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William Seaman, MD

TitleProfessor
SchoolUCSF School of Medicine
DepartmentMedicine
Address500 Parnassus Avenue
San Francisco CA 94117
Phone415-514-0732
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    Other Positions
    TitleAssociate Chair of Medicine for Research, Research Director, American Asthma Foundation
    InstitutionUCSF School of Medicine
    DepartmentMedicine


    Collapse Research 
    Collapse Research Activities and Funding
    Role of the Tim-2 Receptor in Immunity and Autoimmunity
    NIH/NIAID R01AI061164Jul 1, 2005 - Mar 31, 2010
    Role: Principal Investigator
    SHPS-1 As a Regulator of Innate Immunity in Arthritis
    NIH/NIAMS R21AR051751Sep 1, 2004 - Aug 31, 2006
    Role: Principal Investigator
    Biology of a New DAP12 Associated Receptor Family
    NIH/NCI R01CA087922May 1, 2001 - Mar 31, 2008
    Role: Principal Investigator
    Alliance for Cellular Signaling
    NIH U54GM062114Sep 1, 2000 - Aug 31, 2008
    Role: Co-Investigator
    TRANSMEMBRANE SIGNALING BY LY-49
    NIH/NCI R01CA069299Jul 1, 1996 - Jun 30, 2000
    Role: Principal Investigator
    TRANSMEMBRANE SIGNALING IN THE ACTIVATION OF NK CELLS
    NIH/NCI R01CA046812Feb 1, 1988 - Jan 31, 1997
    Role: Principal Investigator
    INTESTINAL IMMUNE RESPONSE: REGULATION AND MECHANISMS
    NIH P01AM033004Dec 1, 1983 - Nov 30, 1986
    Role: Co-Investigator
    OXIDATIVE REGULATION OF HUMAN NATURAL KILLER CELLS
    NIH/NCI R01CA034529Jun 1, 1983 - May 31, 1986
    Role: Principal Investigator
    MULTIPURPOSE ARTHRITIS AND MUSCULOSKELETAL DISEASES CTR
    NIH/NIAMS P60AR020684Sep 15, 1977 - Dec 31, 2003
    Role: Co-Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Seaman WE, Locksley RM, Welsh MJ. New blood: Creative funding of disease-specific research. Sci Transl Med. 2015 May 20; 7(288):288ed5. PMID: 25995219.
      View in: PubMed
    2. Hsieh CL, Kim CC, Ryba BE, Niemi EC, Bando JK, Locksley RM, Liu J, Nakamura MC, Seaman WE. Traumatic brain injury induces macrophage subsets in the brain. Eur J Immunol. 2013 Aug; 43(8):2010-22. PMID: 23630120; PMCID: PMC4210355.
    3. Han J, Seaman WE, Di X, Wang W, Willingham M, Torti FM, Torti SV. Iron uptake mediated by binding of H-ferritin to the TIM-2 receptor in mouse cells. PLoS One. 2011; 6(8):e23800. PMID: 21886823; PMCID: PMC3158792.
    4. Rebres RA, Roach TI, Fraser ID, Philip F, Moon C, Lin KM, Liu J, Santat L, Cheadle L, Ross EM, Simon MI, Seaman WE. Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q. J Biol Chem. 2011 Jan 14; 286(2):942-51. PMID: 21036901; PMCID: PMC3020779.
    5. Rebres RA, Moon C, Decamp D, Lin KM, Fraser ID, Milne SB, Roach TI, Brown HA, Seaman WE. Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2. J Leukoc Biol. 2010 Jun; 87(6):1041-57. PMID: 20200401; PMCID: PMC2872536.
    6. Li L, Fang CJ, Ryan JC, Niemi EC, Lebrón JA, Björkman PJ, Arase H, Torti FM, Torti SV, Nakamura MC, Seaman WE. Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A. 2010 Feb 23; 107(8):3505-10. PMID: 20133674; PMCID: PMC2840523.
    7. Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, Nakamura MC, Seaman WE. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J Neurochem. 2009 May; 109(4):1144-56. PMID: 19302484; PMCID: PMC3087597.
    8. N'Diaye EN, Branda CS, Branda SS, Nevarez L, Colonna M, Lowell C, Hamerman JA, Seaman WE. TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria. J Cell Biol. 2009 Jan 26; 184(2):215-23. PMID: 19171755; PMCID: PMC2654305.
    9. Todorich B, Zhang X, Slagle-Webb B, Seaman WE, Connor JR. Tim-2 is the receptor for H-ferritin on oligodendrocytes. J Neurochem. 2008 Dec; 107(6):1495-505. PMID: 19014383.
      View in: PubMed
    10. Roach TI, Rebres RA, Fraser ID, Decamp DL, Lin KM, Sternweis PC, Simon MI, Seaman WE. Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium. J Biol Chem. 2008 Jun 20; 283(25):17351-61. PMID: 18411281; PMCID: PMC2427365.
    11. Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD. The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12. Infect Immun. 2008 Jun; 76(6):2439-47. PMID: 18391000; PMCID: PMC2423085.
    12. Shin KJ, Wall EA, Zavzavadjian JR, Santat LA, Liu J, Hwang JI, Rebres R, Roach T, Seaman W, Simon MI, Fraser ID. A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13759-64. PMID: 16945906; PMCID: PMC1557799.
    13. Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12. J Immunol. 2006 Aug 15; 177(4):2051-5. PMID: 16887962.
      View in: PubMed
    14. Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J Bone Miner Res. 2006 Feb; 21(2):237-45. PMID: 16418779.
      View in: PubMed
    15. Seaman WE. Clinical academic rheumatology: comment on the article by Wickersham et al. Arthritis Rheum. 2005 Oct 15; 53(5):800; author reply 800-1. PMID: 16208663.
      View in: PubMed
    16. Chen TT, Li L, Chung DH, Allen CD, Torti SV, Torti FM, Cyster JG, Chen CY, Brodsky FM, Niemi EC, Nakamura MC, Seaman WE, Daws MR. TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med. 2005 Oct 03; 202(7):955-65. PMID: 16203866; PMCID: PMC2213179.
    17. Zhu X, Hart R, Chang MS, Kim JW, Lee SY, Cao YA, Mock D, Ke E, Saunders B, Alexander A, Grossoehme J, Lin KM, Yan Z, Hsueh R, Lee J, Scheuermann RH, Fruman DA, Seaman W, Subramaniam S, Sternweis P, Simon MI, Choi S. Analysis of the major patterns of B cell gene expression changes in response to short-term stimulation with 33 single ligands. J Immunol. 2004 Dec 15; 173(12):7141-9. PMID: 15585835.
      View in: PubMed
    18. Chen TT, Brown EJ, Huang EJ, Seaman WE. Expression and activation of signal regulatory protein alpha on astrocytomas. Cancer Res. 2004 Jan 01; 64(1):117-27. PMID: 14729615.
      View in: PubMed
    19. Chung DH, Humphrey MB, Nakamura MC, Ginzinger DG, Seaman WE, Daws MR. CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation. J Immunol. 2003 Dec 15; 171(12):6541-8. PMID: 14662855.
      View in: PubMed
    20. Daws MR, Sullam PM, Niemi EC, Chen TT, Tchao NK, Seaman WE. Pattern recognition by TREM-2: binding of anionic ligands. J Immunol. 2003 Jul 15; 171(2):594-9. PMID: 12847223.
      View in: PubMed
    21. Gilman AG, Simon MI, Bourne HR, Harris BA, Long R, Ross EM, Stull JT, Taussig R, Bourne HR, Arkin AP, Cobb MH, Cyster JG, Devreotes PN, Ferrell JE, Fruman D, Gold M, Weiss A, Stull JT, Berridge MJ, Cantley LC, Catterall WA, Coughlin SR, Olson EN, Smith TF, Brugge JS, Botstein D, Dixon JE, Hunter T, Lefkowitz RJ, Pawson AJ, Sternberg PW, Varmus H, Subramaniam S, Sinkovits RS, Li J, Mock D, Ning Y, Saunders B, Sternweis PC, Hilgemann D, Scheuermann RH, DeCamp D, Hsueh R, Lin KM, Ni Y, Seaman WE, Simpson PC, O'Connell TD, Roach T, Simon MI, Choi S, Eversole-Cire P, Fraser I, Mumby MC, Zhao Y, Brekken D, Shu H, Meyer T, Chandy G, Heo WD, Liou J, O'Rourke N, Verghese M, Mumby SM, Han H, Brown HA, Forrester JS, Ivanova P, Milne SB, Casey PJ, Harden TK, Arkin AP, Doyle J, Gray ML, Meyer T, Michnick S, Schmidt MA, Toner M, Tsien RY, Natarajan M, Ranganathan R, Sambrano GR. Overview of the Alliance for Cellular Signaling. Nature. 2002 Dec 12; 420(6916):703-6. PMID: 12478301.
      View in: PubMed
    22. Chung DH, Seaman WE, Daws MR. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur J Immunol. 2002 Jan; 32(1):59-66. PMID: 11754004.
      View in: PubMed
    23. Nakamura MC, Seaman WE. Ligand interactions by activating and inhibitory Ly-49 receptors. Immunol Rev. 2001 Jun; 181:138-48. PMID: 11513135.
      View in: PubMed
    24. Daws MR, Lanier LL, Seaman WE, Ryan JC. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur J Immunol. 2001 Mar; 31(3):783-91. PMID: 11241283.
      View in: PubMed
    25. Nakamura MC, Hayashi S, Niemi EC, Ryan JC, Seaman WE. Activating Ly-49D and inhibitory Ly-49A natural killer cell receptors demonstrate distinct requirements for interaction with H2-D(d). J Exp Med. 2000 Aug 07; 192(3):447-54. PMID: 10934233; PMCID: PMC2193226.
    26. Seaman WE. Natural killer cells and natural killer T cells. Arthritis Rheum. 2000 Jun; 43(6):1204-17. PMID: 10857779.
      View in: PubMed
    27. Nakamura MC, Naper C, Niemi EC, Spusta SC, Rolstad B, Butcher GW, Seaman WE, Ryan JC. Natural killing of xenogeneic cells mediated by the mouse Ly-49D receptor. J Immunol. 1999 Nov 01; 163(9):4694-700. PMID: 10528166.
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    28. Nakamura MC, Linnemeyer PA, Niemi EC, Mason LH, Ortaldo JR, Ryan JC, Seaman WE. Mouse Ly-49D recognizes H-2Dd and activates natural killer cell cytotoxicity. J Exp Med. 1999 Feb 01; 189(3):493-500. PMID: 9927511; PMCID: PMC2192910.
    29. McVicar DW, Taylor LS, Gosselin P, Willette-Brown J, Mikhael AI, Geahlen RL, Nakamura MC, Linnemeyer P, Seaman WE, Anderson SK, Ortaldo JR, Mason LH. DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem. 1998 Dec 04; 273(49):32934-42. PMID: 9830044.
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    30. Sundbäck J, Nakamura MC, Waldenström M, Niemi EC, Seaman WE, Ryan JC, Kärre K. The alpha2 domain of H-2Dd restricts the allelic specificity of the murine NK cell inhibitory receptor Ly-49A. J Immunol. 1998 Jun 15; 160(12):5971-8. PMID: 9637511.
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    31. Rolstad B, Seaman WE. Natural killer cells and recognition of MHC class I molecules: new perspectives and challenges in immunology. Scand J Immunol. 1998 May; 47(5):412-25. PMID: 9627124.
      View in: PubMed
    32. Nakamura MC, Niemi EC, Fisher MJ, Shultz LD, Seaman WE, Ryan JC. Mouse Ly-49A interrupts early signaling events in natural killer cell cytotoxicity and functionally associates with the SHP-1 tyrosine phosphatase. J Exp Med. 1997 Feb 17; 185(4):673-84. PMID: 9034146; PMCID: PMC2196152.
    33. Ryan JC, Seaman WE. Divergent functions of lectin-like receptors on NK cells. Immunol Rev. 1997 Feb; 155:79-89. PMID: 9059884.
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    34. Dissen E, Ryan JC, Seaman WE, Fossum S. An autosomal dominant locus, Nka, mapping to the Ly-49 region of a rat natural killer (NK) gene complex, controls NK cell lysis of allogeneic lymphocytes. J Exp Med. 1996 May 01; 183(5):2197-207. PMID: 8642329; PMCID: PMC2192580.
    35. Seaman WE, Daniels B, Ryan J, Nakamura M, Niemi E. Recognition and signaling by mouse Ly-49 receptors. Chem Immunol. 1996; 64:19-27. PMID: 8942069.
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    36. Ryan JC, Niemi EC, Nakamura MC, Seaman WE. NKR-P1A is a target-specific receptor that activates natural killer cell cytotoxicity. J Exp Med. 1995 May 01; 181(5):1911-5. PMID: 7722466; PMCID: PMC2191987.
    37. Yokoyama WM, Daniels BF, Seaman WE, Hunziker R, Margulies DH, Smith HR. A family of murine NK cell receptors specific for target cell MHC class I molecules. Semin Immunol. 1995 Apr; 7(2):89-101. PMID: 7579199.
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    38. Daniels BF, Nakamura MC, Rosen SD, Yokoyama WM, Seaman WE. Ly-49A, a receptor for H-2Dd, has a functional carbohydrate recognition domain. Immunity. 1994 Dec; 1(9):785-92. PMID: 7895167.
      View in: PubMed
    39. Daniels BF, Karlhofer FM, Seaman WE, Yokoyama WM. A natural killer cell receptor specific for a major histocompatibility complex class I molecule. J Exp Med. 1994 Aug 01; 180(2):687-92. PMID: 8046342; PMCID: PMC2191615.
    40. Yokoyama WM, Seaman WE. The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu Rev Immunol. 1993; 11:613-35. PMID: 8476574.
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    41. Ryan JC, Turck J, Niemi EC, Yokoyama WM, Seaman W. Molecular cloning of the NK1.1 antigen, a member of the NKR-P1 family of natural killer cell activation molecules. J Immunol. 1992 Sep 01; 149(5):1631-5. PMID: 1506685.
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    42. Bell GM, Seaman W, Niemi EC, Imboden JB. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. J Exp Med. 1992 Feb 01; 175(2):527-36. PMID: 1346273; PMCID: PMC2119111.
    43. Yokoyama WM, Ryan JC, Hunter JJ, Smith HR, Stark M, Seaman WE. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 01; 147(9):3229-36. PMID: 1680927.
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    44. Ryan JC, Niemi EC, Goldfien RD, Hiserodt JC, Seaman W. NKR-P1, an activating molecule on rat natural killer cells, stimulates phosphoinositide turnover and a rise in intracellular calcium. J Immunol. 1991 Nov 01; 147(9):3244-50. PMID: 1919012.
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    45. Goldfien RD, Seaman WE, Hempel WM, Imboden JB. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. J Immunol. 1991 Jun 01; 146(11):3703-8. PMID: 2033247.
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    46. Imboden JB, Bell G, Seaman W. Characterization of signal-transducing molecules on natural killer cells. Biochem Soc Trans. 1991 Apr; 19(2):265-8. PMID: 1679728.
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    47. Seaman W, Niemi EC, Stark MR, Goldfien RD, Pollock AS, Imboden JB. Molecular cloning of gp42, a cell-surface molecule that is selectively induced on rat natural killer cells by interleukin 2: glycolipid membrane anchoring and capacity for transmembrane signaling. J Exp Med. 1991 Jan 01; 173(1):251-60. PMID: 1845873; PMCID: PMC2118766.
    48. Imboden JB, Eriksson EC, McCutcheon M, Reynolds CW, Seaman W. Identification and characterization of a cell-surface molecule that is selectively induced on rat lymphokine-activated killer cells. J Immunol. 1989 Nov 01; 143(9):3100-3. PMID: 2809220.
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    49. Carteron NL, Wofsy D, Seaman W. Induction of immune tolerance during administration of monoclonal antibody to L3T4 does not depend on depletion of L3T4+ cells. J Immunol. 1988 Feb 01; 140(3):713-6. PMID: 2448372.
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    50. Goetzl EJ, Sherman JW, Ratnoff WD, Harvey JP, Eriksson E, Seaman W, Baud L, Koo CH. Receptor-specific mechanisms for the responses of human leukocytes to leukotrienes. Ann N Y Acad Sci. 1988; 524:345-55. PMID: 2837968.
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    51. Seaman WE, Wofsy D. Selective manipulation of the immune response in vivo by monoclonal antibodies. Annu Rev Med. 1988; 39:231-41. PMID: 3285774.
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    52. Petri M, Dobrow R, Neiman R, Whiting-O'Keefe Q, Seaman WE. Randomized, double-blind, placebo-controlled study of the treatment of the painful shoulder. Arthritis Rheum. 1987 Sep; 30(9):1040-5. PMID: 3311051.
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    53. Harper SE, Roubinian JR, Seaman W. Regulation of autoimmunity and donor cell engraftment by recipient Lyt-2+ cells during the graft-versus-host reaction. J Exp Med. 1987 Sep 01; 166(3):657-67. PMID: 2957456; PMCID: PMC2188701.
    54. Seaman WE, Sleisenger M, Eriksson E, Koo GC. Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity. J Immunol. 1987 Jun 15; 138(12):4539-44. PMID: 3584981.
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    55. Seaman WE, Eriksson E, Dobrow R, Imboden JB. Inositol trisphosphate is generated by a rat natural killer cell tumor in response to target cells or to crosslinked monoclonal antibody OX-34: possible signaling role for the OX-34 determinant during activation by target cells. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4239-43. PMID: 3495804; PMCID: PMC305060.
    56. Wofsy D, Seaman W. Reversal of advanced murine lupus in NZB/NZW F1 mice by treatment with monoclonal antibody to L3T4. J Immunol. 1987 May 15; 138(10):3247-53. PMID: 3106478.
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    57. Woodcock J, Wofsy D, Eriksson E, Scott JH, Seaman W. Rejection of skin grafts and generation of cytotoxic T cells by mice depleted of L3T4+ cells. Transplantation. 1986 Dec; 42(6):636-42. PMID: 2947360.
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    58. Gutstein NL, Seaman W, Scott JH, Wofsy D. Induction of immune tolerance by administration of monoclonal antibody to L3T4. J Immunol. 1986 Aug 15; 137(4):1127-32. PMID: 3090139.
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    59. Van Dyke C, Stesin A, Jones R, Chuntharapai A, Seaman W. Cocaine increases natural killer cell activity. J Clin Invest. 1986 Apr; 77(4):1387-90. PMID: 2937807; PMCID: PMC424504.
    60. Wofsy D, Seaman W. Analysis of the function of L3T4+ T cells by in vivo treatment with monoclonal antibody to L3T4. Immunol Res. 1986; 5(2):97-105. PMID: 3093610.
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    61. Wofsy D, Mayes DC, Woodcock J, Seaman W. Inhibition of humoral immunity in vivo by monoclonal antibody to L3T4: studies with soluble antigens in intact mice. J Immunol. 1985 Sep; 135(3):1698-701. PMID: 3160776.
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    62. Hendler PL, Lavoie PE, Werb Z, Chan J, Seaman WE. Human synovial dendritic cells. Direct observation of transition to fibroblasts. J Rheumatol. 1985 Aug; 12(4):660-4. PMID: 3863955.
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    63. Wofsy D, Ledbetter JA, Hendler PL, Seaman WE. Treatment of murine lupus with monoclonal anti-T cell antibody. J Immunol. 1985 Feb; 134(2):852-7. PMID: 3871218.
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    64. Wofsy D, Seaman WE. Successful treatment of autoimmunity in NZB/NZW F1 mice with monoclonal antibody to L3T4. J Exp Med. 1985 Feb 01; 161(2):378-91. PMID: 3919141; PMCID: PMC2187572.
    65. Heyworth MF, Owen RL, Seaman WE, Schaefer FW, Jones AL. Harvesting of leukocytes from intestinal lumen in murine giardiasis and preliminary characterization of these cells. Dig Dis Sci. 1985 Feb; 30(2):149-53. PMID: 3881233.
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    66. Seaman WE, Woodcock J. Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid. J Allergy Clin Immunol. 1984 Sep; 74(3 Pt 2):407-11. PMID: 6432881.
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    67. Wofsy D, Hardy RR, Seaman WE. The proliferating cells in autoimmune MRL/lpr mice lack L3T4, an antigen on "helper" T cells that is involved in the response to class II major histocompatibility antigens. J Immunol. 1984 Jun; 132(6):2686-9. PMID: 6144707.
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    68. Wofsy D, Kerger CE, Seaman WE. Monocytosis in the BXSB model for systemic lupus erythematosus. J Exp Med. 1984 Feb 01; 159(2):629-34. PMID: 6363600; PMCID: PMC2187231.
    69. Seaman WE. Human natural killer cell activity is reversibly inhibited by antagonists of lipoxygenation. J Immunol. 1983 Dec; 131(6):2953-7. PMID: 6417236.
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    70. Miyasaka N, Seaman W, Bakshi A, Sauvezie B, Strand V, Pope R, Talal N. Natural killing activity in Sjögren's syndrome. An analysis of defective mechanisms. Arthritis Rheum. 1983 Aug; 26(8):954-60. PMID: 6882489.
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    71. Seaman WE, Wofsy D, Greenspan JS, Ledbetter JA. Treatment of autoimmune MRL/Ipr mice with monoclonal antibody to Thy-1.2: a single injection has sustained effects on lymphoproliferation and renal disease. J Immunol. 1983 Apr; 130(4):1713-8. PMID: 6187819.
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    72. Wofsy D, Ledbetter JA, Roubinian JR, Seaman WE, Talal N. Thymic influences on autoimmunity in MRL-lpr mice. Scand J Immunol. 1982 Jul; 16(1):51-8. PMID: 6981841.
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    73. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Suppression of natural killing in vitro by monocytes and polymorphonuclear leukocytes: requirement for reactive metabolites of oxygen. J Clin Invest. 1982 Apr; 69(4):876-88. PMID: 7076851; PMCID: PMC370142.
    74. Ledbetter JA, Seaman WE. The Lyt-2, Lyt-3 macromolecules: structural and functional studies. Immunol Rev. 1982; 68:197-218. PMID: 6757107.
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    75. Loeb JM, Talal N, Abensohn-Lee M, Seaman WE. Suppression or enhancement of natural killing does not alter tolerance to bovine gamma globulin. J Clin Lab Immunol. 1981 Nov; 6(3):215-20. PMID: 6175754.
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    76. Seaman WE, Talal N, Herzenberg LA, Herzenberg LA, Ledbetter JA. Surface antigens on mouse natural killer cells: use of monoclonal antibodies to inhibit or to enrich cytotoxic activity. J Immunol. 1981 Sep; 127(3):982-6. PMID: 6790624.
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    77. Seaman WE, Talal N. Natural killing by spleen cells from W/Wv and Sl/Sld anemic mice. Exp Hematol. 1981 Aug; 9(7):691-6. PMID: 7318972.
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    78. Ledbetter JA, Seaman WE, Tsu TT, Herzenberg LA. Lyt-2 and lyt-3 antigens are on two different polypeptide subunits linked by disulfide bonds. Relationship of subunits to T cell cytolytic activity. J Exp Med. 1981 Jun 01; 153(6):1503-16. PMID: 6166718; PMCID: PMC2186177.
    79. Seaman WE, Gindhart TD, Blackman MA, Dalal B, Talal N, Werb Z. Natural killing of tumor cells by human peripheral blood cells. Suppression of killing in vitro by tumor-promoting phorbol diesters. J Clin Invest. 1981 May; 67(5):1324-33. PMID: 6939690; PMCID: PMC370699.
    80. Seaman WE, Blackman MA, Greenspan JS, Talal N. Effect of 89Sr on immunity and autoimmunity in NZB/NZW F1 mice. J Immunol. 1980 Feb; 124(2):812-8. PMID: 6985937.
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    81. Seaman W, Merigan TC, Talal N. Natural killing in estrogen-treated mice responds poorly to poly I.C despite normal stimulation of circulating interferon. J Immunol. 1979 Dec; 123(6):2903-5. PMID: 227961.
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    82. Seaman W, Gindhart TD. Effect of estrogen on natural killer cells. Arthritis Rheum. 1979 Nov; 22(11):1234-40. PMID: 389248.
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    83. Seaman W, Gindhart TD, Greenspan JS, Blackman MA, Talal N. Natural killer cells, bone, and the bone marrow: studies in estrogen-treated mice and in congenitally osteopetrotic (mi/mi) mice. J Immunol. 1979 Jun; 122(6):2541-7. PMID: 376736.
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    84. Seaman W, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N. beta-Estradiol reduces natural killer cells in mice. J Immunol. 1978 Dec; 121(6):2193-8. PMID: 722074.
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    85. Seaman WE. Hepatic injury due to acetaminophen or salicylates. West J Med. 1978 Aug; 129(2):136-7. PMID: 18748273.
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    86. Plotz P, Kimberly R, Gill JR, Seaman W. Letter: Effect of salicylates on creatinine clearance. Br Med J. 1976 Aug 14; 2(6032):421-2. PMID: 947455; PMCID: PMC1687554.
    87. Seaman WE, Plotz PH. Effect of aspirin on liver tests in patients with RA or SLE and in normal volunteers. Arthritis Rheum. 1976 Mar-Apr; 19(2):155-60. PMID: 1259798.
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    88. Decker JL, Steinberg AD, Gershwin ME, Seaman W, Klippel JH, Plotz PH, Paget SA. Systemic lupus erythematosus. Contrasts and comparisons. Ann Intern Med. 1975 Mar; 82(3):391-404. PMID: 1115477.
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    89. Aptekar RG, Klippel JH, Becker KE, Carson DA, Seaman WE, Decker JL. Avascular necrosis of the talus, scaphoid, and metatarsal head in systemic lupus erythematosus. Clin Orthop Relat Res. 1974 Jun; (101):127-8. PMID: 4837924.
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    90. Seaman WE, Plotz PH, Ishak KG. Proceedings: Aspirin-induced hepatotoxicity in patients with RA or systemic lupus erythematosus (SLE). Arthritis Rheum. 1974 May-Jun; 17(3):325. PMID: 4825655.
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