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Aaron Fields, PhD

Title(s)Associate Professor, Orthopaedic Surgery
SchoolSchool of Medicine
Phone415-476-0960
ORCID ORCID Icon0000-0001-6460-4506 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of DenverBS2005Mechanical Engineering
    University of California, BerkeleyPhD2010Mechanical Engineering
    University of California, San FranciscoPostdoctoral Fellowship2013Orthopaedic Surgery
    Collapse Awards and Honors
    U.S. Bone and Joint Initiative2015Young Investigator Initiative
    Orthopaedic Research Society2017Spine Section Podium Award
    North American Spine Society2018Young Investigator Research Grant Award
    International Society for the Study of the Lumbar Spine2019Best Basic Science Poster Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    Novel imaging of endplate biomarkers in chronic low back pain
    NIH/NIAMS UH2AR076719Sep 26, 2019 - Aug 31, 2021
    Role: Principal Investigator
    Does enhancing cartilage endplate permeability improve nucleus pulposus cell function?
    North American Spine Society Jan 1, 2019 - Dec 31, 2019
    Role: Principal Investigator
    Role of the cartilage endplate in spinal disc degeneration
    NIH/NIAMS R01AR070198Apr 1, 2017 - Jan 31, 2022
    Role: Principal Investigator
    Does Cartilage Endplate Permeability Impact Nucleus Pulposus Cell Function?
    North American Spine Society Jan 1, 2017 - Dec 31, 2017
    Role: Principal Investigator
    Measurement of the effect of cartilage endplate permeability on disc cell function using in situ hybridization
    UCSF Core Center for Musculoskeletal Biology in Medicine Jun 1, 2016 - May 31, 2017
    Role: Principal Investigator
    Enhancing endplate permeability to treat or prevent intervertebral disc degeneration
    UCSF Center for Disruptive Musculoskeletal Innovation Oct 1, 2015 - Sep 30, 2016
    Role: Principal Investigator
    Cartilage endplate composition and disc degeneration: investigating nutrient diffusion and disc cell viability
    UCSF School of Medicine Jul 1, 2015 - Jun 30, 2016
    Role: Principal Investigator
    Endplate dysfunction and disc degeneration: investigating solute transport, disc cell viability and new imaging methods
    UCSF Core Center for Musculoskeletal Biology in Medicine Apr 3, 2015 - Jun 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Mazur CM, Woo JJ, Yee CS, Fields AJ, Acevedo C, Bailey KN, Kaya S, Fowler TW, Lotz JC, Dang A, Kuo AC, Vail TP, Alliston T. Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis. Bone Res. 2019; 7:34. PMID: 31700695.
      View in: PubMed
    2. Fields AJ, Battié MC, Herzog RJ, Jarvik JG, Krug R, Link TM, Lotz JC, O'Neill CW, Sharma A. Measuring and reporting of vertebral endplate bone marrow lesions as seen on MRI (Modic changes): recommendations from the ISSLS Degenerative Spinal Phenotypes Group. Eur Spine J. 2019 Oct; 28(10):2266-2274. PMID: 31446492.
      View in: PubMed
    3. Bailey JF, Fields AJ, Ballatori A, Cohen D, Jain D, Coughlin D, O'Neill C, McCormick Z, Han M, Krug R, Demir-Deviren S, Lotz JC. The Relationship Between Endplate Pathology and Patient-reported Symptoms for Chronic Low Back Pain Depends on Lumbar Paraspinal Muscle Quality. Spine (Phila Pa 1976). 2019 Jul 15; 44(14):1010-1017. PMID: 30896590.
      View in: PubMed
    4. Dolor A, Sampson SL, Lazar AA, Lotz JC, Szoka FC, Fields AJ. Matrix modification for enhancing the transport properties of the human cartilage endplate to improve disc nutrition. PLoS One. 2019; 14(4):e0215218. PMID: 30970007.
      View in: PubMed
    5. Wong J, Sampson SL, Bell-Briones H, Ouyang A, Lazar AA, Lotz JC, Fields AJ. Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy. Osteoarthritis Cartilage. 2019 Jun; 27(6):956-964. PMID: 30721733.
      View in: PubMed
    6. Krug R, Joseph GB, Han M, Fields A, Cheung J, Mundada M, Bailey J, Rochette A, Ballatori A, McCulloch CE, McCormick Z, O'Neill C, Link TM, Lotz J. Associations between vertebral body fat fraction and intervertebral disc biochemical composition as assessed by quantitative MRI. J Magn Reson Imaging. 2019 Oct; 50(4):1219-1226. PMID: 30701594.
      View in: PubMed
    7. Herber CB, Krause WC, Wang L, Bayrer JR, Li A, Schmitz M, Fields A, Ford B, Zhang Z, Reid MS, Nomura DK, Nissenson RA, Correa SM, Ingraham HA. Estrogen signaling in arcuate Kiss1 neurons suppresses a sex-dependent female circuit promoting dense strong bones. Nat Commun. 2019 01 11; 10(1):163. PMID: 30635563.
      View in: PubMed
    8. Sampson SL, Sylvia M, Fields AJ. Effects of dynamic loading on solute transport through the human cartilage endplate. J Biomech. 2019 01 23; 83:273-279. PMID: 30554819.
      View in: PubMed
    9. Fields AJ, Ballatori A, Liebenberg EC, Lotz JC. Contribution of the endplates to disc degeneration. Curr Mol Biol Rep. 2018 Dec; 4(4):151-160. PMID: 30546999.
      View in: PubMed
    10. Berg-Johansen B, Jain D, Liebenberg EC, Fields AJ, Link TM, O'Neill CW, Lotz JC. Tidemark Avulsions are a Predominant Form of Endplate Irregularity. Spine (Phila Pa 1976). 2018 08; 43(16):1095-1101. PMID: 29315127.
      View in: PubMed
    11. Woronowicz KC, Gline SE, Herfat ST, Fields AJ, Schneider RA. FGF and TGFß signaling link form and function during jaw development and evolution. Dev Biol. 2018 12 01; 444 Suppl 1:S219-S236. PMID: 29753626.
      View in: PubMed
    12. Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 05 15; 43(10):E592-E600. PMID: 28984733.
      View in: PubMed
    13. Martin JT, Gullbrand SE, Fields AJ, Purmessur D, Diwan AD, Oxland TR, Chiba K, Guilak F, Hoyland JA, Iatridis JC. Publication trends in spine research from 2007 to 2016: Comparison of the Orthopaedic Research Society Spine Section and the International Society for the Study of the Lumbar Spine. JOR Spine. 2018 Mar; 1(1):e1006. PMID: 29770804.
      View in: PubMed
    14. Dudli S, Enns-Bray W, Pauchard Y, Römmeler A, Fields AJ, Ferguson SJ, Helgason B. Larger vertebral endplate concavities cause higher failure load and work at failure under high-rate impact loading of rabbit spinal explants. J Mech Behav Biomed Mater. 2018 04; 80:104-110. PMID: 29414464.
      View in: PubMed
    15. Acevedo C, Sylvia M, Schaible E, Graham JL, Stanhope KL, Metz LN, Gludovatz B, Schwartz AV, Ritchie RO, Alliston TN, Havel PJ, Fields AJ. Contributions of Material Properties and Structure to Increased Bone Fragility for a Given Bone Mass in the UCD-T2DM Rat Model of Type 2 Diabetes. J Bone Miner Res. 2018 06; 33(6):1066-1075. PMID: 29342321.
      View in: PubMed
    16. Berg-Johansen B, Fields AJ, Liebenberg EC, Li A, Lotz JC. Structure-function relationships at the human spinal disc-vertebra interface. J Orthop Res. 2018 01; 36(1):192-201. PMID: 28590060.
      View in: PubMed
    17. Millard SM, Wang L, Wattanachanya L, O'Carroll D, Fields AJ, Pang J, Kazakia G, Lotz JC, Nissenson RA. Role of Osteoblast Gi Signaling in Age-Related Bone Loss in Female Mice. Endocrinology. 2017 06 01; 158(6):1715-1726. PMID: 28407060.
      View in: PubMed
    18. Fowler TW, Acevedo C, Mazur CM, Hall-Glenn F, Fields AJ, Bale HA, Ritchie RO, Lotz JC, Vail TP, Alliston T. Glucocorticoid suppression of osteocyte perilacunar remodeling is associated with subchondral bone degeneration in osteonecrosis. Sci Rep. 2017 03 22; 7:44618. PMID: 28327602.
      View in: PubMed
    19. Dudli S, Fields AJ, Samartzis D, Karppinen J, Lotz JC. Pathobiology of Modic changes. Eur Spine J. 2016 11; 25(11):3723-3734. PMID: 26914098.
      View in: PubMed
    20. Nawathe S, Yang H, Fields AJ, Bouxsein ML, Keaveny TM. Theoretical effects of fully ductile versus fully brittle behaviors of bone tissue on the strength of the human proximal femur and vertebral body. J Biomech. 2015 May 01; 48(7):1264-9. PMID: 25828400.
      View in: PubMed
    21. Fields AJ, Berg-Johansen B, Metz LN, Miller S, La B, Liebenberg EC, Coughlin DG, Graham JL, Stanhope KL, Havel PJ, Lotz JC. Alterations in intervertebral disc composition, matrix homeostasis and biomechanical behavior in the UCD-T2DM rat model of type 2 diabetes. J Orthop Res. 2015 May; 33(5):738-46. PMID: 25641259.
      View in: PubMed
    22. Wang J, Zhou B, Liu XS, Fields AJ, Sanyal A, Shi X, Adams M, Keaveny TM, Guo XE. Trabecular plates and rods determine elastic modulus and yield strength of human trabecular bone. Bone. 2015 Mar; 72:71-80. PMID: 25460571.
      View in: PubMed
    23. Fields AJ, Han M, Krug R, Lotz JC. Cartilaginous end plates: Quantitative MR imaging with very short echo times-orientation dependence and correlation with biochemical composition. Radiology. 2015 Feb; 274(2):482-9. PMID: 25302832.
      View in: PubMed
    24. Bailey JF, Fields AJ, Liebenberg E, Mattison JA, Lotz JC, Kramer PA. Comparison of vertebral and intervertebral disc lesions in aging humans and rhesus monkeys. Osteoarthritis Cartilage. 2014 Jul; 22(7):980-5. PMID: 24821664.
      View in: PubMed
    25. Sahli F, Cuellar J, Pérez A, Fields AJ, Campos M, Ramos-Grez J. Structural parameters determining the strength of the porcine vertebral body affected by tumours. Comput Methods Biomech Biomed Engin. 2015; 18(8):890-9. PMID: 24460089.
      View in: PubMed
    26. Zhou B, Liu XS, Wang J, Lu XL, Fields AJ, Guo XE. Dependence of mechanical properties of trabecular bone on plate-rod microstructure determined by individual trabecula segmentation (ITS). J Biomech. 2014 Feb 07; 47(3):702-8. PMID: 24360196.
      View in: PubMed
    27. Fields AJ, Rodriguez D, Gary KN, Liebenberg EC, Lotz JC. Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine. J Orthop Res. 2014 Feb; 32(2):245-52. PMID: 24273192.
      View in: PubMed
    28. Fields AJ, Liebenberg EC, Lotz JC. Innervation of pathologies in the lumbar vertebral end plate and intervertebral disc. Spine J. 2014 Mar 01; 14(3):513-21. PMID: 24139753.
      View in: PubMed
    29. Lotz JC, Fields AJ, Liebenberg EC. The role of the vertebral end plate in low back pain. Global Spine J. 2013 Jun; 3(3):153-64. PMID: 24436866.
      View in: PubMed
    30. Fields AJ, Sahli F, Rodriguez AG, Lotz JC. Seeing double: a comparison of microstructure, biomechanical function, and adjacent disc health between double- and single-layer vertebral endplates. Spine (Phila Pa 1976). 2012 Oct 01; 37(21):E1310-7. PMID: 22781006.
      View in: PubMed
    31. Fields AJ, Nawathe S, Eswaran SK, Jekir MG, Adams MF, Papadopoulos P, Keaveny TM. Vertebral fragility and structural redundancy. J Bone Miner Res. 2012 Oct; 27(10):2152-8. PMID: 22623120.
      View in: PubMed
    32. Yang H, Nawathe S, Fields AJ, Keaveny TM. Micromechanics of the human vertebral body for forward flexion. J Biomech. 2012 Aug 09; 45(12):2142-8. PMID: 22704826.
      View in: PubMed
    33. Fields AJ, Keaveny TM. Trabecular architecture and vertebral fragility in osteoporosis. Curr Osteoporos Rep. 2012 Jun; 10(2):132-40. PMID: 22492119.
      View in: PubMed
    34. Fields AJ, Lee GL, Liu XS, Jekir MG, Guo XE, Keaveny TM. Influence of vertical trabeculae on the compressive strength of the human vertebra. J Bone Miner Res. 2011 Feb; 26(2):263-9. PMID: 20715186.
      View in: PubMed
    35. Fields AJ, Lee GL, Keaveny TM. Mechanisms of initial endplate failure in the human vertebral body. J Biomech. 2010 Dec 01; 43(16):3126-31. PMID: 20817162.
      View in: PubMed
    36. Fields AJ, Eswaran SK, Jekir MG, Keaveny TM. Role of trabecular microarchitecture in whole-vertebral body biomechanical behavior. J Bone Miner Res. 2009 Sep; 24(9):1523-30. PMID: 19338454.
      View in: PubMed
    37. Eswaran SK, Fields AJ, Nagarathnam P, Keaveny TM. Multi-scale modeling of the human vertebral body: comparison of micro-CT based high-resolution and continuum-level models. Pac Symp Biocomput. 2009; 293-303. PMID: 19209709.
      View in: PubMed
    38. Laz PJ, Pal S, Fields A, Petrella AJ, Rullkoetter PJ. Effects of knee simulator loading and alignment variability on predicted implant mechanics: a probabilistic study. J Orthop Res. 2006 Dec; 24(12):2212-21. PMID: 17004268.
      View in: PubMed
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