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Wilian Cortopassi Coelho, PhD

TitlePostdoctoral Scholar
SchoolUCSF School of Pharmacy
DepartmentPharmaceutical Chemistry
Address1700 4th St
San Francisco CA 94158
EmailWilian.CortopassiCoelho@ucsf.edu
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    Collapse Biography 
    Collapse Education and Training
    Oxford UniversityDPhilChemistry
    Pontifical Catholic University of Rio de janeiroBScChemistry
    Collapse Awards and Honors
    Merck kGaA2017Runner up prize in the Biopharma Innovation Cup 2017
    Fundacao Estudar2017One of the characters of the book "Cultura de Excelencia" (Culture of Excellence), by David Cohen
    SciFinder2016Future Leaders in Chemistry
    Chemical Information Division of the American Chemical Society2016Scholarship for Scientific Excellence
    Royal Society of Chemistry2016Travel Grant Scholarship
    UK’s National Service for Computational Chemistry Software (NSCCS) 2015Poster prize
    German Chemical Society2015Travel Grant Scholarship
    2013One of the characters of the documentary "Romance de Formacao", by Julia de Simone
    PUC Rio2011Bronze medal at the Challenges in Chemistry Competition
    Annual Meeting of the Brazilian Chemical Society2011Poster prize
    Regional meeting of the Brazilian Chemical Society - Rio de Janeiro2011Poster prize
    Fundação Estudar2010Scholarship for Youth Leadership
    Brazilian Chemistry Olympiad2006Honorable mention

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pliotas C, Grayer SC, Ekkerman S, Chan AK, Healy J, Marius P, Bartlett W, Khan A, Cortopassi WA, Chandler SA, Rasmussen T, Benesch JL, Paton RS, Claridge TDW, Miller S, Booth IR, Naismith JH, Conway SJ. AMP binding stabilizes the KTN domain of the Shewanella denitrificans Kef potassium efflux system. Biochemistry. 2017 Jun 28. PMID: 28656748.
      View in: PubMed
    2. Lin WK, Bolton EL, Cortopassi WA, Wang Y, O'Brien F, Maciejewska M, Jacobson MP, Garnham C, Ruas M, Parrington J, Lei M, Sitsapesan R, Galione A, Terrar DA. Synthesis of the Ca(2+)-mobilizing messengers, NAADP and cADPR, by intracellular CD38 enzyme in mouse heart: role in β-adrenoceptor signaling. J Biol Chem. 2017 May 24. PMID: 28539361.
      View in: PubMed
    3. Cortopassi WA, Kumar K, Paton RS. Cation-Ï€ interactions in CREBBP bromodomain inhibition: an electrostatic model for small-molecule binding affinity and selectivity. Org Biomol Chem. 2016 Nov 22; 14(46):10926-10938. PMID: 27814427.
      View in: PubMed
    4. Cortopassi WA, Kumar K, Duarte F, Pimentel AS, Paton RS. Mechanisms of histone lysine-modifying enzymes: A computational perspective on the role of the protein environment. J Mol Graph Model. 2016 Jun; 67:69-84. PMID: 27258188.
      View in: PubMed
    5. Brand M, Measures AR, Wilson BG, Cortopassi WA, Alexander R, Höss M, Hewings DS, Rooney TP, Paton RS, Conway SJ. Correction to Small Molecule Inhibitors of Bromodomain-Acetyl-lysine Interactions. ACS Chem Biol. 2016 Apr 15; 11(4):1148. PMID: 26756254.
      View in: PubMed
    6. Cortopassi WA, Simion R, Honsby CE, França TC, Paton RS. Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment. Chemistry. 2015 Dec 21; 21(52):18869. PMID: 26663343.
      View in: PubMed
    7. Cortopassi WA, Simion R, Honsby CE, França TC, Paton RS. Dioxygen Binding in the Active Site of Histone Demethylase JMJD2A and the Role of the Protein Environment. Chemistry. 2015 Dec 21; 21(52):18983-92. PMID: 26577067.
      View in: PubMed
    8. Brand M, Measures AR, Measures AM, Wilson BG, Cortopassi WA, Alexander R, Höss M, Hewings DS, Rooney TP, Paton RS, Conway SJ. Small molecule inhibitors of bromodomain-acetyl-lysine interactions. ACS Chem Biol. 2015 Jan 16; 10(1):22-39. PMID: 25549280.
      View in: PubMed
    9. Rooney TP, Filippakopoulos P, Fedorov O, Picaud S, Cortopassi WA, Hay DA, Martin S, Tumber A, Rogers CM, Philpott M, Wang M, Thompson AL, Heightman TD, Pryde DC, Cook A, Paton RS, Müller S, Knapp S, Brennan PE, Conway SJ. A series of potent CREBBP bromodomain ligands reveals an induced-fit pocket stabilized by a cation-π interaction. Angew Chem Int Ed Engl. 2014 Jun 10; 53(24):6126-30. PMID: 24821300; PMCID: PMC4298791.
    10. Cortopassi WA, Penna-Coutinho J, Aguiar AC, Pimentel AS, Buarque CD, Costa PR, Alves BR, França TC, Krettli AU. Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum. PLoS One. 2014; 9(3):e91191. PMID: 24651068; PMCID: PMC3961230.
    11. Aguiar AC, Santos Rde M, Figueiredo FJ, Cortopassi WA, Pimentel AS, França TC, Meneghetti MR, Krettli AU. Antimalarial activity and mechanisms of action of two novel 4-aminoquinolines against chloroquine-resistant parasites. PLoS One. 2012; 7(5):e37259. PMID: 22649514; PMCID: PMC3359361.
    12. Cortopassi WA, Oliveira AA, Guimarães AP, Rennó MN, Krettli AU, França TC. Docking studies on the binding of quinoline derivatives and hematin to Plasmodium falciparum lactate dehydrogenase. J Biomol Struct Dyn. 2011 Aug; 29(1):207-18. PMID: 21696234.
      View in: PubMed
    13. Penna-Coutinho J, Cortopassi WA, Oliveira AA, França TC, Krettli AU. Antimalarial activity of potential inhibitors of Plasmodium falciparum lactate dehydrogenase enzyme selected by docking studies. PLoS One. 2011; 6(7):e21237. PMID: 21779323; PMCID: PMC3136448.
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