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    Xiaosong(Susan) Zhang, MD, PhD

    SchoolUCSF School of Medicine
    Address550 16th. Street
    San Francisco CA 94158
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      Collapse Biography 
      Collapse Education and Training
      Peking Union Medical College, Beijing, ChinaMD degree2004
      Johns Hopkins University School of MedicinePhD degreeDepartment of Pharmacology and Molecular Sciences2010
      Massachusetts General HospitalResidencyInternal Medicine2013
      University of California, San FranciscoClinical FellowshipDepartment of Hematology and Oncology2016
      Collapse Awards and Honors
      American Physician Scientists Association2010Travel Award
      2009Chinese Government Award for Outstanding Students Abroad

      Collapse Overview 
      Collapse Overview
      I am fortunate to have joined the world renowned Dr. Bert Vogelstein’s lab for my PhD thesis research on the genomic studies of human cancers. I co-led the first exomic sequencing of human pancreatic cancer, glioblastoma multiforme (GBM), and medulloblastoma, and published three first co-author papers in Science. We made the seminal discovery that IDH1 was highly mutated in GBM, and showed its importance in human cancer for the first time. This has led to the subsequent mechanistic studies and development of targeted therapies in multiple tumor types with IDH1 mutation. My research was rated as one of the Top Ten Breakthrough of Year 2008 by Science.

      During my PhD study, my second research focus was on novel cancer therapeutics using anaerobic bacteria Clostridium Novyi-NT to treat solid tumors. I was particularly interested in combining the bacterial therapy with novel immunotherapies to achieve greater response in the cancer bearing mice. I have also contributed to the preclinical safety studies and the launch of the phase I clinical trial using Clostridium Novyi-NT to treat patients with advanced solid tumors.

      At UCSF, I continued my translational research in Dr. Andrei Goga's lab. I worked on identification of therapeutic biomarker and development of targeted therapy using breast cancer patient derived xenograft mouse model. We have some very exciting discovery that will be translated into human clinical trial. During my hematology oncology fellowship, I have also developed particular interest in clinical research in GI oncology under the co-mentorship of Drs. Alan Venook and Pamela Munster. This has framed my long term career goal in designing clinical trials and ultimately make an impact on the lives of cancer patients.

      Collapse Interests
      Gastrointestinal cancers, Oncology clinical research, Phase I clinical trial, Global oncology

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Zhang X, Munster PN. New protein kinase inhibitors in breast cancer: afatinib and neratinib. Expert Opin Pharmacother. 2014 Jun; 15(9):1277-88. PMID: 24787047.
        View in: PubMed
      2. Jones S, Li M, Parsons DW, Zhang X, Wesseling J, Kristel P, Schmidt MK, Markowitz S, Yan H, Bigner D, Hruban RH, Eshleman JR, Iacobuzio-Donahue CA, Goggins M, Maitra A, Malek SN, Powell S, Vogelstein B, Kinzler KW, Velculescu VE, Papadopoulos N. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat. 2012 Jan; 33(1):100-3. PMID: 22009941; PMCID: PMC3240719.
      3. Li M, Zhao H, Zhang X, Wood LD, Anders RA, Choti MA, Pawlik TM, Daniel HD, Kannangai R, Offerhaus GJ, Velculescu VE, Wang L, Zhou S, Vogelstein B, Hruban RH, Papadopoulos N, Cai J, Torbenson MS, Kinzler KW. Inactivating mutations of the chromatin remodeling gene ARID2 in hepatocellular carcinoma. Nat Genet. 2011 Sep; 43(9):828-9. PMID: 21822264; PMCID: PMC3163746.
      4. Zhang X, Reis M, Khoriaty R, Li Y, Ouillette P, Samayoa J, Carter H, Karchin R, Li M, Diaz LA, Velculescu VE, Papadopoulos N, Kinzler KW, Vogelstein B, Malek SN. Sequence analysis of 515 kinase genes in chronic lymphocytic leukemia. Leukemia. 2011 Dec; 25(12):1908-10. PMID: 21701494; PMCID: PMC3523306.
      5. Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, Clara C, Phillips PC, Minturn JE, Biegel JA, Judkins AR, Resnick AC, Storm PB, Curran T, He Y, Rasheed BA, Friedman HS, Keir ST, McLendon R, Northcott PA, Taylor MD, Burger PC, Riggins GJ, Karchin R, Parmigiani G, Bigner DD, Yan H, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE. The genetic landscape of the childhood cancer medulloblastoma. Science. 2011 Jan 28; 331(6016):435-9. PMID: 21163964; PMCID: PMC3110744.
      6. Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, Kinzler KW, Velculescu VE, Hruban RH. SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Clin Cancer Res. 2009 Jul 15; 15(14):4674-9. PMID: 19584151; PMCID: PMC2819274.
      7. Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, Hruban RH. Genetic mutations associated with cigarette smoking in pancreatic cancer. Cancer Res. 2009 Apr 15; 69(8):3681-8. PMID: 19351817; PMCID: PMC2669837.
      8. Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JC, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, Kinzler KW, Vogelstein B, Eshleman JR, Goggins M, Klein AP. Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science. 2009 Apr 10; 324(5924):217. PMID: 19264984; PMCID: PMC2684332.
      9. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, Klein AP, Jaffee EM, Goggins M, Maitra A, Iacobuzio-Donahue C, Eshleman JR, Kern SE, Hruban RH, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science. 2008 Sep 26; 321(5897):1801-6. PMID: 18772397; PMCID: PMC2848990.
      10. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA, Hartigan J, Smith DR, Strausberg RL, Marie SK, Shinjo SM, Yan H, Riggins GJ, Bigner DD, Karchin R, Papadopoulos N, Parmigiani G, Vogelstein B, Velculescu VE, Kinzler KW. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008 Sep 26; 321(5897):1807-12. PMID: 18772396; PMCID: PMC2820389.
      11. Diaz LA, Foss CA, Thornton K, Nimmagadda S, Endres CJ, Uzuner O, Seyler TM, Ulrich SD, Conway J, Bettegowda C, Agrawal N, Cheong I, Zhang X, Ladenson PW, Vogelstein BN, Mont MA, Zhou S, Kinzler KW, Vogelstein B, Pomper MG. Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One. 2007; 2(10):e1007. PMID: 17925855; PMCID: PMC1994593.
      12. Lin J, Gan CM, Zhang X, Jones S, Sjöblom T, Wood LD, Parsons DW, Papadopoulos N, Kinzler KW, Vogelstein B, Parmigiani G, Velculescu VE. A multidimensional analysis of genes mutated in breast and colorectal cancers. Genome Res. 2007 Sep; 17(9):1304-18. PMID: 17693572; PMCID: PMC1950899.
      13. Zhang X, Zhao M, Rudek MA, He P, Vogelstein B. Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of DMXAA in human and mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1; 852(1-2):217-22. PMID: 17307035.
        View in: PubMed
      14. Bettegowda C, Huang X, Lin J, Cheong I, Kohli M, Szabo SA, Zhang X, Diaz LA, Velculescu VE, Parmigiani G, Kinzler KW, Vogelstein B, Zhou S. The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT. Nat Biotechnol. 2006 Dec; 24(12):1573-80. PMID: 17115055.
        View in: PubMed
      15. Diaz LA, Cheong I, Foss CA, Zhang X, Peters BA, Agrawal N, Bettegowda C, Karim B, Liu G, Khan K, Huang X, Kohli M, Dang LH, Hwang P, Vogelstein A, Garrett-Mayer E, Kobrin B, Pomper M, Zhou S, Kinzler KW, Vogelstein B, Huso DL. Pharmacologic and toxicologic evaluation of C. novyi-NT spores. Toxicol Sci. 2005 Dec; 88(2):562-75. PMID: 16162850.
        View in: PubMed
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