-
The BACPAC Research Program Data Harmonization: Rationale for Data Elements and Standards. Pain Med. 2023 Jan 31.
Batorsky A, Bowden AE, Darwin J, Fields AJ, Greco CM, Harris RE, Hue TF, Kakyomya J, Mehling W, O'Neill C, Patterson CG, Piva SR, Sollmann N, Toups V, Wasan AD, Wasserman R, Williams DA, Vo NV, Psioda MA, McCumber M. PMID: 36721327.
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PubMed Mentions:
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The Back Pain Consortium (BACPAC) Research Program: Structure, Research Priorities, and Methods. Pain Med. 2023 Jan 09.
Mauck MC, Lotz J, Psioda MA, Carey TS, Clauw DJ, Majumdar S, Marras WS, Vo N, Aylward A, Hoffmeyer A, Zheng P, Ivanova A, McCumber M, Carson C, Anstrom KJ, Bowden AE, Dalton D, Derr L, Dufour J, Fields AJ, Fritz J, Hassett AL, Harte SE, Hue TF, Krug R, Loggia ML, Mageswaran P, McLean SA, Mitchell UH, O'Neill C, Pedoia V, Quirk DA, Rhon DI, Rieke V, Shah L, Sowa G, Spiegel B, Wasan AD, Wey HM, LaVange L. PMID: 36622041.
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PubMed Mentions: Fields:
-
Protocol for Biospecimen Collection and Analysis within the BACPAC Research Program. Pain Med. 2022 Dec 16.
Fields AJ, Dudli S, Schrepf A, Kim A, Pham B, Gallego E, Mendoza S, Meropol SB, Darwin J, Sowa G, Vo NV. PMID: 36525387.
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PubMed Mentions: Fields:
-
Evidence-based interventions to treat chronic low back pain: treatment selection for a personalized medicine approach. Pain Rep. 2022 Sep-Oct; 7(5):e1019.
Mauck MC, Aylward AF, Barton CE, Birckhead B, Carey T, Dalton DM, Fields AJ, Fritz J, Hassett AL, Hoffmeyer A, Jones SB, McLean SA, Mehling WE, O'Neill CW, Schneider MJ, Williams DA, Zheng P, Wasan AD. PMID: 36203645; PMCID: PMC9529058.
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PubMed Mentions:
-
Magnetic resonance imaging of the lumbar spine-recommendations for acquisition and image evaluation from the BACPAC Spine Imaging Working Group. Pain Med. 2022 Sep 07.
Sollmann N, Fields AJ, O'Neill C, Nardo L, Majumdar S, Chin CT, Tosun D, Han M, Vu AT, Ozhinsky E, Shah LM, Harris RE, Lobo R, Anderst W, Herzog R, Psioda MA, Standaert CJ, Price RT, Lotz JC, Link TM, Krug R. PMID: 36069660.
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PubMed Mentions:
1 Fields:
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Influence of patient-specific factors when comparing multifidus fat infiltration between chronic low back pain patients and asymptomatic controls. JOR Spine. 2022 Dec; 5(4):e1217.
Ballatori AM, Shahrestani S, Nyayapati P, Agarwal V, Krug R, Han M, Fields AJ, O'Neill C, Demir-Deviren S, Lotz JC, Bailey JF. PMID: 36601370; PMCID: PMC9799081.
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PubMed Mentions:
-
Spatial distribution of fat infiltration within the paraspinal muscles: implications for chronic low back pain. Eur Spine J. 2022 11; 31(11):2875-2883.
Khattab K, Dziesinski LK, Crawford R, Ballatori A, Nyayapati P, Krug R, Fields A, O'Neill CW, Lotz JC, Bailey JF. PMID: 35776179; PMCID: PMC9637053.
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PubMed Mentions: Fields:
Translation:
Humans
-
The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain. Eur Spine J. 2022 07; 31(7):1866-1872.
Bonnheim NB, Wang L, Lazar AA, Zhou J, Chachad R, Sollmann N, Guo X, Iriondo C, O'Neill C, Lotz JC, Link TM, Krug R, Fields AJ. PMID: 35441890; PMCID: PMC9252939.
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PubMed Mentions:
2 Fields:
Translation:
Humans
-
Using hierarchical unsupervised learning to integrate and reduce multi-level and multi-paraspinal muscle MRI data in relation to low back pain. Eur Spine J. 2022 08; 31(8):2046-2056.
Torres-Espin A, Keller A, Johnson GTA, Fields AJ, Krug R, Ferguson AR, Hargens AR, O'Neill CW, Lotz JC, Bailey JF. PMID: 35333958; PMCID: PMC9338899.
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PubMed Mentions: Fields:
Translation:
Humans
-
Paraspinal Muscle in Chronic Low Back Pain: Comparison Between Standard Parameters and Chemical Shift Encoding-Based Water-Fat MRI. J Magn Reson Imaging. 2022 11; 56(5):1600-1608.
Sollmann N, Bonnheim NB, Joseph GB, Chachad R, Zhou J, Akkaya Z, Pirmoazen AM, Bailey JF, Guo X, Lazar AA, Link TM, Fields AJ, Krug R. PMID: 35285561; PMCID: PMC9470775.
View in:
PubMed Mentions:
2 Fields:
Translation:
Humans
-
Non-enzymatic glycation of annulus fibrosus alters tissue-level failure mechanics in tension. J Mech Behav Biomed Mater. 2022 02; 126:104992.
Werbner B, Lee M, Lee A, Yang L, Habib M, Fields AJ, O'Connell GD. PMID: 34864399.
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PubMed Mentions: Fields:
Translation:
HumansCells
-
Development of a standardized histopathology scoring system for human intervertebral disc degeneration: an Orthopaedic Research Society Spine Section Initiative. JOR Spine. 2021 Jun; 4(2):e1167.
Le Maitre CL, Dahia CL, Giers M, Illien-Junger S, Cicione C, Samartzis D, Vadala G, Fields A, Lotz J. PMID: 34337340; PMCID: PMC8313169.
View in:
PubMed Mentions:
8
-
Measurement of vertebral endplate bone marrow lesion (Modic change) composition with water-fat MRI and relationship to patient-reported outcome measures. Eur Spine J. 2021 09; 30(9):2549-2556.
Fields AJ, Ballatori A, Han M, Bailey JF, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Lotz JC. PMID: 33547944; PMCID: PMC8697722.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Automatic Vertebral Body Segmentation Based on Deep Learning of Dixon Images for Bone Marrow Fat Fraction Quantification. Front Endocrinol (Lausanne). 2020; 11:612.
Zhou J, Damasceno PF, Chachad R, Cheung JR, Ballatori A, Lotz JC, Lazar AA, Link TM, Fields AJ, Krug R. PMID: 32982989; PMCID: PMC7492292.
View in:
PubMed Mentions:
7 Fields:
Translation:
Humans
-
Evaluation of human cartilage endplate composition using MRI: Spatial variation, association with adjacent disc degeneration, and in vivo repeatability. J Orthop Res. 2021 07; 39(7):1470-1478.
Wang L, Han M, Wong J, Zheng P, Lazar AA, Krug R, Fields AJ. PMID: 32592504; PMCID: PMC7765737.
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PubMed Mentions:
6 Fields:
Translation:
HumansCTClinical Trials
-
Serum Biomarkers for Connective Tissue and Basement Membrane Remodeling are Associated with Vertebral Endplate Bone Marrow Lesions as Seen on MRI (Modic Changes). Int J Mol Sci. 2020 May 27; 21(11).
Dudli S, Ballatori A, Bay-Jensen AC, McCormick ZL, O'Neill CW, Demir-Deviren S, Krug R, Heggli I, Juengel A, Karppinen J, Brunner F, Farshad M, Distler O, Lotz JC, Fields AJ. PMID: 32471173; PMCID: PMC7312719.
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PubMed Mentions:
4 Fields:
Translation:
Humans
-
Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. Bone Res. 2019; 7:34.
Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T. PMID: 31700695; PMCID: PMC6828661.
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PubMed Mentions:
30
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Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group. Eur Spine J. 2019 10; 28(10):2266-2274.
Fields AJ, Battié MC, Herzog RJ, Jarvik JG, Krug R, Link TM, Lotz JC, O'Neill CW, Sharma A, ISSLS Degenerative Spinal Phenotypes Group. PMID: 31446492; PMCID: PMC7205555.
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PubMed Mentions:
19 Fields:
Translation:
Humans
-
The Relationship Between Endplate Pathology and Patient-reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality. Spine (Phila Pa 1976). 2019 Jul 15; 44(14):1010-1017.
Bailey JF, Fields AJ, Ballatori A, Cohen D, Jain D, Coughlin D, O'Neill C, McCormick Z, Han M, Krug R, Demir-Deviren S, Lotz JC. PMID: 30896590; PMCID: PMC6597281.
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PubMed Mentions:
24 Fields:
Translation:
Humans
-
Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. PLoS One. 2019; 14(4):e0215218.
Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ. PMID: 30970007; PMCID: PMC6457523.
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PubMed Mentions:
16 Fields:
Translation:
HumansCells
-
Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy. Osteoarthritis Cartilage. 2019 06; 27(6):956-964.
Wong J, Sampson SL, Bell-Briones H, Ouyang A, Lazar AA, Lotz JC, Fields AJ. PMID: 30721733; PMCID: PMC6536352.
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PubMed Mentions:
33 Fields:
Translation:
HumansAnimals
-
Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI. J Magn Reson Imaging. 2019 10; 50(4):1219-1226.
Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J. PMID: 30701594; PMCID: PMC6667309.
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PubMed Mentions:
16 Fields:
Translation:
Humans
-
Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163.
Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. PMID: 30635563; PMCID: PMC6329772.
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PubMed Mentions:
26 Fields:
Translation:
Animals
-
Effects of dynamic loading on solute transport through the human cartilage endplate. J Biomech. 2019 01 23; 83:273-279.
Sampson SL, Sylvia M, Fields AJ. PMID: 30554819; PMCID: PMC6326858.
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PubMed Mentions:
9 Fields:
Translation:
Humans
-
Contribution of the endplates to disc degeneration. Curr Mol Biol Rep. 2018 Dec; 4(4):151-160.
Fields AJ, Ballatori A, Liebenberg EC, Lotz JC. PMID: 30546999; PMCID: PMC6287619.
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PubMed Mentions:
27
-
Tidemark Avulsions are a Predominant Form of Endplate Irregularity. Spine (Phila Pa 1976). 2018 08; 43(16):1095-1101.
Berg-Johansen B, Jain D, Liebenberg EC, Fields AJ, Link TM, O'Neill CW, Lotz JC. PMID: 29315127; PMCID: PMC6035893.
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PubMed Mentions:
6 Fields:
Translation:
Humans
-
FGF and TGFβ signaling link form and function during jaw development and evolution. Dev Biol. 2018 12 01; 444 Suppl 1:S219-S236.
Woronowicz KC, Gline SE, Herfat ST, Fields AJ, Schneider RA. PMID: 29753626; PMCID: PMC6239991.
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PubMed Mentions:
12 Fields:
Translation:
AnimalsCells
-
Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 05 15; 43(10):E592-E600.
Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. PMID: 28984733; PMCID: PMC5882595.
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PubMed Mentions:
19 Fields:
Translation:
Humans
-
Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine. JOR Spine. 2018 Mar; 1(1):e1006.
Martin JT, Gullbrand SE, Fields AJ, Purmessur D, Diwan AD, Oxland TR, Chiba K, Guilak F, Hoyland JA, Iatridis JC. PMID: 29770804; PMCID: PMC5944392.
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PubMed Mentions:
4
-
Larger vertebral endplate concavities cause higher failure load and work at failure under high-rate impact loading of rabbit spinal explants. J Mech Behav Biomed Mater. 2018 04; 80:104-110.
Dudli S, Enns-Bray W, Pauchard Y, Römmeler A, Fields AJ, Ferguson SJ, Helgason B. PMID: 29414464.
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PubMed Mentions:
2 Fields:
Translation:
Animals
-
Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes. J Bone Miner Res. 2018 06; 33(6):1066-1075.
Acevedo C, Sylvia M, Schaible E, Graham JL, Stanhope KL, Metz LN, Gludovatz B, Schwartz AV, Ritchie RO, Alliston TN, Havel PJ, Fields AJ. PMID: 29342321; PMCID: PMC6011658.
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PubMed Mentions:
23 Fields:
Translation:
Animals
-
Structure-function relationships at the human spinal disc-vertebra interface. J Orthop Res. 2018 01; 36(1):192-201.
Berg-Johansen B, Fields AJ, Liebenberg EC, Li A, Lotz JC. PMID: 28590060; PMCID: PMC5720932.
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PubMed Mentions:
12 Fields:
Translation:
Humans
-
Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726.
Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. PMID: 28407060; PMCID: PMC5460929.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
-
Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis. Sci Rep. 2017 03 22; 7:44618.
Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T. PMID: 28327602; PMCID: PMC5361115.
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PubMed Mentions:
37 Fields:
Translation:
HumansAnimalsCells
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Pathobiology of Modic changes. Eur Spine J. 2016 11; 25(11):3723-3734.
Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC. PMID: 26914098; PMCID: PMC5477843.
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PubMed Mentions:
110 Fields:
Translation:
Humans
-
Theoretical effects of fully ductile versus fully brittle behaviors of bone tissue on the strength of the human proximal femur and vertebral body. J Biomech. 2015 May 01; 48(7):1264-9.
Nawathe S, Yang H, Fields AJ, Bouxsein ML, Keaveny TM. PMID: 25828400.
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PubMed Mentions:
8 Fields:
Translation:
Humans
-
Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes. J Orthop Res. 2015 May; 33(5):738-46.
Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ, Lotz JC. PMID: 25641259; PMCID: PMC4408867.
View in:
PubMed Mentions:
51 Fields:
Translation:
Animals
-
Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone. Bone. 2015 Mar; 72:71-80.
Wang J, Zhou B, Liu XS, Fields AJ, Sanyal A, Shi X, Adams M, Keaveny TM, Guo XE. PMID: 25460571; PMCID: PMC4282941.
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PubMed Mentions:
30 Fields:
Translation:
Humans
-
Cartilaginous end plates: Quantitative MR imaging with very short echo times-orientation dependence and correlation with biochemical composition. Radiology. 2015 Feb; 274(2):482-9.
Fields AJ, Han M, Krug R, Lotz JC. PMID: 25302832; PMCID: PMC4314292.
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PubMed Mentions:
31 Fields:
Translation:
Humans
-
Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys. Osteoarthritis Cartilage. 2014 Jul; 22(7):980-5.
Bailey JF, Fields AJ, Liebenberg E, Mattison JA, Lotz JC, Kramer PA. PMID: 24821664; PMCID: PMC4105267.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimals
-
Structural parameters determining the strength of the porcine vertebral body affected by tumours. Comput Methods Biomech Biomed Engin. 2015; 18(8):890-9.
Sahli F, Cuellar J, Pérez A, Fields AJ, Campos M, Ramos-Grez J. PMID: 24460089.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimals
-
Dependence of mechanical properties of trabecular bone on plate-rod microstructure determined by individual trabecula segmentation (ITS). J Biomech. 2014 Feb 07; 47(3):702-8.
Zhou B, Liu XS, Wang J, Lu XL, Fields AJ, Guo XE. PMID: 24360196; PMCID: PMC3925244.
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PubMed Mentions:
25 Fields:
Translation:
Humans
-
Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine. J Orthop Res. 2014 Feb; 32(2):245-52.
Fields AJ, Rodriguez D, Gary KN, Liebenberg EC, Lotz JC. PMID: 24273192; PMCID: PMC4039641.
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PubMed Mentions:
20 Fields:
Translation:
Humans
-
Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc. Spine J. 2014 Mar 01; 14(3):513-21.
Fields AJ, Liebenberg EC, Lotz JC. PMID: 24139753; PMCID: PMC3945018.
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PubMed Mentions:
57 Fields:
Translation:
Humans
-
The role of the vertebral end plate in low back pain. Global Spine J. 2013 Jun; 3(3):153-64.
Lotz JC, Fields AJ, Liebenberg EC. PMID: 24436866; PMCID: PMC3854605.
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PubMed Mentions:
81
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Seeing double: a comparison of microstructure, biomechanical function, and adjacent disc health between double- and single-layer vertebral endplates. Spine (Phila Pa 1976). 2012 Oct 01; 37(21):E1310-7.
Fields AJ, Sahli F, Rodriguez AG, Lotz JC. PMID: 22781006; PMCID: PMC3461110.
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PubMed Mentions:
14 Fields:
Translation:
Humans
-
Vertebral fragility and structural redundancy. J Bone Miner Res. 2012 Oct; 27(10):2152-8.
Fields AJ, Nawathe S, Eswaran SK, Jekir MG, Adams MF, Papadopoulos P, Keaveny TM. PMID: 22623120; PMCID: PMC3440513.
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PubMed Mentions:
12 Fields:
Translation:
Humans
-
Micromechanics of the human vertebral body for forward flexion. J Biomech. 2012 Aug 09; 45(12):2142-8.
Yang H, Nawathe S, Fields AJ, Keaveny TM. PMID: 22704826; PMCID: PMC3415303.
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PubMed Mentions:
6 Fields:
Translation:
Humans
-
Trabecular architecture and vertebral fragility in osteoporosis. Curr Osteoporos Rep. 2012 Jun; 10(2):132-40.
Fields AJ, Keaveny TM. PMID: 22492119.
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PubMed Mentions:
14 Fields:
Translation:
Humans
-
Influence of vertical trabeculae on the compressive strength of the human vertebra. J Bone Miner Res. 2011 Feb; 26(2):263-9.
Fields AJ, Lee GL, Liu XS, Jekir MG, Guo XE, Keaveny TM. PMID: 20715186; PMCID: PMC3179351.
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PubMed Mentions:
25 Fields:
Translation:
Humans
-
Mechanisms of initial endplate failure in the human vertebral body. J Biomech. 2010 Dec 01; 43(16):3126-31.
Fields AJ, Lee GL, Keaveny TM. PMID: 20817162; PMCID: PMC2991488.
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PubMed Mentions:
28 Fields:
Translation:
Humans
-
Role of trabecular microarchitecture in whole-vertebral body biomechanical behavior. J Bone Miner Res. 2009 Sep; 24(9):1523-30.
Fields AJ, Eswaran SK, Jekir MG, Keaveny TM. PMID: 19338454; PMCID: PMC2730926.
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PubMed Mentions:
34 Fields:
Translation:
Humans
-
Multi-scale modeling of the human vertebral body: comparison of micro-CT based high-resolution and continuum-level models. Pac Symp Biocomput. 2009; 293-303.
Eswaran SK, Fields AJ, Nagarathnam P, Keaveny TM. PMID: 19209709.
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PubMed Mentions:
3 Fields:
Translation:
Humans
-
Effects of knee simulator loading and alignment variability on predicted implant mechanics: a probabilistic study. J Orthop Res. 2006 Dec; 24(12):2212-21.
Laz PJ, Pal S, Fields A, Petrella AJ, Rullkoetter PJ. PMID: 17004268.
View in:
PubMed Mentions:
6 Fields:
Translation:
Humans