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Adam Frost, PhD, MD

Title(s)Associate Professor, Biochemistry and Biophysics
SchoolSchool of Medicine
Phone415-514-4825
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    Collapse Research 
    Collapse Research Activities and Funding
    Glacios? Cryo Transmission Electron Microscope with 200 kV XFEG optics
    NIH S10OD026881Aug 6, 2019 - Aug 5, 2020
    Role: Principal Investigator
    Regulated Mitochondrial Morphology
    NIH/NIGMS R01GM127673Sep 19, 2018 - Aug 31, 2022
    Role: Principal Investigator
    Toward Atomic Resolution of Membranes and Membrane-Associated Machines
    NIH/NIGMS DP2GM110772Sep 30, 2013 - Jun 30, 2018
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kalia R, Frost A. Open and cut: allosteric motion and membrane fission by dynamin superfamily proteins. Mol Biol Cell. 2019 Aug 01; 30(17):2097-2104. PMID: 31365329.
      View in: PubMed
    2. Kenner LR, Anand AA, Nguyen HC, Myasnikov AG, Klose CJ, McGeever LA, Tsai JC, Miller-Vedam LE, Walter P, Frost A. eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response. Science. 2019 05 03; 364(6439):491-495. PMID: 31048491.
      View in: PubMed
    3. Ruiz K, Thaker TM, Agnew C, Miller-Vedam L, Trenker R, Herrera C, Ingaramo M, Toso D, Frost A, Jura N. Functional role of PGAM5 multimeric assemblies and their polymerization into filaments. Nat Commun. 2019 01 31; 10(1):531. PMID: 30705304.
      View in: PubMed
    4. Dennis AM, Volz E, Frost ASMSDW, Hossain M, Poon AFY, Rebeiro PF, Vermund SH, Sterling TR, Kalish ML. HIV-1 Transmission Clustering and Phylodynamics Highlight the Important Role of Young Men Who Have Sex with Men. AIDS Res Hum Retroviruses. 2018 10; 34(10):879-888. PMID: 30027754.
      View in: PubMed
    5. Romanov V, Samuel R, Chaharlang M, Jafek AR, Frost A, Gale BK. FDM 3D Printing of High-Pressure, Heat-Resistant, Transparent Microfluidic Devices. Anal Chem. 2018 09 04; 90(17):10450-10456. PMID: 30071717.
      View in: PubMed
    6. McCullough J, Frost A, Sundquist WI. Structures, Functions, and Dynamics of ESCRT-III/Vps4 Membrane Remodeling and Fission Complexes. Annu Rev Cell Dev Biol. 2018 10 06; 34:85-109. PMID: 30095293.
      View in: PubMed
    7. Kalia R, Wang RY, Yusuf A, Thomas PV, Agard DA, Shaw JM, Frost A. Structural basis of mitochondrial receptor binding and constriction by DRP1. Nature. 2018 06; 558(7710):401-405. PMID: 29899447.
      View in: PubMed
    8. Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J. Vms1p is a release factor for the ribosome-associated quality control complex. Nat Commun. 2018 06 06; 9(1):2197. PMID: 29875445.
      View in: PubMed
    9. Shurtleff MJ, Itzhak DN, Hussmann JA, Schirle Oakdale NT, Costa EA, Jonikas M, Weibezahn J, Popova KD, Jan CH, Sinitcyn P, Vembar SS, Hernandez H, Cox J, Burlingame AL, Brodsky JL, Frost A, Borner GH, Weissman JS. The ER membrane protein complex interacts cotranslationally to enable biogenesis of multipass membrane proteins. Elife. 2018 05 29; 7. PMID: 29809151.
      View in: PubMed
    10. Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science. 2018 03 30; 359(6383). PMID: 29599213.
      View in: PubMed
    11. Hohendahl A, Talledge N, Galli V, Shen PS, Humbert F, De Camilli P, Frost A, Roux A. Structural inhibition of dynamin-mediated membrane fission by endophilin. Elife. 2017 09 21; 6. PMID: 28933693.
      View in: PubMed
    12. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Science. 2017 07 28; 357(6349):414-417. PMID: 28751611.
      View in: PubMed
    13. Osuna BA, Howard CJ, Kc S, Frost A, Weinberg DE. In vitro analysis of RQC activities provides insights into the mechanism and function of CAT tailing. Elife. 2017 07 18; 6. PMID: 28718767.
      View in: PubMed
    14. Gu M, LaJoie D, Chen OS, von Appen A, Ladinsky MS, Redd MJ, Nikolova L, Bjorkman PJ, Sundquist WI, Ullman KS, Frost A. LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells. Proc Natl Acad Sci U S A. 2017 03 14; 114(11):E2166-E2175. PMID: 28242692.
      View in: PubMed
    15. McBride HM, Frost A. Cell biology: Double agents for mitochondrial division. Nature. 2016 12 01; 540(7631):43-44. PMID: 27880759.
      View in: PubMed
    16. Antonny B, Burd C, De Camilli P, Chen E, Daumke O, Faelber K, Ford M, Frolov VA, Frost A, Hinshaw JE, Kirchhausen T, Kozlov MM, Lenz M, Low HH, McMahon H, Merrifield C, Pollard TD, Robinson PJ, Roux A, Schmid S. Membrane fission by dynamin: what we know and what we need to know. EMBO J. 2016 11 02; 35(21):2270-2284. PMID: 27670760.
      View in: PubMed
    17. Hwang J, Ribbens D, Raychaudhuri S, Cairns L, Gu H, Frost A, Urban S, Espenshade PJ. A Golgi rhomboid protease Rbd2 recruits Cdc48 to cleave yeast SREBP. EMBO J. 2016 11 02; 35(21):2332-2349. PMID: 27655872.
      View in: PubMed
    18. Heider MR, Gu M, Duffy CM, Mirza AM, Marcotte LL, Walls AC, Farrall N, Hakhverdyan Z, Field MC, Rout MP, Frost A, Munson M. Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Nat Struct Mol Biol. 2016 Jan; 23(1):59-66. PMID: 26656853.
      View in: PubMed
    19. McCullough J, Clippinger AK, Talledge N, Skowyra ML, Saunders MG, Naismith TV, Colf LA, Afonine P, Arthur C, Sundquist WI, Hanson PI, Frost A. Structure and membrane remodeling activity of ESCRT-III helical polymers. Science. 2015 Dec 18; 350(6267):1548-51. PMID: 26634441.
      View in: PubMed
    20. Kalia R, Talledge N, Frost A. Structural and functional studies of membrane remodeling machines. Methods Cell Biol. 2015; 128:165-200. PMID: 25997348.
      View in: PubMed
    21. Shen PS, Park J, Qin Y, Li X, Parsawar K, Larson MH, Cox J, Cheng Y, Lambowitz AM, Weissman JS, Brandman O, Frost A. Protein synthesis. Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains. Science. 2015 Jan 02; 347(6217):75-8. PMID: 25554787.
      View in: PubMed
    22. Koirala S, Guo Q, Kalia R, Bui HT, Eckert DM, Frost A, Shaw JM. Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Proc Natl Acad Sci U S A. 2013 Apr 09; 110(15):E1342-51. PMID: 23530241.
      View in: PubMed
    23. Brandman O, Stewart-Ornstein J, Wong D, Larson A, Williams CC, Li GW, Zhou S, King D, Shen PS, Weibezahn J, Dunn JG, Rouskin S, Inada T, Frost A, Weissman JS. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell. 2012 Nov 21; 151(5):1042-54. PMID: 23178123.
      View in: PubMed
    24. Frost A, Elgort MG, Brandman O, Ives C, Collins SR, Miller-Vedam L, Weibezahn J, Hein MY, Poser I, Mann M, Hyman AA, Weissman JS. Functional repurposing revealed by comparing S. pombe and S. cerevisiae genetic interactions. Cell. 2012 Jun 08; 149(6):1339-52. PMID: 22682253.
      View in: PubMed
    25. Busath DD, Woodbury DJ, Frost A. Endosis and exosis: new names for fusion and budding. J Membr Biol. 2012 Nov; 245(11):759-60. PMID: 22653449.
      View in: PubMed
    26. Mim C, Cui H, Gawronski-Salerno JA, Frost A, Lyman E, Voth GA, Unger VM. Structural basis of membrane bending by the N-BAR protein endophilin. Cell. 2012 Mar 30; 149(1):137-45. PMID: 22464326.
      View in: PubMed
    27. Frost A. Membrane trafficking: decoding vesicle identity with contrasting chemistries. Curr Biol. 2011 Oct 11; 21(19):R811-3. PMID: 21996503.
      View in: PubMed
    28. Guerrier S, Coutinho-Budd J, Sassa T, Gresset A, Jordan NV, Chen K, Jin WL, Frost A, Polleux F. The F-BAR domain of srGAP2 induces membrane protrusions required for neuronal migration and morphogenesis. Cell. 2009 Sep 04; 138(5):990-1004. PMID: 19737524.
      View in: PubMed
    29. Frost A, Unger VM, De Camilli P. The BAR domain superfamily: membrane-molding macromolecules. Cell. 2009 Apr 17; 137(2):191-6. PMID: 19379681.
      View in: PubMed
    30. Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM. Structural basis of membrane invagination by F-BAR domains. Cell. 2008 Mar 07; 132(5):807-17. PMID: 18329367.
      View in: PubMed
    31. Frost A, De Camilli P, Unger VM. F-BAR proteins join the BAR family fold. Structure. 2007 Jul; 15(7):751-3. PMID: 17637334.
      View in: PubMed
    32. Roux A, Uyhazi K, Frost A, De Camilli P. GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission. Nature. 2006 May 25; 441(7092):528-31. PMID: 16648839.
      View in: PubMed
    33. Cole CD, Frost AS, Thompson N, Cotten M, Cross TA, Busath DD. Noncontact dipole effects on channel permeation. VI. 5F- and 6F-Trp gramicidin channel currents. Biophys J. 2002 Oct; 83(4):1974-86. PMID: 12324416.
      View in: PubMed
    34. Lax I, Wong A, Lamothe B, Lee A, Frost A, Hawes J, Schlessinger J. The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors. Mol Cell. 2002 Oct; 10(4):709-19. PMID: 12419216.
      View in: PubMed
    35. Jackson ME, Frost AS, Moghaddam B. Stimulation of prefrontal cortex at physiologically relevant frequencies inhibits dopamine release in the nucleus accumbens. J Neurochem. 2001 Aug; 78(4):920-3. PMID: 11520912.
      View in: PubMed