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    Warren Gasper, MD

    TitleAssistant Professor
    SchoolUCSF School of Medicine
    Address400 Parnassus Ave, UC Clinics
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      University of California, San FranciscoVascular Surgeyr FellowshipSchool of Medicine2013
      University of California, San FranciscoGeneral Surgery ResidencySchool of Medicine2010
      Univeristy of Maryland, BaltimoreM.D.School of Medicine2003

      Collapse Overview 
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      My current research interests fall broadly into the categories of vein / vein graft physiology and advanced endovascular aneurysm therapies. Over the past 4 years I have been working with Dr Michael Conte and Dr Christopher Owens in the UCSF Division of Vascular and Endovascular Surgery on several projects involving vein graft physiology, which have lead to several presentations at national meetings as well as publications. We have found that after lower extremity bypass surgery most luminal dilation occurs early (30 days) and is typically complete by 3 months. However, the response is not uniform and it appears that a mixture of local factors (e.g. vein diameter and quality), biologic factors (e.g. preoperative hsCRP levels) and systemic factors (e.g. race, indication for bypass surgery) are involved in the remodeling response.
      My second major area of research interest is advanced endovascular therapies for aortic aneurysms. The development and widespread adoption of endovascular stent-grafts for infrarenal aortic aneurysms and thoracic aortic aneurysms have dramatically reduced the physiologic demands, complication rates and length of hospitalization for patients undergoing infrarenal or thoracic aortic aneurysm repairs compared to open techniques. However, aneurysms of thoracoabdominal, paravisceral and/or pararenal aorta require even more demanding operations with a higher rate of complications and longer hospitalizations. For the past 4 years I have worked with Dr. Timothy Chuter and Dr. Linda Reilly in the UCSF Division of Vascular and Endovascular Surgery to develop the multi-branched endovascular thoracoabdominal aneurysm repair technique. The technique is being studied under an FDA IDE in a CHR-approved study at UCSF and the San Francisco VA. As the co-principal investigator, I am responsible for overseeing the regulatory and subject care activities for the study at the San Francisco VA. This work has included consultations in the outpatient clinic, planning and performing the multi-branched endovascular repairs and analyzing the results of the study.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Causey MW, Ahmed A, Wu B, Gasper WJ, Reyzelman A, Vartanian SM, Hiramoto JS, Conte MS. Society for Vascular Surgery limb stage and patient risk correlate with outcomes in an amputation prevention program. J Vasc Surg. 2016 Jun; 63(6):1563-1573.e2. PMID: 27036309.
        View in: PubMed
      2. Grenon SM, Owens CD, Alley H, Perez S, Whooley MA, Neylan TC, Aschbacher K, Gasper WJ, Hilton JF, Cohen BE. Posttraumatic Stress Disorder Is Associated With Worse Endothelial Function Among Veterans. J Am Heart Assoc. 2016; 5(3). PMID: 27009621.
        View in: PubMed
      3. Ramanan B, Fernandez CC, Sobel JD, Gasper WJ, Vartanian SM, Reilly LM, Chuter TA, Hiramoto JS. Low-profile versus standard-profile multibranched thoracoabdominal aortic stent grafts. J Vasc Surg. 2016 Jul; 64(1):39-45. PMID: 26994953.
        View in: PubMed
      4. Fernandez CC, Sobel JD, Gasper WJ, Vartanian SM, Reilly LM, Chuter TA, Hiramoto JS. Standard off-the-shelf versus custom-made multibranched thoracoabdominal aortic stent grafts. J Vasc Surg. 2016 May; 63(5):1208-15. PMID: 26817612.
        View in: PubMed
      5. Zhu C, Haraldsson H, Faraji F, Owens C, Gasper W, Ahn S, Liu J, Laub G, Hope MD, Saloner D. Isotropic 3D black blood MRI of abdominal aortic aneurysm wall and intraluminal thrombus. Magn Reson Imaging. 2016 Jan; 34(1):18-25. PMID: 26471514.
        View in: PubMed
      6. Hope MD, Gasper WJ, Rapp J, Owens CD, Haraldsson H, Saloner D. Vascular inflammation in a growing iliac artery aneurysm. Clin Nucl Med. 2015 Jun; 40(6):e323-4. PMID: 25674872.
        View in: PubMed
      7. Han SM, Gasper WJ, Chuter TA. Endovascular rescue after inadvertent false lumen stent graft implantation. J Vasc Surg. 2016 Feb; 63(2):518-22. PMID: 25595403.
        View in: PubMed
      8. Sobel JD, Vartanian SM, Gasper WJ, Hiramoto JS, Chuter TA, Reilly LM. Lower extremity weakness after endovascular aneurysm repair with multibranched thoracoabdominal stent grafts. J Vasc Surg. 2015 Mar; 61(3):623-8. PMID: 25457458.
        View in: PubMed
      9. Alley H, Owens CD, Gasper WJ, Grenon SM. Ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery in clinical research. J Vis Exp. 2014; (92):e52070. PMID: 25406739; PMCID: PMC4353419.
      10. Chong KC, Owens CD, Park M, Alley HF, Boscardin WJ, Conte MS, Gasper WJ, Grenon SM. Relationship between kidney disease and endothelial function in peripheral artery disease. J Vasc Surg. 2014 Dec; 60(6):1605-11. PMID: 25441679; PMCID: PMC4254442 [Available on 12/01/15].
      11. Walker JP, Nosova E, Sigovan M, Rapp J, Grenon MS, Owens CD, Gasper WJ, Saloner DA. Ferumoxytol-enhanced magnetic resonance angiography is a feasible method for the clinical evaluation of lower extremity arterial disease. Ann Vasc Surg. 2015 Jan; 29(1):63-8. PMID: 25269682.
        View in: PubMed
      12. Walker JP, Hiramoto JS, Gasper WJ, Auyang P, Conte MS, Rapp JH, Lovett DH, Owens CD. Vitamin D deficiency is associated with mortality and adverse vascular access outcomes in patients with end-stage renal disease. J Vasc Surg. 2014 Jul; 60(1):176-83. PMID: 24582700; PMCID: PMC4074433.
      13. Owens CD, Gasper WJ, Walker JP, Alley HF, Conte MS, Grenon SM. Safety and feasibility of adjunctive dexamethasone infusion into the adventitia of the femoropopliteal artery following endovascular revascularization. J Vasc Surg. 2014 Apr; 59(4):1016-24. PMID: 24423476; PMCID: PMC4391811.
      14. Grenon SM, Chong K, Alley H, Nosova E, Gasper W, Hiramoto J, Boscardin WJ, Owens CD. Walking disability in patients with peripheral artery disease is associated with arterial endothelial function. J Vasc Surg. 2014 Apr; 59(4):1025-34. PMID: 24423479; PMCID: PMC3966931.
      15. Gasper WJ, Jimenez CA, Walker J, Conte MS, Seward K, Owens CD. Adventitial nab-rapamycin injection reduces porcine femoral artery luminal stenosis induced by balloon angioplasty via inhibition of medial proliferation and adventitial inflammation. Circ Cardiovasc Interv. 2013 Dec; 6(6):701-9. PMID: 24221390; PMCID: PMC3888086.
      16. Owens CD, Gasper WJ, Rahman AS, Conte MS. Vein graft failure. J Vasc Surg. 2015 Jan; 61(1):203-16. PMID: 24095042; PMCID: PMC4391818 [Available on 01/01/16].
      17. Gasper WJ, Reilly LM, Rapp JH, Grenon SM, Hiramoto JS, Sobel JD, Chuter TA. Assessing the anatomic applicability of the multibranched endovascular repair of thoracoabdominal aortic aneurysm technique. J Vasc Surg. 2013 Jun; 57(6):1553-8; discussion 1558. PMID: 23395201.
        View in: PubMed
      18. Conte MS, Owens CD, Belkin M, Creager MA, Edwards KL, Gasper WJ, Kenagy RD, LeBoeuf RC, Sobel M, Clowes A. A single nucleotide polymorphism in the p27(Kip1) gene is associated with primary patency of lower extremity vein bypass grafts. J Vasc Surg. 2013 May; 57(5):1179-85.e1-2. PMID: 23312942; PMCID: PMC3644510.
      19. Sigovan M, Rayz V, Gasper W, Alley HF, Owens CD, Saloner D. Vascular remodeling in autogenous arterio-venous fistulas by MRI and CFD. Ann Biomed Eng. 2013 Apr; 41(4):657-68. PMID: 23188560; PMCID: PMC3606670.
      20. Gasper WJ, Owens CD, Kim JM, Hills N, Belkin M, Creager MA, Conte MS. Thirty-day vein remodeling is predictive of midterm graft patency after lower extremity bypass. J Vasc Surg. 2013 Jan; 57(1):9-18. PMID: 22960020; PMCID: PMC3529790.
      21. Sigovan M, Gasper W, Alley HF, Owens CD, Saloner D. USPIO-enhanced MR angiography of arteriovenous fistulas in patients with renal failure. Radiology. 2012 Nov; 265(2):584-90. PMID: 22875796; PMCID: PMC3480811.
      22. Owens CD, Kim JM, Hevelone ND, Gasper WJ, Belkin M, Creager MA, Conte MS. An integrated biochemical prediction model of all-cause mortality in patients undergoing lower extremity bypass surgery for advanced peripheral artery disease. J Vasc Surg. 2012 Sep; 56(3):686-95. PMID: 22554422; PMCID: PMC3413780.
      23. Gasper WJ, Runge SJ, Owens CD. Management of infrapopliteal peripheral arterial occlusive disease. Curr Treat Options Cardiovasc Med. 2012 Apr; 14(2):136-48. PMID: 22249766.
        View in: PubMed
      24. Dubin R, Owens C, Gasper W, Ganz P, Johansen K. Associations of endothelial dysfunction and arterial stiffness with intradialytic hypotension and hypertension. Hemodial Int. 2011 Jul; 15(3):350-8. PMID: 21658174; PMCID: PMC3143472.
      25. Owens CD, Gasper WJ, Conte MS. Assessing drug elution technologies in the superficial femoral artery. Panminerva Med. 2011 Mar; 53(1):37-49. PMID: 21346703.
        View in: PubMed
      26. Roll GR, Ma S, Gasper WJ, Patti M, Way LW, Carter J. Excellent outcomes of laparoscopic esophagomyotomy for achalasia in patients older than 60 years of age. Surg Endosc. 2010 Oct; 24(10):2562-6. PMID: 20361213; PMCID: PMC2945469.
      27. Gasper WJ, Glidden DV, Jin C, Way LW, Patti MG. Has recognition of the relationship between mortality rates and hospital volume for major cancer surgery in California made a difference?: A follow-up analysis of another decade. Ann Surg. 2009 Sep; 250(3):472-83. PMID: 19730178.
        View in: PubMed
      28. Patti MG, Gasper WJ, Fisichella PM, Nipomnick I, Palazzo F. Gastroesophageal reflux disease and connective tissue disorders: pathophysiology and implications for treatment. J Gastrointest Surg. 2008 Nov; 12(11):1900-6. PMID: 18766408.
        View in: PubMed
      29. Jancelewicz T, Vu LT, Shawo AE, Yeh B, Gasper WJ, Harris HW. Predicting strangulated small bowel obstruction: an old problem revisited. J Gastrointest Surg. 2009 Jan; 13(1):93-9. PMID: 18685902.
        View in: PubMed
      30. Imhof I, Gasper WJ, Derynck R. Association of tetraspanin CD9 with transmembrane TGF{alpha} confers alterations in cell-surface presentation of TGF{alpha} and cytoskeletal organization. J Cell Sci. 2008 Jul 1; 121(Pt 13):2265-74. PMID: 18544636.
        View in: PubMed
      31. Gasper WJ, Sweet MP, Golden JA, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Patti MG. Lung transplantation in patients with connective tissue disorders and esophageal dysmotility. Dis Esophagus. 2008; 21(7):650-5. PMID: 18459990.
        View in: PubMed
      32. Gasper WJ, Jamshidi R, Theodore PR. Palliation of thoracic malignancies. Surg Oncol. 2007 Dec; 16(4):259-65. PMID: 17904357.
        View in: PubMed
      33. Sweet MP, Nipomnick I, Gasper WJ, Bagatelos K, Ostroff JW, Fisichella PM, Way LW, Patti MG. The outcome of laparoscopic Heller myotomy for achalasia is not influenced by the degree of esophageal dilatation. J Gastrointest Surg. 2008 Jan; 12(1):159-65. PMID: 17710504.
        View in: PubMed
      34. Gasper WJ, Sweet MP, Hoopes C, Leard LE, Kleinhenz ME, Hays SR, Golden JA, Patti MG. Antireflux surgery for patients with end-stage lung disease before and after lung transplantation. Surg Endosc. 2008 Feb; 22(2):495-500. PMID: 17704875.
        View in: PubMed
      35. Zhang L, Gasper WJ, Stass SA, Ioffe OB, Davis MA, Mixson AJ. Angiogenic inhibition mediated by a DNAzyme that targets vascular endothelial growth factor receptor 2. Cancer Res. 2002 Oct 1; 62(19):5463-9. PMID: 12359754.
        View in: PubMed
      36. Chen QR, Zhang L, Gasper W, Mixson AJ. Targeting tumor angiogenesis with gene therapy. Mol Genet Metab. 2001 Sep-Oct; 74(1-2):120-7. PMID: 11592809.
        View in: PubMed
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