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Yen-Sin Ang, PhD

TitlePostdoctoral fellow
SchoolUCSF School of Medicine
DepartmentGladstone Institutes
Address
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    Collapse Biography 
    Collapse Education and Training
    Mount Sinai School of MedicinePh.D.
    National University of SingaporeB.Sc.
    Collapse Awards and Honors
    American Heart Association2016Louis N. and Arnold M. Katz Basic Research Prize
    American Heart Association2017 - 2019Scientist Development Grant
    American Heart Association2013 - 2015Postdoctoral Fellowship
    Mount Sinai School of Medicine2012Terry Ann Krulwich Doctoral Dissertation Prize
    University of Edinburgh (declined)2006Darwin Trust Scholarship

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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ribeiro AJ, Schwab O, Mandegar MA, Ang YS, Conklin BR, Srivastava D, Pruitt BL. Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes. Circ Res. 2017 Apr 11. PMID: 28400398.
      View in: PubMed
    2. Mohamed TM, Stone NR, Berry EC, Radzinsky E, Huang Y, Pratt K, Ang YS, Yu P, Wang H, Tang S, Magnitsky S, Ding S, Ivey KN, Srivastava D. Chemical Enhancement of In Vitro and In Vivo Direct Cardiac Reprogramming. Circulation. 2016 Nov 10. PMID: 27834668.
      View in: PubMed
    3. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, Ren S, Wang X, Chen I, Wang H, Gao C, Yokota T, Ang Y, Li S, Cass A, Vondriska TM, Li G, Deb A, Srivastava D, Yang HT, Xiao X, Li H, Wang Y, et al. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. Nat Med. 2016 Sep 12. PMID: 27618650.
      View in: PubMed
    4. Ribeiro AJ, Ang YS, Fu JD, Rivas RN, Mohamed TM, Higgs GC, Srivastava D, Pruitt BL. Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness. Proc Natl Acad Sci U S A. 2015 Oct 13; 112(41):12705-10. PMID: 26417073; PMCID: PMC4611612 [Available on 04/13/16].
    5. Ang YS, Srivastava D. Oxygen: double-edged sword in cardiac function and repair. Circ Res. 2014 Oct 24; 115(10):824-5. PMID: 25342770.
      View in: PubMed
    6. Xu H, Ang YS, Sevilla A, Lemischka IR, Ma'ayan A. Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells. PLoS Comput Biol. 2014 Aug; 10(8):e1003777. PMID: 25122140; PMCID: PMC4133156.
    7. Heidersbach A, Saxby C, Carver-Moore K, Huang Y, Ang YS, de Jong PJ, Ivey KN, Srivastava D. microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart. Elife. 2013; 2:e01323. PMID: 24252873; PMCID: PMC3833424.
    8. Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 2012 Aug 3; 11(2):179-94. PMID: 22862944; PMCID: PMC3413175.
    9. Fidalgo M, Shekar PC, Ang YS, Fujiwara Y, Orkin SH, Wang J. Zfp281 functions as a transcriptional repressor for pluripotency of mouse embryonic stem cells. Stem Cells. 2011 Nov; 29(11):1705-16. PMID: 21915945; PMCID: PMC3272666.
    10. Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells. Stem Cells. 2011 Jun; 29(6):964-71. PMID: 21563278.
      View in: PubMed
    11. Ang YS, Gaspar-Maia A, Lemischka IR, Bernstein E. Stem cells and reprogramming: breaking the epigenetic barrier? Trends Pharmacol Sci. 2011 Jul; 32(7):394-401. PMID: 21621281; PMCID: PMC3128683.
    12. Carvajal-Vergara X, Sevilla A, D'Souza SL, Ang YS, Schaniel C, Lee DF, Yang L, Kaplan AD, Adler ED, Rozov R, Ge Y, Cohen N, Edelmann LJ, Chang B, Waghray A, Su J, Pardo S, Lichtenbelt KD, Tartaglia M, Gelb BD, Lemischka IR. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature. 2010 Jun 10; 465(7299):808-12. PMID: 20535210; PMCID: PMC2885001.
    13. Tsai SY, Clavel C, Kim S, Ang YS, Grisanti L, Lee DF, Kelley K, Rendl M. Oct4 and klf4 reprogram dermal papilla cells into induced pluripotent stem cells. Stem Cells. 2010 Feb; 28(2):221-8. PMID: 20014278.
      View in: PubMed
    14. Schaniel C, Ang YS, Ratnakumar K, Cormier C, James T, Bernstein E, Lemischka IR, Paddison PJ. Smarcc1/Baf155 couples self-renewal gene repression with changes in chromatin structure in mouse embryonic stem cells. Stem Cells. 2009 Dec; 27(12):2979-91. PMID: 19785031.
      View in: PubMed
    15. Tam WL, Lim CY, Han J, Zhang J, Ang YS, Ng HH, Yang H, Lim B. T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways. Stem Cells. 2008 Aug; 26(8):2019-31. PMID: 18467660; PMCID: PMC2692055.
    16. Tay YM, Tam WL, Ang YS, Gaughwin PM, Yang H, Wang W, Liu R, George J, Ng HH, Perera RJ, Lufkin T, Rigoutsos I, Thomson AM, Lim B. MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1. Stem Cells. 2008 Jan; 26(1):17-29. PMID: 17916804.
      View in: PubMed
    17. Tam WL, Ang YS, Lim B. The molecular basis of ageing in stem cells. Mech Ageing Dev. 2007 Jan; 128(1):137-48. PMID: 17134742.
      View in: PubMed
    18. Miranda KC, Huynh T, Tay Y, Ang YS, Tam WL, Thomson AM, Lim B, Rigoutsos I. A pattern-based method for the identification of MicroRNA binding sites and their corresponding heteroduplexes. Cell. 2006 Sep 22; 126(6):1203-17. PMID: 16990141.
      View in: PubMed
    19. Chew JL, Loh YH, Zhang W, Chen X, Tam WL, Yeap LS, Li P, Ang YS, Lim B, Robson P, Ng HH. Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol. 2005 Jul; 25(14):6031-46. PMID: 15988017; PMCID: PMC1168830.
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