Young-Wook Jun, PhD

TitleAssociate Professor
SchoolUCSF School of Medicine
Address2340 Sutter Street
San Francisco CA 94115
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    Collapse Overview
    Young-Wook Jun, PhD, is an Associate Professor and he is the Director of the Nano-Probing Single Biomolecule Dynamics Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his PhD from the Korea Advanced Institute of Science and Technology in Seoul, South Korea, and he completed a postdoctoral from Yonsei University, Seoul, South Korea, followed by a postdoctoral from the University of California, Berkeley.

    Dr. Jun’s research interests include nanoprobing systems to investigate the single molecule dynamics of biomolecules involved in cellular developments such as gene regulation, cell-to-cell communications, and neuron circuit formation. His research on “Nanocrystal-Molecules as Probes for Monitoring the Dynamics of Biomolecular Machineries at the Single Molecule Level” will contribute to a foundation of a new field by providing a comprehensive understanding of the nanocrystal molecules including the fabrication, surface chemistry, scaling laws of magnetic, plasmonic, and charge coupling, and their behaviors in cells.

    Dr. Jun has been invited to speak both national and internationally. He has contributed to over 40 articles, and 5 book chapters.

    Nano-bio Research, Notch and E-cadherin

    Nanotechnology, Chemistry, Bioengineering

    Professional Interests:
    Nanotechnology, optical microscopy, single molecule imaging, notch signaling, neural development, angiogenesis

    Education and Training:
    • PhD: Korea Advanced Institute of Science and Technology, Seoul, South Korea – Chemistry
    • Postdoctoral: Yonsei University, Seoul, South Korea – Chemistry
    • Postdoctoral: University of California, Berkeley – Chemistry

    Awards and Honors:
    • 2012 Department of Otolaryngology, UCSF - The Endowed Hemming Fellows
    • 2010 The New Innovator Research Award – UCSF/Sandler Foundation
    • 2005 IUPAC Prize for Young Chemist: The Honorable Mention Award - International Union of Pure and Applied Chemistry (IUPAC)

    Collapse Research 
    Collapse Research Activities and Funding
    In situ Investigation of dynamic protein-protein interactions in live cells via Magnetic Co-concentration (MCoC)
    NIH/NCI R21CA224364Jan 1, 2018 - Dec 31, 2019
    Role: Principal Investigator
    Nanomodules for interrogating chemical, spatial, and mechanical dynamics of cell surface receptors
    NIH/NIGMS R01GM126542Sep 15, 2017 - Jul 31, 2021
    Role: Principal Investigator
    Interrogation of mechanotransduction ion channels via nanoruler force microscopy and mechanogenetic nanomodules
    NIH 1R21NS103240-01Jul 1, 2017 - Jun 30, 2019
    Role: Principal Investigator
    Spatial Mutation of Membrane Protein Assembly Dynamics Using Nano-Actuators
    NIH/NHLBI R21HL123329Sep 1, 2014 - Jun 30, 2016
    Role: Principal Investigator
    Spatiotemporal Control of Dynamic Notch Signaling with Subcellular Resolution
    NIH/NIGMS R01GM112081Aug 1, 2014 - Jul 31, 2019
    Role: Principal Investigator
    Small, modular, and monovalent Quantum Dots for single molecule imaging of Notch
    NIH/NIBIB R21EB018044Mar 1, 2014 - Feb 29, 2016
    Role: Principal Investigator
    Single Molecule Imaging of Guided Axonal Development using Plasmon Nanorulers
    NIH/NIBIB R21EB015088Mar 15, 2012 - Feb 28, 2014
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889. PMID: 28817122.
      View in: PubMed
    2. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2016 Jun 02; 165(6):1507-1518. PMID: 27180907; PMCID: PMC4892966 [Available on 06/02/17].
    3. Daeha Seo, Hyunjung Lee, Jung-uk Lee, Thomas Haas, Young-wook Jun. Monovalent plasmonic nanoparticles for biological applications. Proceedings of SPIE--the International Society for Optical Engineering. 2016; 9722:972201.
    4. Mabray MC, Lillaney P, Sze CH, Losey AD, Yang J, Kondapavulur S, Liu D, Saeed M, Patel A, Cooke D, Jun YW, El-Sayed I, Wilson M, Hetts SW. In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study. J Vasc Interv Radiol. 2016 Mar; 27(3):426-32.e1. PMID: 26706187; PMCID: PMC4769113 [Available on 03/01/17].
    5. Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ. Production and targeting of monovalent quantum dots. J Vis Exp. 2014 Oct 23; (92):e52198. PMID: 25407345; PMCID: PMC4309134.
    6. Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS. Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia. ACS Nano. 2014 Sep 23; 8(9):9199-208. PMID: 25166742; PMCID: PMC4174091.
    7. Tajon C, Jun YW, Craik CS. Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology. Methods Enzymol. 2014; 544:271-97. PMID: 24974294.
      View in: PubMed
    8. Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP. MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction. Cancer Discov. 2014 Feb; 4(2):200-15. PMID: 24362263; PMCID: PMC4248023.
    9. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5. PMID: 24122039; PMCID: PMC3968776.
    10. Hu Y, Jun YS. Biotite dissolution in brine at varied temperatures and CO2 pressures: its activation energy and potential CO2 intercalation. Langmuir. 2012 Oct 16; 28(41):14633-41. PMID: 22989382.
      View in: PubMed
    11. Sheikholeslami S, Jun YW, Jain PK, Alivisatos AP. Coupling of optical resonances in a compositionally asymmetric plasmonic nanoparticle dimer. Nano Lett. 2010 Jul 14; 10(7):2655-60. PMID: 20536212.
      View in: PubMed
    12. Park J, Zheng H, Jun YW, Alivisatos AP. Hetero-epitaxial anion exchange yields single-crystalline hollow nanoparticles. J Am Chem Soc. 2009 Oct 07; 131(39):13943-5. PMID: 19788329.
      View in: PubMed
    13. Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP. Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17735-40. PMID: 19805121; PMCID: PMC2764940.
    14. Zheng H, Smith RK, Jun YW, Kisielowski C, Dahmen U, Alivisatos AP. Observation of single colloidal platinum nanocrystal growth trajectories. Science. 2009 Jun 05; 324(5932):1309-12. PMID: 19498166.
      View in: PubMed
    15. Jun YW, Seo JW, Cheon J. Nanoscaling laws of magnetic nanoparticles and their applicabilities in biomedical sciences. Acc Chem Res. 2008 Feb; 41(2):179-89. PMID: 18281944.
      View in: PubMed
    16. Jun YW, Lee JH, Cheon J. Chemical design of nanoparticle probes for high-performance magnetic resonance imaging. Angew Chem Int Ed Engl. 2008; 47(28):5122-35. PMID: 18574805.
      View in: PubMed
    17. Park JI, Jun YW, Choi JS, Cheon J. Highly crystalline anisotropic superstructures via magnetic field induced nanoparticle assembly. Chem Commun (Camb). 2007 Dec 21; (47):5001-3. PMID: 18049733.
      View in: PubMed
    18. Yong-Min Huh, Eun-Sook Lee, Jae-Hyun Lee, Young-wook Jun, Pyung-Hwan Kim, Chae-Ok Yun, Joo-Hang Kim, Jin-Suck Suh, Jinwoo Cheon. Hybrid Nanoparticles for Magnetic Resonance Imaging of Target-Specific Viral Gene Delivery. Advanced Materials. 2007; 19(20):3109-12.
    19. Seo JW, Jun YW, Park SW, Nah H, Moon T, Park B, Kim JG, Kim YJ, Cheon J. Two-dimensional nanosheet crystals. Angew Chem Int Ed Engl. 2007; 46(46):8828-31. PMID: 17939146.
      View in: PubMed
    20. Jun YW, Jang JT, Cheon J. Magnetic nanoparticle assisted molecular MR imaging. Adv Exp Med Biol. 2007; 620:85-106. PMID: 18217337.
      View in: PubMed
    21. Lee JH, Huh YM, Jun YW, Seo JW, Jang JT, Song HT, Kim S, Cho EJ, Yoon HG, Suh JS, Cheon J. Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging. Nat Med. 2007 Jan; 13(1):95-9. PMID: 17187073.
      View in: PubMed
    22. Choi JS, Jun YW, Yeon SI, Kim HC, Shin JS, Cheon J. Biocompatible heterostructured nanoparticles for multimodal biological detection. J Am Chem Soc. 2006 Dec 20; 128(50):15982-3. PMID: 17165720.
      View in: PubMed
    23. Lee JH, Jun YW, Yeon SI, Shin JS, Cheon J. Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma. Angew Chem Int Ed Engl. 2006 Dec 11; 45(48):8160-2. PMID: 17103471.
      View in: PubMed
    24. Jun YW, Choi JS, Cheon J. Heterostructured magnetic nanoparticles: their versatility and high performance capabilities. Chem Commun (Camb). 2007 Mar 28; (12):1203-14. PMID: 17356759.
      View in: PubMed
    25. Jun YW, Choi JS, Cheon J. Shape control of semiconductor and metal oxide nanocrystals through nonhydrolytic colloidal routes. Angew Chem Int Ed Engl. 2006 May 19; 45(21):3414-39. PMID: 16642516.
      View in: PubMed
    26. Jun YS, Martin ST. Cobalt alters the growth of a manganese oxide film. Langmuir. 2006 Feb 28; 22(5):2235-40. PMID: 16489812.
      View in: PubMed
    27. Cheon J, Park JI, Choi JS, Jun YW, Kim S, Kim MG, Kim YM, Kim YJ. Magnetic superlattices and their nanoscale phase transition effects. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3023-7. PMID: 16492783; PMCID: PMC1413888.
    28. Lee HY, Ryu S, Kang H, Jun YW, Cheon J. Selective catalytic activity of ball-shaped Pd@MCM-48 nanocatalysts. Chem Commun (Camb). 2006 Mar 28; (12):1325-7. PMID: 16538262.
      View in: PubMed
    29. Casula MF, Jun YW, Zaziski DJ, Chan EM, Corrias A, Alivisatos AP. The concept of delayed nucleation in nanocrystal growth demonstrated for the case of iron oxide nanodisks. J Am Chem Soc. 2006 Feb 08; 128(5):1675-82. PMID: 16448141.
      View in: PubMed
    30. Huh YM, Jun YW, Song HT, Kim S, Choi JS, Lee JH, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J. In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals. J Am Chem Soc. 2005 Sep 07; 127(35):12387-91. PMID: 16131220.
      View in: PubMed
    31. Jun YW, Lee JH, Choi JS, Cheon J. Symmetry-controlled colloidal nanocrystals: nonhydrolytic chemical synthesis and shape determining parameters. J Phys Chem B. 2005 Aug 11; 109(31):14795-806. PMID: 16852873.
      View in: PubMed
    32. Song HT, Choi JS, Huh YM, Kim S, Jun YW, Suh JS, Cheon J. Surface modulation of magnetic nanocrystals in the development of highly efficient magnetic resonance probes for intracellular labeling. J Am Chem Soc. 2005 Jul 20; 127(28):9992-3. PMID: 16011350.
      View in: PubMed
    33. Jun YW, Huh YM, Choi JS, Lee JH, Song HT, Kim S, Yoon S, Kim KS, Shin JS, Suh JS, Cheon J. Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging. J Am Chem Soc. 2005 Apr 27; 127(16):5732-3. PMID: 15839639.
      View in: PubMed
    34. Seo JW, Jun YW, Ko SJ, Cheon J. In situ one-pot synthesis of 1-dimensional transition metal oxide nanocrystals. J Phys Chem B. 2005 Mar 31; 109(12):5389-91. PMID: 16851566.
      View in: PubMed
    35. Young-wook Jun, Jung-wook Seo, Sang Jun Oh, Jinwoo Cheon. Recent advances in the shape control of inorganic nano-building blocks. Coordination Chemistry Reviews. 2005; 249(17-18):1766-75.
    36. In I, Jun YW, Kim YJ, Kim SY. Spontaneous one dimensional arrangement of spherical Au nanoparticles with liquid crystal ligands. Chem Commun (Camb). 2005 Feb 14; (6):800-1. PMID: 15685343.
      View in: PubMed
    37. Insik In, Young-Wook Jun, Yun Jun Kim, Sang Youl Kim. Thiacrownether-mediated Size-controlled Assembly of Gold Nanoparticles. Chemistry Letters. 2004; 33(11):1530-1.
    38. Park JI, Kim MG, Jun YW, Lee JS, Lee WR, Cheon J. Characterization of superparamagnetic "core-shell" nanoparticles and monitoring their anisotropic phase transition to ferromagnetic "solid solution" nanoalloys. J Am Chem Soc. 2004 Jul 28; 126(29):9072-8. PMID: 15264840.
      View in: PubMed
    39. Jun YW, Casula MF, Sim JH, Kim SY, Cheon J, Alivisatos AP. Surfactant-assisted elimination of a high energy facet as a means of controlling the shapes of TiO2 nanocrystals. J Am Chem Soc. 2003 Dec 24; 125(51):15981-5. PMID: 14677990.
      View in: PubMed
    40. Kim YH, Jun YW, Jun BH, Lee SM, Cheon J. Sterically induced shape and crystalline phase control of GaP nanocrystals. J Am Chem Soc. 2002 Nov 20; 124(46):13656-7. PMID: 12431078.
      View in: PubMed
    41. Lee SM, Jun YW, Cho SN, Cheon J. Single-crystalline star-shaped nanocrystals and their evolution: programming the geometry of nano-building blocks. J Am Chem Soc. 2002 Sep 25; 124(38):11244-5. PMID: 12236719.
      View in: PubMed
    42. Park JI, Kang NJ, Jun YW, Oh SJ, Ri HC, Cheon J. Superlattice and magnetism directed by the size and shape of nanocrystals. Chemphyschem. 2002 Jun 17; 3(6):543-7. PMID: 12465496.
      View in: PubMed
    43. Jun YW, Jung YY, Cheon J. Architectural control of magnetic semiconductor nanocrystals. J Am Chem Soc. 2002 Jan 30; 124(4):615-9. PMID: 11804492.
      View in: PubMed
    44. Jun YW, Lee SM, Kang NJ, Cheon J. Controlled synthesis of multi-armed CdS nanorod architectures using monosurfactant system. J Am Chem Soc. 2001 May 30; 123(21):5150-1. PMID: 11457367.
      View in: PubMed
    45. Young-wook Jun, Chang-Shik Choi, Jinwoo Cheon. Size and shape controlled ZnTe nanocrystals with quantum confinement effect. Chemical Communications. 2000; 2001:101-2.
    46. Hongkyu Kang, Young-wook Jun, Jong-Il Park, Kyung-Bok Lee, and Jinwoo Cheon. Synthesis of Porous Palladium Superlattice Nanoballs and Nanowires. Chemistry of Materials. 2000; 12(12):3530-2.
    47. Young-wook Jun, Ja-Eung Koo, Jinwoo Cheon. One-step synthesis of size tuned zinc selenide quantum dots via a temperature controlled molecular precursor approach. Chemical Communications. 2000; 2000:1243-4.
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