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    Yanjun Fu, PhD

    TitleAssociate Research Scientist
    SchoolUCSF School of Medicine
    Address513 Parnassus Ave, Med Sci
    San Francisco CA 94143

      At the interface of synthetic chemistry and radiology (or medical imaging), I have been working in the field of imaging contrast agents for 10+ years: molecular design, chemical synthesis, formulation, in vitro and in vivo comprehensive characterization of new imaging contrast agents, mainly macromolecular types, for CT and MRI (as well as for dual-energy CT namely DECT, and optical imaging) in various diseases models with various species.

      In a highly multidisciplinary environment and clinically-relevant atmosphere, it has been quite fun and inspiring to experience, see, and feel how modern robust imaging modalities and technique coupled with new imaging contrast agents already can or potentially could enormously help researchers, radiologists and other physicians to improve imaging diagnosis and disease therapy evaluation and management individually, at both the preclinical and clinical levels.

      Meanwhile i have been quite interested in designing and synthesizing novel molecular imaging probes to improve the understanding of biology of some diseases.

      Molecular design, synthesis and evaluation of new contrast agents for CT and MRI; innovative macromolecular contrast agents; molecular imaging of cancer, inflammation, fibrosis.

       ORNG Applications 
       Awarded Grants

      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Schneider JG, Wang ZJ, Wang W, Yee J, Fu Y, Yeh BM. Patient-tailored scan delay for multiphase liver CT: improved scan quality and lesion conspicuity with a novel timing bolus method. AJR Am J Roentgenol. 2014 Feb; 202(2):318-23.
        View in: PubMed
      2. Cyran CC, Fu Y, Rogut V, Chaopathomkul B, Wendland MF, Shames DM, Brasch RC. Evaluation of a novel macromolecular cascade-polymer contrast medium for dynamic contrast-enhanced MRI monitoring of antiangiogenic bevacizumab therapy in a human melanoma model. Acad Radiol. 2013 Oct; 20(10):1256-63.
        View in: PubMed PMC3874547
      3. Mongan J, Rathnayake S, Fu Y, Gao DW, Yeh BM. Extravasated contrast material in penetrating abdominopelvic trauma: dual-contrast dual-energy CT for improved diagnosis--preliminary results in an animal model. Radiology. 2013 Sep; 268(3):738-42.
        View in: PubMed PMC3750414
      4. Varenika V, Fu Y, Maher JJ, Gao D, Kakar S, Cabarrus MC, Yeh BM. Hepatic fibrosis: evaluation with semiquantitative contrast-enhanced CT. Radiology. 2013 Jan; 266(1):151-8.
        View in: PubMed PMC3528968
      5. Hope TA, Leboit PE, High WA, Fu Y, Brasch RC. Evaluation of imatinib mesylate as a possible treatment for nephrogenic systemic fibrosis in a rat model. Magn Reson Imaging. 2013 Jan; 31(1):139-44.
        View in: PubMed
      6. Mongan J, Rathnayake S, Fu Y, Wang R, Jones EF, Gao DW, Yeh BM. In vivo differentiation of complementary contrast media at dual-energy CT. Radiology. 2012 Oct; 265(1):267-72.
        View in: PubMed PMC3447173
      7. Hope TA, Doherty A, Fu Y, Aslam R, Qayyum A, Brasch RC. Gadolinium accumulation and fibrosis in the liver after administration of gadoxetate disodium in a rat model of active hepatic fibrosis. Radiology. 2012 Aug; 264(2):423-7.
        View in: PubMed
      8. Cyran CC, Sennino B, Fu Y, Rogut V, Shames DM, Chaopathomkul B, Wendland MF, McDonald DM, Brasch RC, Raatschen HJ. Permeability to macromolecular contrast media quantified by dynamic MRI correlates with tumor tissue assays of vascular endothelial growth factor (VEGF). Eur J Radiol. 2012 May; 81(5):891-6.
        View in: PubMed PMC3242157
      9. Wang ZJ, Chen KS, Gould R, Coakley FV, Fu Y, Yeh BM. Positive enteric contrast material for abdominal and pelvic CT with automatic exposure control: what is the effect on patient radiation exposure? Eur J Radiol. 2011 Aug; 79(2):e58-62.
        View in: PubMed PMC4117209
      10. Chou SH, Wang ZJ, Kuo J, Cabarrus M, Fu Y, Aslam R, Yee J, Zimmet JM, Shunk K, Elicker B, Yeh BM. Persistent renal enhancement after intra-arterial versus intravenous iodixanol administration. Eur J Radiol. 2011 Nov; 80(2):378-86.
        View in: PubMed PMC3160516
      11. Kumar R, Wang ZJ, Forsythe C, Fu Y, Chen YY, Yeh BM. Dual energy CT monitoring of the renal corticomedullary sodium gradient in swine. Eur J Radiol. 2012 Mar; 81(3):423-9.
        View in: PubMed PMC4130239
      12. Kumar R, Wang ZJ, Fu Y, Forsythe C, Webb EM, Yeh BM. Visualization of renal medullary hyperattenuation at unenhanced CT: what is the effect of furosemide administration? Radiology. 2010 May; 255(2):495-500.
        View in: PubMed PMC4128916
      13. Raatschen HJ, Fu Y, Rogut V, Simon GH, Sennino B, Wolf KJ, Brasch RC. [Effects of MRI-assayed microvascular permeability on the accumulation of vinorelbine in xenograft tumors]. Rofo. 2010 Feb; 182(2):133-9.
        View in: PubMed
      14. Sennino B, Raatschen HJ, Wendland MF, Fu Y, You WK, Shames DM, McDonald DM, Brasch RC. Correlative dynamic contrast MRI and microscopic assessments of tumor vascularity in RIP-Tag2 transgenic mice. Magn Reson Med. 2009 Sep; 62(3):616-25.
        View in: PubMed
      15. Benedetti N, Aslam R, Wang ZJ, Joe BN, Fu Y, Yee J, Yeh BM. Delayed enhancement of ascites after i.v. contrast material administration at CT: time course and clinical correlation. AJR Am J Roentgenol. 2009 Sep; 193(3):732-7.
        View in: PubMed PMC2962936
      16. Raatschen HJ, Fu Y, Brasch RC, Pietsch H, Shames DM, Yeh BM. In vivo monitoring of angiogenesis inhibitory treatment effects by dynamic contrast-enhanced computed tomography in a xenograft tumor model. Invest Radiol. 2009 May; 44(5):265-70.
        View in: PubMed PMC4115801
      17. Boddington S, Sutton EJ, Jones E, Purcell DD, Henning TD, Tavri S, Meier R, Sista A, Fu Y, Daldrup-Link H. Improved fluorescence of indocyanine green in vitro and in vivo after simple cooling procedures. Contrast Media Mol Imaging. 2008 Sep-Oct; 3(5):191-7.
        View in: PubMed
      18. Cyran CC, Sennino B, Chaopathomkul B, Fu Y, Rogut VS, Shames DM, Wendland MF, McDonald DM, Brasch RC. Magnetic resonance imaging for monitoring the effects of thalidomide on experimental human breast cancers. Eur Radiol. 2009 Jan; 19(1):121-31.
        View in: PubMed
      19. Wang ZJ, Coakley FV, Fu Y, Joe BN, Prevrhal S, Landeras LA, Webb EM, Yeh BM. Renal cyst pseudoenhancement at multidetector CT: what are the effects of number of detectors and peak tube voltage? Radiology. 2008 Sep; 248(3):910-6.
        View in: PubMed PMC2798095
      20. Cyran CC, Sennino B, Chaopathomkul B, Fu Y, Rogut V, Shames DM, Wendland MF, McDonald DM, Brasch RC. Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature. Invest Radiol. 2008 May; 43(5):298-305.
        View in: PubMed
      21. Raatschen HJ, Simon GH, Fu Y, Sennino B, Shames DM, Wendland MF, McDonald DM, Brasch RC. Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats. Radiology. 2008 May; 247(2):391-9.
        View in: PubMed
      22. Cyran CC, Fu Y, Raatschen HJ, Rogut V, Chaopathomkul B, Shames DM, Wendland MF, Yeh BM, Brasch RC. New macromolecular polymeric MRI contrast agents for application in the differentiation of cancer from benign soft tissues. J Magn Reson Imaging. 2008 Mar; 27(3):581-9.
        View in: PubMed
      23. Hsu CT, Wang ZJ, Yu AS, Gould RG, Fu Y, Joe BN, Qayyum A, Breiman RS, Coakley FV, Yeh BM. Physiology of renal medullary tip hyperattenuation at unenhanced CT: urinary specific gravity and the NaCl concentration gradient. Radiology. 2008 Apr; 247(1):147-53.
        View in: PubMed
      24. Fu Y, Raatschen HJ, Nitecki DE, Wendland MF, Novikov V, Fournier LS, Cyran C, Rogut V, Shames DM, Brasch RC. Cascade polymeric MRI contrast media derived from poly(ethylene glycol) cores: initial syntheses and characterizations. Biomacromolecules. 2007 May; 8(5):1519-29.
        View in: PubMed
      25. Saborowski O, Simon GH, Raatschen HJ, Wendland MF, Fu Y, Henning T, Baehner R, Corot C, Chen MH, Daldrup-Link HE. MR imaging of antigen-induced arthritis with a new, folate receptor-targeted contrast agent. Contrast Media Mol Imaging. 2007 Mar-Apr; 2(2):72-81.
        View in: PubMed
      26. Fournier LS, Novikov V, Lucidi V, Fu Y, Miller T, Floyd E, Shames DM, Brasch RC. MR monitoring of cyclooxygenase-2 inhibition of angiogenesis in a human breast cancer model in rats. Radiology. 2007 Apr; 243(1):105-11.
        View in: PubMed
      27. Henning TD, Saborowski O, Golovko D, Boddington S, Bauer JS, Fu Y, Meier R, Pietsch H, Sennino B, McDonald DM, Daldrup-Link HE. Cell labeling with the positive MR contrast agent Gadofluorine M. Eur Radiol. 2007 May; 17(5):1226-34.
        View in: PubMed
      28. Raatschen HJ, Fu Y, Shames DM, Wendland MF, Brasch RC. Magnetic resonance imaging enhancement of normal tissues and tumors using macromolecular Gd-based cascade polymer contrast agents: preclinical evaluations. Invest Radiol. 2006 Dec; 41(12):860-7.
        View in: PubMed
      29. Fu Y, Nitecki DE, Maltby D, Simon GH, Berejnoi K, Raatschen HJ, Yeh BM, Shames DM, Brasch RC. Dendritic iodinated contrast agents with PEG-cores for CT imaging: synthesis and preliminary characterization. Bioconjug Chem. 2006 Jul-Aug; 17(4):1043-56.
        View in: PubMed
      30. Simon GH, von Vopelius-Feldt J, Wendland MF, Fu Y, Piontek G, Schlegel J, Chen MH, Daldrup-Link HE. MRI of arthritis: comparison of ultrasmall superparamagnetic iron oxide vs. Gd-DTPA. J Magn Reson Imaging. 2006 May; 23(5):720-7.
        View in: PubMed
      31. Raatschen HJ, Swain R, Shames DM, Fu Y, Boyd Z, Zierhut ML, Wendland MF, Misselwitz B, Weinmann HJ, Wolf KJ, Brasch RC. MRI tumor characterization using Gd-GlyMe-DOTA-perfluorooctyl-mannose-conjugate (Gadofluorine M), a protein-avid contrast agent. Contrast Media Mol Imaging. 2006 May-Jun; 1(3):113-20.
        View in: PubMed
      32. Simon GH, von Vopelius-Feldt J, Fu Y, Schlegel J, Pinotek G, Wendland MF, Chen MH, Daldrup-Link HE. Ultrasmall supraparamagnetic iron oxide-enhanced magnetic resonance imaging of antigen-induced arthritis: a comparative study between SHU 555 C, ferumoxtran-10, and ferumoxytol. Invest Radiol. 2006 Jan; 41(1):45-51.
        View in: PubMed
      33. Simon GH, Bauer J, Saborovski O, Fu Y, Corot C, Wendland MF, Daldrup-Link HE. T1 and T2 relaxivity of intracellular and extracellular USPIO at 1.5T and 3T clinical MR scanning. Eur Radiol. 2006 Mar; 16(3):738-45.
        View in: PubMed
      34. Simon GH, Raatschen HJ, Wendland MF, von Vopelius-Feldt J, Fu Y, Chen MH, Daldrup-Link HE. Ultrasmall superparamagnetic iron-oxide-enhanced MR imaging of normal bone marrow in rodents: original research original research. Acad Radiol. 2005 Sep; 12(9):1190-7.
        View in: PubMed
      35. Simon GH, Fu Y, Berejnoi K, Fournier LS, Lucidi V, Yeh B, Shames DM, Brasch RC. Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer. Invest Radiol. 2005 Sep; 40(9):614-20.
        View in: PubMed
      36. Wiart M, Fournier LS, Novikov VY, Shames DM, Roberts TP, Fu Y, Shalinsky DR, Brasch RC. Magnetic resonance imaging detects early changes in microvascular permeability in xenograft tumors after treatment with the matrix metalloprotease inhibitor Prinomastat. Technol Cancer Res Treat. 2004 Aug; 3(4):377-82.
        View in: PubMed
      37. Laurent S, Vander Elst L, Fu Y, Muller RN. Synthesis and physicochemical characterization of Gd-DTPA-B(sLex)A, a new MRI contrast agent targeted to inflammation. Bioconjug Chem. 2004 Jan-Feb; 15(1):99-103.
        View in: PubMed
      38. Turetschek K, Preda A, Floyd E, Shames DM, Novikov V, Roberts TP, Wood JM, Fu Y, Carter WO, Brasch RC. MRI monitoring of tumor response following angiogenesis inhibition in an experimental human breast cancer model. Eur J Nucl Med Mol Imaging. 2003 Mar; 30(3):448-55.
        View in: PubMed
      39. Turetschek K, Preda A, Floyd E, Shames DM, Novikov V, Roberts TP, Wood JM, Fu Y, Carter WO, Brasch RC. MRI monitoring of tumor response to a novel VEGF tyrosine kinase inhibitor in an experimental breast cancer model. Acad Radiol. 2002 Aug; 9 Suppl 2:S519-20.
        View in: PubMed
      40. Fu Y, Laurent S, and Muller RN . Synthesis of a Sialyl Lewis X Mimetic Conjugated with DTPA, Potential Ligand of New Contrast Agents for Medical Imaging. European Journal of Organic Chemistry. 2002; 23:3966-3973.
      41. Fu Y and Zhuo R . Studies on hepatocyte-targeting MRI macromolecular contrast media. Chemical Research in Chinese Universities. (English). 1997; 13(3):348-353.
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