898.
        View in: PubMed
      18. McKnight TR. Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism. Semin Oncol. 2004 Oct; 31(5):605-17. PMID: 15497114.
        View in: PubMed
      19. Mamot C, Nguyen JB, Pourdehnad M, Hadaczek P, Saito R, Bringas JR, Drummond DC, Hong K, Kirpotin DB, McKnight T, Berger MS, Park JW, Bankiewicz KS. Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol. 2004 May; 68(1):1-9. PMID: 15174514.
        View in: PubMed
      20. Lee MC, Pirzkall A, McKnight TR, Nelson SJ. 1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classification. J Magn Reson Imaging. 2004 Apr; 19(4):379-88. PMID: 15065160.
        View in: PubMed
      21. Saito R, Bringas JR, McKnight TR, Wendland MF, Mamot C, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz KS. Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res. 2004 Apr 1; 64(7):2572-9. PMID: 15059914.
        View in: PubMed
      22. McKnight TR, Curry FE. Mechanisms of heterogeneous endothelial cytoplasmic calcium increases in venular microvessels. Microcirculation. 2002 Dec; 9(6):537-50. PMID: 12483550.
        View in: PubMed
      23. Nelson SJ, McKnight TR, Henry RG. Characterization of untreated gliomas by magnetic resonance spectroscopic imaging. Neuroimaging Clin N Am. 2002 Nov; 12(4):599-613. PMID: 12687914.
        View in: PubMed
      24. Nelson SJ, Graves E, Pirzkall A, Li X, Antiniw Chan A, Vigneron DB, McKnight TR. In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging. 2002 Oct; 16(4):464-76. PMID: 12353260.
        View in: PubMed
      25. McKnight TR, von dem Bussche MH, Vigneron DB, Lu Y, Berger MS, McDermott MW, Dillon WP, Graves EE, Pirzkall A, Nelson SJ. Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presence. J Neurosurg. 2002 Oct; 97(4):794-802. PMID: 12405365.
        View in: PubMed
      26. Li X, Lu Y, Pirzkall A, McKnight T, Nelson SJ. Analysis of the spatial characteristics of metabolic abnormalities in newly diagnosed glioma patients. J Magn Reson Imaging. 2002 Sep; 16(3):229-37. PMID: 12205577.
        View in: PubMed
      27. Pirzkall A, Nelson SJ, McKnight TR, Takahashi MM, Li X, Graves EE, Verhey LJ, Wara WW, Larson DA, Sneed PK. Metabolic imaging of low-grade gliomas with three-dimensional magnetic resonance spectroscopy. Int J Radiat Oncol Biol Phys. 2002 Aug 1; 53(5):1254-64. PMID: 12128127.
        View in: PubMed
      28. Pirzkall A, McKnight TR, Graves EE, Carol MP, Sneed PK, Wara WW, Nelson SJ, Verhey LJ, Larson DA. MR-spectroscopy guided target delineation for high-grade gliomas. Int J Radiat Oncol Biol Phys. 2001 Jul 15; 50(4):915-28. PMID: 11429219.
        View in: PubMed
      29. McKnight TR, Noworolski SM, Vigneron DB, Nelson SJ. An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma. J Magn Reson Imaging. 2001 Feb; 13(2):167-77. PMID: 11169821.
        View in: PubMed
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