Adam Frost, PhD, MD

Title(s)Associate Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Address600 16th St
San Francisco CA 94158
ORCID ORCID Icon0000-0003-2231-2577 Additional info
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    Glacios? Cryo Transmission Electron Microscope with 200 kV XFEG optics
    NIH S10OD026881Aug 6, 2019 - Aug 5, 2021
    Role: Principal Investigator
    Regulated Mitochondrial Morphology
    NIH R01GM127673Sep 19, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Structure and Mechanism: Hsp90 proteostasis, cilia biogenesis and the jumbo phage ?nucleus?
    NIH R35GM118099Jun 1, 2016 - May 31, 2026
    Role: Co-Principal Investigator
    Toward Atomic Resolution of Membranes and Membrane-Associated Machines
    NIH DP2GM110772Sep 30, 2013 - May 31, 2018
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A point mutation in the nucleotide exchange factor eIF2B constitutively activates the integrated stress response by allosteric modulation. Elife. 2022 Apr 13; 11. Boone M, Wang L, Lawrence RE, Frost A, Walter P, Schoof M. PMID: 35416150.
      View in: PubMed   Mentions:
    2. Directed evolution of the rRNA methylating enzyme Cfr reveals molecular basis of antibiotic resistance. Elife. 2022 01 11; 11. Tsai K, Stojkovic V, Noda-Garcia L, Young ID, Myasnikov AG, Kleinman J, Palla A, Floor SN, Frost A, Fraser JS, Tawfik DS, Fujimori DG. PMID: 35015630; PMCID: PMC8752094.
      View in: PubMed   Mentions:
    3. Viral evasion of the integrated stress response through antagonism of eIF2-P binding to eIF2B. Nat Commun. 2021 12 07; 12(1):7103. Schoof M, Wang L, Cogan JZ, Lawrence RE, Boone M, Wuerth JD, Frost A, Walter P. PMID: 34876554; PMCID: PMC8651678.
      View in: PubMed   Mentions:
    4. Ribosome-associated quality control and CAT tailing. Crit Rev Biochem Mol Biol. 2021 12; 56(6):603-620. Howard CJ, Frost A. PMID: 34233554.
      View in: PubMed   Mentions:    Fields:    
    5. Activation of the Exocyst Tethering Complex for SNARE Complex Regulation and Membrane Fusion. The FASEB Journal. 2021 May 14; 35(S1). Munson MM, Lepore LD, Feyder FM, Rossi RG, Czuchra CA, Martínez-Núñez ML, Kenner KL, Frost FA, Brennwald BP. .
      View in: Publisher Site   Mentions:
    6. eIF2B Conformation and Assembly State Regulate the Integrated Stress Response. The FASEB Journal. 2021 May 14; 35(S1). Schoof SM, Boone BM, Wang WL, Lawrence LR, Frost FA, Walter WP. .
      View in: Publisher Site   Mentions:
    7. Practical considerations for using K3 cameras in CDS mode for high-resolution and high-throughput single particle cryo-EM. J Struct Biol. 2021 09; 213(3):107745. Sun M, Azumaya CM, Tse E, Bulkley DP, Harrington MB, Gilbert G, Frost A, Southworth D, Verba KA, Cheng Y, Agard DA. PMID: 33984504.
      View in: PubMed   Mentions:    Fields:    
    8. Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis. Nat Plants. 2021 04; 7(4):437-444. Nguyen HC, Melo AA, Kruk J, Frost A, Gabruk M. PMID: 33875834.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    9. eIF2B conformation and assembly state regulate the integrated stress response. Elife. 2021 03 10; 10. Schoof M, Boone M, Wang L, Lawrence R, Frost A, Walter P. PMID: 33688831; PMCID: PMC7990499.
      View in: PubMed   Mentions: 3     Fields:    
    10. Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients. Elife. 2020 11 25; 9. Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS. PMID: 33236988; PMCID: PMC7785296.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    11. Practical Considerations of Using the K3 Camera in CDS Mode for High-resolution and High-throughput Single Particle Cryo-EM. Microscopy and Microanalysis. 2020 Jul 30; 1-1. Sun SM, Azumaya AC, Tse TE, Southworth SD, Verba VK, Frost FA, Cheng CY, Agard AD. .
      View in: Publisher Site   Mentions:
    12. GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control. Mol Cell. 2020 09 17; 79(6):950-962.e6. Hickey KL, Dickson K, Cogan JZ, Replogle JM, Schoof M, D'Orazio KN, Sinha NK, Hussmann JA, Jost M, Frost A, Green R, Weissman JS, Kostova KK. PMID: 32726578; PMCID: PMC7891188.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    13. LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation. Nature. 2020 06; 582(7810):115-118. von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A. PMID: 32494070; PMCID: PMC7321842.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    14. Membrane constriction and thinning by sequential ESCRT-III polymerization. Nat Struct Mol Biol. 2020 04; 27(4):392-399. Nguyen HC, Talledge N, McCullough J, Sharma A, Moss FR, Iwasa JH, Vershinin MD, Sundquist WI, Frost A. PMID: 32251413; PMCID: PMC7343221.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Activation of the Exocyst Tethering Complex for SNARE Complex Regulation and Membrane Fusion. The FASEB Journal. 2020 Apr 1; 34(S1):1-1. Munson MM, Lepore LD, Feyder FM, Rossi RG, Czuchra CA, Kenner KL, Martínez-Núñez ML, Frost FA, Brennwald BP. .
      View in: Publisher Site   Mentions:
    16. Assessment of the nucleotide modifications in the high-resolution cryo-electron microscopy structure of the Escherichia coli 50S subunit. Nucleic Acids Res. 2020 03 18; 48(5):2723-2732. Stojkovic V, Myasnikov AG, Young ID, Frost A, Fraser JS, Fujimori DG. PMID: 31989172; PMCID: PMC7049716.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    17. Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases. J Cell Biol. 2020 02 03; 219(2). Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P. PMID: 31904797; PMCID: PMC7041683.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    18. Exocyst Tethering Complex Regulation of SNARE Proteins and Membrane Fusion. Biophysical Journal. 2020 Feb 1; 118(3):340a-341a. Munson MM, Lepore LD, Feyder FM, Rossi RG, Czuchra CA, Kenner KL, Martinez-Nunez ML, Forson FJ, Frost FA, Brennwald BP. .
      View in: Publisher Site   Mentions:
    19. Membrane Constriction and Thinning by Sequential ESCRT-III Polymerization. Biophysical Journal. 2020 Feb 1; 118(3):88a. Nguyen NH, Talledge TN, McCullough MJ, Sharma SA, Moss MF, Iwasa IJ, Vershinin VM, Sundquist SW, Frost FA. .
      View in: Publisher Site   Mentions:
    20. Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. Mol Biol Cell. 2019 08 01; 30(17):2097-2104. Kalia R, Frost A. PMID: 31365329; PMCID: PMC6743466.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    21. A Tunable Microfluidic Device Enables Cargo Encapsulation by Cell- or Organelle-Sized Lipid Vesicles Comprising Asymmetric Lipid Bilayers. Adv Biosyst. 2019 Jul; 3(7). Romanov V, McCullough J, Gale BK, Frost A. PMID: 31428671; PMCID: PMC6699779.
      View in: PubMed   Mentions: 2  
    22. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science. 2019 05 03; 364(6439):491-495. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. PMID: 31048491; PMCID: PMC6601628.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    23. Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Nat Commun. 2019 01 31; 10(1):531. Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N. PMID: 30705304; PMCID: PMC6355839.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    24. FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices. Anal Chem. 2018 09 04; 90(17):10450-10456. Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK. PMID: 30071717; PMCID: PMC6538390.
      View in: PubMed   Mentions: 10     Fields:    
    25. Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. Annu Rev Cell Dev Biol. 2018 10 06; 34:85-109. McCullough J, Frost A, Sundquist WI. PMID: 30095293; PMCID: PMC6241870.
      View in: PubMed   Mentions: 48     Fields:    Translation:AnimalsCells
    26. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018 06; 558(7710):401-405. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A. PMID: 29899447; PMCID: PMC6120343.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansCells
    27. Vms1p is a release factor for the ribosome-associated quality control complex. Nat Commun. 2018 06 06; 9(1):2197. Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J. PMID: 29875445; PMCID: PMC5989216.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    28. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife. 2018 05 29; 7. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS. PMID: 29809151; PMCID: PMC5995541.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
    29. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science. 2018 03 30; 359(6383). Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. PMID: 29599213; PMCID: PMC6120582.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    30. Structural inhibition of dynamin-mediated membrane fission by endophilin. Elife. 2017 09 21; 6. Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A. PMID: 28933693; PMCID: PMC5663480.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    31. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Science. 2017 07 28; 357(6349):414-417. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS. PMID: 28751611; PMCID: PMC5673106.
      View in: PubMed   Mentions: 35     Fields:    Translation:AnimalsCells
    32. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. Elife. 2017 07 18; 6. Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE. PMID: 28718767; PMCID: PMC5562442.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    33. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2166-E2175. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A. PMID: 28242692; PMCID: PMC5358359.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    34. Cell biology: Double agents for mitochondrial division. Nature. 2016 12 01; 540(7631):43-44. McBride HM, Frost A. PMID: 27880759.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    35. Membrane fission by dynamin: what we know and what we need to know. EMBO J. 2016 11 02; 35(21):2270-2284. Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S. PMID: 27670760; PMCID: PMC5090216.
      View in: PubMed   Mentions: 138     Fields:    Translation:HumansAnimalsCells
    36. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J. 2016 11 02; 35(21):2332-2349. Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ. PMID: 27655872; PMCID: PMC5090219.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    37. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Nat Struct Mol Biol. 2016 Jan; 23(1):59-66. Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M. PMID: 26656853; PMCID: PMC4752824.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    38. Structure and membrane remodeling activity of ESCRT-III helical polymers. Science. 2015 Dec 18; 350(6267):1548-51. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A. PMID: 26634441; PMCID: PMC4684769.
      View in: PubMed   Mentions: 78     Fields:    Translation:HumansCells
    39. Structural and functional studies of membrane remodeling machines. Methods Cell Biol. 2015; 128:165-200. Kalia R, Talledge N, Frost A. PMID: 25997348; PMCID: PMC6089609.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    40. Molecular Mechanism of ESCRT-III Filament Formation. The FASEB Journal. 2015 Apr 1; 29. McCullough MJ, Colf CL, Saunders SM, Lalonde LM, Mercenne MG, Sundquist SW, Frost FA. .
      View in: Publisher Site   Mentions:
    41. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science. 2015 Jan 02; 347(6217):75-8. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A. PMID: 25554787; PMCID: PMC4451101.
      View in: PubMed   Mentions: 98     Fields:    Translation:AnimalsCells
    42. Structural basis of membrane deformation by the ESCRT-III family of proteins (107.4). The FASEB Journal. 2014 Apr 1; 28. Frost FA, Sundquist SW, McCullough MJ, Saunders SM. .
      View in: Publisher Site   Mentions:
    43. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):E1342-51. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM. PMID: 23530241; PMCID: PMC3625255.
      View in: PubMed   Mentions: 83     Fields:    Translation:HumansAnimalsCells
    44. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21; 151(5):1042-54. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS. PMID: 23178123; PMCID: PMC3534965.
      View in: PubMed   Mentions: 246     Fields:    Translation:AnimalsCells
    45. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell. 2012 Jun 08; 149(6):1339-52. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS. PMID: 22682253; PMCID: PMC3613983.
      View in: PubMed   Mentions: 73     Fields:    Translation:AnimalsCells
    46. Endosis and exosis: new names for fusion and budding. J Membr Biol. 2012 Nov; 245(11):759-60. Busath DD, Woodbury DJ, Frost A. PMID: 22653449.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    47. Structural basis of membrane bending by the N-BAR protein endophilin. Cell. 2012 Mar 30; 149(1):137-45. Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM. PMID: 22464326; PMCID: PMC3319357.
      View in: PubMed   Mentions: 109     Fields:    Translation:AnimalsCells
    48. Membrane trafficking: decoding vesicle identity with contrasting chemistries. Curr Biol. 2011 Oct 11; 21(19):R811-3. Frost A. PMID: 21996503.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    49. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell. 2009 Sep 04; 138(5):990-1004. Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F. PMID: 19737524; PMCID: PMC2797480.
      View in: PubMed   Mentions: 137     Fields:    Translation:AnimalsCells
    50. The BAR domain superfamily: membrane-molding macromolecules. Cell. 2009 Apr 17; 137(2):191-6. Frost A, Unger VM, De Camilli P. PMID: 19379681; PMCID: PMC4832598.
      View in: PubMed   Mentions: 265     Fields:    Translation:HumansAnimalsCells
    51. Mechanistic Insights into Membrane Remodeling Through BAR-Domain Proteins. The FASEB Journal. 2009 Apr 1; 23:82.2-82.2. Frost FA, Mim MC, Perera PR, Spasov SK, Egelman EE, De Camilli DP, Unger UV. .
      View in: Publisher Site   Mentions:
    52. Structural basis of membrane invagination by F-BAR domains. Cell. 2008 Mar 07; 132(5):807-17. Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM. PMID: 18329367; PMCID: PMC2384079.
      View in: PubMed   Mentions: 255     Fields:    Translation:HumansAnimalsCells
    53. F-BAR proteins join the BAR family fold. Structure. 2007 Jul; 15(7):751-3. Frost A, De Camilli P, Unger VM. PMID: 17637334.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    54. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature. 2006 May 25; 441(7092):528-31. Roux A, Uyhazi K, Frost A, De Camilli P. PMID: 16648839.
      View in: PubMed   Mentions: 187     Fields:    Translation:AnimalsCells
    55. Noncontact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents. Biophys J. 2002 Oct; 83(4):1974-86. Cole CD, Frost AS, Thompson N, Cotten M, Cross TA, Busath DD. PMID: 12324416; PMCID: PMC1302287.
      View in: PubMed   Mentions: 11     Fields:    
    56. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Mol Cell. 2002 Oct; 10(4):709-19. Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, Schlessinger J. PMID: 12419216.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansAnimalsCells
    57. Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens. J Neurochem. 2001 Aug; 78(4):920-3. Jackson ME, Frost AS, Moghaddam B. PMID: 11520912.
      View in: PubMed   Mentions: 36     Fields:    Translation:Animals
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