Loading...

Aaron Tward, MD, PhD

Title(s)Assistant Professor, Otolaryngology
SchoolSchool of Medicine
Phone415-353-2757
ORCID ORCID Icon0000-0003-4868-8732 Additional info
vCardDownload vCard

    Collapse Biography 
    Collapse Education and Training
    UCLAB.S.1999Microbiology and Molecular Genetics
    UCLAM.A.1999Microbiology and Molecular Genetics
    UCSFPh.D.2005Biomedical Sciences
    UCSFM.D.2007Medicine
    Harvard Medical School/Massachusetts Eye and Ear InfirmaryResidency2012Otolaryngology - Head and Neck Surgery
    Harvard Medical School/Massachusetts Eye and Ear InfirmaryFellowship2014Neurotology

    Collapse Overview 
    Collapse Overview
    Aaron D. Tward M.D., Ph.D., is a board-certified, fellowship-trained surgeon who specializes in the diagnosis and treatment of disorders of the ear and skull base.

    Dr. Tward has particular clinical interests in cochlear implantation, management of benign and malignant tumors of the skull base including acoustic neuroma (vestibular schwannoma), surgery for chronic otitis media, stapedectomy, superior semi-circular canal dehiscence repair, and endoscopic surgery of the ear and skull base.

    Dr. Tward’s research interests include tumor biology, the genetics and genomics of disorders of the head and neck, the development and physiology of the organs of hearing, and clinical outcomes of surgery of the ear and skull base.

    Education and Training:
    • Undergraduate: University of California, Los Angeles, B.S. - Microbiology and Molecular Genetics
    • Graduate School: University of California, Los Angeles, M.A. - Microbiology and Molecular Genetics, Lab of A. Jake Lusis
    • Graduate School: University of California, San Francisco, Ph.D. - Biomedical Sciences, Lab of J. Michael Bishop
    • Medical School: University of California, San Francisco, M.D.
    • Internship: Brigham and Women’s Hospital, Harvard Medical School - General Surgery

    • Residency: Otolaryngology – Head and Neck Surgery
    Harvard Medical School Residency Program in Otolaryngology
    Massachusetts Eye and Ear Infirmary
    Massachusetts General Hospital
    Brigham and Women’s Hospital
    Beth Israel-Deaconess Medical Center
    Boston Children’s Hospital

    • Clinical Fellowship: Otology, Neurotology, and Skull Base Surgery
    Harvard Medical School
    Massachusetts Eye and Ear Infirmary
    Massachusetts General Hospital
    (Michael J. McKenna and Daniel J. Lee Fellowship directors)

    • Post Doctoral: The Broad Institute of MIT and Harvard
    Lab of Todd R. Golub

    • Diplomate, American Board of Otolaryngology
    • License, Medical Board of California

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Stacey M Frumm, Kevin Shengyang Yu, Joseph Chang, Jordan A Briscoe, Katharine P Lee, Lauren E Byrnes, Julie B Sneddon, Aaron D Tward. A hierarchy of migratory keratinocytes maintains the tympanic membrane. 2019 Jul 1; 687947.
      View in: Publisher Site
    2. Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM. Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer. Elife. 2019 05 28; 8. PMID: 31134896.
      View in: PubMed
    3. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 03 19; 50(3):707-722.e6. PMID: 30824323.
      View in: PubMed
    4. Chari DA, Frumm SM, Akil O, Tward AD. Cellular Dynamics in Early Healing of Mouse Tympanic Membranes. Otol Neurotol. 2019 02; 40(2):e160-e166. PMID: 30570602.
      View in: PubMed
    5. Breshears JD, Chang J, Molinaro AM, Sneed PK, McDermott MW, Tward A, Theodosopoulos PV. Temporal Dynamics of Pseudoprogression After Gamma Knife Radiosurgery for Vestibular Schwannomas-A Retrospective Volumetric Study. Neurosurgery. 2019 01 01; 84(1):123-131. PMID: 29518221.
      View in: PubMed
    6. Chang J, Breshears JD, Molinaro AM, Sneed PK, McDermott MW, Theodosopoulos PV, Tward AD. Impact of pretreatment growth on Tumor control for vestibular schwannomas following gamma knife. Laryngoscope. 2019 03; 129(3):743-747. PMID: 30408172.
      View in: PubMed
    7. Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922. PMID: 30254276.
      View in: PubMed
    8. Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N. Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 04 05; 173(2):321-337.e10. PMID: 29625050.
      View in: PubMed
    9. Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 03; 10(3). PMID: 29335337.
      View in: PubMed
    10. Jonathan Breshears, Joseph Chang, Annette Molinaro, Penny Sneed, Michael Mcdermott, Aaron Tward, Philip Theodosopoulos. Duration and Timing of Transient Tumor Enlargement after Gamma Knife Radiosurgery for Vestibular Schwannomas. 2018 Feb 1; 79(S 01):s1-s188.
      View in: Publisher Site
    11. Stephen T. Magill, Philip V. Theodosopoulos, Aaron D. Tward, Steven W. Cheung, Michael W. McDermott. Meningiomas of the Cerebellopontine Angle. 2018 Jan 1; 103-113.
      View in: Publisher Site
    12. Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528. PMID: 28576768.
      View in: PubMed
    13. Roman Camarda, Alicia Y. Zhou, Rebecca A. Kohnz, Sanjeev Balakrishnan, Celine Mahieu, Brittany Anderton, Henok Eyob, Shingo Kajimura, Aaron Tward, Gregor Krings, Daniel K. Nomura, Andrei Goga. Abstract 2673: Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. 2016 Jul 15; 2673-2673.
      View in: Publisher Site
    14. Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016 04; 22(4):427-32. PMID: 26950360.
      View in: PubMed
    15. Puram SV, Tward AD, Jung DH, Dilger AE, Herrmann BS, Duhaime AC, Barker FG, Lee DJ. Auditory brainstem implantation in a 16-month-old boy with cochlear hypoplasia. Otol Neurotol. 2015 Apr; 36(4):618-24. PMID: 25473959.
      View in: PubMed
    16. Li J, Chanrion M, Sawey E, Wang T, Chow E, Tward A, Su Y, Xue W, Lucito R, Zender L, Lowe SW, Bishop JM, Powers S. Reciprocal interaction of Wnt and RXR-a pathways in hepatocyte development and hepatocellular carcinoma. PLoS One. 2015; 10(3):e0118480. PMID: 25738607.
      View in: PubMed
    17. Mroz EA, Tward AD, Tward AM, Hammon RJ, Ren Y, Rocco JW. Intra-tumor genetic heterogeneity and mortality in head and neck cancer: analysis of data from the Cancer Genome Atlas. PLoS Med. 2015 Feb; 12(2):e1001786. PMID: 25668320.
      View in: PubMed
    18. Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015 Jan 29; 517(7536):576-82. PMID: 25631445.
      View in: PubMed
    19. Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R. Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15544-9. PMID: 25313082.
      View in: PubMed
    20. J.W. Rocco, A.D. Tward, Y. Ren, R.J. Hammon, E.A. Mroz. Mutant-Allele Tumor Heterogeneity (MATH) Adds to Human Papillomavirus (HPV) Status in Predicting Outcome in Head-and-Neck Squamous Cell Carcinoma (HNSCC) Molecular Biology and Therapeutics. 2014 Feb 1; 88(2):467-468.
      View in: Publisher Site
    21. Mroz EA, Tward AD, Pickering CR, Myers JN, Ferris RL, Rocco JW. High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma. Cancer. 2013 Aug 15; 119(16):3034-42. PMID: 23696076.
      View in: PubMed
    22. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26; 333(6046):1157-60. PMID: 21798893.
      View in: PubMed
    23. Lee SA, Ho C, Roy R, Kosinski C, Patil MA, Tward AD, Fridlyand J, Chen X. Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. Hepatology. 2008 Apr; 47(4):1200-10. PMID: 18214995.
      View in: PubMed
    24. C.E. Furlong, R.J Richter, W.-F. Li, V.H. Brophy, C. Carlson, M. Rieder, D. Nickerson, L.G. Costa, J. Ranchalis, A.J. Lusis, D.M. Shih, A. Tward, G.P. Jarvik. The Functional Consequences of Polymorphisms in the Human PON1 Gene. 2008 Jan 1; 267-281.
      View in: Publisher Site
    25. Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM. Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14771-6. PMID: 17785413.
      View in: PubMed
    26. Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7. PMID: 17589519.
      View in: PubMed
    27. Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO. Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14842-7. PMID: 17003113.
      View in: PubMed
    28. Bhasin KK, Yu JM, Tward A, Shih D, Campbell DA, Lusis AJ. Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Exp Parasitol. 2006 Nov; 114(3):240-5. PMID: 16682028.
      View in: PubMed
    29. Sheth SS, Bodnar JS, Ghazalpour A, Thipphavong CK, Tsutsumi S, Tward AD, Demant P, Kodama T, Aburatani H, Lusis AJ. Hepatocellular carcinoma in Txnip-deficient mice. Oncogene. 2006 Jun 15; 25(25):3528-36. PMID: 16607285.
      View in: PubMed
    30. Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG. Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology. 2005 Aug; 26(4):651-9. PMID: 16112327.
      View in: PubMed
    31. Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet Genomics. 2005 Aug; 15(8):589-98. PMID: 16007003.
      View in: PubMed
    32. Tward AD, Jones KD, Yant S, Kay MA, Wang R, Bishop JM. Genomic progression in mouse models for liver tumors. Cold Spring Harb Symp Quant Biol. 2005; 70:217-24. PMID: 16869757.
      View in: PubMed
    33. Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. Paraoxonase 1 (PON1) status and risk of insecticide exposure. J Biochem Mol Toxicol. 2005; 19(3):182-3. PMID: 15977192.
      View in: PubMed
    34. Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80. PMID: 12874251.
      View in: PubMed
    35. Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM, Tward A, Lusis AJ, Jack RM, Costa LG, Furlong CE. Expression of human paraoxonase (PON1) during development. Pharmacogenetics. 2003 Jun; 13(6):357-64. PMID: 12777966.
      View in: PubMed
    36. Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW, Lusis AJ, Shih DM. Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation. 2002 Jul 23; 106(4):484-90. PMID: 12135950.
      View in: PubMed
    37. Tward AD, Patterson HA. MSJAMA. From grave robbing to gifting: cadaver supply in the United States. JAMA. 2002 Mar 06; 287(9):1183. PMID: 11879122.
      View in: PubMed
    38. Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics. 2000 Dec; 10(9):767-79. PMID: 11191881.
      View in: PubMed
    39. Gatti RA, Tward A, Concannon P. Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations. Mol Genet Metab. 1999 Dec; 68(4):419-23. PMID: 10607471.
      View in: PubMed
    Aaron's Networks
    Concepts
    Derived automatically from this person's publications.
    See all (231) concept(s)
    _
    Co-Authors
    People in Profiles who have published with this person.
    See all (34) people
    _
    Similar People
    People who share similar concepts with this person.
    See all (60) people
    _
    Same Department
    Search Department
    ↑