Adam Renslo, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Address600 16th St
San Francisco CA 94158
Phone415-514-9698
ORCID ORCID Icon0000-0002-1240-2846 Additional info
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    Collapse Biography 
    Collapse Education and Training
    St. Olaf College, Northfield, MNB.A.05/1993Chemistry
    Massachusetts Institute of Technology, Cambridge, MAPh.D.05/1998Organic Chemistry

    Collapse Overview 
    Collapse Overview
    My research group is engaged at the interface of chemistry and biology. As medicinal chemists, we design and synthesize small molecules that modulate disease pathology at the level of the enzyme, cell, and whole animal, with active projects in cancer, infectious disease, and neurodegeneration. Our group also developed a parallel synthetic methodology to produce a library of disulfide 'fragments', thereby enabling cysteine-disulfide (Tethering) screening at UCSF. Finally, we design, synthesize and validate novel small molecule probes for the study of labile ferrous iron in biology and disease. Most recently, we described the first of a new class of activity-based probes for proximity labelling of proteins in an iron-dependent fashion, thus enabling the first chemoproteomic studies of the labile iron 'interactome'.
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    Collapse Research 
    Collapse Research Activities and Funding
    Developing a pretargeting strategy to detect Fe(II) for nuclear medicine applications
    NIH R01EB029429Jul 1, 2021 - Mar 31, 2025
    Role: Co-Principal Investigator
    Evolution and inhibition of carbapenemase in beta-lactam resistance
    NIH R01AI161762Apr 6, 2021 - Mar 31, 2026
    Role: Co-Principal Investigator
    Understanding Efficacy and Fe(II)-Promoted Activation of 1,2,4-Trioxolanes in Cancer
    NIH R01CA260860Apr 1, 2021 - Mar 31, 2026
    Role: Co-Principal Investigator
    Discovery of Novel Antimalarial Leads Targeting Translational Repression in Plasmodium parasites
    NIH R21AI135495Feb 1, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Expanding the Chemical Biology of K2P Channels with Selective Cellular and In vivo Probes
    NIH R01MH116278Mar 1, 2018 - Jan 31, 2021
    Role: Principal Investigator
    Biophysical Fragment Screening and Structure Determination for Class A, B, and D Carbapenemases
    NIH R21AI135489Dec 4, 2017 - Nov 30, 2019
    Role: Principal Investigator
    Chemical Methods for Ferrous Iron Dependent Drug Delivery
    NIH R01AI105106May 29, 2013 - Aug 31, 2023
    Role: Principal Investigator
    Chemical Methods for Ferrous Iron Targeted Drug Delivery
    NIH R21AI094433Mar 1, 2011 - Feb 28, 2013
    Role: Principal Investigator
    Identification of Anti-HIV Lead Compounds Targeting Rev
    NIH R41AI076087Jan 1, 2009 - Dec 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 2021 09 22; 10. Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, Renslo AR, Arkin MR, Huang B, Lu B, Sirota M, Guo S. PMID: 34550070.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Emerging role of ferrous iron in bacterial growth and host-pathogen interaction: New tools for chemical (micro)biology and antibacterial therapy. Curr Opin Chem Biol. 2021 04; 61:170-178. Gonciarz RL, Renslo AR. PMID: 33714882.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    3. Ferrous Iron-Dependent Pharmacology. Trends Pharmacol Sci. 2021 01; 42(1):7-18. Gonciarz RL, Collisson EA, Renslo AR. PMID: 33261861.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    4. Ferronostics: Measuring Tumoral Ferrous Iron with PET to Predict Sensitivity to Iron-Targeted Cancer Therapies. J Nucl Med. 2021 Jul 01; 62(7):949-955. Zhao N, Huang Y, Wang YH, Muir RK, Chen YC, Wei J, Hooshdaran N, Viswanath P, Seo Y, Ruggero D, Renslo AR, Evans MJ. PMID: 33246980.
      View in: PubMed   Mentions: 1     Fields:    
    5. Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors. ACS Infect Dis. 2021 05 14; 7(5):1077-1088. Jílková A, Rubešová P, Fanfrlík J, Fajtová P, Rezácová P, Brynda J, Lepšík M, Mertlíková-Kaiserová H, Emal CD, Renslo AR, Roush WR, Horn M, Caffrey CR, Mareš M. PMID: 33175511.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    6. Reactivity-Based Probe of the Iron(II)-Dependent Interactome Identifies New Cellular Modulators of Ferroptosis. J Am Chem Soc. 2020 11 11; 142(45):19085-19093. Chen YC, Oses-Prieto JA, Pope LE, Burlingame AL, Dixon SJ, Renslo AR. PMID: 33124817.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    7. Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy. ACS Infect Dis. 2020 07 10; 6(7):1827-1835. Blank BR, Gonciarz RL, Talukder P, Gut J, Legac J, Rosenthal PJ, Renslo AR. PMID: 32369341.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    8. Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine. ACS Chem Biol. 2020 06 19; 15(6):1392-1400. Bashore C, Jaishankar P, Skelton NJ, Fuhrmann J, Hearn BR, Liu PS, Renslo AR, Dueber EC. PMID: 32302100.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    9. Oscillatory cAMP signaling rapidly alters H3K4 methylation. Life Sci Alliance. 2020 01; 3(1). Huff TC, Camarena V, Sant DW, Wilkes Z, Van Booven D, Aron AT, Muir RK, Renslo AR, Chang CJ, Monje PV, Wang G. PMID: 31882444.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    10. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J Med Chem. 2019 09 26; 62(18):8480-8496. Pemberton OA, Jaishankar P, Akhtar A, Adams JL, Shaw LN, Renslo AR, Chen Y. PMID: 31483651.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome. Brain Commun. 2019; 1(1):fcz008. Griffin AL, Jaishankar P, Grandjean JM, Olson SH, Renslo AR, Baraban SC. PMID: 31667472.
      View in: PubMed   Mentions:
    12. Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound. Cell Chem Biol. 2019 09 19; 26(9):1295-1305.e6. Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR. PMID: 31353319.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    13. Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor. ACS Infect Dis. 2019 08 09; 5(8):1366-1375. Blank BR, Talukder P, Muir RK, Green ER, Skaar EP, Renslo AR. PMID: 31140267.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    14. An Empirical Study of Amide-Heteroarene π-Stacking Interactions Using Reversible Inhibitors of a Bacterial Serine Hydrolase. Org Chem Front. 2019 Jun 07; 6(11):1749-1756. DeFrees K, Kemp MT, ElHilali-Pollard X, Zhang X, Mohamed A, Chen Y, Renslo AR. PMID: 32774871.
      View in: PubMed   Mentions:
    15. Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. ACS Infect Dis. 2019 06 14; 5(6):1013-1021. Torelli NJ, Akhtar A, DeFrees K, Jaishankar P, Pemberton OA, Zhang X, Johnson C, Renslo AR, Chen Y. PMID: 30942078.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    16. Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography. ACS Cent Sci. 2019 Apr 24; 5(4):727-736. Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ. PMID: 31041393.
      View in: PubMed   Mentions:
    17. Cilia-Associated Oxysterols Activate Smoothened. Mol Cell. 2018 10 18; 72(2):316-327.e5. Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. PMID: 30340023.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
    18. Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels. ACS Chem Neurosci. 2018 12 19; 9(12):3153-3165. Pope L, Arrigoni C, Lou H, Bryant C, Gallardo-Godoy A, Renslo AR, Minor DL. PMID: 30089357.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    19. Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases. Antimicrob Agents Chemother. 2018 08; 62(8). Pemberton OA, Zhang X, Nichols DA, DeFrees K, Jaishankar P, Bonnet R, Adams J, Shaw LN, Renslo AR, Chen Y. PMID: 29844038.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    20. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science. 2018 03 30; 359(6383). Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. PMID: 29599213.
      View in: PubMed   Mentions: 45     Fields:    Translation:HumansCells
    21. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 05 07; 15(5):2054-2059. Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR. PMID: 29569925.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    22. cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool. Elife. 2017 12 14; 6. Camarena V, Sant DW, Huff TC, Mustafi S, Muir RK, Aron AT, Chang CJ, Renslo AR, Monje PV, Wang G. PMID: 29239726.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    23. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):12669-12674. Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ. PMID: 29138321.
      View in: PubMed   Mentions: 27     Fields:    Translation:AnimalsCells
    24. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 10 26; 550(7677):534-538. Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE. PMID: 29045385.
      View in: PubMed   Mentions: 85     Fields:    Translation:HumansAnimalsCells
    25. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol. 2017 12 21; 24(12):1455-1466.e14. Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM. PMID: 29033317.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    26. A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments. SLAS Discov. 2018 02; 23(2):183-192. Hallenbeck KK, Davies JL, Merron C, Ogden P, Sijbesma E, Ottmann C, Renslo AR, Wilson C, Arkin MR. PMID: 28945980.
      View in: PubMed   Mentions: 3     Fields:    
    27. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases. J Am Chem Soc. 2017 08 30; 139(34):11650-11653. Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS. PMID: 28759216.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    28. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. J Med Chem. 2017 07 27; 60(14):6400-6407. Blank BR, Gut J, Rosenthal PJ, Renslo AR. PMID: 28692297.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    29. Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes. Antimicrob Agents Chemother. 2017 07; 61(7). Nakamura RL, Burlingame MA, Yang S, Crosby DC, Talbot DJ, Chui K, Frankel AD, Renslo AR. PMID: 28416550.
      View in: PubMed   Mentions: 2     Fields:    
    30. Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery. Curr Top Med Chem. 2017; 17(1):4-15. Hallenbeck KK, Turner DM, Renslo AR, Arkin MR. PMID: 27449257.
      View in: PubMed   Mentions: 12     Fields:    Translation:Cells
    31. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. J Med Chem. 2016 12 22; 59(24):11161-11170. Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. PMID: 27936709.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. Elife. 2016 07 20; 5. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. PMID: 27435960.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    33. A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol. 2016 09; 12(9):680-5. Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. PMID: 27376690.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    34. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. PMID: 26789650.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    35. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. ACS Med Chem Lett. 2015 Nov 12; 6(11):1145-9. Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. PMID: 26617969.
      View in: PubMed   Mentions:
    36. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. Sci Rep. 2015 Sep 25; 5:13891. Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ. PMID: 26403635.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    37. Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions. Antimicrob Agents Chemother. 2015 Oct; 59(10):6463-70. Peniche AG, Renslo AR, Melby PC, Travi BL. PMID: 26239994.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    38. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. PMID: 26224882.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimals
    39. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4834-4837. Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. PMID: 26144347.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    40. Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography. J Am Chem Soc. 2015 Jul 01; 137(25):8086-95. Nichols DA, Hargis JC, Sanishvili R, Jaishankar P, Defrees K, Smith EW, Wang KK, Prati F, Renslo AR, Woodcock HL, Chen Y. PMID: 26057252.
      View in: PubMed   Mentions: 26     Fields:    Translation:Cells
    41. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. PMID: 25875391.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansCells
    42. A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP. J Biomol Screen. 2015 Jul; 20(6):788-800. Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. PMID: 25690569.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    43. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr; 116:76-84. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. PMID: 25666761.
      View in: PubMed   Mentions: 233     Fields:    Translation:HumansAnimalsCells
    44. Simple plate-based, parallel synthesis of disulfide fragments using the CuAAC click reaction. ACS Comb Sci. 2014 Dec 08; 16(12):661-4. Turner DM, Tom CT, Renslo AR. PMID: 25353066.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    45. Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery. Org Lett. 2014 Nov 07; 16(21):5776-9. Fontaine SD, DiPasquale AG, Renslo AR. PMID: 25331549.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    46. Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51. Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. PMID: 25314098.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
    47. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. PMID: 25281737.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    48. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. PMID: 24977643.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    49. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. PMID: 24820073.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    50. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Comb Chem High Throughput Screen. 2014 May; 17(4):333-42. Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. PMID: 24661212.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    51. Successes and challenges in phenotype-based lead discovery for prion diseases. J Med Chem. 2014 Aug 28; 57(16):6919-29. Ghaemmaghami S, Russo M, Renslo AR. PMID: 24762293.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    52. Fragment-based inhibitor discovery against β-lactamase. Future Med Chem. 2014 Mar; 6(4):413-27. Nichols DA, Renslo AR, Chen Y. PMID: 24635522.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    53. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorg Med Chem. 2014 Mar 15; 22(6):1960-72. Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB. PMID: 24530226.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    54. Antimalarial Drug Discovery: From Quinine to the Dream of Eradication. ACS Med Chem Lett. 2013 Dec 12; 4(12):1126-1128. Renslo AR. PMID: 24790706.
      View in: PubMed   Mentions:
    55. Tailoring small molecules for an allosteric site on procaspase-6. ChemMedChem. 2014 Jan; 9(1):73-7, 2. Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. PMID: 24259468.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    56. Modulating caspase activity: beyond the active site. Curr Opin Struct Biol. 2013 Dec; 23(6):812-9. Murray J, Renslo AR. PMID: 24215810.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    57. Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18244-9. Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M. PMID: 24145449.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    58. Drug resistance confounding prion therapeutics. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):E4160-9. Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. PMID: 24128760.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimalsCells
    59. Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major. Antimicrob Agents Chemother. 2014; 58(1):78-87. Peniche AG, Osorio Y, Renslo AR, Frantz DE, Melby PC, Travi BL. PMID: 24126577.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    60. Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. Bioorg Med Chem. 2013 Dec 15; 21(24):7999-8012. Silber BM, Gever JR, Li Z, Gallardo-Godoy A, Renslo AR, Widjaja K, Irwin JJ, Rao S, Jacobson MP, Ghaemmaghami S, Prusiner SB. PMID: 24183589.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    61. Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice. J Pharmacol Exp Ther. 2013 Nov; 347(2):325-38. Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB. PMID: 23965382.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    62. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 09; 2:e00712. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. PMID: 23853713.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    63. Genetic and neural mechanisms that inhibit Drosophila from mating with other species. Cell. 2013 Jul 03; 154(1):89-102. Fan P, Manoli DS, Ahmed OM, Chen Y, Agarwal N, Kwong S, Cai AG, Neitz J, Renslo A, Baker BS, Shah NM. PMID: 23810192.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    64. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51. Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. PMID: 23738709.
      View in: PubMed   Mentions: 38     Fields:    Translation:AnimalsCells
    65. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28; 2:e00498. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. PMID: 23741617.
      View in: PubMed   Mentions: 221     Fields:    Translation:HumansAnimalsCells
    66. 2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. ChemMedChem. 2013 May; 8(5):847-57. Li Z, Silber BM, Rao S, Gever JR, Bryant C, Gallardo-Godoy A, Dolghih E, Widjaja K, Elepano M, Jacobson MP, Prusiner SB, Renslo AR. PMID: 23509039.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    67. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. PMID: 23417511.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    68. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. PMID: 23400640.
      View in: PubMed   Mentions:
    69. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS One. 2012; 7(12):e50864. Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. PMID: 23227217.
      View in: PubMed   Mentions: 13     Fields:    Translation:Cells
    70. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite. Future Med Chem. 2012 Dec; 4(18):2241-9. Mahajan SS, Gut J, Rosenthal PJ, Renslo AR. PMID: 23234548.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    71. Predicting and improving the membrane permeability of peptidic small molecules. J Med Chem. 2012 Apr 12; 55(7):3163-9. Rafi SB, Hearn BR, Vedantham P, Jacobson MP, Renslo AR. PMID: 22394492.
      View in: PubMed   Mentions: 16     Fields:    Translation:AnimalsCells
    72. Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A β-lactamase. J Med Chem. 2012 Mar 08; 55(5):2163-72. Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y. PMID: 22296601.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    73. Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes. J Med Chem. 2011 Dec 08; 54(23):8207-13. Hartwig CL, Lauterwasser EM, Mahajan SS, Hoke JM, Cooper RA, Renslo AR. PMID: 22023506.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    74. Drug discovery for neglected tropical diseases at the Sandler Center. Future Med Chem. 2011 Aug; 3(10):1279-88. Robertson SA, Renslo AR. PMID: 21859302.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    75. Predicting binding to p-glycoprotein by flexible receptor docking. PLoS Comput Biol. 2011 Jun; 7(6):e1002083. Dolghih E, Bryant C, Renslo AR, Jacobson MP. PMID: 21731480.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    76. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. PMID: 21572521.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    77. Simple one-pot synthesis of disulfide fragments for use in disulfide-exchange screening. ACS Comb Sci. 2011 May 09; 13(3):205-8. Burlingame MA, Tom CT, Renslo AR. PMID: 21500860.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    78. Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system. PLoS Negl Trop Dis. 2011 Feb 15; 5(2):e962. Osorio Y, Travi BL, Renslo AR, Peniche AG, Melby PC. PMID: 21358812.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    79. A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite. ChemMedChem. 2011 Mar 07; 6(3):415-9. Mahajan SS, Deu E, Lauterwasser EM, Leyva MJ, Ellman JA, Bogyo M, Renslo AR. PMID: 21360816.
      View in: PubMed   Mentions: 14     Fields:    Translation:Animals
    80. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24; 54(4):1010-21. Gallardo-Godoy A, Gever J, Fife KL, Silber BM, Prusiner SB, Renslo AR. PMID: 21247166.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    81. Antibacterial oxazolidinones: emerging structure-toxicity relationships. Expert Rev Anti Infect Ther. 2010 May; 8(5):565-74. Renslo AR. PMID: 20455685.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    82. Small-Molecule Inhibitors of the Androgen Receptor US Patent 7,696,227. 2010. .
    83. N-Aryl-2-oxazolidinone-5-carboxamides and Their Derivatives. US Patent 7,645,781. 2010. .
    84. Discovery of 2-aminothiazoles as potent antiprion compounds. J Virol. 2010 Apr; 84(7):3408-12. Ghaemmaghami S, May BC, Renslo AR, Prusiner SB. PMID: 20032192.
      View in: PubMed   Mentions: 37     Fields:    Translation:AnimalsCells
    85. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6218-21. Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. PMID: 19773167.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    86. Divergent modes of enzyme inhibition in a homologous structure-activity series. J Med Chem. 2009 Aug 27; 52(16):5005-8. Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. PMID: 19637873.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    87. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009 Jul 14; 3(7):e478. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR. PMID: 19597541.
      View in: PubMed   Mentions: 95     Fields:    Translation:Animals
    88. When Medical Need is not Matched by Market Opportunity. Pharma Focus Asia. 2008; 9:24-26. .
    89. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):624-8. Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. PMID: 18055204.
      View in: PubMed   Mentions: 13     Fields:    Translation:Animals
    90. A practical synthesis of differentially protected 2-(hydroxymethyl)piperazines. J Org Chem. 2007 Oct 26; 72(22):8591-2. Gao H, Renslo AR. PMID: 17915928.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    91. A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5036-40. Renslo AR, Atuegbu A, Herradura P, Jaishankar P, Ji M, Leach KL, Huband MD, Dermyer MR, Wu L, Vara Prasad JV, Gordeev MF. PMID: 17681758.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    92. The Echinocandins: Total and Semi-Synthetic Approaches in Anti-fungal Drug Discovery. Anti-infective Agents in Medicinal Chemistry. 2007; 6:201-212. .
    93. Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues. US Patent 7,279,494. 2007. .
    94. Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006 Dec; 2(12):701-10. Renslo AR, McKerrow JH. PMID: 17108988.
      View in: PubMed   Mentions: 86     Fields:    Translation:HumansAnimals
    95. Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. Bioorg Med Chem Lett. 2006 Jul 01; 16(13):3475-8. Renslo AR, Luehr GW, Lam S, Westlund NE, Gómez M, Hackbarth CJ, Patel DV, Gordeev MF. PMID: 16644216.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    96. Recent developments in the identification of novel oxazolidinone antibacterial agents. Bioorg Med Chem. 2006 Jun 15; 14(12):4227-40. Renslo AR, Luehr GW, Gordeev MF. PMID: 16527486.
      View in: PubMed   Mentions: 11     Fields:    Translation:Cells
    97. Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones. Bioorg Med Chem Lett. 2006 Mar 01; 16(5):1126-9. Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gómez M, Blais J, Huband M, Vara Prasad JV, Gordeev MF. PMID: 16387498.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    98. N-Aryl-2-oxazolidinone-5-carboxamides and Their Derivatives. US Patent 7,141,588. 2006. .
    99. Antimicrobial Dihydrothiazine and Dihydrothiopyran Oxazolidinones. US Patent 7,101,874. 2006. .
    100. Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. J Med Chem. 2005 Jul 28; 48(15):5009-24. Renslo AR, Jaishankar P, Venkatachalam R, Hackbarth C, Lopez S, Patel DV, Gordeev MF. PMID: 16033280.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    101. Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate. Org Lett. 2005 Jun 23; 7(13):2627-30. Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gordeev MF. PMID: 15957907.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    102. Antimicrobial [3.1.0] Bicyclic Oxazolidinone Derivatives. US Patent 6,875,784. 2005.
    103. N-Aryl-2-oxazolidinone-5-carboxamides and Their Derivatives. US Patent 6,919,329. 2005. .
    104. Antimicrobial Dihydrothiazine and Dihydrothiopyran Oxazolidinones. US Patent 6,884,813. 2005. .
    105. Intramolecular [4 + 2] cycloadditions of iminoacetonitriles: a new class of azadienophiles for hetero Diels-Alder reactions. J Am Chem Soc. 2003 Apr 30; 125(17):4970-1. Amos DT, Renslo AR, Danheiser RL. PMID: 12708834.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    106. Preparation of Substituted Pyridines via Regiocontrolled [4+2] Cycloadditions of Oximinosulfonates: Methyl 5-Methylpyridine-2-Carboxylate. Org. Syn. 2003; 80:133-143. .
    107. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We are pleased to acknowledge advice from Professors Stephen Craig and Dmitry Rudkevich. Angew Chem Int Ed Engl. 2001 04 01; 40(7):1221-1222. Wash PL, Renslo AR, Rebek J. PMID: 11301430.
      View in: PubMed   Mentions: 5     Fields:    
    108. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion. Angew. Chem. Int. Ed. 2001; 40:1221-1222.
    109. Molecular Recognition with Introverted Functionality We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We thank Prof. Dmitry Rudkevich and Dr. Paul Wash and Dr. Laura Pasternack for helpful advice and instrumental support. Angew Chem Int Ed Engl. 2000 09 15; 39(18):3281-3283. Renslo AR, Rebek J. PMID: 11028077.
      View in: PubMed   Mentions: 11     Fields:    
    110. Nanoscale Container Structures and Their Host - Guest Properties We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. Dr. Laura Pasternack and Dr. Takeharu Haino are sincerely acknowledged for assistance with the 2D NMR experiments and experimental advise, respectively. Angew Chem Int Ed Engl. 2000 03; 39(6):1076-1079. Tucci FC, Renslo AR, Rudkevich DM, Rebek Jr J. PMID: 10760927.
      View in: PubMed   Mentions: 1     Fields:    
    111. Nanoscale Container Structures and their Host¬–Guest Properties. Angew. Chem. Int. Ed. 2000; 39:1076-1079.
    112. Synthesis and Assembly of Self-Complementary Cavitands. J. Am. Chem. Soc. 2000; 122:4573-4582. .
    113. Molecular Recognition with Introverted Functionality. Angew. Chem. Int. Ed. 2000; 39:3281-3283.
    114. Silica-Promoted Diels–Alder Reactions in Carbon Dioxide from Gaseous to Supercritical Conditions. J. Phys. Chem. B. 1999; 103:2878-2887. .
    115. Self-Complementary Cavitands. J. Am. Chem. Soc. 1999; 121:7459-7460.
    116. Encapsulation of Ion-Molecule Complexes: Second-Sphere Supramolecular Chemistry. J. Am. Chem. Soc. 1999; 121:7455-7456.
    117. Synthesis of Substituted Pyridines via Regiocontrolled [4+2] Cycloadditions of Oximinosulfonates. J. Org. Chem. 1998; 63:7840-7850.
    118. Concerning the Regiochemical Course of the Diels-Alder Reaction in Supercritical Carbon Dioxide. J Org Chem. 1997 Jun 27; 62(13):4530-4533. Renslo AR, Weinstein RD, Tester JW, Danheiser RL. PMID: 11671790.
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    119. Concerning the Regiochemical Course of the Diels–Alder Reaction in Supercritical Carbon Dioxide. J. Org. Chem. 1997; 62:4530-4533.
    120. Kinetic Correlation of Diels–Alder Reactions in Supercritical Carbon Dioxide. J. Phys. Chem. 1996; 100:12337-12341.
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