Christian Vaisse, MD, PhD

Title(s)Professor, Diabetes Center
SchoolSchool of Medicine
Address513 Parnassus Ave, HSW, #1113
San Francisco CA 94143
Phone415-514-0530
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    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    From Obesity GWAS to therapeutic targets
    NIH R01DK124769Jul 1, 2020 - Jun 30, 2025
    Role: Principal Investigator
    Obesity in Ciliopathies: How Neuronal Primary Cilia Control Appetite
    NIH R01DK106404Jun 1, 2016 - Jul 31, 2026
    Role: Principal Investigator
    UCSF Nutrition Obesity Research Center
    NIH P30DK098722Aug 1, 2015 - Jul 31, 2025
    Role: Principal Investigator
    Identification & functional characterization of SIM1 obesity-associated variants
    NIH R01DK090382May 1, 2012 - Mar 31, 2016
    Role: Principal Investigator
    Role of Pro-opiomelanocortin mutations in human obesity
    NIH R01DK068152Sep 15, 2005 - Jul 31, 2010
    Role: Principal Investigator
    Diabetes Research Center
    NIH P30DK063720Sep 1, 2002 - Mar 31, 2021
    Role: Co-Investigator
    The Melanocortin-4 Receptor in Human Obesity
    NIH R01DK060540Feb 15, 2002 - Aug 31, 2025
    Role: Principal Investigator
    The Melanocortin-4 Receptor in Human Obesity
    NIH R56DK060540Feb 15, 2002 - Aug 31, 2020
    Role: Principal Investigator
    PEDIATRIC CLINICAL RESEARCH CENTER
    NIH M01RR001271Dec 1, 1981 - Mar 31, 2007
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000079Dec 1, 1974 - Mar 31, 2009
    Role: Co-Investigator
    General Clinical Research Center
    NIH M01RR000083Oct 1, 1974 - Nov 30, 2007
    Role: Co-Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Author Correction: Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nat Metab. 2024 Mar 01. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. PMID: 38429391.
      View in: PubMed   Mentions:    Fields:    
    2. Postnatal Dynamic Ciliary ARL13B and ADCY3 Localization in the Mouse Brain. Cells. 2024 Jan 30; 13(3). Brewer KK, Brewer KM, Terry TT, Caspary T, Vaisse C, Berbari NF. PMID: 38334651; PMCID: PMC10854790.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Identification of AgRP cells in the murine hindbrain that drive feeding. Mol Metab. 2024 Feb; 80:101886. Bachor TP, Hwang E, Yulyaningsih E, Attal K, Mifsud F, Pham V, Vagena E, Huarcaya R, Valdearcos M, Vaisse C, Williams KW, Emmerson PJ, Xu AW. PMID: 38246589; PMCID: PMC10844855.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    4. Ciliary ARL13B prevents obesity in mice. bioRxiv. 2023 Aug 04. Terry TT, Gigante ED, Alexandre CM, Brewer KM, Engle SE, Yue X, Berbari NF, Vaisse C, Caspary T. PMID: 37577625; PMCID: PMC10418222.
      View in: PubMed   Mentions:
    5. 1522-P: Identification of AgRP Cells in the Murine Hindbrain That Drive Feeding. Diabetes. 2023 Jun 20; 72(Supplement_1). BACHOR BT, ATTAL AK, VAGENA VE, MIFSUD MF, PHAM PV, VALDEARCOS-CONTRERAS VM, VAISSE VC, XU XA. .
      View in: Publisher Site   Mentions:
    6. Physiological Condition-Dependent Changes in Ciliary GPCR Localization in the Brain. eNeuro. 2023 03; 10(3). Brewer KM, Engle SE, Bansal R, Brewer KK, Jasso KR, McIntyre JC, Vaisse C, Reiter JF, Berbari NF. PMID: 36849261; PMCID: PMC10012409.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    7. MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R. JCI Insight. 2023 Jan 24; 8(2). Bernard A, Ojeda Naharros I, Yue X, Mifsud F, Blake A, Bourgain-Guglielmetti F, Ciprin J, Zhang S, McDaid E, Kim K, Nachury MV, Reiter JF, Vaisse C. PMID: 36692018; PMCID: PMC9977312.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. Sci Adv. 2022 Mar 11; 8(10):eabj2917. Jiang Z, Elsarrag SZ, Duan Q, LaGory EL, Wang Z, Alexanian M, McMahon S, Rulifson IC, Winchester S, Wang Y, Vaisse C, Brown JD, Quattrocelli M, Lin CY, Haldar SM. PMID: 35263131; PMCID: PMC8906731.
      View in: PubMed   Mentions: 2     Fields:    
    9. Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. J Clin Invest. 2021 05 03; 131(9). Wang Y, Bernard A, Comblain F, Yue X, Paillart C, Zhang S, Reiter JF, Vaisse C. PMID: 33938449; PMCID: PMC8087202.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    10. OR04-01 MRAP2 Regulates Energy Homeostasis by Promoting Primary Cilia Localization of MC4R. Journal of the Endocrine Society. 2020 May 8; 4(Supplement_1):or04-01-. Bernard BA, Naharros NI, Guglielmetti GF, Yue YX, Vaisse VC. .
      View in: Publisher Site   Mentions:
    11. Detailed 3-dimensional body shape features predict body composition, blood metabolites, and functional strength: the Shape Up! studies. Am J Clin Nutr. 2019 12 01; 110(6):1316-1326. Ng BK, Sommer MJ, Wong MC, Pagano I, Nie Y, Fan B, Kennedy S, Bourgeois B, Kelly N, Liu YE, Hwaung P, Garber AK, Chow D, Vaisse C, Curless B, Heymsfield SB, Shepherd JA. PMID: 31553429; PMCID: PMC6885475.
      View in: PubMed   Mentions: 38     Fields:    Translation:Humans
    12. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. . 2019 Sep 12. N NM, S SR, S ST, L LM, Y YW, A AB, A AH, WL WE, C CV, N NA. .
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    13. Genomic and epigenomic mapping of leptin-responsive neuronal populations involved in body weight regulation. Nat Metab. 2019 04; 1(4):475-484. Inoue F, Eckalbar WL, Wang Y, Murphy KK, Matharu N, Vaisse C, Ahituv N. PMID: 31535083; PMCID: PMC6750255.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. CRISPR-mediated activation of a promoter or enhancer rescues obesity caused by haploinsufficiency. Science. 2019 01 18; 363(6424). Matharu N, Rattanasopha S, Tamura S, Maliskova L, Wang Y, Bernard A, Hardin A, Eckalbar WL, Vaisse C, Ahituv N. PMID: 30545847; PMCID: PMC6570489.
      View in: PubMed   Mentions: 121     Fields:    Translation:AnimalsCells
    15. Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. Nat Genet. 2018 02; 50(2):180-185. Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. PMID: 29311635; PMCID: PMC5805646.
      View in: PubMed   Mentions: 100     Fields:    Translation:HumansAnimalsCells
    16. Cilia and Obesity. Cold Spring Harb Perspect Biol. 2017 Jul 05; 9(7). Vaisse C, Reiter JF, Berbari NF. PMID: 28096262; PMCID: PMC5495057.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    17. Acute Lesioning and Rapid Repair of Hypothalamic Neurons outside the Blood-Brain Barrier. Cell Rep. 2017 06 13; 19(11):2257-2271. Yulyaningsih E, Rudenko IA, Valdearcos M, Dahlén E, Vagena E, Chan A, Alvarez-Buylla A, Vaisse C, Koliwad SK, Xu AW. PMID: 28614713; PMCID: PMC5651178.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    18. The Association of Serum Leptin with Mortality in Older Adults. PLoS One. 2015; 10(10):e0140763. Mishra S, Harris TB, Hsueh WC, Hue T, Leak TS, Li R, Mehta M, Vaisse C, Sahyoun NR. PMID: 26473487; PMCID: PMC4608587.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCTClinical Trials
    19. Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. PLoS One. 2014; 9(5):e96805. Evans DS, Calton MA, Kim MJ, Kwok PY, Miljkovic I, Harris T, Koster A, Liu Y, Tranah GJ, Ahituv N, Hsueh WC, Vaisse C. PMID: 24820477; PMCID: PMC4018404.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    20. Hyperphagia: current concepts and future directions proceedings of the 2nd international conference on hyperphagia. Obesity (Silver Spring). 2014 Feb; 22 Suppl 1:S1-S17. Heymsfield SB, Avena NM, Baier L, Brantley P, Bray GA, Burnett LC, Butler MG, Driscoll DJ, Egli D, Elmquist J, Forster JL, Goldstone AP, Gourash LM, Greenway FL, Han JC, Kane JG, Leibel RL, Loos RJ, Scheimann AO, Roth CL, Seeley RJ, Sheffield V, Tauber M, Vaisse C, Wang L, Waterland RA, Wevrick R, Yanovski JA, Zinn AR. PMID: 24574081; PMCID: PMC4159941.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    21. Functional characterization of SIM1-associated enhancers. Hum Mol Genet. 2014 Apr 01; 23(7):1700-8. Kim MJ, Oksenberg N, Hoffmann TJ, Vaisse C, Ahituv N. PMID: 24203700; PMCID: PMC3943516.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    22. The melanocortin system and insulin resistance in humans: insights from a patient with complete POMC deficiency and type 1 diabetes mellitus. Int J Obes (Lond). 2014 Jan; 38(1):148-51. Aslan IR, Ranadive SA, Valle I, Kollipara S, Noble JA, Vaisse C. PMID: 23649472; PMCID: PMC4648369.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    23. Mechanism of N-terminal modulation of activity at the melanocortin-4 receptor GPCR. Nat Chem Biol. 2012 Aug; 8(8):725-30. Ersoy BA, Pardo L, Zhang S, Thompson DA, Millhauser G, Govaerts C, Vaisse C. PMID: 22729149; PMCID: PMC3657613.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    24. Weight loss after Roux-en-Y gastric bypass in obese patients heterozygous for MC4R mutations. Obes Surg. 2011 Jul; 21(7):930-4. Aslan IR, Campos GM, Calton MA, Evans DS, Merriman RB, Vaisse C. PMID: 20957447; PMCID: PMC3119798.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    25. Replication and extension of association between common genetic variants in SIM1 and human adiposity. Obesity (Silver Spring). 2011 Dec; 19(12):2394-2403. Swarbrick MM, Evans DS, Valle MI, Favre H, Wu SH, Njajou OT, Li R, Zmuda JM, Miljkovic I, Harris TB, Kwok PY, Vaisse C, Hsueh WC. PMID: 21512513; PMCID: PMC4646950.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    26. Monogenic Disorders Within the Energy Balance Pathway. Obesity Before Birth. 2011 Jan 1; 30:53-69. Aslan AI, Ranadive RS, Vaisse VC. .
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    27. Changes in cortical bone response to high-fat diet from adolescence to adulthood in mice. Osteoporos Int. 2011 Aug; 22(8):2283-93. Ionova-Martin SS, Wade JM, Tang S, Shahnazari M, Ager JW, Lane NE, Yao W, Alliston T, Vaisse C, Ritchie RO. PMID: 20941479; PMCID: PMC3132390.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
    28. Systematic examination of the SIM1 gene region: Replication and extension of association between common genetic variants and adiposity. Obesity Research & Clinical Practice. 2010 Oct 1; 4:s10-s11. Swarbrick SM, Evans ED, Ascencio AM, Favre FH, Wu WS, Njajou NO, Li LR, Zmuda ZJ, Miljkovic MI, Harris HT, Kwok KP, Vaisse VC, Hsueh HW. .
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    29. Bariatric surgery in a patient with complete MC4R deficiency. Int J Obes (Lond). 2011 Mar; 35(3):457-61. Aslan IR, Ranadive SA, Ersoy BA, Rogers SJ, Lustig RH, Vaisse C. PMID: 20733581; PMCID: PMC4648366.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    30. Reduced size-independent mechanical properties of cortical bone in high-fat diet-induced obesity. Bone. 2010 Jan; 46(1):217-25. Ionova-Martin SS, Do SH, Barth HD, Szadkowska M, Porter AE, Ager JW, Ager JW, Alliston T, Vaisse C, Ritchie RO. PMID: 19853069; PMCID: PMC4501030.
      View in: PubMed   Mentions: 44     Fields:    Translation:Animals
    31. In silico mutagenesis: a case study of the melanocortin 4 receptor. FASEB J. 2009 Sep; 23(9):3059-69. Bromberg Y, Overton J, Vaisse C, Leibel RL, Rost B. PMID: 19417090; PMCID: PMC2735358.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    32. Narrowing down the role of common variants in the genetic predisposition to obesity. Genome Med. 2009 Mar 11; 1(3):31. Calton MA, Vaisse C. PMID: 19341502; PMCID: PMC2664942.
      View in: PubMed   Mentions: 4     Fields:    
    33. Identification, characterization and rescue of a novel vasopressin-2 receptor mutation causing nephrogenic diabetes insipidus. Clin Endocrinol (Oxf). 2009 Sep; 71(3):388-93. Ranadive SA, Ersoy B, Favre H, Cheung CC, Rosenthal SM, Miller WL, Vaisse C. PMID: 19170711; PMCID: PMC5881569.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    34. Association of functionally significant Melanocortin-4 but not Melanocortin-3 receptor mutations with severe adult obesity in a large North American case-control study. Hum Mol Genet. 2009 Mar 15; 18(6):1140-7. Calton MA, Ersoy BA, Zhang S, Kane JP, Malloy MJ, Pullinger CR, Bromberg Y, Pennacchio LA, Dent R, McPherson R, Ahituv N, Vaisse C. PMID: 19091795; PMCID: PMC2649015.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    35. Unexpected endocrine features and normal pigmentation in a young adult patient carrying a novel homozygous mutation in the POMC gene. J Clin Endocrinol Metab. 2008 Dec; 93(12):4955-62. Clément K, Dubern B, Mencarelli M, Czernichow P, Ito S, Wakamatsu K, Barsh GS, Vaisse C, Leger J. PMID: 18765507; PMCID: PMC2729235.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    36. Lessons from extreme human obesity: monogenic disorders. Endocrinol Metab Clin North Am. 2008 Sep; 37(3):733-51, x. Ranadive SA, Vaisse C. PMID: 18775361; PMCID: PMC5877402.
      View in: PubMed   Mentions: 46     Fields:    Translation:Humans
    37. Mutational analysis of the pro-opiomelanocortin gene in French obese children led to the identification of a novel deleterious heterozygous mutation located in the alpha-melanocyte stimulating hormone domain. Pediatr Res. 2008 Feb; 63(2):211-6. Dubern B, Lubrano-Berthelier C, Mencarelli M, Ersoy B, Frelut ML, Bouglé D, Costes B, Simon C, Tounian P, Vaisse C, Clement K. PMID: 18091355.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    38. Gender and neurogenin3 influence the pathogenesis of ketosis-prone diabetes. Diabetes Obes Metab. 2008 Sep; 10(10):912-20. Louet JF, Smith SB, Gautier JF, Molokhia M, Virally ML, Kevorkian JP, Guillausseau PJ, Vexiau P, Charpentier G, German MS, Vaisse C, Urbanek M, Mauvais-Jarvis F. PMID: 18093211.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    39. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS One. 2007 Aug 01; 2(7):e668. Srinivasan S, Santiago P, Lubrano C, Vaisse C, Conklin BR. PMID: 17668051; PMCID: PMC1930153.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    40. Medical sequencing at the extremes of human body mass. Am J Hum Genet. 2007 Apr; 80(4):779-91. Ahituv N, Kavaslar N, Schackwitz W, Ustaszewska A, Martin J, Hebert S, Doelle H, Ersoy B, Kryukov G, Schmidt S, Yosef N, Ruppin E, Sharan R, Vaisse C, Sunyaev S, Dent R, Cohen J, McPherson R, Pennacchio LA. PMID: 17357083; PMCID: PMC1852707.
      View in: PubMed   Mentions: 136     Fields:    Translation:Humans
    41. MUTATIONAL ANALYSIS OF THE PROOPIOMELANOCORTIN GENE IN OBESE CHILDREN. Journal of Pediatric Gastroenterology and Nutrition. 2006 May 1; 42(5):e81-e81. Dubern DB, Lubrano-berthelier LC, Bouglé BD, Frelut FM, Simon SC, Vaisse VC, Clément CK, Tounian TP. .
      View in: Publisher Site   Mentions:
    42. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating. J Clin Endocrinol Metab. 2006 May; 91(5):1811-8. Lubrano-Berthelier C, Dubern B, Lacorte JM, Picard F, Shapiro A, Zhang S, Bertrais S, Hercberg S, Basdevant A, Clement K, Vaisse C. PMID: 16507637.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansCells
    43. Obesity-associated mutations in the melanocortin 4 receptor provide novel insights into its function. Peptides. 2005 Oct; 26(10):1909-19. Govaerts C, Srinivasan S, Shapiro A, Zhang S, Picard F, Clement K, Lubrano-Berthelier C, Vaisse C. PMID: 16083993.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansAnimals
    44. Lack of support for the association between GAD2 polymorphisms and severe human obesity. PLoS Biol. 2005 Sep; 3(9):e315. Swarbrick MM, Waldenmaier B, Pennacchio LA, Lind DL, Cavazos MM, Geller F, Merriman R, Ustaszewska A, Malloy M, Scherag A, Hsueh WC, Rief W, Mauvais-Jarvis F, Pullinger CR, Kane JP, Dent R, McPherson R, Kwok PY, Hinney A, Hebebrand J, Vaisse C. PMID: 16122350; PMCID: PMC1193520.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    45. High prevalence of glucose-6-phosphate dehydrogenase deficiency without gene mutation suggests a novel genetic mechanism predisposing to ketosis-prone diabetes. J Clin Endocrinol Metab. 2005 Aug; 90(8):4446-51. Sobngwi E, Gautier JF, Kevorkian JP, Villette JM, Riveline JP, Zhang S, Vexiau P, Leal SM, Vaisse C, Mauvais-Jarvis F. PMID: 15914531; PMCID: PMC6143174.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    46. Leptin regulation of bone resorption by the sympathetic nervous system and CART. Nature. 2005 Mar 24; 434(7032):514-20. Elefteriou F, Ahn JD, Takeda S, Starbuck M, Yang X, Liu X, Kondo H, Richards WG, Bannon TW, Noda M, Clement K, Vaisse C, Karsenty G. PMID: 15724149.
      View in: PubMed   Mentions: 444     Fields:    Translation:HumansAnimalsCells
    47. A statistical approach for array CGH data analysis. BMC Bioinformatics. 2005 Feb 11; 6:27. Picard F, Robin S, Lavielle M, Vaisse C, Daudin JJ. PMID: 15705208; PMCID: PMC549559.
      View in: PubMed   Mentions: 104     Fields:    Translation:HumansCells
    48. PAX4 gene variations predispose to ketosis-prone diabetes. Hum Mol Genet. 2004 Dec 15; 13(24):3151-9. Mauvais-Jarvis F, Smith SB, Le May C, Leal SM, Gautier JF, Molokhia M, Riveline JP, Rajan AS, Kevorkian JP, Zhang S, Vexiau P, German MS, Vaisse C. PMID: 15509590; PMCID: PMC6145178.
      View in: PubMed   Mentions: 42     Fields:    Translation:Humans
    49. Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J Clin Invest. 2004 Oct; 114(8):1158-64. Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. PMID: 15489963; PMCID: PMC522250.
      View in: PubMed   Mentions: 79     Fields:    Translation:HumansAnimalsCells
    50. A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans. J Clin Endocrinol Metab. 2004 May; 89(5):2028-32. Lubrano-Berthelier C, Le Stunff C, Bougnères P, Vaisse C. PMID: 15126516.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    51. Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance. Diabetes. 2004 Mar; 53(3):645-53. Mauvais-Jarvis F, Sobngwi E, Porcher R, Riveline JP, Kevorkian JP, Vaisse C, Charpentier G, Guillausseau PJ, Vexiau P, Gautier JF. PMID: 14988248.
      View in: PubMed   Mentions: 98     Fields:    Translation:Humans
    52. The human MC4R promoter: characterization and role in obesity. Diabetes. 2003 Dec; 52(12):2996-3000. Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C. PMID: 14633862.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    53. Emerging trends in the search for genetic variants predisposing to human obesity. Curr Opin Clin Nutr Metab Care. 2003 Jul; 6(4):369-75. Swarbrick MM, Vaisse C. PMID: 12806208.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    54. Molecular genetics of human obesity-associated MC4R mutations. Ann N Y Acad Sci. 2003 Jun; 994:49-57. Lubrano-Berthelier C, Cavazos M, Dubern B, Shapiro A, Stunff CL, Zhang S, Picart F, Govaerts C, Froguel P, Bougneres P, Clement K, Vaisse C. PMID: 12851297.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    55. Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Ann N Y Acad Sci. 2003 Jun; 994:225-32. Srinivasan S, Vaisse C, Conklin BR. PMID: 12851320.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    56. Intracellular retention is a common characteristic of childhood obesity-associated MC4R mutations. Hum Mol Genet. 2003 Jan 15; 12(2):145-53. Lubrano-Berthelier C, Durand E, Dubern B, Shapiro A, Dazin P, Weill J, Ferron C, Froguel P, Vaisse C. PMID: 12499395.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    57. Elevated plasma ghrelin levels in Prader Willi syndrome. Nat Med. 2002 Jul; 8(7):643-4. Cummings DE, Clement K, Purnell JQ, Vaisse C, Foster KE, Frayo RS, Schwartz MW, Basdevant A, Weigle DS. PMID: 12091883.
      View in: PubMed   Mentions: 145     Fields:    Translation:Humans
    58. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. Hum Hered. 2000 Nov-Dec; 50(6):370-81. Navas MA, Vaisse C, Boger S, Heimesaat M, Kollee LA, Stoffel M. PMID: 10899756.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    59. Soluble leptin receptor in serum of subjects with complete resistance to leptin: relation to fat mass. Diabetes. 2000 Aug; 49(8):1347-52. Lahlou N, Clement K, Carel JC, Vaisse C, Lotton C, Le Bihan Y, Basdevant A, Lebouc Y, Froguel P, Roger M, Guy-Grand B. PMID: 10923636.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    60. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest. 2000 Jul; 106(2):253-62. Vaisse C, Clement K, Durand E, Hercberg S, Guy-Grand B, Froguel P. PMID: 10903341; PMCID: PMC314306.
      View in: PubMed   Mentions: 215     Fields:    Translation:Humans
    61. The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. Int J Obes Relat Metab Disord. 2000 Mar; 24(3):391-3. Clement K, Hercberg S, Passinge B, Galan P, Varroud-Vial M, Shuldiner AR, Beamer BA, Charpentier G, Guy-Grand B, Froguel P, Vaisse C. PMID: 10757637.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    62. Glycodelin: a pane in the implantation window. Semin Reprod Med. 2000; 18(3):289-98. Mueller MD, Vigne JL, Vaisse C, Taylor RN. PMID: 11299967.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    63. Promegestone (R5020) and mifepristone (RU486) both function as progestational agonists of human glycodelin gene expression in isolated human epithelial cells. J Clin Endocrinol Metab. 1998 Nov; 83(11):4006-12. Taylor RN, Savouret JF, Vaisse C, Vigne JL, Ryan I, Hornung D, Seppälä M, Milgrom E. PMID: 9814484.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    64. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet. 1998 Oct; 20(2):113-4. Vaisse C, Clement K, Guy-Grand B, Froguel P. PMID: 9771699.
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    65. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature. 1998 Mar 26; 392(6674):398-401. Clément K, Vaisse C, Lahlou N, Cabrol S, Pelloux V, Cassuto D, Gourmelen M, Dina C, Chambaz J, Lacorte JM, Basdevant A, Bougnères P, Lebouc Y, Froguel P, Guy-Grand B. PMID: 9537324.
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    66. La mutation du gène du récepteur de la leptine entraîne chez l'homme une obésité massive associée à des anomalies hypothalamo-hypophysaires. Médecine/sciences. 1998 Jan 1; 14(5):675. Clément CK, Vaisse VC, Basdevant BA, Guy-Grand GB, Froguel FP. .
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    67. Pancreatic islet expression studies and polymorphic DNA markers in the genes encoding hepatocyte nuclear factor-3alpha, -3beta, -3gamma, -4gamma, and -6. Diabetes. 1997 Aug; 46(8):1364-7. Vaisse C, Kim J, Espinosa R, Le Beau MM, Stoffel M. PMID: 9231664.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    68. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet. 1996 Sep; 14(1):95-7. Vaisse C, Halaas JL, Horvath CM, Darnell JE, Stoffel M, Friedman JM. PMID: 8782827.
      View in: PubMed   Mentions: 294     Fields:    Translation:AnimalsCells
    69. Gln-Arg192 polymorphism of paraoxonase and coronary heart disease in type 2 diabetes. Lancet. 1995 Sep 30; 346(8979):869-72. Ruiz J, Blanché H, James RW, Garin MC, Vaisse C, Charpentier G, Cohen N, Morabia A, Passa P, Froguel P. PMID: 7564671.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    70. Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity. N Engl J Med. 1995 Aug 10; 333(6):352-4. Clément K, Vaisse C, Manning BS, Basdevant A, Guy-Grand B, Ruiz J, Silver KD, Shuldiner AR, Froguel P, Strosberg AD. PMID: 7609752.
      View in: PubMed   Mentions: 96     Fields:    Translation:HumansCells
    71. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Nat Genet. 1995 Mar; 9(3):299-304. Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, Poller W, Velho G, Carcassi C, Contu L, Julier C, et al. PMID: 7773293.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    72. Expression and regulation of adrenodoxin and P450scc mRNA in rodent tissues. DNA Cell Biol. 1991 Jun; 10(5):339-47. Mellon SH, Kushner JA, Vaisse C. PMID: 1863358.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    73. The human placental protein 14 (PP14) gene is localized on chromosome 9q34. Hum Genet. 1991 Mar; 86(5):515-8. Van Cong N, Vaisse C, Gross MS, Slim R, Milgrom E, Bernheim A. PMID: 2016092.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    74. Human placental protein 14 gene: sequence and characterization of a short duplication. DNA Cell Biol. 1990 Jul-Aug; 9(6):401-13. Vaisse C, Atger M, Potier B, Milgrom E. PMID: 2206398.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    75. cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells. Proc Natl Acad Sci U S A. 1989 Oct; 86(20):7775-9. Mellon SH, Vaisse C. PMID: 2554289; PMCID: PMC298153.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
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