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ORAOV1, CCND1, and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma. Mol Cancer Res. 2024 02 01; 22(2):152-168.
Mahieu CI, Mancini AG, Vikram EP, Planells-Palop V, Joseph NM, Tward AD. PMID: 37930255; PMCID: PMC10831340.
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PubMed Mentions:
1 Fields:
Translation:
HumansCells
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CompHEAR: A Customizable and Scalable Web-Enabled Auditory Performance Evaluation Platform for Cochlear Implant Sound Processing Research. bioRxiv. 2023 Dec 23.
Merrill K, Muller L, Beim JA, Hehrmann P, Swan D, Alfsmann D, Spahr T, Litvak L, Oxenham AJ, Tward AD. PMID: 38187767; PMCID: PMC10769353.
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PubMed Mentions:
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Epimorphic regeneration in the mammalian tympanic membrane. NPJ Regen Med. 2023 Oct 18; 8(1):58.
Scaria SM, Frumm SM, Vikram EP, Easow SA, Sheth AH, Shamir ER, Yu SK, Tward AD. PMID: 37852984; PMCID: PMC10584978.
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PubMed Mentions:
1
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Specific Oral Microbial Differences in Proteobacteria and Bacteroidetes Are Associated with Distinct Sites When Moving from Healthy Mucosa to Oral Dysplasia-A Microbiome and Gene Profiling Study and Focused Review. Microorganisms. 2023 Sep 07; 11(9).
Radaic A, Shamir ER, Jones K, Villa A, Garud NR, Tward AD, Kamarajan P, Kapila YL. PMID: 37764094; PMCID: PMC10534919.
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PubMed Mentions:
2
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Electrical Determinants of Tinnitus Extinction in a Cochlear Implant Patient. Otol Neurotol. 2023 01 01; 44(1):e8-e12.
Muller L, Gilbert M, Jiam NT, Limb CJ, Tward AD. PMID: 36509436.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Endoscopic Medial Reepithelization for Inflammatory Canal Stenosis. Otol Neurotol. 2022 09 01; 43(8):973-977.
Scaria SM, Tward AD. PMID: 35970160; PMCID: PMC9387548.
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PubMed Mentions: Fields:
Translation:
Humans
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Repair of the Murine Tympanic Membrane Displays Hallmarks of Regeneration. The FASEB Journal. 2022 May 13; 36(S1).
Scaria SS, Frumm FS, Sheth SA, Tward TA. .
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607 Gene Editing/Gene Therapies: HIGHLY EFFICIENT GENOME ENGINEERING OF PRIMARY ADULT KERATINOCYTES FOR THE DEVELOPMENT OF NOVEL CELL THERAPIES. Cytotherapy. 2022 May 1; 24(5):s140-s141.
Mahieu MC, Mancini MA, beckett bC, Tward TA. .
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608 Gene Editing/Gene Therapies: SCALABLE GENOME ENGINEERING OF ADULT KERATINOCYTES FOR THE DEVELOPMENT OF NOVEL CELL THERAPEUTICS. Cytotherapy. 2022 May 1; 24(5):s141.
Mahieu MC, Mancini MA, Beckett BC, Tward TA. .
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A Rare Complication of Chronic Otitis Media: Central Skull Base Osteomyelitis Managed With Combined Endoscopic Transmastoid and Transsphenoidal Debridement. Otol Neurotol. 2022 03 01; 43(3):e344-e347.
Suresh K, Chari DA, Bartholomew RA, Tward AD, Kozin ED, Barshak MB, Holbrook EH, Lee DJ. PMID: 35147606.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Author Correction: A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nat Commun. 2021 Oct 06; 12(1):5951.
Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG. PMID: 34615857; PMCID: PMC8494928.
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PubMed Mentions: Fields:
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Human melanocyte development and melanoma dedifferentiation at single-cell resolution. Nat Cell Biol. 2021 09; 23(9):1035-1047.
Belote RL, Le D, Maynard A, Lang UE, Sinclair A, Lohman BK, Planells-Palop V, Baskin L, Tward AD, Darmanis S, Judson-Torres RL. PMID: 34475532.
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PubMed Mentions:
52 Fields:
Translation:
HumansCells
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Abstract 3112: Human melanocyte development and melanoma dedifferentiation at single cell resolution. Cancer Research. 2021 Jul 1; 81(13_Supplement):3112-3112.
Belote BR, Le LD, Maynard MA, Lang LU, Sinclair SA, Planells-Palop PV, Baskin BL, Tward TA, Darmanis DS, Judson-Torres JR. .
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Scalable genome engineering of adult keratinocytes for the development of novel cell therapeutics. Cytotherapy. 2021 May 1; 23(5):s153.
Mahieu MC, Mancini MA, beckett bC, Tward TA. .
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A Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane. Cell Stem Cell. 2021 02 04; 28(2):315-330.e5.
Frumm SM, Yu SK, Chang J, Artichoker JA, Scaria SM, Lee KP, Byrnes LE, Sneddon JB, Tward AD. PMID: 33181078; PMCID: PMC8962966.
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PubMed Mentions:
7 Fields:
Translation:
HumansCells
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A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nat Commun. 2020 11 06; 11(1):5628.
Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG. PMID: 33159074; PMCID: PMC7648648.
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PubMed Mentions:
53 Fields:
Translation:
Animals
-
Abstract 4903: Minimal mutational determinants of human squamous cell carcinoma. Cancer Research. 2020 Aug 15; 80(16_Supplement):4903-4903.
Planells-Palop PV, Koo KA, Malave MH, Lee LK, Tward TA. .
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Abstract B40: Minimal mutational determinants of human squamous cell carcinoma. Cancer Research. 2020 Jun 1; 80(11_Supplement):b40-b40.
Planells-Palop PV, Koo KA, Malave MH, Lee LK, Tward TA. .
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Transcriptional control of subtype switching ensures adaptation and growth of pancreatic cancer. Elife. 2019 05 28; 8.
Adams CR, Htwe HH, Marsh T, Wang AL, Montoya ML, Subbaraj L, Tward AD, Bardeesy N, Perera RM. PMID: 31134896; PMCID: PMC6538376.
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PubMed Mentions:
42 Fields:
Translation:
HumansAnimalsCells
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Adventitial stromal cells define group 2 innate lymphoid cell tissue niches. The Journal of Immunology. 2019 May 1; 202(1_Supplement):129.1-129.1.
Molofsky MA, Dahlgren DM, Jones JS, Dubinin DA, Farhat FS, Ortiz-Carpena OJ, Yu YK, Lee LK, Wang WC, Molofsky MA, Tward TA, Krummel KM, Peng PT. .
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Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity. 2019 03 19; 50(3):707-722.e6.
Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. PMID: 30824323; PMCID: PMC6553479.
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PubMed Mentions:
156 Fields:
Translation:
AnimalsCells
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Cellular Dynamics in Early Healing of Mouse Tympanic Membranes. Otol Neurotol. 2019 02; 40(2):e160-e166.
Chari DA, Frumm SM, Akil O, Tward AD. PMID: 30570602.
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PubMed Mentions:
7 Fields:
Translation:
Animals
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Temporal Dynamics of Pseudoprogression After Gamma Knife Radiosurgery for Vestibular Schwannomas-A Retrospective Volumetric Study. Neurosurgery. 2019 01 01; 84(1):123-131.
Breshears JD, Chang J, Molinaro AM, Sneed PK, McDermott MW, Tward A, Theodosopoulos PV. PMID: 29518221.
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PubMed Mentions:
17 Fields:
Translation:
Humans
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Impact of pretreatment growth on Tumor control for vestibular schwannomas following gamma knife. Laryngoscope. 2019 03; 129(3):743-747.
Chang J, Breshears JD, Molinaro AM, Sneed PK, McDermott MW, Theodosopoulos PV, Tward AD. PMID: 30408172.
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PubMed Mentions:
1 Fields:
Translation:
Humans
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Lineage dynamics of murine pancreatic development at single-cell resolution. Nat Commun. 2018 09 25; 9(1):3922.
Byrnes LE, Wong DM, Subramaniam M, Meyer NP, Gilchrist CL, Knox SM, Tward AD, Ye CJ, Sneddon JB. PMID: 30254276; PMCID: PMC6156586.
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PubMed Mentions:
83 Fields:
Translation:
HumansAnimalsCells
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Oncogenic Signaling Pathways in The Cancer Genome Atlas. Cell. 2018 04 05; 173(2):321-337.e10.
Sanchez-Vega F, Mina M, Armenia J, Chatila WK, Luna A, La KC, Dimitriadoy S, Liu DL, Kantheti HS, Saghafinia S, Chakravarty D, Daian F, Gao Q, Bailey MH, Liang WW, Foltz SM, Shmulevich I, Ding L, Heins Z, Ochoa A, Gross B, Gao J, Zhang H, Kundra R, Kandoth C, Bahceci I, Dervishi L, Dogrusoz U, Zhou W, Shen H, Laird PW, Way GP, Greene CS, Liang H, Xiao Y, Wang C, Iavarone A, Berger AH, Bivona TG, Lazar AJ, Hammer GD, Giordano T, Kwong LN, McArthur G, Huang C, Tward AD, Frederick MJ, McCormick F, Meyerson M, Cancer Genome Atlas Research Network, Van Allen EM, Cherniack AD, Ciriello G, Sander C, Schultz N. PMID: 29625050; PMCID: PMC6070353.
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PubMed Mentions:
1404 Fields:
Translation:
HumansCells
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Salivary glands regenerate after radiation injury through SOX2-mediated secretory cell replacement. EMBO Mol Med. 2018 03; 10(3).
Emmerson E, May AJ, Berthoin L, Cruz-Pacheco N, Nathan S, Mattingly AJ, Chang JL, Ryan WR, Tward AD, Knox SM. PMID: 29335337; PMCID: PMC5840548.
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PubMed Mentions:
56 Fields:
Translation:
HumansAnimalsCellsPHPublic Health
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Duration and Timing of Transient Tumor Enlargement after Gamma Knife Radiosurgery for Vestibular Schwannomas. Journal of Neurological Surgery Part B Skull Base. 2018 Feb 1; 79(S 01):s1-s188.
Breshears BJ, Chang CJ, Molinaro MA, Sneed SP, Mcdermott MM, Tward TA, Theodosopoulos TP. .
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Meningiomas of the Cerebellopontine Angle. Skull Base Surgery of the Posterior Fossa. 2018 Jan 1; 103-113.
Magill MS, Theodosopoulos TP, Tward TA, Cheung CS, McDermott MM. .
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Defining epithelial cell dynamics and lineage relationships in the developing lacrimal gland. Development. 2017 07 01; 144(13):2517-2528.
Farmer DT, Nathan S, Finley JK, Shengyang Yu K, Emmerson E, Byrnes LE, Sneddon JB, McManus MT, Tward AD, Knox SM. PMID: 28576768; PMCID: PMC5536870.
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PubMed Mentions:
30 Fields:
Translation:
HumansAnimalsCells
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Abstract 2673: Inhibition of fatty-acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Molecular and Cellular Biology, Genetics. 2016 Jul 15; 2673-2673.
Camarda CR, Zhou ZA, Kohnz KR, Balakrishnan BS, Mahieu MC, Anderton AB, Eyob EH, Kajimura KS, Tward TA, Krings KG, Nomura ND, Goga GA. .
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Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016 04; 22(4):427-32.
Camarda R, Zhou AY, Kohnz RA, Balakrishnan S, Mahieu C, Anderton B, Eyob H, Kajimura S, Tward A, Krings G, Nomura DK, Goga A. PMID: 26950360; PMCID: PMC4892846.
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PubMed Mentions:
275 Fields:
Translation:
HumansCells
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Auditory brainstem implantation in a 16-month-old boy with cochlear hypoplasia. Otol Neurotol. 2015 Apr; 36(4):618-24.
Puram SV, Tward AD, Jung DH, Dilger AE, Herrmann BS, Duhaime AC, Barker FG, Lee DJ. PMID: 25473959.
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PubMed Mentions:
3 Fields:
Translation:
HumansCTClinical Trials
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Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma. PLoS One. 2015; 10(3):e0118480.
Li J, Chanrion M, Sawey E, Wang T, Chow E, Tward A, Su Y, Xue W, Lucito R, Zender L, Lowe SW, Bishop JM, Powers S. PMID: 25738607; PMCID: PMC4349704.
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PubMed Mentions:
8 Fields:
Translation:
HumansAnimalsCells
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Intra-tumor genetic heterogeneity and mortality in head and neck cancer: analysis of data from the Cancer Genome Atlas. PLoS Med. 2015 Feb; 12(2):e1001786.
Mroz EA, Tward AD, Tward AM, Hammon RJ, Ren Y, Rocco JW. PMID: 25668320; PMCID: PMC4323109.
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PubMed Mentions:
152 Fields:
Translation:
HumansCells
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Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature. 2015 Jan 29; 517(7536):576-82.
Cancer Genome Atlas Network. PMID: 25631445; PMCID: PMC4311405.
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PubMed Mentions:
1946 Fields:
Translation:
HumansCells
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Characterization of HPV and host genome interactions in primary head and neck cancers. Proc Natl Acad Sci U S A. 2014 Oct 28; 111(43):15544-9.
Parfenov M, Pedamallu CS, Gehlenborg N, Freeman SS, Danilova L, Bristow CA, Lee S, Hadjipanayis AG, Ivanova EV, Wilkerson MD, Protopopov A, Yang L, Seth S, Song X, Tang J, Ren X, Zhang J, Pantazi A, Santoso N, Xu AW, Mahadeshwar H, Wheeler DA, Haddad RI, Jung J, Ojesina AI, Issaeva N, Yarbrough WG, Hayes DN, Grandis JR, El-Naggar AK, Meyerson M, Park PJ, Chin L, Seidman JG, Hammerman PS, Kucherlapati R, Cancer Genome Atlas Network. PMID: 25313082; PMCID: PMC4217452.
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PubMed Mentions:
207 Fields:
Translation:
HumansCells
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Mutant-Allele Tumor Heterogeneity (MATH) Adds to Human Papillomavirus (HPV) Status in Predicting Outcome in Head-and-Neck Squamous Cell Carcinoma (HNSCC) Molecular Biology and Therapeutics. International Journal of Radiation Oncology • Biology • Physics. 2014 Feb 1; 88(2):467-468.
Rocco RJ, Tward TA, Ren RY, Hammon HR, Mroz ME. .
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High intratumor genetic heterogeneity is related to worse outcome in patients with head and neck squamous cell carcinoma. Cancer. 2013 Aug 15; 119(16):3034-42.
Mroz EA, Tward AD, Pickering CR, Myers JN, Ferris RL, Rocco JW. PMID: 23696076; PMCID: PMC3735618.
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PubMed Mentions:
127 Fields:
Translation:
Humans
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The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26; 333(6046):1157-60.
Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, Kryukov GV, Lawrence MS, Sougnez C, McKenna A, Shefler E, Ramos AH, Stojanov P, Carter SL, Voet D, Cortés ML, Auclair D, Berger MF, Saksena G, Guiducci C, Onofrio RC, Parkin M, Romkes M, Weissfeld JL, Seethala RR, Wang L, Rangel-Escareño C, Fernandez-Lopez JC, Hidalgo-Miranda A, Melendez-Zajgla J, Winckler W, Ardlie K, Gabriel SB, Meyerson M, Lander ES, Getz G, Golub TR, Garraway LA, Grandis JR. PMID: 21798893; PMCID: PMC3415217.
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PubMed Mentions:
1317 Fields:
Translation:
HumansAnimalsCells
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Integration of genomic analysis and in vivo transfection to identify sprouty 2 as a candidate tumor suppressor in liver cancer. Hepatology. 2008 Apr; 47(4):1200-10.
Lee SA, Ho C, Roy R, Kosinski C, Patil MA, Tward AD, Fridlyand J, Chen X. PMID: 18214995.
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PubMed Mentions:
56 Fields:
Translation:
HumansAnimals
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The Functional Consequences of Polymorphisms in the Human PON1 Gene. The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism. 2008 Jan 1; 267-281.
Furlong FC, Richter RR, Li LW, Brophy BV, Carlson CC, Rieder RM, Nickerson ND, Costa CL, Ranchalis RJ, Lusis LA, Shih SD, Tward TA, Jarvik JG. .
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Distinct pathways of genomic progression to benign and malignant tumors of the liver. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14771-6.
Tward AD, Jones KD, Yant S, Cheung ST, Fan ST, Chen X, Kay MA, Wang R, Bishop JM. PMID: 17785413; PMCID: PMC1964540.
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PubMed Mentions:
123 Fields:
Translation:
HumansAnimals
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Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med. 2007 Jul; 13(7):820-7.
Goga A, Yang D, Tward AD, Morgan DO, Bishop JM. PMID: 17589519.
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PubMed Mentions:
176 Fields:
Translation:
HumansAnimalsCells
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Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A. 2006 Oct 03; 103(40):14842-7.
Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO. PMID: 17003113; PMCID: PMC1578503.
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PubMed Mentions:
134 Fields:
Translation:
HumansCells
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Trypanosoma congolense: paraoxonase 1 prolongs survival of infected mice. Exp Parasitol. 2006 Nov; 114(3):240-5.
Bhasin KK, Yu JM, Tward A, Shih D, Campbell DA, Lusis AJ. PMID: 16682028.
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PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Hepatocellular carcinoma in Txnip-deficient mice. Oncogene. 2006 Jun 15; 25(25):3528-36.
Sheth SS, Bodnar JS, Ghazalpour A, Thipphavong CK, Tsutsumi S, Tward AD, Demant P, Kodama T, Aburatani H, Lusis AJ. PMID: 16607285.
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PubMed Mentions:
70 Fields:
Translation:
Animals
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Role of paraoxonase (PON1) status in pesticide sensitivity: genetic and temporal determinants. Neurotoxicology. 2005 Aug; 26(4):651-9.
Furlong CE, Cole TB, Jarvik GP, Pettan-Brewer C, Geiss GK, Richter RJ, Shih DM, Tward AD, Lusis AJ, Costa LG. PMID: 16112327.
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PubMed Mentions:
23 Fields:
Translation:
HumansAnimals
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Toxicity of chlorpyrifos and chlorpyrifos oxon in a transgenic mouse model of the human paraoxonase (PON1) Q192R polymorphism. Pharmacogenet Genomics. 2005 Aug; 15(8):589-98.
Cole TB, Walter BJ, Shih DM, Tward AD, Lusis AJ, Timchalk C, Richter RJ, Costa LG, Furlong CE. PMID: 16007003.
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PubMed Mentions:
35 Fields:
Translation:
HumansAnimals
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Genomic progression in mouse models for liver tumors. Cold Spring Harb Symp Quant Biol. 2005; 70:217-24.
Tward AD, Jones KD, Yant S, Kay MA, Wang R, Bishop JM. PMID: 16869757.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Paraoxonase 1 (PON1) status and risk of insecticide exposure. J Biochem Mol Toxicol. 2005; 19(3):182-3.
Furlong CE, Cole TB, Walter BJ, Shih DM, Tward A, Lusis AJ, Timchalk C, Richter RJ, Costa LG. PMID: 15977192.
View in:
PubMed Mentions:
2 Fields:
Translation:
HumansAnimals
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Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse. J Immunol. 2003 Aug 01; 171(3):1572-80.
Araujo JA, Meng L, Tward AD, Hancock WW, Zhai Y, Lee A, Ishikawa K, Iyer S, Buelow R, Busuttil RW, Shih DM, Lusis AJ, Kupiec-Weglinski JW. PMID: 12874251.
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PubMed Mentions:
25 Fields:
Translation:
Animals
-
Expression of human paraoxonase (PON1) during development. Pharmacogenetics. 2003 Jun; 13(6):357-64.
Cole TB, Jampsa RL, Walter BJ, Arndt TL, Richter RJ, Shih DM, Tward A, Lusis AJ, Jack RM, Costa LG, Furlong CE. PMID: 12777966.
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PubMed Mentions:
55 Fields:
Translation:
HumansAnimals
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Decreased atherosclerotic lesion formation in human serum paraoxonase transgenic mice. Circulation. 2002 Jul 23; 106(4):484-90.
Tward A, Xia YR, Wang XP, Shi YS, Park C, Castellani LW, Lusis AJ, Shih DM. PMID: 12135950.
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PubMed Mentions:
115 Fields:
Translation:
HumansAnimals
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MSJAMA. From grave robbing to gifting: cadaver supply in the United States. JAMA. 2002 Mar 06; 287(9):1183.
Tward AD, Patterson HA. PMID: 11879122.
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PubMed Mentions:
4 Fields:
Translation:
Humans
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Catalytic efficiency determines the in-vivo efficacy of PON1 for detoxifying organophosphorus compounds. Pharmacogenetics. 2000 Dec; 10(9):767-79.
Li WF, Costa LG, Richter RJ, Hagen T, Shih DM, Tward A, Lusis AJ, Furlong CE. PMID: 11191881.
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PubMed Mentions:
76 Fields:
Translation:
HumansAnimalsCells
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Cancer risk in ATM heterozygotes: a model of phenotypic and mechanistic differences between missense and truncating mutations. Mol Genet Metab. 1999 Dec; 68(4):419-23.
Gatti RA, Tward A, Concannon P. PMID: 10607471.
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PubMed Mentions:
50 Fields:
Translation:
Humans