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Adam Frost, PhD, MD

Title(s)Associate Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
Phone415-514-4825
ORCID ORCID Icon0000-0003-2231-2577 Additional info
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    Collapse Research 
    Collapse Research Activities and Funding
    Glacios? Cryo Transmission Electron Microscope with 200 kV XFEG optics
    NIH S10OD026881Aug 6, 2019 - Aug 5, 2020
    Role: Principal Investigator
    Regulated Mitochondrial Morphology
    NIH/NIGMS R01GM127673Sep 19, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Toward Atomic Resolution of Membranes and Membrane-Associated Machines
    NIH/NIGMS DP2GM110772Sep 30, 2013 - May 31, 2018
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation. Nature. 2020 Jun; 582(7810):115-118. von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A. PMID: 32494070.
      View in: PubMed   Mentions:    Fields:    
    2. Membrane constriction and thinning by sequential ESCRT-III polymerization. Nat Struct Mol Biol. 2020 04; 27(4):392-399. Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR, Iwasa JH, Vershinin MD, Sundquist WI, Frost A. PMID: 32251413.
      View in: PubMed   Mentions: 1     Fields:    
    3. Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit. Nucleic Acids Res. 2020 03 18; 48(5):2723-2732. Stojkovic V, Myasnikov AG, Young ID, Frost A, Fraser JS, Fujimori DG. PMID: 31989172.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    4. Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases. J Cell Biol. 2020 Feb 03; 219(2). Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P. PMID: 31904797.
      View in: PubMed   Mentions: 2     Fields:    
    5. Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. Mol Biol Cell. 2019 08 01; 30(17):2097-2104. Kalia R, Frost A. PMID: 31365329.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    6. A Tunable Microfluidic Device Enables Cargo Encapsulation by Cell- or Organelle-Sized Lipid Vesicles Comprising Asymmetric Lipid Bilayers. Adv Biosyst. 2019 Jul; 3(7). Romanov V, McCullough J, Gale BK, Frost A. PMID: 31428671.
      View in: PubMed   Mentions:
    7. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science. 2019 05 03; 364(6439):491-495. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. PMID: 31048491.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    8. Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Nat Commun. 2019 01 31; 10(1):531. Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N. PMID: 30705304.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    9. FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices. Anal Chem. 2018 09 04; 90(17):10450-10456. Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK. PMID: 30071717.
      View in: PubMed   Mentions: 1     Fields:    
    10. Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. Annu Rev Cell Dev Biol. 2018 10 06; 34:85-109. McCullough J, Frost A, Sundquist WI. PMID: 30095293.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    11. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018 06; 558(7710):401-405. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A. PMID: 29899447.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    12. Vms1p is a release factor for the ribosome-associated quality control complex. Nat Commun. 2018 06 06; 9(1):2197. Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J. PMID: 29875445.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    13. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife. 2018 05 29; 7. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS. PMID: 29809151.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    14. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science. 2018 03 30; 359(6383). Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. PMID: 29599213.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    15. Structural inhibition of dynamin-mediated membrane fission by endophilin. Elife. 2017 09 21; 6. Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A. PMID: 28933693.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Science. 2017 07 28; 357(6349):414-417. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS. PMID: 28751611.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    17. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. Elife. 2017 07 18; 6. Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE. PMID: 28718767.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    18. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2166-E2175. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A. PMID: 28242692.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    19. Cell biology: Double agents for mitochondrial division. Nature. 2016 12 01; 540(7631):43-44. McBride HM, Frost A. PMID: 27880759.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    20. Membrane fission by dynamin: what we know and what we need to know. EMBO J. 2016 11 02; 35(21):2270-2284. Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S. PMID: 27670760.
      View in: PubMed   Mentions: 74     Fields:    Translation:HumansAnimalsCells
    21. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J. 2016 11 02; 35(21):2332-2349. Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ. PMID: 27655872.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    22. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Nat Struct Mol Biol. 2016 Jan; 23(1):59-66. Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M. PMID: 26656853.
      View in: PubMed   Mentions: 30     Fields:    Translation:AnimalsCells
    23. Structure and membrane remodeling activity of ESCRT-III helical polymers. Science. 2015 Dec 18; 350(6267):1548-51. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A. PMID: 26634441.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansCells
    24. Structural and functional studies of membrane remodeling machines. Methods Cell Biol. 2015; 128:165-200. Kalia R, Talledge N, Frost A. PMID: 25997348.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    25. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science. 2015 Jan 02; 347(6217):75-8. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A. PMID: 25554787.
      View in: PubMed   Mentions: 55     Fields:    Translation:AnimalsCells
    26. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):E1342-51. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM. PMID: 23530241.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansAnimalsCells
    27. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21; 151(5):1042-54. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS. PMID: 23178123.
      View in: PubMed   Mentions: 162     Fields:    Translation:AnimalsCells
    28. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell. 2012 Jun 08; 149(6):1339-52. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS. PMID: 22682253.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    29. Endosis and exosis: new names for fusion and budding. J Membr Biol. 2012 Nov; 245(11):759-60. Busath DD, Woodbury DJ, Frost A. PMID: 22653449.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    30. Structural basis of membrane bending by the N-BAR protein endophilin. Cell. 2012 Mar 30; 149(1):137-45. Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM. PMID: 22464326.
      View in: PubMed   Mentions: 93     Fields:    Translation:AnimalsCells
    31. Membrane trafficking: decoding vesicle identity with contrasting chemistries. Curr Biol. 2011 Oct 11; 21(19):R811-3. Frost A. PMID: 21996503.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    32. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell. 2009 Sep 04; 138(5):990-1004. Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F. PMID: 19737524.
      View in: PubMed   Mentions: 118     Fields:    Translation:AnimalsCells
    33. The BAR domain superfamily: membrane-molding macromolecules. Cell. 2009 Apr 17; 137(2):191-6. Frost A, Unger VM, De Camilli P. PMID: 19379681.
      View in: PubMed   Mentions: 216     Fields:    Translation:HumansAnimalsCells
    34. Structural basis of membrane invagination by F-BAR domains. Cell. 2008 Mar 07; 132(5):807-17. Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM. PMID: 18329367.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansAnimalsCells
    35. F-BAR proteins join the BAR family fold. Structure. 2007 Jul; 15(7):751-3. Frost A, De Camilli P, Unger VM. PMID: 17637334.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    36. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature. 2006 May 25; 441(7092):528-31. Roux A, Uyhazi K, Frost A, De Camilli P. PMID: 16648839.
      View in: PubMed   Mentions: 167     Fields:    Translation:AnimalsCells
    37. Noncontact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents. Biophys J. 2002 Oct; 83(4):1974-86. Cole CD, Frost AS, Thompson N, Cotten M, Cross TA, Busath DD. PMID: 12324416.
      View in: PubMed   Mentions: 10     Fields:    
    38. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Mol Cell. 2002 Oct; 10(4):709-19. Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, Schlessinger J. PMID: 12419216.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    39. Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens. J Neurochem. 2001 Aug; 78(4):920-3. Jackson ME, Frost AS, Moghaddam B. PMID: 11520912.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
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