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    Woody Hopf, PhD

    TitleAssociate Professor
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94158
    Phone415-502-7391
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      Collapse Biography 
      Collapse Education and Training
      Cornell UniversityBANeurobiology1985
      University of California, BerkeleyPhDMolecular Biology1994
      University of California, Berkeley/Athena Postdoctoral FellowNeuroscience1996
      Stanford UniversityPostdoctoral FellowNeuroscience1998

      Collapse Overview 
      Collapse Overview
      Woody Hopf He is a widely recognized leader in the use of innovative methodologies, including the combination of optogenetics, in vitro electrophysiology and novel behavioral paradigms of pathological drinking, to uncover the molecular and circuit mechanisms that drive the excessive alcohol intake that make alcoholism so destructive. His main research goal is to identify specific molecular changes within particular brain areas that anchor binge-like and compulsive alcohol drinking, which will allow development of novel and potent pharmacological and behavioral interventions in human alcoholics. He presently focuses on frontal cortical areas (including the Insula) and downstream targets (nucleus accumbens, central amygdala), and how alcohol-related adaptations and other neuromodulators (dopamine, orexin, CRF) in these regions interact to drive pathological drinking. His work has been published in high impact factor journals such as Neuron, Nature Neuroscience, Journal of Neuroscience and Biological Psychiatry, and he has made major contributions to our understanding of molecular adaptations and brain circuits that promote pathological alcohol and cocaine intake, which could facilitate development of novel therapeutic interventions for the treatment of addiction.

      Collapse Interests
      Rodent models for compulsive alcohol intake. Continued seeking and drinking of alcohol despite adverse legal, health, economic, and societal consequences is a central hallmark of human alcohol use disorders. This compulsive drive for alcohol, defined by resistance to adverse and deleterious consequences, represents a major challenge when attempting to treat alcoholism clinically. Thus, there has long been interest in developing pre-clinical rodent models for the compulsive drug use that characterizes drug addiction. Here, we review recent studies that have attempted to model compulsive aspects of alcohol and cocaine intake in rodents, and consider technical and conceptual issues that need to be addressed when trying to recapitulate compulsive aspects of human addiction.

      Collapse ORNG Applications 
      Collapse Awarded Grants
      Collapse Global Health

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Seif T, Simms JA, Lei K, Wegner S, Bonci A, Messing RO, Hopf FW. D-Serine and D-Cycloserine Reduce Compulsive Alcohol Intake in Rats. Neuropsychopharmacology. 2015 Sep; 40(10):2357-67. PMID: 25801502; PMCID: PMC4538350 [Available on 09/01/16].
      2. Hopf FW, Lesscher HM. Rodent models for compulsive alcohol intake. Alcohol. 2014 May; 48(3):253-64. PMID: 24731992.
        View in: PubMed
      3. Chatterjee S, Santos N, Holgate J, Haass-Koffler CL, Hopf FW, Kharazia V, Lester H, Bonci A, Bartlett SE. The a5 subunit regulates the expression and function of a4*-containing neuronal nicotinic acetylcholine receptors in the ventral-tegmental area. PLoS One. 2013; 8(7):e68300. PMID: 23869214; PMCID: PMC3712017.
      4. Seif T, Chang SJ, Simms JA, Gibb SL, Dadgar J, Chen BT, Harvey BK, Ron D, Messing RO, Bonci A, Hopf FW. Cortical activation of accumbens hyperpolarization-active NMDARs mediates aversion-resistant alcohol intake. Nat Neurosci. 2013 Aug; 16(8):1094-100. PMID: 23817545; PMCID: PMC3939030.
      5. Sparta DR, Hopf FW, Gibb SL, Cho SL, Stuber GD, Messing RO, Ron D, Bonci A. Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area. Alcohol Clin Exp Res. 2013 Oct; 37(10):1680-7. PMID: 23763790; PMCID: PMC3985436.
      6. Hopf FW, Seif T, Chung S, Civelli O. MCH and apomorphine in combination enhance action potential firing of nucleus accumbens shell neurons in vitro. PeerJ. 2013; 1:e61. PMID: 23646281; PMCID: PMC3642701.
      7. Chen BT, Yau HJ, Hatch C, Kusumoto-Yoshida I, Cho SL, Hopf FW, Bonci A. Rescuing cocaine-induced prefrontal cortex hypoactivity prevents compulsive cocaine seeking. Nature. 2013 Apr 18; 496(7445):359-62. PMID: 23552889.
        View in: PubMed
      8. Srinivasan S, Simms JA, Nielsen CK, Lieske SP, Bito-Onon JJ, Yi H, Hopf FW, Bonci A, Bartlett SE. The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration. PLoS One. 2012; 7(9):e44726. PMID: 23028593; PMCID: PMC3448615.
      9. Anzalone A, Lizardi-Ortiz JE, Ramos M, De Mei C, Hopf FW, Iaccarino C, Halbout B, Jacobsen J, Kinoshita C, Welter M, Caron MG, Bonci A, Sulzer D, Borrelli E. Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. J Neurosci. 2012 Jun 27; 32(26):9023-34. PMID: 22745501; PMCID: PMC3752062.
      10. Addolorato G, Leggio L, Hopf FW, Diana M, Bonci A. Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation. Neuropsychopharmacology. 2012 Jan; 37(1):163-77. PMID: 22030714; PMCID: PMC3238087.
      11. Kotowski SJ, Hopf FW, Seif T, Bonci A, von Zastrow M. Endocytosis promotes rapid dopaminergic signaling. Neuron. 2011 Jul 28; 71(2):278-90. PMID: 21791287; PMCID: PMC3417347.
      12. Seif T, Makriyannis A, Kunos G, Bonci A, Hopf FW. The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing. Neuroscience. 2011 Oct 13; 193:21-33. PMID: 21821098; PMCID: PMC3579619.
      13. Hopf FW, Seif T, Bonci A. The SK channel as a novel target for treating alcohol use disorders. Channels (Austin). 2011 Jul-Aug; 5(4):289-92. PMID: 21712648.
        View in: PubMed
      14. Hopf FW, Sparta DR, Bonci A. Translational models of interactions between stress and alcohol consumption: strengths and limitations. ILAR J. 2011; 52(3):239-50. PMID: 23382142.
        View in: PubMed
      15. Hopf FW, Simms JA, Chang SJ, Seif T, Bartlett SE, Bonci A. Chlorzoxazone, an SK-type potassium channel activator used in humans, reduces excessive alcohol intake in rats. Biol Psychiatry. 2011 Apr 1; 69(7):618-24. PMID: 21195386; PMCID: PMC3062269.
      16. Hopf FW, Bonci A. Dnmt3a: addiction's molecular forget-me-not? Nat Neurosci. 2010 Sep; 13(9):1041-3. PMID: 20740031.
        View in: PubMed
      17. Kapfhamer D, Berger KH, Hopf FW, Seif T, Kharazia V, Bonci A, Heberlein U. Protein Phosphatase 2a and glycogen synthase kinase 3 signaling modulate prepulse inhibition of the acoustic startle response by altering cortical M-Type potassium channel activity. J Neurosci. 2010 Jun 30; 30(26):8830-40. PMID: 20592205; PMCID: PMC3842471.
      18. Hopf FW, Chang SJ, Sparta DR, Bowers MS, Bonci A. Motivation for alcohol becomes resistant to quinine adulteration after 3 to 4 months of intermittent alcohol self-administration. Alcohol Clin Exp Res. 2010 Sep 1; 34(9):1565-73. PMID: 20586757; PMCID: PMC2997761.
      19. Hopf FW, Seif T, Mohamedi ML, Chen BT, Bonci A. The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. Eur J Neurosci. 2010 Jun; 31(11):1946-59. PMID: 20497469; PMCID: PMC3077989.
      20. Hopf FW, Bowers MS, Chang SJ, Chen BT, Martin M, Seif T, Cho SL, Tye K, Bonci A. Reduced nucleus accumbens SK channel activity enhances alcohol seeking during abstinence. Neuron. 2010 Mar 11; 65(5):682-94. PMID: 20223203; PMCID: PMC2847608.
      21. Chen BT, Hopf FW, Bonci A. Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. Ann N Y Acad Sci. 2010 Feb; 1187:129-39. PMID: 20201850; PMCID: PMC2886008.
      22. Stuber GD, Hopf FW, Tye KM, Chen BT, Bonci A. Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. Curr Top Behav Neurosci. 2010; 3:3-27. PMID: 21161748.
        View in: PubMed
      23. Abdallah L, Bonasera SJ, Hopf FW, O'Dell L, Giorgetti M, Jongsma M, Carra S, Pierucci M, Di Giovanni G, Esposito E, Parsons LH, Bonci A, Tecott LH. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function. J Neurosci. 2009 Jun 24; 29(25):8156-65. PMID: 19553455; PMCID: PMC3077993.
      24. Hahn J, Hopf FW, Bonci A. Chronic cocaine enhances corticotropin-releasing factor-dependent potentiation of excitatory transmission in ventral tegmental area dopamine neurons. J Neurosci. 2009 May 20; 29(20):6535-44. PMID: 19458224; PMCID: PMC3077990.
      25. Mulholland PJ, Hopf FW, Bukiya AN, Martin GE, Liu J, Dopico AM, Bonci A, Treistman SN, Chandler LJ. Sizing up ethanol-induced plasticity: the role of small and large conductance calcium-activated potassium channels. Alcohol Clin Exp Res. 2009 Jul; 33(7):1125-35. PMID: 19389201; PMCID: PMC2760381.
      26. Chung S, Hopf FW, Nagasaki H, Li CY, Belluzzi JD, Bonci A, Civelli O. The melanin-concentrating hormone system modulates cocaine reward. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6772-7. PMID: 19342492; PMCID: PMC2672513.
      27. Hopf W, Hopf CG, Glöbel B. About radioactivity in some PMMA bone cements. Acta Orthop Belg. 1990; 56(2):443-4. PMID: 2239190.
        View in: PubMed
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