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    Tricia Janak, PhD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94143
    Phone415-502-7382

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Saunders BT, Janak PH. Nucleus accumbens plasticity underlies multifaceted behavioral changes associated with addiction. Biol Psychiatry. 2014 Jan 15; 75(2):92-3.
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      2. Keiflin R, Reese RM, Woods CA, Janak PH. The orbitofrontal cortex as part of a hierarchical neural system mediating choice between two good options. J Neurosci. 2013 Oct 2; 33(40):15989-98.
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      3. Barak S, Liu F, Ben Hamida S, Yowell QV, Neasta J, Kharazia V, Janak PH, Ron D. Disruption of alcohol-related memories by mTORC1 inhibition prevents relapse. Nat Neurosci. 2013 Aug; 16(8):1111-7.
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      4. Chaudhri N, Woods CA, Sahuque LL, Gill TM, Janak PH. Unilateral inactivation of the basolateral amygdala attenuates context-induced renewal of Pavlovian-conditioned alcohol-seeking. Eur J Neurosci. 2013 Sep; 38(5):2751-61.
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      5. Steinberg EE, Keiflin R, Boivin JR, Witten IB, Deisseroth K, Janak PH. A causal link between prediction errors, dopamine neurons and learning. Nat Neurosci. 2013 Jul; 16(7):966-73.
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      6. Sangha S, Chadick JZ, Janak PH. Safety encoding in the basal amygdala. J Neurosci. 2013 Feb 27; 33(9):3744-51.
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      7. Jeanblanc J, Logrip ML, Janak PH, Ron D. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur J Neurosci. 2013 Feb; 37(4):607-12.
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      8. Ben Hamida S, Neasta J, Lasek AW, Kharazia V, Zou M, Carnicella S, Janak PH, Ron D. The small G protein H-Ras in the mesolimbic system is a molecular gateway to alcohol-seeking and excessive drinking behaviors. J Neurosci. 2012 Nov 7; 32(45):15849-58.
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      9. Steinberg EE, Janak PH. Establishing causality for dopamine in neural function and behavior with optogenetics. Brain Res. 2013 May 20; 1511:46-64.
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      10. Corbit LH, Nie H, Janak PH. Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum. Biol Psychiatry. 2012 Sep 1; 72(5):389-95.
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      11. Li J, Nie H, Bian W, Dave V, Janak PH, Ye JH. Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption. J Pharmacol Exp Ther. 2012 Apr; 341(1):196-204.
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      12. Lim JP, Zou ME, Janak PH, Messing RO. Responses to ethanol in C57BL/6 versus C57BL/6 × 129 hybrid mice. Brain Behav. 2012 Jan; 2(1):22-31.
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      13. Shabel SJ, Schairer W, Donahue RJ, Powell V, Janak PH. Similar neural activity during fear and disgust in the rat basolateral amygdala. PLoS One. 2011; 6(12):e27797.
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      14. Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K. Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron. 2011 Dec 8; 72(5):721-33.
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      15. Janak PH, Bowers MS, Corbit LH. Compound stimulus presentation and the norepinephrine reuptake inhibitor atomoxetine enhance long-term extinction of cocaine-seeking behavior. Neuropsychopharmacology. 2012 Mar; 37(4):975-85.
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      16. Rewal M, Donahue R, Gill TM, Nie H, Ron D, Janak PH. Alpha4 subunit-containing GABAA receptors in the accumbens shell contribute to the reinforcing effects of alcohol. Addict Biol. 2012 Mar; 17(2):309-21.
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      17. Nie H, Rewal M, Gill TM, Ron D, Janak PH. Extrasynaptic delta-containing GABAA receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4459-64.
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      18. Janak PH, Corbit LH. Deepened extinction following compound stimulus presentation: noradrenergic modulation. Learn Mem. 2011 Jan; 18(1):1-10.
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      19. Gill TM, Castaneda PJ, Janak PH. Dissociable roles of the medial prefrontal cortex and nucleus accumbens core in goal-directed actions for differential reward magnitude. Cereb Cortex. 2010 Dec; 20(12):2884-99.
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      20. Corbit LH, Janak PH. Posterior dorsomedial striatum is critical for both selective instrumental and Pavlovian reward learning. Eur J Neurosci. 2010 Apr; 31(7):1312-21.
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      21. Tye KM, Tye LD, Cone JJ, Hekkelman EF, Janak PH, Bonci A. Methylphenidate facilitates learning-induced amygdala plasticity. Nat Neurosci. 2010 Apr; 13(4):475-81.
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      22. Chen J, Nam HW, Lee MR, Hinton DJ, Choi S, Kim T, Kawamura T, Janak PH, Choi DS. Altered glutamatergic neurotransmission in the striatum regulates ethanol sensitivity and intake in mice lacking ENT1. Behav Brain Res. 2010 Apr 2; 208(2):636-42.
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      23. Tye KM, Cone JJ, Schairer WW, Janak PH. Amygdala neural encoding of the absence of reward during extinction. J Neurosci. 2010 Jan 6; 30(1):116-25.
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      24. Chaudhri N, Sahuque LL, Schairer WW, Janak PH. Separable roles of the nucleus accumbens core and shell in context- and cue-induced alcohol-seeking. Neuropsychopharmacology. 2010 Feb; 35(3):783-91.
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      25. Jeanblanc J, He DY, Carnicella S, Kharazia V, Janak PH, Ron D. Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci. 2009 Oct 28; 29(43):13494-502.
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      26. Chaudhri N, Sahuque LL, Janak PH. Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats. Psychopharmacology (Berl). 2009 Dec; 207(2):303-14.
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      27. Shabel SJ, Janak PH. Substantial similarity in amygdala neuronal activity during conditioned appetitive and aversive emotional arousal. Proc Natl Acad Sci U S A. 2009 Sep 1; 106(35):15031-6.
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      28. Logrip ML, Janak PH, Ron D. Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H. Alcohol. 2009 Aug; 43(5):359-65.
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      29. Mao R, Page DT, Merzlyak I, Kim C, Tecott LH, Janak PH, Rubenstein JL, Sur M. Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons. J Neurodev Disord. 2009 Sep; 1(3):224-36.
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      30. Logrip ML, Janak PH, Ron D. Escalating ethanol intake is associated with altered corticostriatal BDNF expression. J Neurochem. 2009 Jun; 109(5):1459-68.
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      31. Carnicella S, Ahmadiantehrani S, Janak PH, Ron D. GDNF is an endogenous negative regulator of ethanol-mediated reward and of ethanol consumption after a period of abstinence. Alcohol Clin Exp Res. 2009 Jun; 33(6):1012-24.
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      32. Carnicella S, Ahmadiantehrani S, He DY, Nielsen CK, Bartlett SE, Janak PH, Ron D. Cabergoline decreases alcohol drinking and seeking behaviors via glial cell line-derived neurotrophic factor. Biol Psychiatry. 2009 Jul 15; 66(2):146-53.
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      33. Rewal M, Jurd R, Gill TM, He DY, Ron D, Janak PH. Alpha4-containing GABAA receptors in the nucleus accumbens mediate moderate intake of alcohol. J Neurosci. 2009 Jan 14; 29(2):543-9.
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      34. Blaiss CA, Janak PH. The nucleus accumbens core and shell are critical for the expression, but not the consolidation, of Pavlovian conditioned approach. Behav Brain Res. 2009 Jun 8; 200(1):22-32.
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      35. Chaudhri N, Sahuque LL, Cone JJ, Janak PH. Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core. Eur J Neurosci. 2008 Dec; 28(11):2288-98.
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      36. Bowers MS, Hopf FW, Chou JK, Guillory AM, Chang SJ, Janak PH, Bonci A, Diamond I. Nucleus accumbens AGS3 expression drives ethanol seeking through G betagamma. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12533-8.
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      37. Chaudhri N, Sahuque LL, Janak PH. Context-induced relapse of conditioned behavioral responding to ethanol cues in rats. Biol Psychiatry. 2008 Aug 1; 64(3):203-10.
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      38. Carnicella S, Kharazia V, Jeanblanc J, Janak PH, Ron D. GDNF is a fast-acting potent inhibitor of alcohol consumption and relapse. Proc Natl Acad Sci U S A. 2008 Jun 10; 105(23):8114-9.
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      39. Tye KM, Stuber GD, de Ridder B, Bonci A, Janak PH. Rapid strengthening of thalamo-amygdala synapses mediates cue-reward learning. Nature. 2008 Jun 26; 453(7199):1253-7.
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      40. Burattini C, McGeehan AJ, Griffin WC, Gass JT, Kinder JR, Janak PH, Olive MF. A microdialysis study of extracellular levels of acamprosate and naltrexone in the rat brain following acute and repeated administration. Addict Biol. 2008 Mar; 13(1):70-9.
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      41. Logrip ML, Janak PH, Ron D. Dynorphin is a downstream effector of striatal BDNF regulation of ethanol intake. FASEB J. 2008 Jul; 22(7):2393-404.
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      42. Corbit LH, Janak PH. Inactivation of the lateral but not medial dorsal striatum eliminates the excitatory impact of Pavlovian stimuli on instrumental responding. J Neurosci. 2007 Dec 19; 27(51):13977-81.
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      43. Corbit LH, Janak PH, Balleine BW. General and outcome-specific forms of Pavlovian-instrumental transfer: the effect of shifts in motivational state and inactivation of the ventral tegmental area. Eur J Neurosci. 2007 Dec; 26(11):3141-9.
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      44. Bowers MS, Chen BT, Chou JK, Osborne MP, Gass JT, See RE, Bonci A, Janak PH, Olive MF. Acamprosate attenuates cocaine- and cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology (Berl). 2007 Dec; 195(3):397-406.
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      45. Tye KM, Janak PH. Amygdala neurons differentially encode motivation and reinforcement. J Neurosci. 2007 Apr 11; 27(15):3937-45.
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      46. Wang J, Carnicella S, Phamluong K, Jeanblanc J, Ronesi JA, Chaudhri N, Janak PH, Lovinger DM, Ron D. Ethanol induces long-term facilitation of NR2B-NMDA receptor activity in the dorsal striatum: implications for alcohol drinking behavior. J Neurosci. 2007 Mar 28; 27(13):3593-602.
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      47. Lasek AW, Janak PH, He L, Whistler JL, Heberlein U. Downregulation of mu opioid receptor by RNA interference in the ventral tegmental area reduces ethanol consumption in mice. Genes Brain Behav. 2007 Nov; 6(8):728-35.
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      48. Corbit LH, Janak PH. Ethanol-associated cues produce general pavlovian-instrumental transfer. Alcohol Clin Exp Res. 2007 May; 31(5):766-74.
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      49. Blaiss CA, Janak PH. Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach. Neurobiol Learn Mem. 2007 May; 87(4):644-58.
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      50. Zhang J, Pho V, Bonasera SJ, Holtzman J, Tang AT, Hellmuth J, Tang S, Janak PH, Tecott LH, Huang EJ. Essential function of HIPK2 in TGFbeta-dependent survival of midbrain dopamine neurons. Nat Neurosci. 2007 Jan; 10(1):77-86.
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      51. Blaiss CA, Janak PH. Post-training and post-reactivation administration of amphetamine enhances morphine conditioned place preference. Behav Brain Res. 2006 Aug 10; 171(2):329-37.
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      52. Sahuque LL, Kullberg EF, Mcgeehan AJ, Kinder JR, Hicks MP, Blanton MG, Janak PH, Olive MF. Anxiogenic and aversive effects of corticotropin-releasing factor (CRF) in the bed nucleus of the stria terminalis in the rat: role of CRF receptor subtypes. Psychopharmacology (Berl). 2006 May; 186(1):122-32.
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      53. Burattini C, Gill TM, Aicardi G, Janak PH. The ethanol self-administration context as a reinstatement cue: acute effects of naltrexone. Neuroscience. 2006; 139(3):877-87.
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      54. Jeanblanc J, He DY, McGough NN, Logrip ML, Phamluong K, Janak PH, Ron D. The dopamine D3 receptor is part of a homeostatic pathway regulating ethanol consumption. J Neurosci. 2006 Feb 1; 26(5):1457-64.
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      55. Tsiang MT, Janak PH. Alcohol seeking in C57BL/6 mice induced by conditioned cues and contexts in the extinction-reinstatement model. Alcohol. 2006 Feb; 38(2):81-8.
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      56. Janak PH, Wolf FW, Heberlein U, Pandey SC, Logrip ML, Ron D. BIG news in alcohol addiction: new findings on growth factor pathways BDNF, insulin, and GDNF. Alcohol Clin Exp Res. 2006 Feb; 30(2):214-21.
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      57. Zironi I, Burattini C, Aicardi G, Janak PH. Context is a trigger for relapse to alcohol. Behav Brain Res. 2006 Feb 15; 167(1):150-5.
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      58. Purdy RH, Valenzuela CF, Janak PH, Finn DA, Biggio G, Bäckström T. Neuroactive steroids and ethanol. Alcohol Clin Exp Res. 2005 Jul; 29(7):1292-8.
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      59. He DY, McGough NN, Ravindranathan A, Jeanblanc J, Logrip ML, Phamluong K, Janak PH, Ron D. Glial cell line-derived neurotrophic factor mediates the desirable actions of the anti-addiction drug ibogaine against alcohol consumption. J Neurosci. 2005 Jan 19; 25(3):619-28.
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      60. Ron D, Janak PH. GDNF and addiction. Rev Neurosci. 2005; 16(4):277-85.
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      61. McGough NN, He DY, Logrip ML, Jeanblanc J, Phamluong K, Luong K, Kharazia V, Janak PH, Ron D. RACK1 and brain-derived neurotrophic factor: a homeostatic pathway that regulates alcohol addiction. J Neurosci. 2004 Nov 17; 24(46):10542-52.
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      62. Olive MF, McGeehan AJ, Kinder JR, McMahon T, Hodge CW, Janak PH, Messing RO. The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. Mol Pharmacol. 2005 Feb; 67(2):349-55.
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      63. Janak PH, Chen MT, Caulder T. Dynamics of neural coding in the accumbens during extinction and reinstatement of rewarded behavior. Behav Brain Res. 2004 Sep 23; 154(1):125-35.
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      64. Arolfo MP, Yao L, Gordon AS, Diamond I, Janak PH. Ethanol operant self-administration in rats is regulated by adenosine A2 receptors. Alcohol Clin Exp Res. 2004 Sep; 28(9):1308-16.
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      65. Mcgeehan AJ, Janak PH, Olive MF. Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. Psychopharmacology (Berl). 2004 Jul; 174(2):266-73.
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      66. Yaka R, Tang KC, Camarini R, Janak PH, Ron D. Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Alcohol Clin Exp Res. 2003 Nov; 27(11):1736-42.
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      67. Janak PH, Michael Gill T. Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose. Alcohol. 2003 May; 30(1):1-7.
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      68. Nie H, Janak PH. Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats. Psychopharmacology (Berl). 2003 Jul; 168(1-2):222-8.
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      69. Yao L, Arolfo MP, Dohrman DP, Jiang Z, Fan P, Fuchs S, Janak PH, Gordon AS, Diamond I. betagamma Dimers mediate synergy of dopamine D2 and adenosine A2 receptor-stimulated PKA signaling and regulate ethanol consumption. Cell. 2002 Jun 14; 109(6):733-43.
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      70. Nadal R, Armario A, Janak PH. Positive relationship between activity in a novel environment and operant ethanol self-administration in rats. Psychopharmacology (Berl). 2002 Jul; 162(3):333-8.
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      71. Chen MT, Morales M, Woodward DJ, Hoffer BJ, Janak PH. In vivo extracellular recording of striatal neurons in the awake rat following unilateral 6-hydroxydopamine lesions. Exp Neurol. 2001 Sep; 171(1):72-83.
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      72. Chang JY, Janak PH, Woodward DJ. Neuronal and behavioral correlations in the medial prefrontal cortex and nucleus accumbens during cocaine self-administration by rats. Neuroscience. 2000; 99(3):433-43.
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      73. Woodward DJ, Chang JY, Janak P, Azarov A, Anstrom K. Activity patterns in mesolimbic regions in rats during operant tasks for reward. Prog Brain Res. 2000; 126:303-22.
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      74. Morrow AL, Janis GC, VanDoren MJ, Matthews DB, Samson HH, Janak PH, Grant KA. Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action? Alcohol Clin Exp Res. 1999 Dec; 23(12):1933-40.
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      75. Woodward DJ, Chang JY, Janak P, Azarov A, Anstrom K. Mesolimbic neuronal activity across behavioral states. Ann N Y Acad Sci. 1999 Jun 29; 877:91-112.
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      76. Janak PH, Chang JY, Woodward DJ. Neuronal spike activity in the nucleus accumbens of behaving rats during ethanol self-administration. Brain Res. 1999 Jan 30; 817(1-2):172-84.
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      77. Janak PH, Redfern JE, Samson HH. The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone. Alcohol Clin Exp Res. 1998 Aug; 22(5):1106-12.
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      78. Chang JY, Janak PH, Woodward DJ. Comparison of mesocorticolimbic neuronal responses during cocaine and heroin self-administration in freely moving rats. J Neurosci. 1998 Apr 15; 18(8):3098-115.
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      79. Woodward DJ, Janak PH, Chang JY. Ethanol action on neural networks studied with multineuron recording in freely moving animals. Alcohol Clin Exp Res. 1998 Feb; 22(1):10-22.
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      80. Janak PH, Hernandez RV, Rule RR, Martinez JL. Rapid decay of cocaine-induced behavioral sensitization of locomotor behavior. Behav Brain Res. 1997 Nov; 88(2):195-9.
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      81. Chang JY, Zhang L, Janak PH, Woodward DJ. Neuronal responses in prefrontal cortex and nucleus accumbens during heroin self-administration in freely moving rats. Brain Res. 1997 Apr 18; 754(1-2):12-20.
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      82. Janak PH, Rodriguez WA, Martinez JL. Cocaine impairs acquisition of an autoshaped lever-touch response. Psychopharmacology (Berl). 1997 Apr; 130(3):213-21.
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      83. Janak PH, Manly JJ, Martinez JL. [Leu]enkephalin enhances active avoidance conditioning in rats and mice. Neuropsychopharmacology. 1994 Feb; 10(1):53-60.
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      84. Janak PH, Schulteis G, Martinez JL. Uptake and metabolism of [3H]-Leu-enkephalin following either its intraperitoneal or subcutaneous administration to mice. Peptides. 1992 May-Jun; 13(3):551-5.
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      85. Weinberger SB, Riedel CA, Janak PH, Martinez JL. Cocaine enhances one-way avoidance responding in mice. Pharmacol Biochem Behav. 1992 Apr; 41(4):851-4.
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      86. Janak PH, Martinez JL. Cocaine and amphetamine facilitate retention of jump-up responding in rats. Pharmacol Biochem Behav. 1992 Apr; 41(4):837-40.
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      87. Ivens IA, Janak PH, Martinez JL. Microdialysis measurement of striatal dopamine levels in freely moving rats after cocaine or amphetamine treatment. Proc West Pharmacol Soc. 1992; 35:165-9.
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      88. Janak PH, Keppel G, Martinez JL. Cocaine enhances retention of avoidance conditioning in rats. Psychopharmacology (Berl). 1992; 106(3):383-7.
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      89. Janak PH, Martinez JL. Only tyrosine-containing metabolites of [Leu]enkephalin impair active avoidance conditioning in mice. Pharmacol Biochem Behav. 1990 Dec; 37(4):655-9.
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      90. Martinez JL, Janak PH, Weinberger SB, Schulteis G, Derrick BE. Enkephalin influences on behavioral and neural plasticity: mechanisms of action. NIDA Res Monogr. 1990; 97:48-78.
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      91. Martinez JL, Schulteis G, Janak PH, Weinberger SB. Behavioral assessment of forgetting in aged rodents and its relationship to peripheral sympathetic function. Neurobiol Aging. 1988 Sep-Dec; 9(5-6):697-708.
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