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Atul Butte, MD, PhD

Title(s)Professor, Pediatrics
SchoolSchool of Medicine
Address490 Illinois Street
San Francisco CA 94158
Phone415-514-0528
ORCID ORCID Icon0000-0002-7433-2740 Additional info
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    Other Positions
    Title(s)Priscilla Chan and Mark Zuckerberg Distinguished Professor


    Collapse Biography 
    Collapse Education and Training
    Brown University, Providence, RIA.B. (Honors)05/1991Computer Science
    Brown University School of Medicine, Providence, RIM.D.05/1995Medicine
    Harvard Medical School, Boston, MAPh.D.2004Health Sciences and Technology (HST)
    Collapse Awards and Honors
    Boy Scouts of America1984Eagle Scout
    Obama Administration White House2013Champion of Change in Open Science
    American Society of Clinical Investigation2013Elected into the American Society of Clinical Investigation (ASCI)
    Society for Pediatric Research2014E. Mead Johnson Award
    National Academy of Medicine2015Elected into the National Academy of Medicine

    Collapse Overview 
    Collapse Overview
    Atul Butte, MD, PhD
    Priscilla Chan and Mark Zuckerberg Distinguished Professor of Pediatrics, Bioengineering and Therapeutic Sciences, and Epidemiology and Biostatistics at UCSF
    Director, Bakar Computational Health Sciences Institute, UCSF
    Chief Data Scientist, University of California Health System (UC Health)

    Atul Butte, MD, PhD is the Priscilla Chan and Mark Zuckerberg Distinguished Professor and inaugural Director of the Bakar Computational Health Sciences Institute (bchsi.ucsf.edu) at the University of California, San Francisco (UCSF). Dr. Butte is also the Chief Data Scientist for the entire University of California Health System, with 20 health professional schools, 6 medical schools, 5 academic medical centers, 10 hospitals, and over 1000 care delivery sites. Dr. Butte has been continually funded by NIH for 20 years, is an inventor on 24 patents, and has authored over 200 publications, with research repeatedly featured in the New York Times, Wall Street Journal, and Wired Magazine. Dr. Butte was elected into the National Academy of Medicine in 2015, and in 2013, he was recognized by the Obama Administration as a White House Champion of Change in Open Science for promoting science through publicly available data. Dr. Butte is also a founder of three investor-backed data-driven companies: Personalis (IPO, 2019), providing medical genome sequencing services, Carmenta (acquired by Progenity, 2015), discovering diagnostics for pregnancy complications, and NuMedii, finding new uses for drugs through open molecular data. Dr. Butte trained in Computer Science at Brown University, worked as a software engineer at Apple and Microsoft, received his MD at Brown University, trained in Pediatrics and Pediatric Endocrinology at Children's Hospital Boston, then received his PhD from Harvard Medical School and MIT.

    Collapse Research 
    Collapse Research Activities and Funding
    Computational models of naturally acquired immunity to falciparum malaria
    NIH/NIAID U01AI150741Apr 1, 2020 - Mar 31, 2025
    Role: Co-Principal Investigator
    California Precision Medicine Consortium
    NIH OT2OD024611Sep 27, 2016 - Aug 31, 2017
    Role: Co-Principal Investigator
    Integrative Analysis of Genomic, Epigenomic and Phenotypic Data for Disease Stratification of Endometriosis
    NIH/NICHD R01HD089511Sep 26, 2016 - Apr 30, 2021
    Role: Co-Principal Investigator
    Stanford and Northrop Grumman proposal for the Oncology Models Forum
    NIH/NCI U24CA195858Sep 1, 2015 - Aug 31, 2020
    Role: Principal Investigator
    Biorepository of Human iPSCs for Studying Dilated and Hypertrophic Cardiomyopathy
    NIH/NHLBI R24HL117756Apr 15, 2014 - Mar 31, 2019
    Role: Co-Principal Investigator
    Vaccination and infection: indicators of immunological health and responsiveness
    NIH U19AI090019Jul 12, 2010 - Jun 30, 2016
    Role: Co-Investigator
    Integrating Microarray and Proteomic Data by Ontology-based Annotation
    NIH/NLM R01LM009719Sep 30, 2008 - Sep 29, 2013
    Role: Principal Investigator
    Comparative functional genomics for lung cancer gene discovery
    NIH/NCI R01CA138256Sep 23, 2008 - Jul 31, 2014
    Role: Co-Principal Investigator
    Enabling new translational discoveries using a genomic data-driven nosology
    NIH/NIGMS R01GM079719Sep 30, 2006 - Mar 31, 2016
    Role: Principal Investigator
    CREATION AND APPLICATION OF A DIABETES KNOWLEDGE BASE
    NIH/NLM K22LM008261Jan 15, 2005 - May 31, 2008
    Role: Principal Investigator
    Adaptive and Innate Immunity, Memory and Repertoire in Vaccination and Infection
    NIH U19AI057229Sep 1, 2003 - Mar 31, 2019
    Role: Co-Investigator

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    Collapse Global Health
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The Case for Algorithmic Stewardship for Artificial Intelligence and Machine Learning Technologies. JAMA. 2020 Sep 14. Eaneff S, Obermeyer Z, Butte AJ. PMID: 32926087.
      View in: PubMed   Mentions:    Fields:    
    2. Minimum information about clinical artificial intelligence modeling: the MI-CLAIM checklist. Nat Med. 2020 Sep; 26(9):1320-1324. Norgeot B, Quer G, Beaulieu-Jones BK, Torkamani A, Dias R, Gianfrancesco M, Arnaout R, Kohane IS, Saria S, Topol E, Obermeyer Z, Yu B, Butte AJ. PMID: 32908275.
      View in: PubMed   Mentions:    Fields:    
    3. A robust and interpretable end-to-end deep learning model for cytometry data. Proc Natl Acad Sci U S A. 2020 Aug 14. Hu Z, Tang A, Singh J, Bhattacharya S, Butte AJ. PMID: 32801215.
      View in: PubMed   Mentions:    Fields:    
    4. CovidCounties - an interactive, real-time tracker of the COVID-19 pandemic at the level of US counties. medRxiv. 2020 May 02. Arneson D, Elliott M, Mosenia A, Oskotsky B, Vashisht R, Zack T, Bleicher P, Butte AJ, Rudrapatna VA. PMID: 32511606.
      View in: PubMed   Mentions:
    5. Protected Health Information filter (Philter): accurately and securely de-identifying free-text clinical notes. NPJ Digit Med. 2020; 3:57. Norgeot B, Muenzen K, Peterson TA, Fan X, Glicksberg BS, Schenk G, Rutenberg E, Oskotsky B, Sirota M, Yazdany J, Schmajuk G, Ludwig D, Goldstein T, Butte AJ. PMID: 32337372.
      View in: PubMed   Mentions:
    6. Predicting Inpatient Medication Orders From Electronic Health Record Data. Clin Pharmacol Ther. 2020 Jul; 108(1):145-154. Rough K, Dai AM, Zhang K, Xue Y, Vardoulakis LM, Cui C, Butte AJ, Howell MD, Rajkomar A. PMID: 32141068.
      View in: PubMed   Mentions:    Fields:    
    7. Meta-Analysis of Vaginal Microbiome Data Provides New Insights Into Preterm Birth. Front Microbiol. 2020; 11:476. Kosti I, Lyalina S, Pollard KS, Butte AJ, Sirota M. PMID: 32322240.
      View in: PubMed   Mentions:
    8. Time for NIH to lead on data sharing. Science. 2020 03 20; 367(6484):1308-1309. Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R. PMID: 32193313.
      View in: PubMed   Mentions: 1     Fields:    
    9. Accuracy of medical billing data against the electronic health record in the measurement of colorectal cancer screening rates. BMJ Open Qual. 2020 03; 9(1). Rudrapatna VA, Glicksberg BS, Avila P, Harding-Theobald E, Wang C, Butte AJ. PMID: 32209595.
      View in: PubMed   Mentions:
    10. Recent Advances in Systems and Network Medicine: Meeting Report from the First International Conference in Systems and Network Medicine. Syst Med (New Rochelle). 2020; 3(1):22-35. Kurnat-Thoma E, Baranova A, Baird P, Brodsky E, Butte AJ, Cheema AK, Cheng F, Dutta S, Grant C, Giordano J, Maitland-van der Zee AH, Fridsma DB, Jarrin R, Kann MG, Keeney J, Loscalzo J, Madhavan G, Maron BA, McBride DK, McKean M, Mun SK, Palmer JC, Patel B, Parakh K, Pariser AR, Pristipino C, Radstake TRDJ, Rajasimha HK, Rouse WB, Rozman D, Saleh A, Schmidt HHHW, Schultz N, Sethi T, Silverman EK, Skopac J, Svab I, Trujillo S, Valentine JE, Verma D, West BJ, Vasudevan S. PMID: 32226924.
      View in: PubMed   Mentions:
    11. Explanatory Model of Dry Eye Disease Using Health and Nutrition Examinations: Machine Learning and Network-Based Factor Analysis From a National Survey. JMIR Med Inform. 2020 Feb 20; 8(2):e16153. Nam SM, Peterson TA, Butte AJ, Seo KY, Han HW. PMID: 32130150.
      View in: PubMed   Mentions:
    12. Opportunities and challenges in using real-world data for health care. J Clin Invest. 2020 Feb 03; 130(2):565-574. Rudrapatna VA, Butte AJ. PMID: 32011317.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Corticosteroid use is not associated with improved outcomes in acute exacerbation of IPF. Respirology. 2020 Jun; 25(6):629-635. Farrand E, Vittinghoff E, Ley B, Butte AJ, Collard HR. PMID: 31846126.
      View in: PubMed   Mentions: 1     Fields:    
    14. Heterogeneity in HIV and cellular transcription profiles in cell line models of latent and productive infection: implications for HIV latency. Retrovirology. 2019 11 11; 16(1):32. Telwatte S, Morón-López S, Aran D, Kim P, Hsieh C, Joshi S, Montano M, Greene WC, Butte AJ, Wong JK, Yukl SA. PMID: 31711503.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. PatientExploreR: an extensible application for dynamic visualization of patient clinical history from electronic health records in the OMOP common data model. Bioinformatics. 2019 11 01; 35(21):4515-4518. Glicksberg BS, Oskotsky B, Thangaraj PM, Giangreco N, Badgeley MA, Johnson KW, Datta D, Rudrapatna VA, Rappoport N, Shervey MM, Miotto R, Goldstein TC, Rutenberg E, Frazier R, Lee N, Israni S, Larsen R, Percha B, Li L, Dudley JT, Tatonetti NP, Butte AJ. PMID: 31214700.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    16. Tracing diagnosis trajectories over millions of patients reveal an unexpected risk in schizophrenia. Sci Data. 2019 10 15; 6(1):201. Paik H, Kan MJ, Rappoport N, Hadley D, Sirota M, Chen B, Manber U, Cho SB, Butte AJ. PMID: 31615985.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types. Nat Commun. 2019 08 08; 10(1):3574. Yu K, Chen B, Aran D, Charalel J, Yau C, Wolf DM, van 't Veer LJ, Butte AJ, Goldstein T, Sirota M. PMID: 31395879.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    18. Integrating biomedical research and electronic health records to create knowledge-based biologically meaningful machine-readable embeddings. Nat Commun. 2019 07 10; 10(1):3045. Nelson CA, Butte AJ, Baranzini SE. PMID: 31292438.
      View in: PubMed   Mentions: 2     Fields:    
    19. A longitudinal big data approach for precision health. Nat Med. 2019 05; 25(5):792-804. Schüssler-Fiorenza Rose SM, Contrepois K, Moneghetti KJ, Zhou W, Mishra T, Mataraso S, Dagan-Rosenfeld O, Ganz AB, Dunn J, Hornburg D, Rego S, Perelman D, Ahadi S, Sailani MR, Zhou Y, Leopold SR, Chen J, Ashland M, Christle JW, Avina M, Limcaoco P, Ruiz C, Tan M, Butte AJ, Weinstock GM, Slavich GM, Sodergren E, McLaughlin TL, Haddad F, Snyder MP. PMID: 31068711.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansCells
    20. Closing the Evidence Gap in Interstitial Lung Disease. The Promise of Real-World Data. Am J Respir Crit Care Med. 2019 05 01; 199(9):1061-1065. Farrand E, Anstrom KJ, Bernard G, Butte AJ, Iribarren C, Ley B, Martinez FJ, Collard HR. PMID: 30452876.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Assessment of Postdonation Outcomes in US Living Kidney Donors Using Publicly Available Data Sets. JAMA Netw Open. 2019 04 05; 2(4):e191851. Chen J, Bhattacharya S, Sirota M, Laiudompitak S, Schaefer H, Thomson E, Wiser J, Sarwal MM, Butte AJ. PMID: 30977847.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Robust prediction of clinical outcomes using cytometry data. Bioinformatics. 2019 04 01; 35(7):1197-1203. Hu Z, Glicksberg BS, Butte AJ. PMID: 30169745.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    23. Assessment of a Deep Learning Model Based on Electronic Health Record Data to Forecast Clinical Outcomes in Patients With Rheumatoid Arthritis. JAMA Netw Open. 2019 03 01; 2(3):e190606. Norgeot B, Glicksberg BS, Trupin L, Lituiev D, Gianfrancesco M, Oskotsky B, Schmajuk G, Yazdany J, Butte AJ. PMID: 30874779.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. A pilot study showing a stronger H1N1 influenza vaccination response during pregnancy in women who subsequently deliver preterm. J Reprod Immunol. 2019 04; 132:16-20. Andorf S, Bhattacharya S, Gaudilliere B, Shaw GM, Stevenson DK, Butte AJ, Sirota M. PMID: 30852461.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    25. Prototype of running clinical trials in an untrustworthy environment using blockchain. Nat Commun. 2019 02 22; 10(1):917. Wong DR, Bhattacharya S, Butte AJ. PMID: 30796226.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    26. Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage. Nat Immunol. 2019 02; 20(2):163-172. Aran D, Looney AP, Liu L, Wu E, Fong V, Hsu A, Chak S, Naikawadi RP, Wolters PJ, Abate AR, Butte AJ, Bhattacharya M. PMID: 30643263.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansAnimalsCells
    27. ROMOP: a light-weight R package for interfacing with OMOP-formatted electronic health record data. JAMIA Open. 2019 Apr; 2(1):10-14. Glicksberg BS, Oskotsky B, Giangreco N, Thangaraj PM, Rudrapatna V, Datta D, Frazier R, Lee N, Larsen R, Tatonetti NP, Butte AJ. PMID: 31633087.
      View in: PubMed   Mentions:
    28. A call for deep-learning healthcare. Nat Med. 2019 Jan; 25(1):14-15. Norgeot B, Glicksberg BS, Butte AJ. PMID: 30617337.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    29. Better medicine through machine learning: What's real, and what's artificial? PLoS Med. 2018 12; 15(12):e1002721. Saria S, Butte A, Sheikh A. PMID: 30596635.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    30. Author Correction: Enabling precision medicine in neonatology, an integrated repository for preterm birth research. Sci Data. 2018 12 18; 5(1):3. Sirota M, Thomas CG, Liu R, Zuhl M, Banerjee P, Wong RJ, Quaintance CC, Leite R, Chubiz J, Anderson R, Chappell J, Kim M, Grobman W, Zhang G, Rokas A, Muglia LJ, Ober C, England SK, Macones G, Driscoll D, Parry S, Shaw GM, Stevenson DK, Simpson JL, Thomson E, Butte AJ. PMID: 30563979.
      View in: PubMed   Mentions:    Fields:    
    31. Personal Mutanomes Meet Modern Oncology Drug Discovery and Precision Health. Pharmacol Rev. 2019 01; 71(1):1-19. Cheng F, Liang H, Butte AJ, Eng C, Nussinov R. PMID: 30545954.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Open data informatics and data repurposing for IBD. Nat Rev Gastroenterol Hepatol. 2018 12; 15(12):715-716. Rudrapatna VA, Butte AJ. PMID: 30061595.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    33. The 10,000 Immunomes Project: Building a Resource for Human Immunology. Cell Rep. 2018 Nov 13; 25(7):1995. Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ. PMID: 30428364.
      View in: PubMed   Mentions: 3     Fields:    
    34. Enabling precision medicine in neonatology, an integrated repository for preterm birth research. Sci Data. 2018 11 06; 5:180219. Sirota M, Thomas CG, Liu R, Zuhl M, Banerjee P, Wong RJ, Quaintance CC, Leite R, Chubiz J, Anderson R, Chappell J, Kim M, Grobman W, Zhang G, Rokas A, England SK, Parry S, Shaw GM, Simpson JL, Thomson E, Butte AJ. PMID: 30398470.
      View in: PubMed   Mentions: 1     Fields:    
    35. The 10,000 Immunomes Project: Building a Resource for Human Immunology. Cell Rep. 2018 10 09; 25(2):513-522.e3. Zalocusky KA, Kan MJ, Hu Z, Dunn P, Thomson E, Wiser J, Bhattacharya S, Butte AJ. PMID: 30304689.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    36. MetaCyto: A Tool for Automated Meta-analysis of Mass and Flow Cytometry Data. Cell Rep. 2018 07 31; 24(5):1377-1388. Hu Z, Jujjavarapu C, Hughey JJ, Andorf S, Lee HC, Gherardini PF, Spitzer MH, Thomas CG, Campbell J, Dunn P, Wiser J, Kidd BA, Dudley JT, Nolan GP, Bhattacharya S, Butte AJ. PMID: 30067990.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Scalable and accurate deep learning with electronic health records. NPJ Digit Med. 2018; 1:18. Rajkomar A, Oren E, Chen K, Dai AM, Hajaj N, Hardt M, Liu PJ, Liu X, Marcus J, Sun M, Sundberg P, Yee H, Zhang K, Zhang Y, Flores G, Duggan GE, Irvine J, Le Q, Litsch K, Mossin A, Tansuwan J, Wexler J, Wilson J, Ludwig D, Volchenboum SL, Chou K, Pearson M, Madabushi S, Shah NH, Butte AJ, Howell MD, Cui C, Corrado GS, Dean J. PMID: 31304302.
      View in: PubMed   Mentions:
    38. The Atacama skeleton. Genome Res. 2018 05; 28(5):607-608. Nolan G, Butte A. PMID: 29602903.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Whole-genome sequencing of Atacama skeleton shows novel mutations linked with dysplasia. Genome Res. 2018 04; 28(4):423-431. Bhattacharya S, Li J, Sockell A, Kan MJ, Bava FA, Chen SC, Ávila-Arcos MC, Ji X, Smith E, Asadi NB, Lachman RS, Lam HYK, Bustamante CD, Butte AJ, Nolan GP. PMID: 29567674.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    40. ImmPort, toward repurposing of open access immunological assay data for translational and clinical research. Sci Data. 2018 02 27; 5:180015. Bhattacharya S, Dunn P, Thomas CG, Smith B, Schaefer H, Chen J, Hu Z, Zalocusky KA, Shankar RD, Shen-Orr SS, Thomson E, Wiser J, Butte AJ. PMID: 29485622.
      View in: PubMed   Mentions: 37     Fields:    
    41. Are minor alleles more likely to be risk alleles? BMC Med Genomics. 2018 01 19; 11(1):3. Kido T, Sikora-Wohlfeld W, Kawashima M, Kikuchi S, Kamatani N, Patwardhan A, Chen R, Sirota M, Kodama K, Hadley D, Butte AJ. PMID: 29351777.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    42. A genome-wide association study identifies only two ancestry specific variants associated with spontaneous preterm birth. Sci Rep. 2018 01 09; 8(1):226. Rappoport N, Toung J, Hadley D, Wong RJ, Fujioka K, Reuter J, Abbott CW, Oh S, Hu D, Eng C, Huntsman S, Bodian DL, Niederhuber JE, Hong X, Zhang G, Sikora-Wohfeld W, Gignoux CR, Wang H, Oehlert J, Jelliffe-Pawlowski LL, Gould JB, Darmstadt GL, Wang X, Bustamante CD, Snyder MP, Ziv E, Patsopoulos NA, Muglia LJ, Burchard E, Shaw GM, O'Brodovich HM, Stevenson DK, Butte AJ, Sirota M. PMID: 29317701.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    43. Risky Business: Meeting the Structural Needs of Transdisciplinary Science. J Pediatr. 2017 12; 191:255-258. Wise PH, Shaw GM, Druzin ML, Darmstadt GL, Quaintance C, Mäkinen E, Relman DA, Quake SR, Butte AJ, Angst MS, Muglia LJ, Macones G, Driscoll D, Ober C, Simpson JL, Katz M, Howse J, Stevenson DK. PMID: 29173314.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    44. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017 11 15; 18(1):220. Aran D, Hu Z, Butte AJ. PMID: 29141660.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansCells
    45. Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight. 2017 11 02; 2(21). Mirza AN, Fry MA, Urman NM, Atwood SX, Roffey J, Ott GR, Chen B, Lee A, Brown AS, Aasi SZ, Hollmig T, Ator MA, Dorsey BD, Ruggeri BR, Zificsak CA, Sirota M, Tang JY, Butte A, Epstein E, Sarin KY, Oro AE. PMID: 29093271.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    46. PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models. Cancer Res. 2017 11 01; 77(21):e62-e66. Meehan TF, Conte N, Goldstein T, Inghirami G, Murakami MA, Brabetz S, Gu Z, Wiser JA, Dunn P, Begley DA, Krupke DM, Bertotti A, Bruna A, Brush MH, Byrne AT, Caldas C, Christie AL, Clark DA, Dowst H, Dry JR, Doroshow JH, Duchamp O, Evrard YA, Ferretti S, Frese KK, Goodwin NC, Greenawalt D, Haendel MA, Hermans E, Houghton PJ, Jonkers J, Kemper K, Khor TO, Lewis MT, Lloyd KCK, Mason J, Medico E, Neuhauser SB, Olson JM, Peeper DS, Rueda OM, Seong JK, Trusolino L, Vinolo E, Wechsler-Reya RJ, Weinstock DM, Welm A, Weroha SJ, Amant F, Pfister SM, Kool M, Parkinson H, Butte AJ, Bult CJ. PMID: 29092942.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    47. Future cancer research priorities in the USA: a Lancet Oncology Commission. Lancet Oncol. 2017 11; 18(11):e653-e706. Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A. PMID: 29208398.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    48. Comprehensive analysis of normal adjacent to tumor transcriptomes. Nat Commun. 2017 10 20; 8(1):1077. Aran D, Camarda R, Odegaard J, Paik H, Oskotsky B, Krings G, Goga A, Sirota M, Butte AJ. PMID: 29057876.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    49. Precision annotation of digital samples in NCBI's gene expression omnibus. Sci Data. 2017 09 19; 4:170125. Hadley D, Pan J, El-Sayed O, Aljabban J, Aljabban I, Azad TD, Hadied MO, Raza S, Rayikanti BA, Chen B, Paik H, Aran D, Spatz J, Himmelstein D, Panahiazar M, Bhattacharya S, Sirota M, Musen MA, Butte AJ. PMID: 28925997.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    50. Big data opens a window onto wellness. Nat Biotechnol. 2017 08 08; 35(8):720-721. Butte AJ. PMID: 28787419.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    51. Reversal of cancer gene expression correlates with drug efficacy and reveals therapeutic targets. Nat Commun. 2017 07 12; 8:16022. Chen B, Ma L, Paik H, Sirota M, Wei W, Chua MS, So S, Butte AJ. PMID: 28699633.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    52. Cancer Cell-Autonomous Parainflammation Mimics Immune Cell Infiltration. Cancer Res. 2017 07 15; 77(14):3740-3744. Lasry A, Aran D, Butte AJ, Ben-Neriah Y. PMID: 28667073.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    53. RImmPort: an R/Bioconductor package that enables ready-for-analysis immunology research data. Bioinformatics. 2017 04 01; 33(7):1101-1103. Shankar RD, Bhattacharya S, Jujjavarapu C, Andorf S, Wiser JA, Butte AJ. PMID: 28057685.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    54. Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. Gastroenterology. 2017 06; 152(8):2022-2036. Chen B, Wei W, Ma L, Yang B, Gill RM, Chua MS, Butte AJ, So S. PMID: 28284560.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    55. Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer's disease. Alzheimers Res Ther. 2017 Feb 17; 9(1):10. Geifman N, Brinton RD, Kennedy RE, Schneider LS, Butte AJ. PMID: 28212683.
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    56. In silico and in vitro drug screening identifies new therapeutic approaches for Ewing sarcoma. Oncotarget. 2017 Jan 17; 8(3):4079-4095. Pessetto ZY, Chen B, Alturkmani H, Hyter S, Flynn CA, Baltezor M, Ma Y, Rosenthal HG, Neville KA, Weir SJ, Butte AJ, Godwin AK. PMID: 27863422.
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    57. Solving Immunology? Trends Immunol. 2017 02; 38(2):116-127. Vodovotz Y, Xia A, Read EL, Bassaganya-Riera J, Hafler DA, Sontag E, Wang J, Tsang JS, Day JD, Kleinstein SH, Butte AJ, Altman MC, Hammond R, Sealfon SC. PMID: 27986392.
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    58. Integrating Clinical Phenotype and Gene Expression Data to Prioritize Novel Drug Uses. CPT Pharmacometrics Syst Pharmacol. 2016 11; 5(11):599-607. Paik H, Chen B, Sirota M, Hadley D, Butte AJ. PMID: 27860440.
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    59. It takes a genome to understand a village: Population scale precision medicine. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12344-12346. Butte AJ. PMID: 27791179.
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    60. Defective Signaling in the JAK-STAT Pathway Tracks with Chronic Inflammation and Cardiovascular Risk in Aging Humans. Cell Syst. 2016 10 26; 3(4):374-384.e4. Shen-Orr SS, Furman D, Kidd BA, Hadad F, Lovelace P, Huang YW, Rosenberg-Hasson Y, Mackey S, Grisar FA, Pickman Y, Maecker HT, Chien YH, Dekker CL, Wu JC, Butte AJ, Davis MM. PMID: 27746093.
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    61. Differential Phasing between Circadian Clocks in the Brain and Peripheral Organs in Humans. J Biol Rhythms. 2016 12; 31(6):588-597. Hughey JJ, Butte AJ. PMID: 27702781.
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    62. Digitally deconvolving the tumor microenvironment. Genome Biol. 2016 08 22; 17(1):175. Aran D, Butte AJ. PMID: 27549319.
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    63. Widespread parainflammation in human cancer. Genome Biol. 2016 07 08; 17(1):145. Aran D, Lasry A, Zinger A, Biton M, Pikarsky E, Hellman A, Butte AJ, Ben-Neriah Y. PMID: 27386949.
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    64. Identification of matrix metalloproteinase-12 as a candidate molecule for prevention and treatment of cardiometabolic disease. Mol Med. 2016 Oct; 22:487-496. Amor M, Moreno Viedma V, Sarabi A, Grün NG, Itariu B, Leitner L, Steiner I, Bilban M, Kodama K, Butte AJ, Staffler G, Zeyda M, Stulnig TM. PMID: 27385318.
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    65. Microfluidic single-cell transcriptional analysis rationally identifies novel surface marker profiles to enhance cell-based therapies. Nat Commun. 2016 06 21; 7:11945. Rennert RC, Januszyk M, Sorkin M, Rodrigues M, Maan ZN, Duscher D, Whittam AJ, Kosaraju R, Chung MT, Paik K, Li AY, Findlay M, Glotzbach JP, Butte AJ, Gurtner GC. PMID: 27324848.
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    66. A patient-level data meta-analysis of standard-of-care treatments from eight prostate cancer clinical trials. Sci Data. 2016 May 10; 3:160027. Geifman N, Butte AJ. PMID: 27163794.
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    67. Cross-tissue Analysis of Gene and Protein Expression in Normal and Cancer Tissues. Sci Rep. 2016 05 04; 6:24799. Kosti I, Jain N, Aran D, Butte AJ, Sirota M. PMID: 27142790.
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    68. Constraints on Biological Mechanism from Disease Comorbidity Using Electronic Medical Records and Database of Genetic Variants. PLoS Comput Biol. 2016 Apr; 12(4):e1004885. Bagley SC, Sirota M, Chen R, Butte AJ, Altman RB. PMID: 27115429.
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    69. Expression-Based Genome-Wide Association Study Links Vitamin D-Binding Protein With Autoantigenicity in Type 1 Diabetes. Diabetes. 2016 May; 65(5):1341-9. Kodama K, Zhao Z, Toda K, Yip L, Fuhlbrigge R, Miao D, Fathman CG, Yamada S, Butte AJ, Yu L. PMID: 26983959.
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    70. Leveraging big data to transform target selection and drug discovery. Clin Pharmacol Ther. 2016 Mar; 99(3):285-97. Chen B, Butte AJ. PMID: 26659699.
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    71. Corrigendum: Systematic pan-cancer analysis of tumour purity. Nat Commun. 2016 Feb 05; 7:10707. Aran D, Sirota M, Butte AJ. PMID: 26848121.
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    72. ZeitZeiger: supervised learning for high-dimensional data from an oscillatory system. Nucleic Acids Res. 2016 05 05; 44(8):e80. Hughey JJ, Hastie T, Butte AJ. PMID: 26819407.
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    73. Compendium of Immune Signatures Identifies Conserved and Species-Specific Biology in Response to Inflammation. Immunity. 2016 Jan 19; 44(1):194-206. Godec J, Tan Y, Liberzon A, Tamayo P, Bhattacharya S, Butte AJ, Mesirov JP, Haining WN. PMID: 26795250.
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    74. DO CANCER CLINICAL TRIAL POPULATIONS TRULY REPRESENT CANCER PATIENTS? A COMPARISON OF OPEN CLINICAL TRIALS TO THE CANCER GENOME ATLAS. Pac Symp Biocomput. 2016; 21:309-20. Geifman N, Butte AJ. PMID: 26776196.
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    75. Genetic analysis in a patient with nine primary malignant neoplasms: a rare case of Li-Fraumeni syndrome. Oncol Rep. 2016 Mar; 35(3):1519-28. Li X, Kang J, Pan Q, Sikora-Wohlfeld W, Zhao D, Meng C, Bai C, Patwardhan A, Chen R, Ren H, Butte AJ, Ding K. PMID: 26707089.
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    78. Opening clinical trial data: are the voluntary data-sharing portals enough? BMC Med. 2015 Nov 11; 13:280. Geifman N, Bollyky J, Bhattacharya S, Butte AJ. PMID: 26560699.
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    79. Relating Chemical Structure to Cellular Response: An Integrative Analysis of Gene Expression, Bioactivity, and Structural Data Across 11,000 Compounds. CPT Pharmacometrics Syst Pharmacol. 2015 Oct; 4(10):576-84. Chen B, Greenside P, Paik H, Sirota M, Hadley D, Butte AJ. PMID: 26535158.
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    80. Reanalysis of the Rituximab in ANCA-Associated Vasculitis trial identifies granulocyte subsets as a novel early marker of successful treatment. Arthritis Res Ther. 2015 Sep 21; 17:262. Nasrallah M, Pouliot Y, Hartmann B, Dunn P, Thomson E, Wiser J, Butte AJ. PMID: 26387933.
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    82. Serological targeted analysis of an ITIH4 peptide isoform: a preterm birth biomarker and its associated SNP implications. J Genet Genomics. 2015 Sep 20; 42(9):507-10. Tan Z, Hu Z, Cai EY, Alev C, Yang T, Li Z, Sung J, El-Sayed YY, Shaw GM, Stevenson DK, Butte AJ, Sheng G, Sylvester KG, Cohen HJ, Ling XB. PMID: 26408095.
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    83. Relating hepatocellular carcinoma tumor samples and cell lines using gene expression data in translational research. BMC Med Genomics. 2015; 8 Suppl 2:S5. Chen B, Sirota M, Fan-Minogue H, Hadley D, Butte AJ. PMID: 26043652.
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    85. The receptor CD44 is associated with systemic insulin resistance and proinflammatory macrophages in human adipose tissue. Diabetologia. 2015 Jul; 58(7):1579-86. Liu LF, Kodama K, Wei K, Tolentino LL, Choi O, Engleman EG, Butte AJ, McLaughlin T. PMID: 25952479.
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    86. Heterogeneity in recent-onset type 1 diabetes - a clinical trial perspective. Diabetes Metab Res Rev. 2015 Sep; 31(6):588-94. Bollyky JB, Xu P, Butte AJ, Wilson DM, Beam CA, Greenbaum CJ. PMID: 25689602.
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    87. A survey of current trends in computational drug repositioning. Brief Bioinform. 2016 Jan; 17(1):2-12. Li J, Zheng S, Chen B, Butte AJ, Swamidass SJ, Lu Z. PMID: 25832646.
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    88. Robust meta-analysis of gene expression using the elastic net. Nucleic Acids Res. 2015 Jul 13; 43(12):e79. Hughey JJ, Butte AJ. PMID: 25829177.
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    89. Repurpose terbutaline sulfate for amyotrophic lateral sclerosis using electronic medical records. Sci Rep. 2015 Mar 05; 5:8580. Paik H, Chung AY, Park HC, Park RW, Suk K, Kim J, Kim H, Lee K, Butte AJ. PMID: 25739475.
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    90. Variation in the human immune system is largely driven by non-heritable influences. Cell. 2015 Jan 15; 160(1-2):37-47. Brodin P, Jojic V, Gao T, Bhattacharya S, Angel CJ, Furman D, Shen-Orr S, Dekker CL, Swan GE, Butte AJ, Maecker HT, Davis MM. PMID: 25594173.
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    91. Characteristics of drug combination therapy in oncology by analyzing clinical trial data on ClinicalTrials.gov. Pac Symp Biocomput. 2015; 68-79. Wu M, Sirota M, Butte AJ, Chen B. PMID: 25592569.
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    93. Aging disrupts cell subpopulation dynamics and diminishes the function of mesenchymal stem cells. Sci Rep. 2014 Nov 21; 4:7144. Duscher D, Rennert RC, Januszyk M, Anghel E, Maan ZN, Whittam AJ, Perez MG, Kosaraju R, Hu MS, Walmsley GG, Atashroo D, Khong S, Butte AJ, Gurtner GC. PMID: 25413454.
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    97. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature. 2014 Jun 12; 510(7504):283-7. Mazur PK, Reynoird N, Khatri P, Jansen PW, Wilkinson AW, Liu S, Barbash O, Van Aller GS, Huddleston M, Dhanak D, Tummino PJ, Kruger RG, Garcia BA, Butte AJ, Vermeulen M, Sage J, Gozani O. PMID: 24847881.
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    99. ImmPort: disseminating data to the public for the future of immunology. Immunol Res. 2014 May; 58(2-3):234-9. Bhattacharya S, Andorf S, Gomes L, Dunn P, Schaefer H, Pontius J, Berger P, Desborough V, Smith T, Campbell J, Thomson E, Monteiro R, Guimaraes P, Walters B, Wiser J, Butte AJ. PMID: 24791905.
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    101. Diabetes irreversibly depletes bone marrow-derived mesenchymal progenitor cell subpopulations. Diabetes. 2014 Sep; 63(9):3047-56. Januszyk M, Sorkin M, Glotzbach JP, Vial IN, Maan ZN, Rennert RC, Duscher D, Thangarajah H, Longaker MT, Butte AJ, Gurtner GC. PMID: 24740572.
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    102. Collaborative biomedicine in the age of big data: the case of cancer. J Med Internet Res. 2014 Apr 07; 16(4):e101. Shaikh AR, Butte AJ, Schully SD, Dalton WS, Khoury MJ, Hesse BW. PMID: 24711045.
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    103. Mutations in NGLY1 cause an inherited disorder of the endoplasmic reticulum-associated degradation pathway. Genet Med. 2014 Oct; 16(10):751-8. Enns GM, Shashi V, Bainbridge M, Gambello MJ, Zahir FR, Bast T, Crimian R, Schoch K, Platt J, Cox R, Bernstein JA, Scavina M, Walter RS, Bibb A, Jones M, Hegde M, Graham BH, Need AC, Oviedo A, Schaaf CP, Boyle S, Butte AJ, Chen R, Chen R, Clark MJ, Haraksingh R, Cowan TM, He P, Langlois S, Zoghbi HY, Snyder M, Gibbs RA, Freeze HH, Goldstein DB. PMID: 24651605.
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    104. A meta-analysis of lung cancer gene expression identifies PTK7 as a survival gene in lung adenocarcinoma. Cancer Res. 2014 May 15; 74(10):2892-902. Chen R, Khatri P, Mazur PK, Polin M, Zheng Y, Vaka D, Hoang CD, Shrager J, Xu Y, Vicent S, Butte AJ, Sweet-Cordero EA. PMID: 24654231.
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    106. Investigation of maternal environmental exposures in association with self-reported preterm birth. Reprod Toxicol. 2014 Jun; 45:1-7. Patel CJ, Yang T, Hu Z, Wen Q, Sung J, El-Sayed YY, Cohen H, Gould J, Stevenson DK, Shaw GM, Ling XB, Butte AJ. PMID: 24373932.
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    107. Network medicine in disease analysis and therapeutics. Clin Pharmacol Ther. 2013 Dec; 94(6):627-9. Chen B, Butte AJ. PMID: 24241637.
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    108. Integrating multiple 'omics' analyses identifies serological protein biomarkers for preeclampsia. BMC Med. 2013 Nov 06; 11:236. Liu LY, Yang T, Ji J, Wen Q, Morgan AA, Jin B, Chen G, Lyell DJ, Stevenson DK, Ling XB, Butte AJ. PMID: 24195779.
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    109. A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation. J Exp Med. 2013 Oct 21; 210(11):2205-21. Khatri P, Roedder S, Kimura N, De Vusser K, Morgan AA, Gong Y, Fischbein MP, Robbins RC, Naesens M, Butte AJ, Sarwal MM. PMID: 24127489.
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    110. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013 Dec; 3(12):1364-77. Jahchan NS, Dudley JT, Mazur PK, Flores N, Yang D, Palmerton A, Zmoos AF, Vaka D, Tran KQ, Zhou M, Krasinska K, Riess JW, Neal JW, Khatri P, Park KS, Butte AJ, Sage J. PMID: 24078773.
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    112. Making it personal: translational bioinformatics. J Am Med Inform Assoc. 2013 Jul-Aug; 20(4):595-6. Butte AJ, Ohno-Machado L. PMID: 23757438.
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    129. Population genetic inference from personal genome data: impact of ancestry and admixture on human genomic variation. Am J Hum Genet. 2012 Oct 05; 91(4):660-71. Kidd JM, Gravel S, Byrnes J, Moreno-Estrada A, Musharoff S, Bryc K, Degenhardt JD, Brisbin A, Sheth V, Chen R, McLaughlin SF, Peckham HE, Omberg L, Bormann Chung CA, Stanley S, Pearlstein K, Levandowsky E, Acevedo-Acevedo S, Auton A, Keinan A, Acuña-Alonzo V, Barquera-Lozano R, Canizales-Quinteros S, Eng C, Burchard EG, Russell A, Reynolds A, Clark AG, Reese MG, Lincoln SE, Butte AJ, De La Vega FM, Bustamante CD. PMID: 23040495.
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    130. A peripheral blood diagnostic test for acute rejection in renal transplantation. Am J Transplant. 2012 Oct; 12(10):2710-8. Li L, Khatri P, Sigdel TK, Tran T, Ying L, Vitalone MJ, Chen A, Hsieh S, Dai H, Zhang M, Naesens M, Zarkhin V, Sansanwal P, Chen R, Mindrinos M, Xiao W, Benfield M, Ettenger RB, Dharnidharka V, Mathias R, Portale A, McDonald R, Harmon W, Kershaw D, Vehaskari VM, Kamil E, Baluarte HJ, Warady B, Davis R, Butte AJ, Salvatierra O, Sarwal MM. PMID: 23009139.
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    131. Cross-species functional analysis of cancer-associated fibroblasts identifies a critical role for CLCF1 and IL-6 in non-small cell lung cancer in vivo. Cancer Res. 2012 Nov 15; 72(22):5744-56. Vicent S, Sayles LC, Vaka D, Khatri P, Gevaert O, Chen R, Zheng Y, Gillespie AK, Clarke N, Xu Y, Shrager J, Hoang CD, Plevritis S, Butte AJ, Sweet-Cordero EA. PMID: 22962265.
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    132. Sequencing and analysis of a South Asian-Indian personal genome. BMC Genomics. 2012 Aug 31; 13:440. Gupta R, Ratan A, Rajesh C, Chen R, Kim HL, Burhans R, Miller W, Santhosh S, Davuluri RV, Butte AJ, Schuster SC, Seshagiri S, Thomas G. PMID: 22938532.
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    133. Leveraging models of cell regulation and GWAS data in integrative network-based association studies. Nat Genet. 2012 Jul 27; 44(8):841-7. Califano A, Butte AJ, Friend S, Ideker T, Schadt E. PMID: 22836096.
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    134. Identification of cell surface targets through meta-analysis of microarray data. Neoplasia. 2012 Jul; 14(7):666-9. Haeberle H, Dudley JT, Liu JT, Butte AJ, Contag CH. PMID: 22904683.
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    135. Data-driven integration of epidemiological and toxicological data to select candidate interacting genes and environmental factors in association with disease. Bioinformatics. 2012 Jun 15; 28(12):i121-6. Patel CJ, Chen R, Butte AJ. PMID: 22689751.
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    136. Integrative approach to pain genetics identifies pain sensitivity loci across diseases. PLoS Comput Biol. 2012; 8(6):e1002538. Ruau D, Dudley JT, Chen R, Phillips NG, Swan GE, Lazzeroni LC, Clark JD, Butte AJ, Angst MS. PMID: 22685391.
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    137. Human genomic disease variants: a neutral evolutionary explanation. Genome Res. 2012 Aug; 22(8):1383-94. Dudley JT, Kim Y, Liu L, Markov GJ, Gerold K, Chen R, Butte AJ, Kumar S. PMID: 22665443.
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    138. Clinical utility of sequence-based genotype compared with that derivable from genotyping arrays. J Am Med Inform Assoc. 2012 Jun; 19(e1):e21-7. Morgan AA, Chen R, Butte AJ. PMID: 22718036.
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    139. Translational bioinformatics: data-driven drug discovery and development. Clin Pharmacol Ther. 2012 Jun; 91(6):949-52. Butte AJ, Ito S. PMID: 22609903.
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    140. Integration of disease-specific single nucleotide polymorphisms, expression quantitative trait loci and coexpression networks reveal novel candidate genes for type 2 diabetes. Diabetologia. 2012 Aug; 55(8):2205-13. Kang HP, Yang X, Chen R, Zhang B, Corona E, Schadt EE, Butte AJ. PMID: 22584726.
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    141. Neonatal Informatics: Transforming Neonatal Care Through Translational Bioinformatics. Neoreviews. 2012 May 01; 13(5):e281-e284. Palma JP, Benitz WE, Tarczy-Hornoch P, Butte AJ, Longhurst CA. PMID: 22924023.
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    142. Type 2 diabetes risk alleles demonstrate extreme directional differentiation among human populations, compared to other diseases. PLoS Genet. 2012; 8(4):e1002621. Chen R, Corona E, Sikora M, Dudley JT, Morgan AA, Moreno-Estrada A, Nilsen GB, Ruau D, Lincoln SE, Bustamante CD, Butte AJ. PMID: 22511877.
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    143. Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A. 2012 May 01; 109(18):7049-54. Kodama K, Horikoshi M, Toda K, Yamada S, Hara K, Irie J, Sirota M, Morgan AA, Chen R, Ohtsu H, Maeda S, Kadowaki T, Butte AJ. PMID: 22499789.
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    144. Quantifying multi-ethnic representation in genetic studies of high mortality diseases. AMIA Jt Summits Transl Sci Proc. 2012; 2012:11-8. Chen R, Dudley JT, Ruau D, Butte AJ. PMID: 22779041.
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    145. Coanalysis of GWAS with eQTLs reveals disease-tissue associations. AMIA Jt Summits Transl Sci Proc. 2012; 2012:35-41. Kang HP, Morgan AA, Chen R, Schadt EE, Butte AJ. PMID: 22779046.
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    146. Personal omics profiling reveals dynamic molecular and medical phenotypes. Cell. 2012 Mar 16; 148(6):1293-307. Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. PMID: 22424236.
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    147. Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol. 2012 Jun; 41(3):828-43. Patel CJ, Cullen MR, Ioannidis JP, Butte AJ. PMID: 22421054.
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    148. Evolutionary meta-analysis of association studies reveals ancient constraints affecting disease marker discovery. Mol Biol Evol. 2012 Sep; 29(9):2087-94. Dudley JT, Chen R, Sanderford M, Butte AJ, Kumar S. PMID: 22389448.
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    149. Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. J Am Med Inform Assoc. 2012 Mar-Apr; 19(2):284-8. Morgan AA, Pyrgos VJ, Nadeau KC, Williamson PR, Butte AJ. PMID: 22319178.
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    150. Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol. 2012; 8(2):e1002375. Khatri P, Sirota M, Butte AJ. PMID: 22383865.
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    151. Sex differences in reported pain across 11,000 patients captured in electronic medical records. J Pain. 2012 Mar; 13(3):228-34. Ruau D, Liu LY, Clark JD, Angst MS, Butte AJ. PMID: 22245360.
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    152. Performance comparison of whole-genome sequencing platforms. Nat Biotechnol. 2011 Dec 18; 30(1):78-82. Lam HY, Clark MJ, Chen R, Chen R, Natsoulis G, O'Huallachain M, Dewey FE, Habegger L, Ashley EA, Gerstein MB, Butte AJ, Ji HP, Snyder M. PMID: 22178993.
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    153. ProfileChaser: searching microarray repositories based on genome-wide patterns of differential expression. Bioinformatics. 2011 Dec 01; 27(23):3317-8. Engreitz JM, Chen R, Morgan AA, Dudley JT, Mallelwar R, Butte AJ. PMID: 21967760.
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    154. Performance comparison of exome DNA sequencing technologies. Nat Biotechnol. 2011 Sep 25; 29(10):908-14. Clark MJ, Chen R, Lam HY, Karczewski KJ, Chen R, Euskirchen G, Butte AJ, Snyder M. PMID: 21947028.
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    155. Phased whole-genome genetic risk in a family quartet using a major allele reference sequence. PLoS Genet. 2011 Sep; 7(9):e1002280. Dewey FE, Chen R, Cordero SP, Ormond KE, Caleshu C, Karczewski KJ, Whirl-Carrillo M, Wheeler MT, Dudley JT, Byrnes JK, Cornejo OE, Knowles JW, Woon M, Sangkuhl K, Gong L, Thorn CF, Hebert JM, Capriotti E, David SP, Pavlovic A, West A, Thakuria JV, Ball MP, Zaranek AW, Rehm HL, Church GM, West JS, Bustamante CD, Snyder M, Altman RB, Klein TE, Butte AJ, Ashley EA. PMID: 21935354.
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    156. Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int. 2011 Dec; 80(12):1364-76. Naesens M, Khatri P, Li L, Sigdel TK, Vitalone MJ, Chen R, Butte AJ, Salvatierra O, Sarwal MM. PMID: 21881554.
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    157. Sex differences in disease risk from reported genome-wide association study findings. Hum Genet. 2012 Mar; 131(3):353-64. Liu LY, Schaub MA, Sirota M, Butte AJ. PMID: 21858542.
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    158. Computational repositioning of the anticonvulsant topiramate for inflammatory bowel disease. Sci Transl Med. 2011 Aug 17; 3(96):96ra76. Dudley JT, Sirota M, Shenoy M, Pai RK, Roedder S, Chiang AP, Morgan AA, Sarwal MM, Pasricha PJ, Butte AJ. PMID: 21849664.
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    159. Discovery and preclinical validation of drug indications using compendia of public gene expression data. Sci Transl Med. 2011 Aug 17; 3(96):96ra77. Sirota M, Dudley JT, Kim J, Chiang AP, Morgan AA, Sweet-Cordero A, Sage J, Butte AJ. PMID: 21849665.
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    160. Identification of an IFN-?/mast cell axis in a mouse model of chronic asthma. J Clin Invest. 2011 Aug; 121(8):3133-43. Yu M, Eckart MR, Morgan AA, Mukai K, Butte AJ, Tsai M, Galli SJ. PMID: 21737883.
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    161. Computationally translating molecular discoveries into tools for medicine: translational bioinformatics articles now featured in JAMIA. J Am Med Inform Assoc. 2011 Jul-Aug; 18(4):352-3. Butte AJ, Shah NH. PMID: 21672904.
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    162. Applications of translational bioinformatics in transplantation. Clin Pharmacol Ther. 2011 Aug; 90(2):323-7. Khatri P, Sarwal MM, Butte AJ. PMID: 21716268.
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    163. The role of bioinformatics in studying rheumatic and autoimmune disorders. Nat Rev Rheumatol. 2011 06 21; 7(8):489-94. Sirota M, Butte AJ. PMID: 21691330.
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    164. Exploiting drug-disease relationships for computational drug repositioning. Brief Bioinform. 2011 Jul; 12(4):303-11. Dudley JT, Deshpande T, Butte AJ. PMID: 21690101.
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    165. Transmission distortion in Crohn's disease risk gene ATG16L1 leads to sex difference in disease association. Inflamm Bowel Dis. 2012 Feb; 18(2):312-22. Liu LY, Schaub MA, Sirota M, Butte AJ. PMID: 21618365.
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    166. Predicting adverse drug reactions using publicly available PubChem BioAssay data. Clin Pharmacol Ther. 2011 Jul; 90(1):90-9. Pouliot Y, Chiang AP, Butte AJ. PMID: 21613989.
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    167. Translational bioinformatics: linking knowledge across biological and clinical realms. J Am Med Inform Assoc. 2011 Jul-Aug; 18(4):354-7. Sarkar IN, Butte AJ, Lussier YA, Tarczy-Hornoch P, Ohno-Machado L. PMID: 21561873.
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    168. Comparison of automated and human assignment of MeSH terms on publicly-available molecular datasets. J Biomed Inform. 2011 Dec; 44 Suppl 1:S39-43. Ruau D, Mbagwu M, Dudley JT, Krishnan V, Butte AJ. PMID: 21420508.
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    169. Transplantomics and biomarkers in organ transplantation: a report from the first international conference. Transplantation. 2011 Feb 27; 91(4):379-82. Sarwal MM, Benjamin J, Butte AJ, Davis MM, Wood K, Chapman J. PMID: 21278631.
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    170. Computational prediction and experimental validation associating FABP-1 and pancreatic adenocarcinoma with diabetes. BMC Gastroenterol. 2011 Jan 20; 11:5. Sharaf RN, Butte AJ, Montgomery KD, Pai R, Dudley JT, Pasricha PJ. PMID: 21251264.
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    171. Matching cancer genomes to established cell lines for personalized oncology. Pac Symp Biocomput. 2011; 243-52. Dudley JT, Chen R, Butte AJ. PMID: 21121052.
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    172. The reference human genome demonstrates high risk of type 1 diabetes and other disorders. Pac Symp Biocomput. 2011; 231-42. Chen R, Butte AJ. PMID: 21121051.
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    173. Protein microarrays discover angiotensinogen and PRKRIP1 as novel targets for autoantibodies in chronic renal disease. Mol Cell Proteomics. 2011 Mar; 10(3):M110.000497. Butte AJ, Sigdel TK, Wadia PP, Miklos DB, Sarwal MM. PMID: 21183621.
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    174. Content-based microarray search using differential expression profiles. BMC Bioinformatics. 2010 Dec 21; 11:603. Engreitz JM, Morgan AA, Dudley JT, Chen R, Thathoo R, Altman RB, Butte AJ. PMID: 21172034.
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    175. In silico research in the era of cloud computing. Nat Biotechnol. 2010 Nov; 28(11):1181-5. Dudley JT, Butte AJ. PMID: 21057489.
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    176. Latent physiological factors of complex human diseases revealed by independent component analysis of clinarrays. BMC Bioinformatics. 2010 Oct 28; 11 Suppl 9:S4. Chen DP, Dudley JT, Butte AJ. PMID: 21044362.
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    177. Comparison of multiplex meta analysis techniques for understanding the acute rejection of solid organ transplants. BMC Bioinformatics. 2010 Oct 28; 11 Suppl 9:S6. Morgan AA, Khatri P, Jones RH, Sarwal MM, Butte AJ. PMID: 21044364.
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    178. An integrative method for scoring candidate genes from association studies: application to warfarin dosing. BMC Bioinformatics. 2010 Oct 28; 11 Suppl 9:S9. Tatonetti NP, Dudley JT, Sagreiya H, Butte AJ, Altman RB. PMID: 21044367.
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    179. Non-synonymous and synonymous coding SNPs show similar likelihood and effect size of human disease association. PLoS One. 2010 Oct 22; 5(10):e13574. Chen R, Davydov EV, Sirota M, Butte AJ. PMID: 21042586.
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    180. Differentially expressed RNA from public microarray data identifies serum protein biomarkers for cross-organ transplant rejection and other conditions. PLoS Comput Biol. 2010 Sep 23; 6(9). Chen R, Sigdel TK, Li L, Kambham N, Dudley JT, Hsieh SC, Klassen RB, Chen A, Caohuu T, Morgan AA, Valantine HA, Khush KK, Sarwal MM, Butte AJ. PMID: 20885780.
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    181. Special article: an optimistic prognosis for the clinical utility of laboratory test data. Anesth Analg. 2010 Oct; 111(4):1026-35. Zheng M, Ravindran P, Wang J, Epstein RH, Chen DP, Butte AJ, Peltz G. PMID: 20810674.
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    182. Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet. 2010 Oct; 3(5):426-35. Wilson KD, Hu S, Venkatasubrahmanyam S, Fu JD, Sun N, Abilez OJ, Baugh JJ, Jia F, Ghosh Z, Li RA, Butte AJ, Wu JC. PMID: 20733065.
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    183. Extreme evolutionary disparities seen in positive selection across seven complex diseases. PLoS One. 2010 Aug 17; 5(8):e12236. Corona E, Dudley JT, Butte AJ. PMID: 20808933.
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    184. Translational bioinformatics in the cloud: an affordable alternative. Genome Med. 2010 Aug 06; 2(8):51. Dudley JT, Pouliot Y, Chen R, Morgan AA, Butte AJ. PMID: 20691073.
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    185. Drug discovery in a multidimensional world: systems, patterns, and networks. J Cardiovasc Transl Res. 2010 Oct; 3(5):438-47. Dudley JT, Schadt E, Sirota M, Butte AJ, Ashley E. PMID: 20677029.
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    186. Biomarker and drug discovery for gastroenterology through translational bioinformatics. Gastroenterology. 2010 Sep; 139(3):735-41, 741.e1. Dudley JT, Butte AJ. PMID: 20650279.
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    187. Getting from genes to function in lung disease: a National Heart, Lung, and Blood Institute workshop report. Am J Respir Crit Care Med. 2010 Sep 15; 182(6):732-7. Ober C, Butte AJ, Elias JA, Lusis AJ, Gan W, Banks-Schlegel S, Schwartz D. PMID: 20558629.
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    188. An Environment-Wide Association Study (EWAS) on type 2 diabetes mellitus. PLoS One. 2010 May 20; 5(5):e10746. Patel CJ, Bhattacharya J, Butte AJ. PMID: 20505766.
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    189. Likelihood ratios for genome medicine. Genome Med. 2010 May 17; 2(5):30. Morgan AA, Chen R, Butte AJ. PMID: 20497613.
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    190. Current methodologies for translational bioinformatics. J Biomed Inform. 2010 Jun; 43(3):355-7. Lussier YA, Butte AJ, Hunter L. PMID: 20470899.
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    191. Predicting environmental chemical factors associated with disease-related gene expression data. BMC Med Genomics. 2010 May 06; 3:17. Patel CJ, Butte AJ. PMID: 20459635.
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    192. Clinical assessment incorporating a personal genome. Lancet. 2010 May 01; 375(9725):1525-35. Ashley EA, Butte AJ, Wheeler MT, Chen R, Klein TE, Dewey FE, Dudley JT, Ormond KE, Pavlovic A, Morgan AA, Pushkarev D, Neff NF, Hudgins L, Gong L, Hodges LM, Berlin DS, Thorn CF, Sangkuhl K, Hebert JM, Woon M, Sagreiya H, Whaley R, Knowles JW, Chou MF, Thakuria JV, Rosenbaum AM, Zaranek AW, Church GM, Greely HT, Quake SR, Altman RB. PMID: 20435227.
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    193. Challenges in the clinical application of whole-genome sequencing. Lancet. 2010 May 15; 375(9727):1749-51. Ormond KE, Wheeler MT, Hudgins L, Klein TE, Butte AJ, Altman RB, Ashley EA, Greely HT. PMID: 20434765.
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    194. Cell type-specific gene expression differences in complex tissues. Nat Methods. 2010 Apr; 7(4):287-9. Shen-Orr SS, Tibshirani R, Khatri P, Bodian DL, Staedtler F, Perry NM, Hastie T, Sarwal MM, Davis MM, Butte AJ. PMID: 20208531.
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    195. Network-based elucidation of human disease similarities reveals common functional modules enriched for pluripotent drug targets. PLoS Comput Biol. 2010 Feb 05; 6(2):e1000662. Suthram S, Dudley JT, Chiang AP, Chen R, Hastie TJ, Butte AJ. PMID: 20140234.
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    196. Identification of complex metabolic states in critically injured patients using bioinformatic cluster analysis. Crit Care. 2010; 14(1):R10. Cohen MJ, Grossman AD, Morabito D, Knudson MM, Butte AJ, Manley GT. PMID: 20122274.
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    197. Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation. Blood. 2010 Mar 11; 115(10):2077-87. Wadia PP, Coram M, Armstrong RJ, Mindrinos M, Butte AJ, Miklos DB. PMID: 20053754.
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    198. Autoimmune disease classification by inverse association with SNP alleles. PLoS Genet. 2009 Dec; 5(12):e1000792. Sirota M, Schaub MA, Batzoglou S, Robinson WH, Butte AJ. PMID: 20041220.
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    199. A quick guide for developing effective bioinformatics programming skills. PLoS Comput Biol. 2009 Dec; 5(12):e1000589. Dudley JT, Butte AJ. PMID: 20041221.
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    200. Validating pathophysiological models of aging using clinical electronic medical records. J Biomed Inform. 2010 Jun; 43(3):358-64. Chen DP, Morgan AA, Butte AJ. PMID: 19958842.
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    201. Dynamism in gene expression across multiple studies. Physiol Genomics. 2010 Feb 04; 40(3):128-40. Morgan AA, Dudley JT, Deshpande T, Butte AJ. PMID: 19920211.
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    202. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 06; 5(5):527-39. Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A. PMID: 19896443.
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    203. Protein microarrays identify antibodies to protein kinase Czeta that are associated with a greater risk of allograft loss in pediatric renal transplant recipients. Kidney Int. 2009 Dec; 76(12):1277-83. Sutherland SM, Li L, Sigdel TK, Wadia PP, Miklos DB, Butte AJ, Sarwal MM. PMID: 19812540.
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    204. Relationship of differential gene expression profiles in CD34+ myelodysplastic syndrome marrow cells to disease subtype and progression. Blood. 2009 Nov 26; 114(23):4847-58. Sridhar K, Ross DT, Tibshirani R, Butte AJ, Greenberg PL. PMID: 19801443.
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    205. Infection in the intensive care unit alters physiological networks. BMC Bioinformatics. 2009 Sep 17; 10 Suppl 9:S4. Grossman AD, Cohen MJ, Manley GT, Butte AJ. PMID: 19761574.
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    206. Disease signatures are robust across tissues and experiments. Mol Syst Biol. 2009; 5:307. Dudley JT, Tibshirani R, Deshpande T, Butte AJ. PMID: 19756046.
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    207. Wiskott-Aldrich syndrome protein is an effector of Kit signaling. Blood. 2009 Oct 01; 114(14):2900-8. Mani M, Venkatasubrahmanyam S, Sanyal M, Levy S, Butte A, Weinberg K, Jahn T. PMID: 19643989.
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    208. Systematic evaluation of drug-disease relationships to identify leads for novel drug uses. Clin Pharmacol Ther. 2009 Nov; 86(5):507-10. Chiang AP, Butte AJ. PMID: 19571805.
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    209. Translational bioinformatics applications in genome medicine. Genome Med. 2009 Jun 29; 1(6):64. Butte AJ. PMID: 19566916.
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    210. A Classifier-based approach to identify genetic similarities between diseases. Bioinformatics. 2009 Jun 15; 25(12):i21-9. Schaub MA, Kaplow IM, Sirota M, Do CB, Butte AJ, Batzoglou S. PMID: 19477990.
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    211. C3 polymorphisms and outcomes of renal allografts. N Engl J Med. 2009 Jun 04; 360(23):2478; author reply 2478-9. Naesens M, Butte AJ, Sarwal MM. PMID: 19504761.
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    212. MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev. 2009 Jun; 18(5):749-58. Wilson KD, Venkatasubrahmanyam S, Jia F, Sun N, Butte AJ, Wu JC. PMID: 19284351.
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    213. Expression of complement components differs between kidney allografts from living and deceased donors. J Am Soc Nephrol. 2009 Aug; 20(8):1839-51. Naesens M, Li L, Ying L, Sansanwal P, Sigdel TK, Hsieh SC, Kambham N, Lerut E, Salvatierra O, Butte AJ, Sarwal MM. PMID: 19443638.
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    214. Identifying compartment-specific non-HLA targets after renal transplantation by integrating transcriptome and "antibodyome" measures. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4148-53. Li L, Wadia P, Chen R, Kambham N, Naesens M, Sigdel TK, Miklos DB, Sarwal MM, Butte AJ. PMID: 19251643.
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    215. Ontology-driven indexing of public datasets for translational bioinformatics. BMC Bioinformatics. 2009 Feb 05; 10 Suppl 2:S1. Shah NH, Jonquet C, Chiang AP, Butte AJ, Chen R, Musen MA. PMID: 19208184.
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    216. The "etiome": identification and clustering of human disease etiological factors. BMC Bioinformatics. 2009 Feb 05; 10 Suppl 2:S14. Liu YI, Wise PH, Butte AJ. PMID: 19208189.
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    217. Selected proceedings of the First Summit on Translational Bioinformatics 2008. BMC Bioinformatics. 2009 Feb 05; 10 Suppl 2:I1. Butte AJ, Sarkar IN, Ramoni M, Lussier Y, Troyanskaya O. PMID: 19208183.
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    218. Data-driven methods to discover molecular determinants of serious adverse drug events. Clin Pharmacol Ther. 2009 Mar; 85(3):259-68. Chiang AP, Butte AJ. PMID: 19177064.
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    219. Identification of discriminating biomarkers for human disease using integrative network biology. Pac Symp Biocomput. 2009; 27-38. Dudley JT, Butte AJ. PMID: 19209693.
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    220. Towards a cytokine-cell interaction knowledgebase of the adaptive immune system. Pac Symp Biocomput. 2009; 439-50. Shen-Orr SS, Goldberger O, Garten Y, Rosenberg-Hasson Y, Lovelace PA, Hirschberg DL, Altman RB, Davis MM, Butte AJ. PMID: 19209721.
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    221. GeneChaser: identifying all biological and clinical conditions in which genes of interest are differentially expressed. BMC Bioinformatics. 2008 Dec 18; 9:548. Chen R, Mallelwar R, Thosar A, Venkatasubrahmanyam S, Butte AJ. PMID: 19094235.
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    222. Report on EU-USA workshop: how systems biology can advance cancer research (27 October 2008). Mol Oncol. 2009 Feb; 3(1):9-17. Aebersold R, Auffray C, Baney E, Barillot E, Brazma A, Brett C, Brunak S, Butte A, Califano A, Celis J, Cufer T, Ferrell J, Galas D, Gallahan D, Gatenby R, Goldbeter A, Hace N, Henney A, Hood L, Iyengar R, Jackson V, Kallioniemi O, Klingmüller U, Kolar P, Kolch W, Kyriakopoulou C, Laplace F, Lehrach H, Marcus F, Matrisian L, Nolan G, Pelkmans L, Potti A, Sander C, Seljak M, Singer D, Sorger P, Stunnenberg H, Superti-Furga G, Uhlen M, Vidal M, Weinstein J, Wigle D, Williams M, Wolkenhauer O, Zhivotovsky B, Zinovyev A, Zupan B. PMID: 19383362.
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    223. FitSNPs: highly differentially expressed genes are more likely to have variants associated with disease. Genome Biol. 2008; 9(12):R170. Chen R, Morgan AA, Dudley J, Deshpande T, Li L, Kodama K, Chiang AP, Butte AJ. PMID: 19061490.
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    224. Expression-based Pathway Signature Analysis (EPSA): mining publicly available microarray data for insight into human disease. BMC Med Genomics. 2008 Oct 20; 1:51. Tenenbaum JD, Walker MG, Utz PJ, Butte AJ. PMID: 18937865.
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    225. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell. 2008 Oct 09; 3(4):416-28. Viatour P, Somervaille TC, Venkatasubrahmanyam S, Kogan S, McLaughlin ME, Weissman IL, Butte AJ, Passegué E, Sage J. PMID: 18940733.
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    226. Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol. 2008 Nov; 129(2):195-201. Kodama K, Butte AJ, Creusot RJ, Su L, Sheng D, Hartnett M, Iwai H, Soares LR, Fathman CG. PMID: 18801706.
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    227. Translational bioinformatics: coming of age. J Am Med Inform Assoc. 2008 Nov-Dec; 15(6):709-14. Butte AJ. PMID: 18755990.
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    228. Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR. J Biomed Inform. 2009 Apr; 42(2):287-95. English SB, Shih SC, Ramoni MF, Smith LE, Butte AJ. PMID: 18790084.
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    229. Medicine. The ultimate model organism. Science. 2008 Apr 18; 320(5874):325-7. Butte AJ. PMID: 18420921.
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    230. Novel integration of hospital electronic medical records and gene expression measurements to identify genetic markers of maturation. Pac Symp Biocomput. 2008; 243-54. Chen DP, Weber SC, Constantinou PS, Ferris TA, Lowe HJ, Butte AJ. PMID: 18229690.
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    231. Enabling integrative genomic analysis of high-impact human diseases through text mining. Pac Symp Biocomput. 2008; 580-91. Dudley J, Butte AJ. PMID: 18229717.
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    232. AILUN: reannotating gene expression data automatically. Nat Methods. 2007 Nov; 4(11):879. Chen R, Li L, Butte AJ. PMID: 17971777.
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    233. Clinical arrays of laboratory measures, or "clinarrays", built from an electronic health record enable disease subtyping by severity. AMIA Annu Symp Proc. 2007 Oct 11; 115-9. Chen DP, Weber SC, Constantinou PS, Ferris TA, Lowe HJ, Butte AJ. PMID: 18693809.
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    234. Methodologies for extracting functional pharmacogenomic experiments from international repository. AMIA Annu Symp Proc. 2007 Oct 11; 463-7. Lin YA, Chiang A, Lin R, Yao P, Chen R, Butte AJ. PMID: 18693879.
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    235. Evaluation and integration of 49 genome-wide experiments and the prediction of previously unknown obesity-related genes. Bioinformatics. 2007 Nov 01; 23(21):2910-7. English SB, Butte AJ. PMID: 17921495.
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    236. Creation and implications of a phenome-genome network. Nat Biotechnol. 2006 Jan; 24(1):55-62. Butte AJ, Kohane IS. PMID: 16404398.
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    237. Multiplexed protein array platforms for analysis of autoimmune diseases. Annu Rev Immunol. 2006; 24:391-418. Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ. PMID: 16551254.
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    238. Finding disease-related genomic experiments within an international repository: first steps in translational bioinformatics. AMIA Annu Symp Proc. 2006; 106-10. Butte AJ, Chen R. PMID: 17238312.
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    239. Genome-wide analysis of host responses to the Pseudomonas aeruginosa type III secretion system yields synergistic effects. Cell Microbiol. 2005 Nov; 7(11):1635-46. Ichikawa JK, English SB, Wolfgang MC, Jackson R, Butte AJ, Lory S. PMID: 16207250.
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    240. Systematic survey reveals general applicability of "guilt-by-association" within gene coexpression networks. BMC Bioinformatics. 2005 Sep 14; 6:227. Wolfe CJ, Kohane IS, Butte AJ. PMID: 16162296.
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    241. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol. 2005 Jun; 7(6):601-11. Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AM, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. PMID: 15895078.
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    242. A computational model to define the molecular causes of type 2 diabetes mellitus. Diabetes Technol Ther. 2005 Apr; 7(2):323-36. Pollard J, Butte AJ, Hoberman S, Joshi M, Levy J, Pappo J. PMID: 15857235.
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    243. Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell. 2004 Aug; 3(4):235-43. Csoka AB, English SB, Simkevich CP, Ginzinger DG, Butte AJ, Schatten GP, Rothman FG, Sedivy JM. PMID: 15268757.
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    244. Conserved mechanisms across development and tumorigenesis revealed by a mouse development perspective of human cancers. Genes Dev. 2004 Mar 15; 18(6):629-40. Kho AT, Zhao Q, Cai Z, Butte AJ, Kim JY, Pomeroy SL, Rowitch DH, Kohane IS. PMID: 15075291.
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    245. Quantifying the relationship between co-expression, co-regulation and gene function. BMC Bioinformatics. 2004 Feb 25; 5:18. Allocco DJ, Kohane IS, Butte AJ. PMID: 15053845.
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    246. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8466-71. Patti ME, Butte AJ, Crunkhorn S, Cusi K, Berria R, Kashyap S, Miyazaki Y, Kohane I, Costello M, Saccone R, Landaker EJ, Goldfine AB, Mun E, DeFronzo R, Finlayson J, Kahn CR, Mandarino LJ. PMID: 12832613.
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    247. Reproducibility of gene expression across generations of Affymetrix microarrays. BMC Bioinformatics. 2003 Jun 25; 4:27. Nimgaonkar A, Sanoudou D, Butte AJ, Haslett JN, Kunkel LM, Beggs AH, Kohane IS. PMID: 12823866.
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    248. PGAGENE: integrating quantitative gene-specific results from the NHLBI programs for genomic applications. Bioinformatics. 2003 Apr 12; 19(6):778-9. Lee K, Kohane IS, Butte AJ. PMID: 12691993.
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    249. Computerized recruiting for clinical trials in real time. Ann Emerg Med. 2003 Feb; 41(2):242-6. Weiner DL, Butte AJ, Hibberd PL, Fleisher GR. PMID: 12548275.
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    250. The use and analysis of microarray data. Nat Rev Drug Discov. 2002 Dec; 1(12):951-60. Butte A. PMID: 12461517.
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    251. Comparing expression profiles of genes with similar promoter regions. Bioinformatics. 2002 Dec; 18(12):1576-84. Park PJ, Butte AJ, Kohane IS. PMID: 12490441.
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    252. Analysis of matched mRNA measurements from two different microarray technologies. Bioinformatics. 2002 Mar; 18(3):405-12. Kuo WP, Jenssen TK, Butte AJ, Ohno-Machado L, Kohane IS. PMID: 11934739.
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    253. Further defining housekeeping, or "maintenance," genes Focus on "A compendium of gene expression in normal human tissues". Physiol Genomics. 2001 Dec 21; 7(2):95-6. Butte AJ, Dzau VJ, Glueck SB. PMID: 11773595.
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    254. Comparing the similarity of time-series gene expression using signal processing metrics. J Biomed Inform. 2001 Dec; 34(6):396-405. Butte AJ, Bao L, Reis BY, Watkins TW, Kohane IS. PMID: 12198759.
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    255. Strict interpretation of vaccination guidelines with computerized algorithms and improper timing of administered doses. Pediatr Infect Dis J. 2001 Jun; 20(6):561-5. Butte AJ, Shaw JS, Bernstein H. PMID: 11419495.
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    256. The personal internetworked notary and guardian. Int J Med Inform. 2001 Jun; 62(1):27-40. Riva A, Mandl KD, Oh DH, Nigrin DJ, Butte A, Szolovits P, Kohane IS. PMID: 11340004.
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    257. Challenges in bioinformatics: infrastructure, models and analytics. Trends Biotechnol. 2001 May; 19(5):159-60. Butte AJ. PMID: 11403022.
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    258. Determining significant fold differences in gene expression analysis. Pac Symp Biocomput. 2001; 6-17. Butte AJ, Ye J, Häring HU, Stumvoll M, White MF, Kohane IS. PMID: 11262977.
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    259. Discovering functional relationships between RNA expression and chemotherapeutic susceptibility using relevance networks. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12182-6. Butte AJ, Tamayo P, Slonim D, Golub TR, Kohane IS. PMID: 11027309.
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    260. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med. 2000 Jul 20; 343(3):185-9. Huang SA, Tu HM, Harney JW, Venihaki M, Butte AJ, Kozakewich HP, Fishman SJ, Larsen PR. PMID: 10900278.
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    261. Mutual information relevance networks: functional genomic clustering using pairwise entropy measurements. Pac Symp Biocomput. 2000; 418-29. Butte AJ, Kohane IS. PMID: 10902190.
      View in: PubMed   Mentions: 262     Fields:    Translation:HumansAnimals
    262. Enrolling patients into clinical trials faster using RealTime Recuiting. Proc AMIA Symp. 2000; 111-5. Butte AJ, Weinstein DA, Kohane IS. PMID: 11079855.
      View in: PubMed   Mentions: 25     Fields:    Translation:Humans
    263. Unsupervised knowledge discovery in medical databases using relevance networks. Proc AMIA Symp. 1999; 711-5. Butte AJ, Kohane IS. PMID: 10566452.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    264. Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. J Biol Chem. 1994 Nov 11; 269(45):27920-4. Quon MJ, Butte AJ, Zarnowski MJ, Sesti G, Cushman SW, Taylor SI. PMID: 7525563.
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    265. Insulin signal transduction pathways. Trends Endocrinol Metab. 1994 Nov; 5(9):369-76. Quon MJ, Butte AJ, Taylor SI. PMID: 18407232.
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    266. Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A. 1994 Jun 07; 91(12):5587-91. Quon MJ, Guerre-Millo M, Zarnowski MJ, Butte AJ, Em M, Cushman SW, Taylor SI. PMID: 8202531.
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    267. Derivation of a scale-independent parameter which characterizes genetic sequence comparisons. Comput Biomed Res. 1993 Dec; 26(6):517-40. DePetrillo PB, Butte AJ. PMID: 8112054.
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