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    Wan Zhu, PhD

    TitlePostdoctoral Scholar
    SchoolUCSF School of Medicine
    Address1001 Potrero Ave
    San Francisco CA 94110
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      Collapse Biography 
      Collapse Education and Training
      University of PittsburghPhD in human geneticsSchool of Public Health2011
      Stanford UniversityPostdoc trainingSchool of Medicine2014
      Collapse Awards and Honors
      Cure HHT foundation 2015 - 2016Young Scholar Research Grant
      Children's Hospital of Pittsburgh, UPMC2008 - 2010Research Administration Committee (RAC) graduate student fellowship
      University of Pittsburgh2011Graduate Student travel award

      Collapse Overview 
      Collapse Overview
      Strong molecular biology and cell biology background in studying transcriptional regulation in cellular systems and disease models.

      Current focus is to design and test AAV mediated gene therapy in mouse models for the treatment of brain arteriovenous malformation.

      Collapse Interests
      AAV mediated gene therapy, brain arteriovenous malformation, CRISPR genome editing, transcriptional regulation, aging and neurodegenerative diseases

      Collapse ORNG Applications 
      Collapse Featured Publications

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Zou D, Luo M, Han Z, Zhan L, Zhu W, Kang S, Bao C, Li Z, Nelson J, Zhang R, Su H. Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture. Mol Neurobiol. 2016 Dec 02. PMID: 27914011.
        View in: PubMed
      2. Swaminathan G, Zhu W, Plowey ED. BECN1/Beclin 1 sorts cell-surface APP/amyloid beta precursor protein for lysosomal degradation. Autophagy. 2016 Oct 7; 0. PMID: 27715386.
        View in: PubMed
      3. Zhang R, Han Z, Degos V, Shen F, Choi EJ, Sun Z, Kang S, Wong M, Zhu W, Zhan L, Arthur HM, Oh SP, Faughnan ME, Su H, et al. Persistent infiltration and pro-inflammatory differentiation of monocytes cause unresolved inflammation in brain arteriovenous malformation. Angiogenesis. 2016 Jun 20. PMID: 27325285.
        View in: PubMed
      4. Wang L, Kang S, Zou D, Zhan L, Li Z, Zhu W, Su H. Bone Fracture Pre-Ischemic Stroke Exacerbates Ischemic Cerebral Injury in Mice. PLoS One. 2016; 11(4):e0153835. PMID: 27089041.
        View in: PubMed
      5. Zhang R, Zhu W, Su H. Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation. Acta Neurochir Suppl. 2016; 121:29-35. PMID: 26463919; PMCID: PMC4654926 [Available on 01/01/16].
      6. Ziskin JL, Greicius MD, Zhu W, Okumu AN, Adams CM, Plowey ED. Neuropathologic analysis of Tyr69His TTR variant meningovascular amyloidosis with dementia. Acta Neuropathol Commun. 2015; 3:43. PMID: 26156087; PMCID: PMC4496870.
      7. Shen F, Mao L, Zhu W, Lawton MT, Pechan P, Colosi P, Wu Z, Scaria A, Su H. Inhibition of pathological brain angiogenesis through systemic delivery of AAV vector expressing soluble FLT1. Gene Ther. 2015 Nov; 22(11):893-900. PMID: 26090874; PMCID: PMC4636448 [Available on 05/01/16].
      8. Zhu W, Swaminathan G, Plowey ED. GA binding protein augments autophagy via transcriptional activation of BECN1-PIK3C3 complex genes. Autophagy. 2014 Sep; 10(9):1622-36. PMID: 25046113; PMCID: PMC4206539.
      9. Plowey ED, Johnson JW, Steer E, Zhu W, Eisenberg DA, Valentino NM, Liu YJ, Chu CT. Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration. Biochim Biophys Acta. 2014 Sep; 1842(9):1596-603. PMID: 24874075; PMCID: PMC4144018.
      10. Henson BJ, Zhu W, Hardaway K, Wetzel JL, Stefan M, Albers KM, Nicholls RD. Transcriptional and post-transcriptional regulation of SPAST, the gene most frequently mutated in hereditary spastic paraplegia. PLoS One. 2012; 7(5):e36505. PMID: 22574173; PMCID: PMC3344893.
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