Aartik Sarma, MD

Title(s)Assistant Professor, Medicine
SchoolSchool of Medicine
ORCID ORCID Icon0000-0002-7508-7345 Additional info
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    Collapse Biography 
    Collapse Education and Training
    UCSFFellowship2020Pulmonology and Critical Care Medicine
    Massachusetts General HospitalResidency2017Internal Medicine
    UCSFMAS2023Clinical and Epidemiologic Research
    Harvard Medical SchoolMD2014
    Brown UniversityScB2008Public Policy, Biomedical Engineering
    Collapse Awards and Honors
    American Society for Clinical Investigation2023Emerging Generation Award

    Collapse Overview 
    Collapse Overview
    I am a physician-scientist at UCSF and affiliate faculty in the UCSF/UC Berkeley Joint Program in Computational Precision Health. My NHLBI-funded research focuses on applying computational methods to understand the biology of critical illness and develop precision treatments for the patients I take care of in the medical and neurological ICUs at UCSF Parnassus.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Evolution and resolution of ARDS molecular phenotypes
    NHLBI K23HL163491May 4, 2023
    Transcriptomic signatures of airway inflammation in acute respiratory diseases
    NIH F32HL151117Mar 1, 2020 - Feb 28, 2022
    Role: Principal Investigator

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    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Biological effects of corticosteroids on pneumococcal pneumonia in Mice-translational significance. Crit Care. 2024 May 29; 28(1):185. Taenaka H, Wick KD, Sarma A, Matsumoto S, Ghale R, Fang X, Maishan M, Gotts JE, Langelier CR, Calfee CS, Matthay MA. PMID: 38807178; PMCID: PMC11134653.
      View in: PubMed   Mentions:
    2. Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Crit Care. 2024 Apr 22; 28(1):132. Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS. PMID: 38649920; PMCID: PMC11034037.
      View in: PubMed   Mentions:
    3. Molecular Phenotypes of Acute Respiratory Distress Syndrome in the ROSE Trial Have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally over Time. Am J Respir Crit Care Med. 2024 Apr 01; 209(7):816-828. Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS. PMID: 38345571; PMCID: PMC10995566.
      View in: PubMed   Mentions:    Fields:    
    4. Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. Am J Respir Crit Care Med. 2024 Apr 01; 209(7):805-815. Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS. PMID: 38190719; PMCID: PMC10995577.
      View in: PubMed   Mentions:    Fields:    
    5. Research Bronchoscopy Standards and the Need for Noninvasive Sampling of the Failing Lungs. Ann Am Thorac Soc. 2024 Jan; 21(1):183-184. Bain W, Bastarache JA, Sarma A, McElvaney NG, Baron RM, McVerry BJ, Kitsios GD. PMID: 37776282; PMCID: PMC10867904.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling. iScience. 2023 Oct 20; 26(10):107813. Hackney JA, Shivram H, Vander Heiden J, Overall C, Orozco L, Gao X, Kim E, West N, Qamra A, Chang D, Chakrabarti A, Choy DF, Combes AJ, Courau T, Fragiadakis GK, Rao AA, Ray A, Tsui J, Hu K, Kuhn NF, Krummel MF, Erle DJ, Kangelaris K, Sarma A, Lyon Z, Calfee CS, Woodruff PG, Ghale R, Mick E, Byrne A, Zha BS, Langelier C, Hendrickson CM, van der Wijst MGP, Hartoularos GC, Grant T, Bueno R, Lee DS, Greenland JR, Sun Y, Perez R, Ogorodnikov A, Ward A, Ye CJ, UCSF COMET Consortium, Ramalingam T, McBride JM, Cai F, Teterina A, Bao M, Tsai L, Rosas IO, Regev A, Kapadia SB, Bauer RN, Rosenberger CM. PMID: 37810211; PMCID: PMC10551843.
      View in: PubMed   Mentions: 1  
    7. Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. Lancet Respir Med. 2023 Nov; 11(11):965-974. Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. PMID: 37633303; PMCID: PMC10841178.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    8. Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19. Res Sq. 2023 Aug 03. Neyton LPA, Patel RK, Sarma A, UCSF COMET Consortium, Willmore A, Haller SC, Kangelaris KN, Eckalbar WL, Erle DJ, Krummel MF, Hendrickson CM, Woodruff PG, Langelier CR, Calfee CS, Fragiadakis GK. PMID: 37577607; PMCID: PMC10418533.
      View in: PubMed   Mentions:
    9. Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection. Front Immunol. 2023; 14:1076772. Maishan M, Sarma A, Chun LF, Caldera S, Fang X, Abbott J, Christenson SA, Langelier CR, Calfee CS, Gotts JE, Matthay MA. PMID: 36999019; PMCID: PMC10043316.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    10. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022 12 22; 7(24). Calabrese DR, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, Tian JJ, Aminian EA, Wang KM, Shemesh A, Punzalan EB, Sarma A, Calfee CS, Christenson SA, Langelier CR, Hays SR, Golden JA, Leard LE, Kleinhenz ME, Kolaitis NA, Shah R, Venado A, Lanier LL, Greenland JR, Sayah DM, Ardehali A, Kukreja J, Weigt SS, Belperio JA, Singer JP, Looney MR. PMID: 36346670; PMCID: PMC9869973.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults. Nat Microbiol. 2022 11; 7(11):1805-1816. Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR. PMID: 36266337; PMCID: PMC9613463.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    12. Impact of e-cigarette aerosol on primary human alveolar epithelial type 2 cells. Am J Physiol Lung Cell Mol Physiol. 2022 08 01; 323(2):L152-L164. Wick KD, Fang X, Maishan M, Matsumoto S, Spottiswoode N, Sarma A, Simoneau C, Khakoo M, Langelier C, Calfee CS, Gotts JE, Matthay MA. PMID: 35670478; PMCID: PMC9559034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    13. Hyperinflammatory ARDS is characterized by interferon-stimulated gene expression, T-cell activation, and an altered metatranscriptome in tracheal aspirates. medRxiv. 2022. Aartik Sarma, Stephanie A. Christenson, Beth Shoshana Zha, Angela Oliveira Pisco, Lucile P.A. Neyton, Eran Mick, Pratik Sinha, Jennifer G. Wilson, Farzad Moazed, Aleksandra Leligdowicz, Manoj V. Maddali, Emily R. Siegel, Zoe Lyon, Hanjing Zhou, Alejandra Jauregui, Rajani Ghale, Saharai Caldera, Paula Hayakawa Serpa, Thomas Deiss, Christina Love, Ashley Byrne, Katrina L. Kalantar, Joseph L. DeRisi, David J. Erle, Matthew F. Krummel, Kirsten N. Kangelaris, Carolyn M. Hendrickson, Prescott G. Woodruff, Michael A. Matthay, COMET Consortium, Charles R. Langelier, Carolyn S. Calfee. View Publication.
    14. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. Lancet Respir Med. 2022 04; 10(4):367-377. Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group. PMID: 35026177; PMCID: PMC8976729.
      View in: PubMed   Mentions: 43     Fields:    Translation:Humans
    15. Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. medRxiv. 2021 Nov 30. Tsitsiklis A, Zha BS, Byrne A, DeVoe C, Rackaityte E, Levan S, Sunshine S, Mick E, Ghale R, Love C, Tarashansky AJ, Pisco A, Albright J, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Detweiler A, Jones NG, Wu B, Darmanis S, Lynch SV, DeRisi JL, COMET Consortium, Matthay MA, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 33791731; PMCID: PMC8010763.
      View in: PubMed   Mentions: 1  
    16. Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS. Nat Commun. 2021 08 26; 12(1):5152. Sarma A, Christenson SA, Byrne A, Mick E, Pisco AO, DeVoe C, Deiss T, Ghale R, Zha BS, Tsitsiklis A, Jauregui A, Moazed F, Detweiler AM, Spottiswoode N, Sinha P, Neff N, Tan M, Serpa PH, Willmore A, Ansel KM, Wilson JG, Leligdowicz A, Siegel ER, Sirota M, DeRisi JL, Matthay MA, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Calfee CS, Langelier CR. PMID: 34446707; PMCID: PMC8390461.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    17. Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study. Thorax. 2022 01; 77(1):13-21. Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS. PMID: 34253679; PMCID: PMC8688287.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    18. The sputum transcriptome better predicts COPD exacerbations after the withdrawal of inhaled corticosteroids than sputum eosinophils. ERJ Open Res. 2021 Jul; 7(3). Ditz B, Sarma A, Kerstjens HAM, Liesker JJW, Bathoorn E, Vonk JM, Bernal V, Horvatovich P, Guryev V, Caldera S, Langelier C, Faiz A, Christenson SA, van den Berge M. PMID: 34235210; PMCID: PMC8255541.
      View in: PubMed   Mentions: 6  
    19. Impaired immune signaling and changes in the lung microbiome precede secondary bacterial pneumonia in COVID-19. Res Sq. 2021 Apr 23. Tsitsiklis A, Zha BS, Byrne A, Devoe C, Levan S, Rackaityte E, Sunshine S, Mick E, Ghale R, Jauregui A, Sarma A, Neff N, Serpa PH, Deiss TJ, Kistler A, Carrillo S, Ansel KM, Leligdowicz A, Christenson S, Jones N, Wu B, Darmanis S, Matthay MA, Lynch SV, DeRisi JL, COMET Consortium, Hendrickson CM, Kangelaris KN, Krummel MF, Woodruff PG, Erle DJ, Rosenberg O, Calfee CS, Langelier CR. PMID: 34013247; PMCID: PMC8132240.
      View in: PubMed   Mentions:
    20. Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention. JAMA Intern Med. 2020 11 01; 180(11):1539-1540. Sarma A, Calfee CS. PMID: 32584940.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    21. Biomarkers and Precision Medicine: State of the Art. Crit Care Clin. 2020 Jan; 36(1):155-165. Sarma A, Calfee CS, Ware LB. PMID: 31733677.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    22. A Systems Approach to Healthcare Innovation Using the MIT Hacking Medicine Model. Cell Syst. 2017 07 26; 5(1):6-10. Gubin TA, Iyer HP, Liew SN, Sarma A, Revelos A, Ribas J, Movassaghi B, Chu ZM, Khalid AN, Majmudar MD, Lee CX. PMID: 28750199.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    23. A novel subtyping assay for detection of Clostridium difficile virulence genes. J Mol Diagn. 2014 Mar; 16(2):244-52. Angione SL, Sarma AA, Novikov A, Seward L, Fieber JH, Mermel LA, Tripathi A. PMID: 24434086; PMCID: PMC3937534.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    24. Abstract 344: Interoperator Variability and Physician Learning with Medical Devices: Experience with Three New Vascular Closure Devices. Circulation Cardiovascular Quality and Outcomes. 2013 May 1; 6(suppl_1). Sarma SA, Normand NS, Hatfield HL, Matheny MM, Resnic RF. .
      View in: Publisher Site   Mentions:
    25. THE LEARNING CURVE FOR MEDICAL DEVICES: EXPERIENCE WITH VASCULAR CLOSURE DEVICES IN MASSACHUSETTS. Journal of the American College of Cardiology. 2013 Mar 1; 61(10):e1502. Sarma SA, Normand NS, Hatfield HL, Matheny MM, Resnic RF. .
      View in: Publisher Site   Mentions:
    26. A systematic review of reported cost for smear and culture tests during multidrug-resistant tuberculosis treatment. PLoS One. 2013; 8(2):e56074. Lu C, Liu Q, Sarma A, Fitzpatrick C, Falzon D, Mitnick CD. PMID: 23457502; PMCID: PMC3574085.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    27. A simple method for amplifying RNA targets (SMART). J Mol Diagn. 2012 Jul; 14(4):328-35. McCalla SE, Ong C, Sarma A, Opal SM, Artenstein AW, Tripathi A. PMID: 22691910; PMCID: PMC3391418.
      View in: PubMed   Mentions: 7     Fields:    
    28. Ligation with nucleic acid sequence-based amplification. J Mol Diagn. 2012 May-Jun; 14(3):206-13. Ong C, Tai W, Sarma A, Opal SM, Artenstein AW, Tripathi A. PMID: 22449695; PMCID: PMC3349837.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    29. The state of health policy education in U.S. medical schools. N Engl J Med. 2011 Mar 10; 364(10):e19. Mou D, Sarma A, Sethi R, Merryman R. PMID: 21345091.
      View in: PubMed   Mentions: 17     Fields:    
    30. Early in vitro transcription termination in human H5 influenza viral RNA synthesis. Appl Biochem Biotechnol. 2011 Jun; 164(4):497-513. Kerby MB, Sarma AA, Patel MS, Artenstein AW, Opal SM, Tripathi A. PMID: 21207185.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
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