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    Walt Holleran, PharmD

    TitleASSOC ADJUNCT PROF-GENCOMP-B
    SchoolUCSF School of Medicine
    DepartmentDermatology
    Address4150 Clement Street
    San Francisco CA 94121
    Phone415-221-4810
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      Collapse Bibliographic 
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Zhang L, Ferreyros M, Feng W, Hupe M, Crumrine DA, Chen J, Elias PM, Holleran WM, Niswander L, Hohl D, Williams T, Torchia EC, Roop DR. Defects in Stratum Corneum Desquamation Are the Predominant Effect of Impaired ABCA12 Function in a Novel Mouse Model of Harlequin Ichthyosis. PLoS One. 2016; 11(8):e0161465. PMID: 27551807.
        View in: PubMed
      2. Park K, Ikushiro H, Seo HS, Shin KO, Kim YI, Kim JY, Lee YM, Yano T, Holleran WM, Elias P, Uchida Y. ER stress stimulates production of the key antimicrobial peptide, cathelicidin, by forming a previously unidentified intracellular S1P signaling complex. Proc Natl Acad Sci U S A. 2016 Mar 8; 113(10):E1334-42. PMID: 26903652.
        View in: PubMed
      3. Tiganescu A, Hupe M, Jiang YJ, Celli A, Uchida Y, Mauro TM, Bikle DD, Elias PM, Holleran WM. UVB induces epidermal 11ß-hydroxysteroid dehydrogenase type 1 activity in vivo. Exp Dermatol. 2015 May; 24(5):370-6. PMID: 25739654.
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      4. Kim YI, Park K, Kim JY, Seo HS, Shin KO, Lee YM, Holleran WM, Elias PM, Uchida Y. An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating ß-defensin production. Mol Cell Biol. 2014 Dec; 34(24):4368-78. PMID: 25312644; PMCID: PMC4248733.
      5. Park K, Kim YI, Shin KO, Seo HS, Kim JY, Mann T, Oda Y, Lee YM, Holleran WM, Elias PM, Uchida Y. The dietary ingredient, genistein, stimulates cathelicidin antimicrobial peptide expression through a novel S1P-dependent mechanism. J Nutr Biochem. 2014 Jul; 25(7):734-40. PMID: 24768661; PMCID: PMC4441818.
      6. Tiganescu A, Hupe M, Uchida Y, Mauro T, Elias PM, Holleran WM. Increased glucocorticoid activation during mouse skin wound healing. J Endocrinol. 2014 Apr; 221(1):51-61. PMID: 24464022.
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      7. Elias PM, Gruber R, Crumrine D, Menon G, Williams ML, Wakefield JS, Holleran WM, Uchida Y. Formation and functions of the corneocyte lipid envelope (CLE). Biochim Biophys Acta. 2014 Mar; 1841(3):314-8. PMID: 24076475; PMCID: PMC3943821.
      8. Loiseau N, Obata Y, Moradian S, Sano H, Yoshino S, Aburai K, Takayama K, Sakamoto K, Holleran WM, Elias PM, Uchida Y. Altered sphingoid base profiles predict compromised membrane structure and permeability in atopic dermatitis. J Dermatol Sci. 2013 Dec; 72(3):296-303. PMID: 24070864; PMCID: PMC3866955.
      9. Youm JK, Park K, Uchida Y, Chan A, Mauro TM, Holleran WM, Elias PM. Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing. Wound Repair Regen. 2013 Sep-Oct; 21(5):715-22. PMID: 23927023; PMCID: PMC4507432.
      10. Bourguignon LY, Wong G, Xia W, Man MQ, Holleran WM, Elias PM. Selective matrix (hyaluronan) interaction with CD44 and RhoGTPase signaling promotes keratinocyte functions and overcomes age-related epidermal dysfunction. J Dermatol Sci. 2013 Oct; 72(1):32-44. PMID: 23790635; PMCID: PMC3775883.
      11. Park K, Elias PM, Hupe M, Borkowski AW, Gallo RL, Shin KO, Lee YM, Holleran WM, Uchida Y. Resveratrol stimulates sphingosine-1-phosphate signaling of cathelicidin production. J Invest Dermatol. 2013 Aug; 133(8):1942-9. PMID: 23856934; PMCID: PMC3753186.
      12. Park K, Elias PM, Shin KO, Lee YM, Hupe M, Borkowski AW, Gallo RL, Saba J, Holleran WM, Uchida Y. A novel role of a lipid species, sphingosine-1-phosphate, in epithelial innate immunity. Mol Cell Biol. 2013 Feb; 33(4):752-62. PMID: 23230267; PMCID: PMC3571353.
      13. Goto-Inoue N, Hayasaka T, Zaima N, Nakajima K, Holleran WM, Sano S, Uchida Y, Setou M. Imaging mass spectrometry visualizes ceramides and the pathogenesis of dorfman-chanarin syndrome due to ceramide metabolic abnormality in the skin. PLoS One. 2012; 7(11):e49519. PMID: 23166695; PMCID: PMC3499467.
      14. Celli A, Mackenzie DS, Zhai Y, Tu CL, Bikle DD, Holleran WM, Uchida Y, Mauro TM. SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease. J Invest Dermatol. 2012 Apr; 132(4):1188-95. PMID: 22277942; PMCID: PMC3305850.
      15. Kim H, Kim J, Park J, Kim SH, Uchida Y, Holleran WM, Cho Y. Water extract of gromwell (Lithospermum erythrorhizon) enhances migration of human keratinocytes and dermal fibroblasts with increased lipid synthesis in an in vitro wound scratch model. Skin Pharmacol Physiol. 2012; 25(2):57-64. PMID: 21986308.
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      16. Chan A, Holleran WM, Ferguson T, Crumrine D, Goker-Alpan O, Schiffmann R, Tayebi N, Ginns EI, Elias PM, Sidransky E. Skin ultrastructural findings in type 2 Gaucher disease: diagnostic implications. Mol Genet Metab. 2011 Dec; 104(4):631-6. PMID: 21982627; PMCID: PMC3224209.
      17. Park K, Elias PM, Oda Y, Mackenzie D, Mauro T, Holleran WM, Uchida Y. Regulation of cathelicidin antimicrobial peptide expression by an endoplasmic reticulum (ER) stress signaling, vitamin D receptor-independent pathway. J Biol Chem. 2011 Sep 30; 286(39):34121-30. PMID: 21832078; PMCID: PMC3190812.
      18. Rodriguez-Martin M, Martin-Ezquerra G, Man MQ, Hupe M, Youm JK, Mackenzie DS, Cho S, Trullas C, Holleran WM, Radek KA, Elias PM. Expression of epidermal CAMP changes in parallel with permeability barrier status. J Invest Dermatol. 2011 Nov; 131(11):2263-70. PMID: 21796152; PMCID: PMC3193540.
      19. Martin-Ezquerra G, Man MQ, Hupe M, Rodriguez-Martin M, Youm JK, Trullas C, Mackenzie DS, Radek KA, Holleran WM, Elias PM. Psychological stress regulates antimicrobial peptide expression by both glucocorticoid and ß-adrenergic mechanisms. Eur J Dermatol. 2011 May; 21 Suppl 2:48-51. PMID: 21628130.
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      20. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Hypertension. 2011 Feb; 57(2):216-22. PMID: 21220706; PMCID: PMC3322545.
      21. Aburai K, Yoshino S, Sakai K, Sakai H, Abe M, Loiseau N, Holleran W, Uchida Y, Sakamoto K. Physicochemical analysis of liposome membranes consisting of model lipids in the stratum corneum. J Oleo Sci. 2011; 60(4):197-202. PMID: 21427516.
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      22. Uchida Y, Houben E, Park K, Douangpanya S, Lee YM, Wu BX, Hannun YA, Radin NS, Elias PM, Holleran WM. Hydrolytic pathway protects against ceramide-induced apoptosis in keratinocytes exposed to UVB. J Invest Dermatol. 2010 Oct; 130(10):2472-80. PMID: 20520628.
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      23. Uchida Y, Cho Y, Moradian S, Kim J, Nakajima K, Crumrine D, Park K, Ujihara M, Akiyama M, Shimizu H, Holleran WM, Sano S, Elias PM. Neutral lipid storage leads to acylceramide deficiency, likely contributing to the pathogenesis of Dorfman-Chanarin syndrome. J Invest Dermatol. 2010 Oct; 130(10):2497-9. PMID: 20520629.
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      24. Hatano Y, Man MQ, Uchida Y, Crumrine D, Mauro TM, Feingold KR, Elias PM, Holleran WM. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. J Allergy Clin Immunol. 2010 Jan; 125(1):160-9.e1-5. PMID: 19818482; PMCID: PMC2859962.
      25. Jiang YJ, Uchida Y, Lu B, Kim P, Mao C, Akiyama M, Elias PM, Holleran WM, Grunfeld C, Feingold KR. Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes. J Biol Chem. 2009 Jul 10; 284(28):18942-52. PMID: 19429679; PMCID: PMC2707228.
      26. Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J Invest Dermatol. 2009 Jul; 129(7):1824-35. PMID: 19177139; PMCID: PMC2695850.
      27. Charruyer A, Bell SM, Kawano M, Douangpanya S, Yen TY, Macher BA, Kumagai K, Hanada K, Holleran WM, Uchida Y. Decreased ceramide transport protein (CERT) function alters sphingomyelin production following UVB irradiation. J Biol Chem. 2008 Jun 13; 283(24):16682-92. PMID: 18411267; PMCID: PMC2423244.
      28. Uchida Y, Holleran WM, Elias PM. On the effects of topical synthetic pseudoceramides: comparison of possible keratinocyte toxicities provoked by the pseudoceramides, PC104 and BIO391, and natural ceramides. J Dermatol Sci. 2008 Jul; 51(1):37-43. PMID: 18396015; PMCID: PMC2410086.
      29. Uchida Y, Holleran WM. Omega-O-acylceramide, a lipid essential for mammalian survival. J Dermatol Sci. 2008 Aug; 51(2):77-87. PMID: 18329855.
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      30. Elias PM, Williams ML, Holleran WM, Jiang YJ, Schmuth M. Pathogenesis of permeability barrier abnormalities in the ichthyoses: inherited disorders of lipid metabolism. J Lipid Res. 2008 Apr; 49(4):697-714. PMID: 18245815; PMCID: PMC2844331.
      31. Liu YY, Yu JY, Yin D, Patwardhan GA, Gupta V, Hirabayashi Y, Holleran WM, Giuliano AE, Jazwinski SM, Gouaze-Andersson V, Consoli DP, Cabot MC. A role for ceramide in driving cancer cell resistance to doxorubicin. FASEB J. 2008 Jul; 22(7):2541-51. PMID: 18245173.
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      32. Man MQ, Hatano Y, Lee SH, Man M, Chang S, Feingold KR, Leung DY, Holleran W, Uchida Y, Elias PM. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol. 2008 Jan; 128(1):79-86. PMID: 17671515; PMCID: PMC2671229.
      33. Houben E, Uchida Y, Nieuwenhuizen WF, De Paepe K, Vanhaecke T, Holleran WM, Rogiers V. Kinetic characteristics of acidic and alkaline ceramidase in human epidermis. Skin Pharmacol Physiol. 2007; 20(4):187-94. PMID: 17396053.
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      34. Uchida Y, Hama H, Alderson NL, Douangpanya S, Wang Y, Crumrine DA, Elias PM, Holleran WM. Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation. J Biol Chem. 2007 May 4; 282(18):13211-9. PMID: 17355976.
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      35. Vasireddy V, Uchida Y, Salem N, Kim SY, Mandal MN, Reddy GB, Bodepudi R, Alderson NL, Brown JC, Hama H, Dlugosz A, Elias PM, Holleran WM, Ayyagari R. Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death. Hum Mol Genet. 2007 Mar 1; 16(5):471-82. PMID: 17208947; PMCID: PMC1839956.
      36. Holleran WM, Takagi Y, Uchida Y. Epidermal sphingolipids: metabolism, function, and roles in skin disorders. FEBS Lett. 2006 Oct 9; 580(23):5456-66. PMID: 16962101.
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      37. Holleran WM, Ziegler SG, Goker-Alpan O, Eblan MJ, Elias PM, Schiffmann R, Sidransky E. Skin abnormalities as an early predictor of neurologic outcome in Gaucher disease. Clin Genet. 2006 Apr; 69(4):355-7. PMID: 16630170.
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      38. Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y. Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis. J Lipid Res. 2006 May; 47(5):1063-70. PMID: 16477081.
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      39. Man MQ, Choi EH, Schmuth M, Crumrine D, Uchida Y, Elias PM, Holleran WM, Feingold KR. Basis for improved permeability barrier homeostasis induced by PPAR and LXR activators: liposensors stimulate lipid synthesis, lamellar body secretion, and post-secretory lipid processing. J Invest Dermatol. 2006 Feb; 126(2):386-92. PMID: 16374473.
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      40. Ting SB, Caddy J, Hislop N, Wilanowski T, Auden A, Zhao LL, Ellis S, Kaur P, Uchida Y, Holleran WM, Elias PM, Cunningham JM, Jane SM. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science. 2005 Apr 15; 308(5720):411-3. PMID: 15831758.
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      41. Ting SB, Caddy J, Wilanowski T, Auden A, Cunningham JM, Elias PM, Holleran WM, Jane SM. The epidermis of grhl3-null mice displays altered lipid processing and cellular hyperproliferation. Organogenesis. 2005 Apr; 2(2):33-5. PMID: 19521564; PMCID: PMC2634083.
      42. Uchida Y, Itoh M, Taguchi Y, Yamaoka S, Umehara H, Ichikawa S, Hirabayashi Y, Holleran WM, Okazaki T. Ceramide reduction and transcriptional up-regulation of glucosylceramide synthase through doxorubicin-activated Sp1 in drug-resistant HL-60/ADR cells. Cancer Res. 2004 Sep 1; 64(17):6271-9. PMID: 15342415.
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      43. Hara-Chikuma M, Takeda J, Tarutani M, Uchida Y, Holleran WM, Endo Y, Elias PM, Inoue S. Epidermal-specific defect of GPI anchor in Pig-a null mice results in Harlequin ichthyosis-like features. J Invest Dermatol. 2004 Sep; 123(3):464-9. PMID: 15304084.
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      44. Behne MJ, Barry NP, Hanson KM, Aronchik I, Clegg RW, Gratton E, Feingold K, Holleran WM, Elias PM, Mauro TM. Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. J Invest Dermatol. 2003 Jun; 120(6):998-1006. PMID: 12787127.
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      45. Uchida Y, Nardo AD, Collins V, Elias PM, Holleran WM. De novo ceramide synthesis participates in the ultraviolet B irradiation-induced apoptosis in undifferentiated cultured human keratinocytes. J Invest Dermatol. 2003 Apr; 120(4):662-9. PMID: 12648232.
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      46. Elias PM, Tsai J, Menon GK, Holleran WM, Feingold KR. The potential of metabolic interventions to enhance transdermal drug delivery. J Investig Dermatol Symp Proc. 2002 Dec; 7(1):79-85. PMID: 12518797.
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      47. Bejaoui K, Uchida Y, Yasuda S, Ho M, Nishijima M, Brown RH, Holleran WM, Hanada K. Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis. J Clin Invest. 2002 Nov; 110(9):1301-8. PMID: 12417569; PMCID: PMC151618.
      48. Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM. NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J Biol Chem. 2002 Dec 6; 277(49):47399-406. PMID: 12221084.
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      49. Uchida Y, Murata S, Schmuth M, Behne MJ, Lee JD, Ichikawa S, Elias PM, Hirabayashi Y, Holleran WM. Glucosylceramide synthesis and synthase expression protect against ceramide-induced stress. J Lipid Res. 2002 Aug; 43(8):1293-302. PMID: 12177173.
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      50. Elias PM, Schmuth M, Uchida Y, Rice RH, Behne M, Crumrine D, Feingold KR, Holleran WM, Pharm D. Basis for the permeability barrier abnormality in lamellar ichthyosis. Exp Dermatol. 2002 Jun; 11(3):248-56. PMID: 12102664.
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      51. Uchida Y, Behne M, Quiec D, Elias PM, Holleran WM. Vitamin C stimulates sphingolipid production and markers of barrier formation in submerged human keratinocyte cultures. J Invest Dermatol. 2001 Nov; 117(5):1307-13. PMID: 11710949.
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      52. Memon RA, Holleran WM, Uchida Y, Moser AH, Grunfeld C, Feingold KR. Regulation of sphingolipid and glycosphingolipid metabolism in extrahepatic tissues by endotoxin. J Lipid Res. 2001 Mar; 42(3):452-9. PMID: 11254758.
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      53. Uchida Y, Hara M, Nishio H, Sidransky E, Inoue S, Otsuka F, Suzuki A, Elias PM, Holleran WM, Hamanaka S. Epidermal sphingomyelins are precursors for selected stratum corneum ceramides. J Lipid Res. 2000 Dec; 41(12):2071-82. PMID: 11108741.
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      54. Elias PM, Fartasch M, Crumrine D, Behne M, Uchida Y, Holleran WM. Origin of the corneocyte lipid envelope (CLE): observations in harlequin ichthyosis and cultured human keratinocytes. J Invest Dermatol. 2000 Oct; 115(4):765-9. PMID: 10998161.
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      55. Schmuth M, Man MQ, Weber F, Gao W, Feingold KR, Fritsch P, Elias PM, Holleran WM. Permeability barrier disorder in Niemann-Pick disease: sphingomyelin-ceramide processing required for normal barrier homeostasis. J Invest Dermatol. 2000 Sep; 115(3):459-66. PMID: 10951284.
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      56. Memon RA, Staprans I, Noor M, Holleran WM, Uchida Y, Moser AH, Feingold KR, Grunfeld C. Infection and inflammation induce LDL oxidation in vivo. Arterioscler Thromb Vasc Biol. 2000 Jun; 20(6):1536-42. PMID: 10845869.
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      57. Behne M, Uchida Y, Seki T, de Montellano PO, Elias PM, Holleran WM. Omega-hydroxyceramides are required for corneocyte lipid envelope (CLE) formation and normal epidermal permeability barrier function. J Invest Dermatol. 2000 Jan; 114(1):185-92. PMID: 10620136.
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      58. Memon RA, Holleran WM, Uchida Y, Moser AH, Ichikawa S, Hirabayashi Y, Grunfeld C, Feingold KR. Regulation of glycosphingolipid metabolism in liver during the acute phase response. J Biol Chem. 1999 Jul 9; 274(28):19707-13. PMID: 10391911.
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      59. Takagi Y, Kriehuber E, Imokawa G, Elias PM, Holleran WM. Beta-glucocerebrosidase activity in mammalian stratum corneum. J Lipid Res. 1999 May; 40(5):861-9. PMID: 10224155.
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      60. Doering T, Holleran WM, Potratz A, Vielhaber G, Elias PM, Suzuki K, Sandhoff K. Sphingolipid activator proteins are required for epidermal permeability barrier formation. J Biol Chem. 1999 Apr 16; 274(16):11038-45. PMID: 10196186.
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      61. Farrell AM, Uchida Y, Nagiec MM, Harris IR, Dickson RC, Elias PM, Holleran WM. UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes. J Lipid Res. 1998 Oct; 39(10):2031-8. PMID: 9788249.
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      62. Memon RA, Holleran WM, Moser AH, Seki T, Uchida Y, Fuller J, Shigenaga JK, Grunfeld C, Feingold KR. Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin. Arterioscler Thromb Vasc Biol. 1998 Aug; 18(8):1257-65. PMID: 9714132.
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      63. Reissner K, Tayebi N, Stubblefield BK, Koprivica V, Blitzer M, Holleran W, Cowan T, Almashanu S, Maddalena A, Karson EM, Sidransky E. Type 2 Gaucher disease with hydrops fetalis in an Ashkenazi Jewish family resulting from a novel recombinant allele and a rare splice junction mutation in the glucocerebrosidase locus. Mol Genet Metab. 1998 Apr; 63(4):281-8. PMID: 9635296.
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      64. Marchell NL, Uchida Y, Brown BE, Elias PM, Holleran WM. Glucosylceramides stimulate mitogenesis in aged murine epidermis. J Invest Dermatol. 1998 Apr; 110(4):383-7. PMID: 9540979.
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      65. Mauro T, Holleran WM, Grayson S, Gao WN, Man MQ, Kriehuber E, Behne M, Feingold KR, Elias PM. Barrier recovery is impeded at neutral pH, independent of ionic effects: implications for extracellular lipid processing. Arch Dermatol Res. 1998 Apr; 290(4):215-22. PMID: 9617442.
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      66. Chujor CS, Feingold KR, Elias PM, Holleran WM. Glucosylceramide synthase activity in murine epidermis: quantitation, localization, regulation, and requirement for barrier homeostasis. J Lipid Res. 1998 Feb; 39(2):277-85. PMID: 9507988.
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      67. Harris IR, Farrell AM, Holleran WM, Jackson S, Grunfeld C, Elias PM, Feingold KR. Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis. J Lipid Res. 1998 Feb; 39(2):412-22. PMID: 9508001.
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      68. Harris IR, Farrell AM, Grunfeld C, Holleran WM, Elias PM, Feingold KR. Permeability barrier disruption coordinately regulates mRNA levels for key enzymes of cholesterol, fatty acid, and ceramide synthesis in the epidermis. J Invest Dermatol. 1997 Dec; 109(6):783-7. PMID: 9406821.
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      69. Holleran WM, Uchida Y, Halkier-Sorensen L, Haratake A, Hara M, Epstein JH, Elias PM. Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function. Photodermatol Photoimmunol Photomed. 1997 Aug; 13(4):117-28. PMID: 9453079.
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      70. Haratake A, Uchida Y, Schmuth M, Tanno O, Yasuda R, Epstein JH, Elias PM, Holleran WM. UVB-induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response. J Invest Dermatol. 1997 May; 108(5):769-75. PMID: 9129231.
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      71. Hanley K, Jiang Y, Holleran WM, Elias PM, Williams ML, Feingold KR. Glucosylceramide metabolism is regulated during normal and hormonally stimulated epidermal barrier development in the rat. J Lipid Res. 1997 Mar; 38(3):576-84. PMID: 9101438.
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      72. Haratake A, Uchida Y, Mimura K, Elias PM, Holleran WM. Intrinsically aged epidermis displays diminished UVB-induced alterations in barrier function associated with decreased proliferation. J Invest Dermatol. 1997 Mar; 108(3):319-23. PMID: 9036932.
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      73. Holleran WM, Galardy RE, Gao WN, Levy D, Tang PC, Elias PM. Matrix metalloproteinase inhibitors reduce phorbol ester-induced cutaneous inflammation and hyperplasia. Arch Dermatol Res. 1997 Feb; 289(3):138-44. PMID: 9128761.
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      74. Sidransky E, Fartasch M, Lee RE, Metlay LA, Abella S, Zimran A, Gao W, Elias PM, Ginns EI, Holleran WM. Epidermal abnormalities may distinguish type 2 from type 1 and type 3 of Gaucher disease. Pediatr Res. 1996 Jan; 39(1):134-41. PMID: 8825398.
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      75. Marsh NL, Elias PM, Holleran WM. Glucosylceramides stimulate murine epidermal hyperproliferation. J Clin Invest. 1995 Jun; 95(6):2903-9. PMID: 7769132; PMCID: PMC295978.
      76. Holleran WM, Gao WN, Feingold KR, Elias PM. Localization of epidermal sphingolipid synthesis and serine palmitoyl transferase activity: alterations imposed by permeability barrier requirements. Arch Dermatol Res. 1995; 287(3-4):254-8. PMID: 7598529.
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      77. Pillai S, Gilliam L, Conrad HE, Holleran WM. Heparin and its non-anticoagulant analogues inhibit human keratinocyte growth without inducing differentiation. J Invest Dermatol. 1994 Nov; 103(5):647-50. PMID: 7963649.
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      78. Holleran WM, Takagi Y, Menon GK, Jackson SM, Lee JM, Feingold KR, Elias PM. Permeability barrier requirements regulate epidermal beta-glucocerebrosidase. J Lipid Res. 1994 May; 35(5):905-12. PMID: 8071612.
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      79. Holleran WM, Ginns EI, Menon GK, Grundmann JU, Fartasch M, McKinney CE, Elias PM, Sidransky E. Consequences of beta-glucocerebrosidase deficiency in epidermis. Ultrastructure and permeability barrier alterations in Gaucher disease. J Clin Invest. 1994 Apr; 93(4):1756-64. PMID: 8163674; PMCID: PMC294236.
      80. Proksch E, Holleran WM, Menon GK, Elias PM, Feingold KR. Barrier function regulates epidermal lipid and DNA synthesis. Br J Dermatol. 1993 May; 128(5):473-82. PMID: 8504036.
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      81. Holleran WM, Takagi Y, Menon GK, Legler G, Feingold KR, Elias PM. Processing of epidermal glucosylceramides is required for optimal mammalian cutaneous permeability barrier function. J Clin Invest. 1993 Apr; 91(4):1656-64. PMID: 8473508; PMCID: PMC288144.
      82. Holleran WM, Takagi Y, Imokawa G, Jackson S, Lee JM, Elias PM. beta-Glucocerebrosidase activity in murine epidermis: characterization and localization in relation to differentiation. J Lipid Res. 1992 Aug; 33(8):1201-9. PMID: 1431599.
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      83. Holleran WM, Man MQ, Gao WN, Menon GK, Elias PM, Feingold KR. Sphingolipids are required for mammalian epidermal barrier function. Inhibition of sphingolipid synthesis delays barrier recovery after acute perturbation. J Clin Invest. 1991 Oct; 88(4):1338-45. PMID: 1918384; PMCID: PMC295604.
      84. Holleran WM, Feingold KR, Man MQ, Gao WN, Lee JM, Elias PM. Regulation of epidermal sphingolipid synthesis by permeability barrier function. J Lipid Res. 1991 Jul; 32(7):1151-8. PMID: 1940639.
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      85. Holleran WM. Lipid modulators of epidermal proliferation and differentiation. Adv Lipid Res. 1991; 24:119-39. PMID: 1763711.
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      86. Holleran WM, Williams ML, Gao WN, Elias PM. Serine-palmitoyl transferase activity in cultured human keratinocytes. J Lipid Res. 1990 Sep; 31(9):1655-61. PMID: 2246616.
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      87. DeGregorio MW, Wiebe VJ, Venook AP, Holleran WM. Elevated plasma tamoxifen levels in a patient with liver obstruction. Cancer Chemother Pharmacol. 1989; 23(3):194-5. PMID: 2924377.
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      88. DeGregorio MW, Gandara DR, Holleran WM, Perez EA, King CC, Wold HG, Montine TJ, Borch RF. High-dose cisplatin with diethyldithiocarbamate (DDTC) rescue therapy: preliminary pharmacologic observations. Cancer Chemother Pharmacol. 1989; 23(5):276-8. PMID: 2539912.
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      89. Maghsoodnia M, Holleran WM, DeGregorio MW. Estrogen priming in advanced breast cancer. Drug Intell Clin Pharm. 1988 Sep; 22(9):672-5. PMID: 3063478.
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      90. Holleran WM, DeGregorio MW. Evolution of high-dose cisplatin. Invest New Drugs. 1988 Jun; 6(2):135-42. PMID: 3049431.
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      91. Holleran WM, DeGregorio MW, Ganapathi R, Wilbur JR, Macher BA. Characterization of cellular lipids in doxorubicin-sensitive and -resistant P388 mouse leukemia cells. Cancer Chemother Pharmacol. 1986; 17(1):11-5. PMID: 3698172.
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      92. DeGregorio MW, Lum BL, Holleran WM, Wilbur BJ, Sikic BI. Preliminary observations of intraperitoneal carboplatin pharmacokinetics during a phase I study of the Northern California Oncology Group. Cancer Chemother Pharmacol. 1986; 18(3):235-8. PMID: 3542268.
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      93. DeGregorio MW, King OY, Holleran WM, Wilbur BJ, Cadman EC, Deisseroth AB, Wilbur JR. Ultrafiltrate and total platinum in plasma and cerebrospinal fluid in a patient with neuroblastoma. Cancer Treat Rep. 1985 Dec; 69(12):1441-2. PMID: 4075318.
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      94. Holleran WM, Wilbur JR, DeGregorio MW. Empiric amphotericin B therapy in patients with acute leukemia. Rev Infect Dis. 1985 Sep-Oct; 7(5):619-24. PMID: 3903941.
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      95. Benz C, DeGregorio M, Saks S, Sambol N, Holleran W, Ignoffo R, Lewis B, Cadman E. Sequential infusions of methotrexate and 5-fluorouracil in advanced cancer: pharmacology, toxicity, and response. Cancer Res. 1985 Jul; 45(7):3354-8. PMID: 4005858.
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      96. DeGregorio MW, Holleran WM, Macher BA, Linker CA, Wilbur JR. Kinetics and sensitivity of daunorubicin in patients with acute leukemia. Cancer Chemother Pharmacol. 1984; 13(3):230-4. PMID: 6488444.
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      97. Lewis MI, Holleran WM. Ectopic thyroid gland in children. Am J Surg. 1968 May; 115(5):688-90. PMID: 5645668.
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      98. SCHMUTZER KJ, HOLLERAN WM, REGAN JF. TUMORS OF THE SMALL BOWEL. Am J Surg. 1964 Aug; 108:270-6. PMID: 14195223.
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      99. POWSNER LG, HOLLERAN WM, ROSS DE. A critical review of 900 cases of gastroduodenal surgery. Am J Gastroenterol. 1960 Feb; 33:163-77. PMID: 14434591.
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