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Adam Numis, MD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-502-1898
ORCID ORCID Icon0000-0002-1594-9812 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Pennsylvania State UniversityBS2004
    Harvard Medical SchoolMD2009

    Collapse Overview 
    Collapse Overview
    Dr. Adam L. Numis is a pediatric neurologist and specialist in epilepsy. He focuses on evaluating and caring for children with epilepsy, particularly those with difficult-to-treat seizures.

    His research includes evaluating the connection between inflammation and epilepsy. His work attempts to understand how inflammatory markers in the blood could help predict which patients might respond best to a particular antiseizure medications, in particular for a severe type of epilepsy termed infantile spasms. Additionally, his work seeks to understand the role inflammation and genetics may play in epilepsy development in certain at-risk populations, including children with neonatal encephalopathy, traumatic brain injuries, and stroke.

    Dr. Numis received his medical degree from Harvard Medical School. He completed a residency in pediatrics at Boston Children's Hospital, a residency in child neurology at UCSF, and fellowships in clinical neurophysiology and epilepsy at the University of California, Los Angeles.

    To make an appointment with Dr. Numis in the Pediatric Center of Excellence, ask your child's pediatrician to fax a referral to (415) 353-2400 or call (855) 722-8273. Learn more at: https://about.ucsfbenioffchildrens.org/schedule

    Collapse Research 
    Collapse Research Activities and Funding
    Evaluating the Role of Inflammation in Neonatal Epileptogenesis
    NIH/NINDS K23NS105918Dec 15, 2018 - Nov 30, 2023
    Role: Principal Investigator

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    Collapse Clinical Trials
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism. Am J Hum Genet. 2020 Aug 06; 107(2):352-363. Guillen Sacoto MJ, Tchasovnikarova IA, Torti E, Forster C, Andrew EH, Anselm I, Baranano KW, Briere LC, Cohen JS, Craigen WJ, Cytrynbaum C, Ekhilevitch N, Elrick MJ, Fatemi A, Fraser JL, Gallagher RC, Guerin A, Haynes D, High FA, Inglese CN, Kiss C, Koenig MK, Krier J, Lindstrom K, Marble M, Meddaugh H, Moran ES, Morel CF, Mu W, Muller EA, Nance J, Natowicz MR, Numis AL, Ostrem B, Pappas J, Stafstrom CE, Streff H, Sweetser DA, Szybowska M, Walker MA, Wang W, Weiss K, Weksberg R, Wheeler PG, Yoon G, Kingston RE, Juusola J. PMID: 32693025.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. ECI biocommentary november 2019. Pediatr Res. 2019 11; 86(5):553. Numis A. PMID: 31476760.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Early changes in pro-inflammatory cytokine levels in neonates with encephalopathy are associated with remote epilepsy. Pediatr Res. 2019 11; 86(5):616-621. Numis AL, Foster-Barber A, Deng X, Rogers EE, Barkovich AJ, Ferriero DM, Glass HC. PMID: 31234194.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    4. Clinical spectrum of STX1B-related epileptic disorders. Neurology. 2019 03 12; 92(11):e1238-e1249. Wolking S, May P, Mei D, Møller RS, Balestrini S, Helbig KL, Altuzarra CD, Chatron N, Kaiwar C, Stöhr K, Widdess-Walsh P, Mendelsohn BA, Numis A, Cilio MR, Van Paesschen W, Svendsen LL, Oates S, Hughes E, Goyal S, Brown K, Sifuentes Saenz M, Dorn T, Muhle H, Pagnamenta AT, Vavoulis DV, Knight SJL, Taylor JC, Canevini MP, Darra F, Gavrilova RH, Powis Z, Tang S, Marquetand J, Armstrong M, McHale D, Klee EW, Kluger GJ, Lowenstein DH, Weckhuysen S, Pal DK, Helbig I, Guerrini R, Thomas RH, Rees MI, Lesca G, Sisodiya SM, Weber YG, Lal D, Marini C, Lerche H, Schubert J. PMID: 30737342.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. Lack of response to quinidine in KCNT1-related neonatal epilepsy. Epilepsia. 2018 10; 59(10):1889-1898. Numis AL, Nair U, Datta AN, Sands TT, Oldham MS, Patel A, Li M, Gazina E, Petrou S, Cilio MR. PMID: 30182418.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    6. Outcomes After Acute Symptomatic Seizures in Children Admitted to a Neonatal Neurocritical Care Service. Pediatr Neurol. 2018 07; 84:39-45. Glass HC, Numis AL, Gano D, Bali V, Rogers EE. PMID: 29886041.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    7. Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy. Epilepsy Behav Case Rep. 2018; 10:21-24. Singhal NS, Numis AL, Lee MB, Chang EF, Sullivan JE, Auguste KI, Rao VR. PMID: 30013930.
      View in: PubMed   Mentions:
    8. Population-based study of ischemic stroke risk after trauma in children and young adults. Neurology. 2017 Dec 05; 89(23):2310-2316. Fox CK, Hills NK, Vinson DR, Numis AL, Dicker RA, Sidney S, Fullerton HJ. PMID: 29117963.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    9. AR2, a novel automatic muscle artifact reduction software method for ictal EEG interpretation: Validation and comparison of performance with commercially available software. F1000Res. 2017; 6:30. Weiss SA, Asadi-Pooya AA, Vangala S, Moy S, Wyeth DH, Orosz I, Gibbs M, Schrader L, Lerner J, Cheng CK, Chang E, Rajaraman R, Keselman I, Churchman P, Bower-Baca C, Numis AL, Ho MG, Rao L, Bhat A, Suski J, Asadollahi M, Ambrose T, Fernandez A, Nei M, Skidmore C, Mintzer S, Eliashiv DS, Mathern GW, Nuwer MR, Sperling M, Engel J, Stern JM. PMID: 28491280.
      View in: PubMed   Mentions:    Fields:    
    10. WONOEP appraisal: Biomarkers of epilepsy-associated comorbidities. Epilepsia. 2017 03; 58(3):331-342. Ravizza T, Onat FY, Brooks-Kayal AR, Depaulis A, Galanopoulou AS, Mazarati A, Numis AL, Sankar R, Friedman A. PMID: 28035782.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    11. Cerebral palsy research funding from the National Institutes of Health, 2001 to 2013. Dev Med Child Neurol. 2015 Oct; 57(10):936-41. Wu YW, Mehravari AS, Numis AL, Gross P. PMID: 25951080.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    12. Early and effective treatment of KCNQ2 encephalopathy. Epilepsia. 2015 May; 56(5):685-91. Pisano T, Numis AL, Heavin SB, Weckhuysen S, Angriman M, Suls A, Podesta B, Thibert RL, Shapiro KA, Guerrini R, Scheffer IE, Marini C, Cilio MR. PMID: 25880994.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    13. Arterial ischemic stroke in children: risk factors and etiologies. Curr Neurol Neurosci Rep. 2014 Jan; 14(1):422. Numis AL, Fox CK. PMID: 24384876.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. KCNQ2 encephalopathy: delineation of the electroclinical phenotype and treatment response. Neurology. 2014 Jan 28; 82(4):368-70. Numis AL, Angriman M, Sullivan JE, Lewis AJ, Striano P, Nabbout R, Cilio MR. PMID: 24371303.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    15. Intraoperative rerupture during surgical treatment of aneurysmal subarachnoid hemorrhage is not associated with an increased risk of vasospasm. J Neurosurg. 2014 Feb; 120(2):409-14. Sheth SA, Hausrath D, Numis AL, Lawton MT, Josephson SA. PMID: 24313615.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Multifocal micronodular pneumocyte hyperplasia: computed tomographic appearance and follow-up in tuberous sclerosis complex. J Comput Assist Tomogr. 2012 Sep-Oct; 36(5):518-22. Muzykewicz DA, Black ME, Muse V, Numis AL, Rajagopal J, Thiele EA, Sharma A. PMID: 22992599.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    17. The relationship of ketosis and growth to the efficacy of the ketogenic diet in infantile spasms. Epilepsy Res. 2011 Sep; 96(1-2):172-5. Numis AL, Yellen MB, Chu-Shore CJ, Pfeifer HH, Thiele EA. PMID: 21700429.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Identification of risk factors for autism spectrum disorders in tuberous sclerosis complex. Neurology. 2011 Mar 15; 76(11):981-7. Numis AL, Major P, Montenegro MA, Muzykewicz DA, Pulsifer MB, Thiele EA. PMID: 21403110.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    19. Characterizing sleep disorders of adults with tuberous sclerosis complex: a questionnaire-based study and review. Epilepsy Behav. 2011 Jan; 20(1):68-74. van Eeghen AM, Numis AI, Staley BA, Therrien SE, Thibert RL, Thiele EA. PMID: 21130696.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    20. TSC1 and TSC2 mutations in patients with lymphangioleiomyomatosis and tuberous sclerosis complex. J Med Genet. 2009 Jul; 46(7):465-8. Muzykewicz DA, Sharma A, Muse V, Numis AL, Rajagopal J, Thiele EA. PMID: 19419980.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    21. Role of mutational analysis in diagnosis of tuberous sclerosis complex. Clin Genet. 2009 Mar; 75(3):282-5. Vail EA, Rakowski SK, Numis AL, Thiele EA. PMID: 19250385.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    22. The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP). Mol Pharmacol. 2004 Sep; 66(3):718-27. Numis AL, Unger EL, Sheridan DL, Chisnell AC, Andrews AM. PMID: 15322265.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    23. Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1. Neurobiol Dis. 2004 Aug; 16(3):572-80. Szapacs ME, Numis AL, Andrews AM. PMID: 15262269.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimals
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