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    William Seaman, MD

    TitleProfessor
    SchoolUCSF School of Medicine
    DepartmentMedicine
    Address500 Parnassus Avenue
    San Francisco CA 94117
    Phone415-514-0732
    vCardDownload vCard
      Other Positions
      TitleAssociate Chair of Medicine for Research, Research Director, American Asthma Foundation


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5. PMID: 25995219.
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      2. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. PMID: 23630120; PMCID: PMC4210355.
      3. Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS One. 2011; 6(8):e23800. PMID: 21886823; PMCID: PMC3158792.
      4. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. J Biol Chem. 2011 Jan 14; 286(2):942-51. PMID: 21036901; PMCID: PMC3020779.
      5. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. J Leukoc Biol. 2010 Jun; 87(6):1041-57. PMID: 20200401; PMCID: PMC2872536.
      6. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3505-10. PMID: 20133674; PMCID: PMC2840523.
      7. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56. PMID: 19302484; PMCID: PMC3087597.
      8. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23. PMID: 19171755; PMCID: PMC2654305.
      9. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR. Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem. 2008 Dec; 107(6):1495-505. PMID: 19014383.
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      10. Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem. 2008 Jun 20; 283(25):17351-61. PMID: 18411281; PMCID: PMC2427365.
      11. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47. PMID: 18391000; PMCID: PMC2423085.
      12. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13759-64. PMID: 16945906; PMCID: PMC1557799.
      13. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006 Aug 15; 177(4):2051-5. PMID: 16887962.
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      14. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb; 21(2):237-45. PMID: 16418779.
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      15. Seaman WE. Clinical academic rheumatology: comment on the article by Wickersham et al. Arthritis Rheum. 2005 Oct 15; 53(5):800; author reply 800-1. PMID: 16208663.
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      16. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 3; 202(7):955-65. PMID: 16203866; PMCID: PMC2213179.
      17. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004 Dec 15; 173(12):7141-9. PMID: 15585835.
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      18. Chen TT, Brown EJ, Huang EJ, Seaman WE. Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res. 2004 Jan 1; 64(1):117-27. PMID: 14729615.
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      19. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15; 171(12):6541-8. PMID: 14662855.
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      20. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. J Immunol. 2003 Jul 15; 171(2):594-9. PMID: 12847223.
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      21. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
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      22. Chung DH, Seaman WE, Daws MR. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur J Immunol. 2002 Jan; 32(1):59-66. PMID: 11754004.
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      23. Nakamura MC, Seaman WE. Ligand interactions by activating and inhibitory Ly-49 receptors. Immunol Rev. 2001 Jun; 181:138-48. PMID: 11513135.
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      24. Daws MR, Lanier LL, Seaman WE, Ryan JC. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol. 2001 Mar; 31(3):783-91. PMID: 11241283.
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      25. Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE. Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d). J Exp Med. 2000 Aug 7; 192(3):447-54. PMID: 10934233; PMCID: PMC2193226.
      26. Seaman WE. Natural killer cells and natural killer T cells. Arthritis Rheum. 2000 Jun; 43(6):1204-17. PMID: 10857779.
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      27. Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. J Immunol. 1999 Nov 1; 163(9):4694-700. PMID: 10528166.
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      28. Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. J Exp Med. 1999 Feb 1; 189(3):493-500. PMID: 9927511; PMCID: PMC2192910.
      29. McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem. 1998 Dec 4; 273(49):32934-42. PMID: 9830044.
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      30. Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. J Immunol. 1998 Jun 15; 160(12):5971-8. PMID: 9637511.
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      31. Rolstad B, Seaman WE. Natural killer cells and recognition of MHC class I molecules: new perspectives and challenges in immunology. Scand J Immunol. 1998 May; 47(5):412-25. PMID: 9627124.
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      32. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med. 1997 Feb 17; 185(4):673-84. PMID: 9034146; PMCID: PMC2196152.
      33. Ryan JC, Seaman WE. Divergent functions of lectin-like receptors on NK cells. Immunol Rev. 1997 Feb; 155:79-89. PMID: 9059884.
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      34. Dissen E, Ryan JC, Seaman WE, Fossum S. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. J Exp Med. 1996 May 1; 183(5):2197-207. PMID: 8642329; PMCID: PMC2192580.
      35. Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E. Recognition and signaling by mouse Ly-49 receptors. Chem Immunol. 1996; 64:19-27. PMID: 8942069.
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      36. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 1995 May 1; 181(5):1911-5. PMID: 7722466; PMCID: PMC2191987.
      37. Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR. A family of murine NK cell receptors specific for target cell MHC class I molecules. Semin Immunol. 1995 Apr; 7(2):89-101. PMID: 7579199.
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      38. Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. Immunity. 1994 Dec; 1(9):785-92. PMID: 7895167.
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      39. Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. J Exp Med. 1994 Aug 1; 180(2):687-92. PMID: 8046342; PMCID: PMC2191615.
      40. Yokoyama WM, Seaman WE. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu Rev Immunol. 1993; 11:613-35. PMID: 8476574.
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      41. Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman WE. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. J Immunol. 1992 Sep 1; 149(5):1631-5. PMID: 1506685.
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      42. Bell GM, Seaman WE, Niemi EC, Imboden JB. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J Exp Med. 1992 Feb 1; 175(2):527-36. PMID: 1346273; PMCID: PMC2119111.
      43. Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 1; 147(9):3229-36. PMID: 1680927.
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      44. Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman WE. NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium. J Immunol. 1991 Nov 1; 147(9):3244-50. PMID: 1919012.
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      45. Goldfien RD, Seaman WE, Hempel WM, Imboden JB. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. J Immunol. 1991 Jun 1; 146(11):3703-8. PMID: 2033247.
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      46. Imboden JB, Bell G, Seaman WE. Characterization of signal-transducing molecules on natural killer cells. Biochem Soc Trans. 1991 Apr; 19(2):265-8. PMID: 1679728.
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      47. Seaman WE, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden JB. Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling. J Exp Med. 1991 Jan 1; 173(1):251-60. PMID: 1845873; PMCID: PMC2118766.
      48. Imboden JB, Eriksson EC, McCutcheon M, Reynolds CW, Seaman WE. Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells. J Immunol. 1989 Nov 1; 143(9):3100-3. PMID: 2809220.
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      49. Carteron NL, Wofsy D, Seaman WE. Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells. J Immunol. 1988 Feb 1; 140(3):713-6. PMID: 2448372.
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      50. Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman WE, Baud L, Koo CH. Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes. Ann N Y Acad Sci. 1988; 524:345-55. PMID: 2837968.
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      51. Seaman WE, Wofsy D. Selective manipulation of the immune response in vivo by monoclonal antibodies. Annu Rev Med. 1988; 39:231-41. PMID: 3285774.
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      52. Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE. Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. Arthritis Rheum. 1987 Sep; 30(9):1040-5. PMID: 3311051.
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      53. Harper SE, Roubinian JR, Seaman WE. Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction. J Exp Med. 1987 Sep 1; 166(3):657-67. PMID: 2957456; PMCID: PMC2188701.
      54. Seaman WE, Sleisenger M, Eriksson E, Koo GC. Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity. J Immunol. 1987 Jun 15; 138(12):4539-44. PMID: 3584981.
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      55. Seaman WE, Eriksson E, Dobrow R, Imboden JB. Inositol trisphosphate is generated by a rat natural killer cell tumor in response to target cells or to crosslinked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cells. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4239-43. PMID: 3495804; PMCID: PMC305060.
      56. Wofsy D, Seaman WE. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J Immunol. 1987 May 15; 138(10):3247-53. PMID: 3106478.
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      57. Woodcock J, Wofsy D, Eriksson E, Scott JH, Seaman WE. Rejection of skin grafts and generation of cytotoxic T cells by mice depleted of L3T4+ cells. Transplantation. 1986 Dec; 42(6):636-42. PMID: 2947360.
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      58. Gutstein NL, Seaman WE, Scott JH, Wofsy D. Induction of immune tolerance by administration of monoclonal antibody to L3T4. J Immunol. 1986 Aug 15; 137(4):1127-32. PMID: 3090139.
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      59. Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W. Cocaine increases natural killer cell activity. J Clin Invest. 1986 Apr; 77(4):1387-90. PMID: 2937807; PMCID: PMC424504.
      60. Wofsy D, Seaman WE. Analysis of the function of L3T4+ T cells by in vivo treatment with monoclonal antibody to L3T4. Immunol Res. 1986; 5(2):97-105. PMID: 3093610.
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      61. Wofsy D, Mayes DC, Woodcock J, Seaman WE. Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice. J Immunol. 1985 Sep; 135(3):1698-701. PMID: 3160776.
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      62. Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE. Human synovial dendritic cells. Direct observation of transition to fibroblasts. J Rheumatol. 1985 Aug; 12(4):660-4. PMID: 3863955.
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      63. Wofsy D, Ledbetter JA, Hendler PL, Seaman WE. Treatment of murine lupus with monoclonal anti-T cell antibody. J Immunol. 1985 Feb; 134(2):852-7. PMID: 3871218.
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      64. Wofsy D, Seaman WE. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J Exp Med. 1985 Feb 1; 161(2):378-91. PMID: 3919141; PMCID: PMC2187572.
      65. Heyworth MF, Owen RL, Seaman WE, Schaefer FW, Jones AL. Harvesting of leukocytes from intestinal lumen in murine giardiasis and preliminary characterization of these cells. Dig Dis Sci. 1985 Feb; 30(2):149-53. PMID: 3881233.
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      66. Seaman WE, Woodcock J. Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid. J Allergy Clin Immunol. 1984 Sep; 74(3 Pt 2):407-11. PMID: 6432881.
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      67. Wofsy D, Hardy RR, Seaman WE. The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens. J Immunol. 1984 Jun; 132(6):2686-9. PMID: 6144707.
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      68. Wofsy D, Kerger CE, Seaman WE. Monocytosis in the BXSB model for systemic lupus erythematosus. J Exp Med. 1984 Feb 1; 159(2):629-34. PMID: 6363600; PMCID: PMC2187231.
      69. Seaman WE. Human natural killer cell activity is reversibly inhibited by antagonists of lipoxygenation. J Immunol. 1983 Dec; 131(6):2953-7. PMID: 6417236.
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      70. Miyasaka N, Seaman W, Bakshi A, Sauvezie B, Strand V, Pope R, Talal N. Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. Arthritis Rheum. 1983 Aug; 26(8):954-60. PMID: 6882489.
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      71. Seaman WE, Wofsy D, Greenspan JS, Ledbetter JA. Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease. J Immunol. 1983 Apr; 130(4):1713-8. PMID: 6187819.
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      72. Wofsy D, Ledbetter JA, Roubinian JR, Seaman WE, Talal N. Thymic influences on autoimmunity in MRL-lpr mice. Scand J Immunol. 1982 Jul; 16(1):51-8. PMID: 6981841.
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      73. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen. J Clin Invest. 1982 Apr; 69(4):876-88. PMID: 7076851; PMCID: PMC370142.
      74. Ledbetter JA, Seaman WE. The Lyt-2, Lyt-3 macromolecules: structural and functional studies. Immunol Rev. 1982; 68:197-218. PMID: 6757107.
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      75. Loeb JM, Talal N, Abensohn-Lee M, Seaman WE. Suppression or enhancement of natural killing does not alter tolerance to bovine gamma globulin. J Clin Lab Immunol. 1981 Nov; 6(3):215-20. PMID: 6175754.
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      76. Seaman WE, Talal N, Herzenberg LA, Herzenberg LA, Ledbetter JA. Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity. J Immunol. 1981 Sep; 127(3):982-6. PMID: 6790624.
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      77. Seaman WE, Talal N. Natural killing by spleen cells from W/Wv and Sl/Sld anemic mice. Exp Hematol. 1981 Aug; 9(7):691-6. PMID: 7318972.
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      78. Ledbetter JA, Seaman WE, Tsu TT, Herzenberg LA. Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity. J Exp Med. 1981 Jun 1; 153(6):1503-16. PMID: 6166718; PMCID: PMC2186177.
      79. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters. J Clin Invest. 1981 May; 67(5):1324-33. PMID: 6939690; PMCID: PMC370699.
      80. Seaman WE, Blackman MA, Greenspan JS, Talal N. Effect of 89Sr on immunity and autoimmunity in NZB/NZW F1 mice. J Immunol. 1980 Feb; 124(2):812-8. PMID: 6985937.
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      81. Seaman WE, Merigan TC, Talal N. Natural killing in estrogen-treated mice responds poorly to poly I.C despite normal stimulation of circulating interferon. J Immunol. 1979 Dec; 123(6):2903-5. PMID: 227961.
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      82. Seaman WE, Gindhart TD. Effect of estrogen on natural killer cells. Arthritis Rheum. 1979 Nov; 22(11):1234-40. PMID: 389248.
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      83. Seaman WE, Gindhart TD, Greenspan JS, Blackman MA, Talal N. Natural killer cells, bone, and the bone marrow: studies in estrogen-treated mice and in congenitally osteopetrotic (mi/mi) mice. J Immunol. 1979 Jun; 122(6):2541-7. PMID: 376736.
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      84. Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N. beta-Estradiol reduces natural killer cells in mice. J Immunol. 1978 Dec; 121(6):2193-8. PMID: 722074.
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      85. Seaman WE. Hepatic injury due to acetaminophen or salicylates. West J Med. 1978 Aug; 129(2):136-7. PMID: 18748273.
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      86. Plotz P, Kimberly R, Gill JR, Seaman W. Letter: Effect of salicylates on creatinine clearance. Br Med J. 1976 Aug 14; 2(6032):421-2. PMID: 947455; PMCID: PMC1687554.
      87. Seaman WE, Plotz PH. Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers. Arthritis Rheum. 1976 Mar-Apr; 19(2):155-60. PMID: 1259798.
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      88. Decker JL, Steinberg AD, Gershwin ME, Seaman WE, Klippel JH, Plotz PH, Paget SA. Systemic lupus erythematosus. Contrasts and comparisons. Ann Intern Med. 1975 Mar; 82(3):391-404. PMID: 1115477.
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      89. Aptekar RG, Klippel JH, Becker KE, Carson DA, Seaman WE, Decker JL. Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus. Clin Orthop Relat Res. 1974 Jun; (101):127-8. PMID: 4837924.
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      90. Seaman WE, Plotz PH, Ishak KG. Proceedings: Aspirin-induced hepatotoxicity in patients with RA or systemic lupus erythematosus (SLE). Arthritis Rheum. 1974 May-Jun; 17(3):325. PMID: 4825655.
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      91. Seaman WE, Ishak KG, Plotz PH. Letter: Aspirin and hepatotoxicity: addendum. Ann Intern Med. 1974 Feb; 80(2):279. PMID: 4811807.
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      92. Seaman WE, Ishak KG, Plotz PH. Aspirin-induced hepatotoxicity in patients with systemic lupus erythematosus. Ann Intern Med. 1974 Jan; 80(1):1-8. PMID: 4810348.
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