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    Zena Vexler, PhD

    TitleProfessor in Residence
    SchoolUCSF School of Medicine
    DepartmentNeurology
    Address675 Nelson Rising Lane
    San Francisco CA 94158
    Phone415-502-2282

       Bibliographic 
       Publications
      Publications by year:
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      1. van Velthoven CT, Sheldon RA, Kavelaars A, Derugin N, Vexler ZS, Willemen HL, Maas M, Heijnen CJ, Ferriero DM. Mesenchymal stem cell transplantation attenuates brain injury after neonatal stroke. Stroke. 2013 May; 44(5):1426-32.
        View in: PubMed
      2. Woo MS, Wang X, Faustino JV, Derugin N, Wendland MF, Zhou P, Iadecola C, Vexler ZS. Genetic deletion of CD36 enhances injury after acute neonatal stroke. Ann Neurol. 2012 Dec; 72(6):961-70.
        View in: PubMed
      3. Fernández-López D, Faustino J, Daneman R, Zhou L, Lee SY, Derugin N, Wendland MF, Vexler ZS. Blood-brain barrier permeability is increased after acute adult stroke but not neonatal stroke in the rat. J Neurosci. 2012 Jul 11; 32(28):9588-600.
        View in: PubMed
      4. Fernández-López D, Faustino J, Derugin N, Wendland M, Lizasoain I, Moro MA, Vexler ZS. Reduced infarct size and accumulation of microglia in rats treated with WIN 55,212-2 after neonatal stroke. Neuroscience. 2012 Apr 5; 207:307-15.
        View in: PubMed
      5. Faustino JV, Wang X, Johnson CE, Klibanov A, Derugin N, Wendland MF, Vexler ZS. Microglial cells contribute to endogenous brain defenses after acute neonatal focal stroke. J Neurosci. 2011 Sep 7; 31(36):12992-3001.
        View in: PubMed
      6. Bowers KJ, Deveber GA, Ferriero DM, Roach ES, Vexler ZS, Maria BL. Cerebrovascular disease in children: recent advances in diagnosis and management. J Child Neurol. 2011 Sep; 26(9):1074-100.
        View in: PubMed
      7. Dzietko M, Wendland M, Derugin N, Ferriero DM, Vexler ZS. Magnetic resonance imaging (MRI) as a translational tool for the study of neonatal stroke. J Child Neurol. 2011 Sep; 26(9):1145-53.
        View in: PubMed
      8. Biran V, Heine VM, Verney C, Sheldon RA, Spadafora R, Vexler ZS, Rowitch DH, Ferriero DM. Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain. Neurobiol Dis. 2011 Jan; 41(1):138-46.
        View in: PubMed
      9. Davis B, Tang J, Zhang L, Mu D, Jiang X, Biran V, Vexler Z, Ferriero DM. Role of vasodilator stimulated phosphoprotein in VEGF induced blood-brain barrier permeability in endothelial cell monolayers. Int J Dev Neurosci. 2010 Oct; 28(6):423-8.
        View in: PubMed
      10. Shimotake J, Derugin N, Wendland M, Vexler ZS, Ferriero DM. Vascular endothelial growth factor receptor-2 inhibition promotes cell death and limits endothelial cell proliferation in a neonatal rodent model of stroke. Stroke. 2010 Feb; 41(2):343-9.
        View in: PubMed
      11. Vexler ZS, Yenari MA. Does inflammation after stroke affect the developing brain differently than adult brain? Dev Neurosci. 2009; 31(5):378-93.
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      12. Wendland MF, Faustino J, West T, Manabat C, Holtzman DM, Vexler ZS. Early diffusion-weighted MRI as a predictor of caspase-3 activation after hypoxic-ischemic insult in neonatal rodents. Stroke. 2008 Jun; 39(6):1862-8.
        View in: PubMed
      13. Gonzalez FF, McQuillen P, Mu D, Chang Y, Wendland M, Vexler Z, Ferriero DM. Erythropoietin enhances long-term neuroprotection and neurogenesis in neonatal stroke. Dev Neurosci. 2007; 29(4-5):321-30.
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      14. Denker SP, Ji S, Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS. Macrophages are comprised of resident brain microglia not infiltrating peripheral monocytes acutely after neonatal stroke. J Neurochem. 2007 Feb; 100(4):893-904.
        View in: PubMed
      15. Vexler ZS, Sharp FR, Feuerstein GZ, Ashwal S, Thoresen M, Yager JY, Ferriero DM. Translational stroke research in the developing brain. Pediatr Neurol. 2006 Jun; 34(6):459-63.
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      16. Dingman A, Lee SY, Derugin N, Wendland MF, Vexler ZS. Aminoguanidine inhibits caspase-3 and calpain activation without affecting microglial activation following neonatal transient cerebral ischemia. J Neurochem. 2006 Mar; 96(5):1467-79.
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      17. Matsumori Y, Northington FJ, Hong SM, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J. Reduction of caspase-8 and -9 cleavage is associated with increased c-FLIP and increased binding of Apaf-1 and Hsp70 after neonatal hypoxic/ischemic injury in mice overexpressing Hsp70. Stroke. 2006 Feb; 37(2):507-12.
        View in: PubMed
      18. Derugin N, Dingman A, Wendland MF, Fox C, Bollen A, Vexler ZS. Magnetic resonance imaging as a surrogate measure for histological sub-chronic endpoint in a neonatal rat stroke model. Brain Res. 2005 Dec 20; 1066(1-2):49-56.
        View in: PubMed
      19. Mu D, Chang YS, Vexler ZS, Ferriero DM. Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. Exp Neurol. 2005 Oct; 195(2):407-15.
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      20. Fox C, Dingman A, Derugin N, Wendland MF, Manabat C, Ji S, Ferriero DM, Vexler ZS. Minocycline confers early but transient protection in the immature brain following focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 2005 Sep; 25(9):1138-49.
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      21. Yenari MA, Liu J, Zheng Z, Vexler ZS, Lee JE, Giffard RG. Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection. Ann N Y Acad Sci. 2005 Aug; 1053:74-83.
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      22. Matsumori Y, Hong SM, Aoyama K, Fan Y, Kayama T, Sheldon RA, Vexler ZS, Ferriero DM, Weinstein PR, Liu J. Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J Cereb Blood Flow Metab. 2005 Jul; 25(7):899-910.
        View in: PubMed
      23. Chang YS, Mu D, Wendland M, Sheldon RA, Vexler ZS, McQuillen PS, Ferriero DM. Erythropoietin improves functional and histological outcome in neonatal stroke. Pediatr Res. 2005 Jul; 58(1):106-11.
        View in: PubMed
      24. Jiang X, Mu D, Manabat C, Koshy AA, Christen S, Täuber MG, Vexler ZS, Ferriero DM. Differential vulnerability of immature murine neurons to oxygen-glucose deprivation. Exp Neurol. 2004 Nov; 190(1):224-32.
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      25. Sheldon RA, Jiang X, Francisco C, Christen S, Vexler ZS, Täuber MG, Ferriero DM. Manipulation of antioxidant pathways in neonatal murine brain. Pediatr Res. 2004 Oct; 56(4):656-62.
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      26. Mu D, Jiang X, Sheldon RA, Fox CK, Hamrick SE, Vexler ZS, Ferriero DM. Regulation of hypoxia-inducible factor 1alpha and induction of vascular endothelial growth factor in a rat neonatal stroke model. Neurobiol Dis. 2003 Dec; 14(3):524-34.
        View in: PubMed
      27. Vexler ZS, Wong A, Francisco C, Manabat C, Christen S, Täuber M, Ferriero DM, Gregory G. Fructose-1,6-bisphosphate preserves intracellular glutathione and protects cortical neurons against oxidative stress. Brain Res. 2003 Jan 17; 960(1-2):90-8.
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      28. Manabat C, Han BH, Wendland M, Derugin N, Fox CK, Choi J, Holtzman DM, Ferriero DM, Vexler ZS. Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain. Stroke. 2003 Jan; 34(1):207-13.
        View in: PubMed
      29. Parent JM, Vexler ZS, Gong C, Derugin N, Ferriero DM. Rat forebrain neurogenesis and striatal neuron replacement after focal stroke. Ann Neurol. 2002 Dec; 52(6):802-13.
        View in: PubMed
      30. Donohoe PH, Fahlman CS, Bickler PE, Vexler ZS, Gregory GA. Neuroprotection and intracellular Ca2+ modulation with fructose-1,6-bisphosphate during in vitro hypoxia-ischemia involves phospholipase C-dependent signaling. Brain Res. 2001 Nov 2; 917(2):158-66.
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      31. Vexler ZS, Ferriero DM. Molecular and biochemical mechanisms of perinatal brain injury. Semin Neonatol. 2001 Apr; 6(2):99-108.
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      32. Derugin N, Wendland M, Muramatsu K, Roberts TP, Gregory G, Ferriero DM, Vexler ZS. Evolution of brain injury after transient middle cerebral artery occlusion in neonatal rats. Stroke. 2000 Jul; 31(7):1752-61.
        View in: PubMed
      33. Vexler Z, Berrios M, Ursell PC, Sola A, Ferriero DM, Gregory GA. Toxicity of fructose-1,6-bisphosphate in developing normoxic rats. Pharmacol Toxicol. 1999 Mar; 84(3):115-21.
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      34. Derugin N, Ferriero DM, Vexler ZS. Neonatal reversible focal cerebral ischemia: a new model. Neurosci Res. 1998 Dec; 32(4):349-53.
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      35. Vexler ZS, Roberts TP, Bollen AW, Derugin N, Arieff AI. Transient cerebral ischemia. Association of apoptosis induction with hypoperfusion. J Clin Invest. 1997 Mar 15; 99(6):1453-9.
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      36. Vexler ZS, Symons M, Barber DL. Activation of Na+-H+ exchange is necessary for RhoA-induced stress fiber formation. J Biol Chem. 1996 Sep 13; 271(37):22281-4.
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      37. Roberts TP, Vexler ZS, Vexler V, Derugin N, Kucharczyk J. Sensitivity of high-speed "perfusion-sensitive" magnetic resonance imaging to mild cerebral ischemia. Eur Radiol. 1996; 6(5):645-9.
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      38. Roberts TP, Vexler ZS, Derugin N, Kozniewska E, Kucharczyk J, Emmett CJ. Evaluation of recombinant human basic fibroblast growth factor (rhbFGF) as a cerebroprotective agent using high speed MR imaging. Brain Res. 1995 Nov 13; 699(1):51-61.
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      39. Arieff AI, Kozniewska E, Roberts TP, Vexler ZS, Ayus JC, Kucharczyk J. Age, gender, and vasopressin affect survival and brain adaptation in rats with metabolic encephalopathy. Am J Physiol. 1995 May; 268(5 Pt 2):R1143-52.
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      40. Kozniewska E, Roberts TP, Vexler ZS, Oseka M, Kucharczyk J, Arieff AI. Hormonal dependence of the effects of metabolic encephalopathy on cerebral perfusion and oxygen utilization in the rat. Circ Res. 1995 Apr; 76(4):551-8.
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      41. Vexler ZS, Roberts TP, Derugin N, Kozniewska E, Arieff AI, Kucharczyk J. Mechanisms of brain injury associated with partial and complete occlusion of the MCA in cat. Acta Neurochir Suppl (Wien). 1994; 60:211-5.
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      42. Vexler ZS, Roberts TP, Kucharczyk J, Arieff AI. Severe brain edema associated with cumulative effects of hyponatremic encephalopathy and ischemic hypoxia. Acta Neurochir Suppl (Wien). 1994; 60:246-9.
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      43. Vexler ZS, Ayus JC, Roberts TP, Fraser CL, Kucharczyk J, Arieff AI. Hypoxic and ischemic hypoxia exacerbate brain injury associated with metabolic encephalopathy in laboratory animals. J Clin Invest. 1994 Jan; 93(1):256-64.
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      44. Roberts TP, Vexler Z, Derugin N, Moseley ME, Kucharczyk J. High-speed MR imaging of ischemic brain injury following stenosis of the middle cerebral artery. J Cereb Blood Flow Metab. 1993 Nov; 13(6):940-6.
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      45. Kucharczyk J, Vexler ZS, Roberts TP, Asgari HS, Mintorovitch J, Derugin N, Watson AD, Moseley ME. Echo-planar perfusion-sensitive MR imaging of acute cerebral ischemia. Radiology. 1993 Sep; 188(3):711-7.
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      46. de Crespigny AJ, Wendland MF, Derugin N, Vexler ZS, Moseley ME. Rapid MR imaging of a vascular challenge to focal ischemia in cat brain. J Magn Reson Imaging. 1993 May-Jun; 3(3):475-81.
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      47. Kucharczyk J, Asgari H, Mintorovitch J, Vexler Z, Rocklage S, Watson A, Moseley M. Cerebrovascular transit characteristics of DyDTPA-BMA and GdDTPA-BMA on normal and ischemic cat brain. AJNR Am J Neuroradiol. 1993 Mar-Apr; 14(2):289-96.
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      48. Moseley ME, Vexler Z, Asgari HS, Mintorovitch J, Derugin N, Rocklage S, Kucharczyk J. Comparison of Gd- and Dy-chelates for T2 contrast-enhanced imaging. Magn Reson Med. 1991 Dec; 22(2):259-64; discussion 265-7.
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      49. Kucharczyk J, Asgari H, Mintorovitch J, Vexler Z, Moseley M, Watson A, Rocklage S. Magnetic resonance imaging of brain perfusion using the nonionic contrast agents Dy-DTPA-BMA and Gd-DTPA-BMA. Invest Radiol. 1991 Nov; 26 Suppl 1:S250-2; discussion S253-4.
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