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Adam Renslo, PhD

Title(s)Professor, Pharmaceutical Chemistry
SchoolSchool of Pharmacy
Phone415-514-9698
ORCID ORCID Icon0000-0002-1240-2846 Additional info
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    Collapse Overview 
    Collapse Overview
    My research group is engaged at the interface of chemistry and biology. As medicinal chemists, we design and synthesize small molecules that modulate disease pathology at the level of the enzyme, cell, and whole animal, with current projects in cancer, infectious disease, and neurodegeneration. As chemical biologists, we employ novel small molecule probes to better understand biological pathways and the mechanisms of small molecule therapeutics. Using such small molecule probes, we are exploring the mechanisms underlying the action of artemisinin and related antimalarial drugs. Finally, we are inventing and employing new platform technologies in an effort to expand the realm of druggable target space and drug-like chemical space. These technologies include fragment-based approaches to target protein-protein interfaces and allosteric modulation of enzymes, the use of novel unnatural amino acids to discover cell-permeable peptides, and new targeted prodrug approaches in cancer and infectious disease.

    Collapse Research 
    Collapse Research Activities and Funding
    Discovery of Novel Antimalarial Leads Targeting Translational Repression in Plasmodium parasites
    NIH/NIAID R21AI135495Feb 1, 2019 - Jan 31, 2021
    Role: Principal Investigator
    Expanding the Chemical Biology of K2P Channels with Selective Cellular and In vivo Probes
    NIH/NIMH R01MH116278Mar 1, 2018 - Jan 31, 2021
    Role: Principal Investigator
    Biophysical Fragment Screening and Structure Determination for Class A, B, and D Carbapenemases
    NIH/NIAID R21AI135489Dec 4, 2017 - Nov 30, 2019
    Role: Principal Investigator
    Chemical Methods for Ferrous Iron Dependent Drug Delivery
    NIH/NIAID R01AI105106May 29, 2013 - Aug 31, 2023
    Role: Principal Investigator
    Chemical Methods for Ferrous Iron Targeted Drug Delivery
    NIH/NIAID R21AI094433Mar 1, 2011 - Feb 28, 2013
    Role: Principal Investigator
    Identification of Anti-HIV Lead Compounds Targeting Rev
    NIH/NIAID R41AI076087Jan 1, 2009 - Dec 31, 2011
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse Global Health
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    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Pemberton OA, Jaishankar P, Akhtar A, Adams JL, Shaw LN, Renslo AR, Chen Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J Med Chem. 2019 Sep 13. PMID: 31483651.
      View in: PubMed
    2. Griffin AL, Jaishankar P, Grandjean JM, Olson SH, Renslo AR, Baraban SC. Zebrafish studies identify serotonin receptors mediating antiepileptic activity in Dravet syndrome. Brain Commun. 2019; 1(1):fcz008. PMID: 31667472.
      View in: PubMed
    3. Ehrnhoefer DE, Skotte NH, Reinshagen J, Qiu X, Windshügel B, Jaishankar P, Ladha S, Petina O, Khankischpur M, Nguyen YTN, Caron NS, Razeto A, Meyer Zu Rheda M, Deng Y, Huynh KT, Wittig I, Gribbon P, Renslo AR, Geffken D, Gul S, Hayden MR. Activation of Caspase-6 Is Promoted by a Mutant Huntingtin Fragment and Blocked by an Allosteric Inhibitor Compound. Cell Chem Biol. 2019 Sep 19; 26(9):1295-1305.e6. PMID: 31353319.
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    4. Blank BR, Talukder P, Muir RK, Green ER, Skaar EP, Renslo AR. Targeting Mobilization of Ferrous Iron in Pseudomonas aeruginosa Infection with an Iron(II)-Caged LpxC Inhibitor. ACS Infect Dis. 2019 Aug 09; 5(8):1366-1375. PMID: 31140267.
      View in: PubMed
    5. Torelli NJ, Akhtar A, DeFrees K, Jaishankar P, Pemberton OA, Zhang X, Johnson C, Renslo AR, Chen Y. Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. ACS Infect Dis. 2019 Jun 14; 5(6):1013-1021. PMID: 30942078.
      View in: PubMed
    6. Muir RK, Zhao N, Wei J, Wang YH, Moroz A, Huang Y, Chen YC, Sriram R, Kurhanewicz J, Ruggero D, Renslo AR, Evans MJ. Measuring Dynamic Changes in the Labile Iron Pool in Vivo with a Reactivity-Based Probe for Positron Emission Tomography. ACS Cent Sci. 2019 Apr 24; 5(4):727-736. PMID: 31041393.
      View in: PubMed
    7. Raleigh DR, Sever N, Choksi PK, Sigg MA, Hines KM, Thompson BM, Elnatan D, Jaishankar P, Bisignano P, Garcia-Gonzalo FR, Krup AL, Eberl M, Byrne EFX, Siebold C, Wong SY, Renslo AR, Grabe M, McDonald JG, Xu L, Beachy PA, Reiter JF. Cilia-Associated Oxysterols Activate Smoothened. Mol Cell. 2018 10 18; 72(2):316-327.e5. PMID: 30340023.
      View in: PubMed
    8. Pope L, Arrigoni C, Lou H, Bryant C, Gallardo-Godoy A, Renslo AR, Minor DL. Protein and Chemical Determinants of BL-1249 Action and Selectivity for K2P Channels. ACS Chem Neurosci. 2018 12 19; 9(12):3153-3165. PMID: 30089357.
      View in: PubMed
    9. Pemberton OA, Zhang X, Nichols DA, DeFrees K, Jaishankar P, Bonnet R, Adams J, Shaw LN, Renslo AR, Chen Y. Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine ß-Lactamases. Antimicrob Agents Chemother. 2018 08; 62(8). PMID: 29844038.
      View in: PubMed
    10. Tsai JC, Miller-Vedam LE, Anand AA, Jaishankar P, Nguyen HC, Renslo AR, Frost A, Walter P. Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule. Science. 2018 03 30; 359(6383). PMID: 29599213.
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    11. Spangler B, Kline T, Hanson J, Li X, Zhou S, Wells JA, Sato AK, Renslo AR. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 05 07; 15(5):2054-2059. PMID: 29569925.
      View in: PubMed
    12. Camarena V, Sant DW, Huff TC, Mustafi S, Muir RK, Aron AT, Chang CJ, Renslo AR, Monje PV, Wang G. cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool. Elife. 2017 12 14; 6. PMID: 29239726.
      View in: PubMed
    13. Aron AT, Heffern MC, Lonergan ZR, Vander Wal MN, Blank BR, Spangler B, Zhang Y, Park HM, Stahl A, Renslo AR, Skaar EP, Chang CJ. In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection. Proc Natl Acad Sci U S A. 2017 11 28; 114(48):12669-12674. PMID: 29138321.
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    14. Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, Bainbridge TW, Kwok MCM, Ma TP, Stiffler Z, Brasher B, Tang Y, Jaishankar P, Hearn BR, Renslo AR, Arkin MR, Cohen F, Yu K, Peale F, Gnad F, Chang MT, Klijn C, Blackwood E, Martin SE, Forrest WF, Ernst JA, Ndubaku C, Wang X, Beresini MH, Tsui V, Schwerdtfeger C, Blake RA, Murray J, Maurer T, Wertz IE. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. 2017 10 26; 550(7677):534-538. PMID: 29045385.
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    15. Gentile DR, Rathinaswamy MK, Jenkins ML, Moss SM, Siempelkamp BD, Renslo AR, Burke JE, Shokat KM. Ras Binder Induces a Modified Switch-II Pocket in GTP and GDP States. Cell Chem Biol. 2017 12 21; 24(12):1455-1466.e14. PMID: 29033317.
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    16. Hallenbeck KK, Davies JL, Merron C, Ogden P, Sijbesma E, Ottmann C, Renslo AR, Wilson C, Arkin MR. A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments. SLAS Discov. 2018 02; 23(2):183-192. PMID: 28945980.
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    17. Acker TM, Gable JE, Bohn MF, Jaishankar P, Thompson MC, Fraser JS, Renslo AR, Craik CS. Allosteric Inhibitors, Crystallography, and Comparative Analysis Reveal Network of Coordinated Movement across Human Herpesvirus Proteases. J Am Chem Soc. 2017 08 30; 139(34):11650-11653. PMID: 28759216.
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    18. Blank BR, Gut J, Rosenthal PJ, Renslo AR. Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. J Med Chem. 2017 07 27; 60(14):6400-6407. PMID: 28692297.
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    19. Nakamura RL, Burlingame MA, Yang S, Crosby DC, Talbot DJ, Chui K, Frankel AD, Renslo AR. Identification and Optimization of Thienopyridine Carboxamides as Inhibitors of HIV Regulatory Complexes. Antimicrob Agents Chemother. 2017 07; 61(7). PMID: 28416550.
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    20. Hallenbeck KK, Turner DM, Renslo AR, Arkin MR. Targeting Non-Catalytic Cysteine Residues Through Structure-Guided Drug Discovery. Curr Top Med Chem. 2017; 17(1):4-15. PMID: 27449257.
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    21. Spangler B, Fontaine SD, Shi Y, Sambucetti L, Mattis AN, Hann B, Wells JA, Renslo AR. A Novel Tumor-Activated Prodrug Strategy Targeting Ferrous Iron Is Effective in Multiple Preclinical Cancer Models. J Med Chem. 2016 12 22; 59(24):11161-11170. PMID: 27936709.
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    22. Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6a branch. Elife. 2016 07 20; 5. PMID: 27435960.
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    23. Spangler B, Morgan CW, Fontaine SD, Vander Wal MN, Chang CJ, Wells JA, Renslo AR. A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol. 2016 09; 12(9):680-5. PMID: 27376690.
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    24. Hearn BR, Jaishankar P, Sidrauski C, Tsai JC, Vedantham P, Fontaine SD, Walter P, Renslo AR. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19; 11(8):870-80. PMID: 26789650.
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    25. Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA, Rosenthal PJ, Bogyo M, Renslo AR. Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. ACS Med Chem Lett. 2015 Nov 12; 6(11):1145-9. PMID: 26617969.
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    26. Mott BT, Eastman RT, Guha R, Sherlach KS, Siriwardana A, Shinn P, McKnight C, Michael S, Lacerda-Queiroz N, Patel PR, Khine P, Sun H, Kasbekar M, Aghdam N, Fontaine SD, Liu D, Mierzwa T, Mathews-Griner LA, Ferrer M, Renslo AR, Inglese J, Yuan J, Roepe PD, Su XZ, Thomas CJ. High-throughput matrix screening identifies synergistic and antagonistic antimalarial drug combinations. Sci Rep. 2015 Sep 25; 5:13891. PMID: 26403635.
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    27. Peniche AG, Renslo AR, Melby PC, Travi BL. Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions. Antimicrob Agents Chemother. 2015 Oct; 59(10):6463-70. PMID: 26239994.
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    28. Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. J Pharmacol Exp Ther. 2015 Oct; 355(1):2-12. PMID: 26224882.
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    29. Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorg Med Chem Lett. 2015 Nov 01; 25(21):4834-4837. PMID: 26144347.
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    30. Nichols DA, Hargis JC, Sanishvili R, Jaishankar P, Defrees K, Smith EW, Wang KK, Prati F, Renslo AR, Woodcock HL, Chen Y. Ligand-Induced Proton Transfer and Low-Barrier Hydrogen Bond Revealed by X-ray Crystallography. J Am Chem Soc. 2015 Jul 01; 137(25):8086-95. PMID: 26057252.
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    31. Sidrauski C, Tsai JC, Kampmann M, Hearn BR, Vedantham P, Jaishankar P, Sokabe M, Mendez AS, Newton BW, Tang EL, Verschueren E, Johnson JR, Krogan NJ, Fraser CS, Weissman JS, Renslo AR, Walter P. Pharmacological dimerization and activation of the exchange factor eIF2B antagonizes the integrated stress response. Elife. 2015 Apr 15; 4:e07314. PMID: 25875391.
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    32. Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP. J Biomol Screen. 2015 Jul; 20(6):788-800. PMID: 25690569.
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    33. Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Protease inhibitors targeting coronavirus and filovirus entry. Antiviral Res. 2015 Apr; 116:76-84. PMID: 25666761.
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    34. Turner DM, Tom CT, Renslo AR. Simple plate-based, parallel synthesis of disulfide fragments using the CuAAC click reaction. ACS Comb Sci. 2014 Dec 08; 16(12):661-4. PMID: 25353066.
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    35. Fontaine SD, DiPasquale AG, Renslo AR. Efficient and stereocontrolled synthesis of 1,2,4-trioxolanes useful for ferrous iron-dependent drug delivery. Org Lett. 2014 Nov 07; 16(21):5776-9. PMID: 25331549.
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    36. Fontaine SD, Spangler B, Gut J, Lauterwasser EM, Rosenthal PJ, Renslo AR. Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51. PMID: 25314098.
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    37. Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, Arkin M, Glynne R, McKerrow J, Siqueira-Neto JL. Lead identification to clinical candidate selection: drugs for Chagas disease. J Biomol Screen. 2015 Jan; 20(1):101-11. PMID: 25281737.
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    38. Gable JE, Lee GM, Jaishankar P, Hearn BR, Waddling CA, Renslo AR, Craik CS. Broad-spectrum allosteric inhibition of herpesvirus proteases. Biochemistry. 2014 Jul 22; 53(28):4648-60. PMID: 24977643.
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    39. Debnath A, Shahinas D, Bryant C, Hirata K, Miyamoto Y, Hwang G, Gut J, Renslo AR, Pillai DR, Eckmann L, Reed SL, McKerrow JH. Hsp90 inhibitors as new leads to target parasitic diarrheal diseases. Antimicrob Agents Chemother. 2014 Jul; 58(7):4138-44. PMID: 24820073.
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    40. Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Comb Chem High Throughput Screen. 2014 May; 17(4):333-42. PMID: 24661212.
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    41. Ghaemmaghami S, Russo M, Renslo AR. Successes and challenges in phenotype-based lead discovery for prion diseases. J Med Chem. 2014 Aug 28; 57(16):6919-29. PMID: 24762293.
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    42. Nichols DA, Renslo AR, Chen Y. Fragment-based inhibitor discovery against ß-lactamase. Future Med Chem. 2014 Mar; 6(4):413-27. PMID: 24635522.
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    43. Silber BM, Gever JR, Rao S, Li Z, Renslo AR, Widjaja K, Wong C, Giles K, Freyman Y, Elepano M, Irwin JJ, Jacobson MP, Prusiner SB. Novel compounds lowering the cellular isoform of the human prion protein in cultured human cells. Bioorg Med Chem. 2014 Mar 15; 22(6):1960-72. PMID: 24530226.
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    44. Renslo AR. Antimalarial Drug Discovery: From Quinine to the Dream of Eradication. ACS Med Chem Lett. 2013 Dec 12; 4(12):1126-1128. PMID: 24790706.
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    45. Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring small molecules for an allosteric site on procaspase-6. ChemMedChem. 2014 Jan; 9(1):73-7, 2. PMID: 24259468.
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    46. Murray J, Renslo AR. Modulating caspase activity: beyond the active site. Curr Opin Struct Biol. 2013 Dec; 23(6):812-9. PMID: 24215810.
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    47. Deu E, Chen IT, Lauterwasser EM, Valderramos J, Li H, Edgington LE, Renslo AR, Bogyo M. Ferrous iron-dependent drug delivery enables controlled and selective release of therapeutic agents in vivo. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18244-9. PMID: 24145449.
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    48. Berry DB, Lu D, Geva M, Watts JC, Bhardwaj S, Oehler A, Renslo AR, DeArmond SJ, Prusiner SB, Giles K. Drug resistance confounding prion therapeutics. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):E4160-9. PMID: 24128760.
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    49. Peniche AG, Osorio Y, Renslo AR, Frantz DE, Melby PC, Travi BL. Development of an ex vivo lymph node explant model for identification of novel molecules active against Leishmania major. Antimicrob Agents Chemother. 2014; 58(1):78-87. PMID: 24126577.
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    50. Silber BM, Gever JR, Li Z, Gallardo-Godoy A, Renslo AR, Widjaja K, Irwin JJ, Rao S, Jacobson MP, Ghaemmaghami S, Prusiner SB. Antiprion compounds that reduce PrP(Sc) levels in dividing and stationary-phase cells. Bioorg Med Chem. 2013 Dec 15; 21(24):7999-8012. PMID: 24183589.
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    51. Lu D, Giles K, Li Z, Rao S, Dolghih E, Gever JR, Geva M, Elepano ML, Oehler A, Bryant C, Renslo AR, Jacobson MP, Dearmond SJ, Silber BM, Prusiner SB. Biaryl amides and hydrazones as therapeutics for prion disease in transgenic mice. J Pharmacol Exp Ther. 2013 Nov; 347(2):325-38. PMID: 23965382.
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    52. Nishino M, Choy JW, Gushwa NN, Oses-Prieto JA, Koupparis K, Burlingame AL, Renslo AR, McKerrow JH, Taunton J. Hypothemycin, a fungal natural product, identifies therapeutic targets in Trypanosoma brucei [corrected]. Elife. 2013 Jul 09; 2:e00712. PMID: 23853713.
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    53. Fan P, Manoli DS, Ahmed OM, Chen Y, Agarwal N, Kwong S, Cai AG, Neitz J, Renslo A, Baker BS, Shah NM. Genetic and neural mechanisms that inhibit Drosophila from mating with other species. Cell. 2013 Jul 03; 154(1):89-102. PMID: 23810192.
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    54. Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. ACS Chem Biol. 2013 Aug 16; 8(8):1841-51. PMID: 23738709.
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    55. Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, Renslo AR, Sonenberg N, Walter P. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2013 May 28; 2:e00498. PMID: 23741617.
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    56. Li Z, Silber BM, Rao S, Gever JR, Bryant C, Gallardo-Godoy A, Dolghih E, Widjaja K, Elepano M, Jacobson MP, Prusiner SB, Renslo AR. 2-Aminothiazoles with improved pharmacotherapeutic properties for treatment of prion disease. ChemMedChem. 2013 May; 8(5):847-57. PMID: 23509039.
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    57. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Pharm Res. 2013 Apr; 30(4):932-50. PMID: 23417511.
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    58. Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, McKerrow JM, Podust LM, Renslo AR. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein J Org Chem. 2013; 9:15-25. PMID: 23400640.
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    59. Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. PLoS One. 2012; 7(12):e50864. PMID: 23227217.
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    60. Mahajan SS, Gut J, Rosenthal PJ, Renslo AR. Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite. Future Med Chem. 2012 Dec; 4(18):2241-9. PMID: 23234548.
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    61. Rafi SB, Hearn BR, Vedantham P, Jacobson MP, Renslo AR. Predicting and improving the membrane permeability of peptidic small molecules. J Med Chem. 2012 Apr 12; 55(7):3163-9. PMID: 22394492.
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    62. Nichols DA, Jaishankar P, Larson W, Smith E, Liu G, Beyrouthy R, Bonnet R, Renslo AR, Chen Y. Structure-based design of potent and ligand-efficient inhibitors of CTX-M class A ß-lactamase. J Med Chem. 2012 Mar 08; 55(5):2163-72. PMID: 22296601.
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    63. Hartwig CL, Lauterwasser EM, Mahajan SS, Hoke JM, Cooper RA, Renslo AR. Investigating the antimalarial action of 1,2,4-trioxolanes with fluorescent chemical probes. J Med Chem. 2011 Dec 08; 54(23):8207-13. PMID: 22023506.
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    64. Robertson SA, Renslo AR. Drug discovery for neglected tropical diseases at the Sandler Center. Future Med Chem. 2011 Aug; 3(10):1279-88. PMID: 21859302.
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    65. Dolghih E, Bryant C, Renslo AR, Jacobson MP. Predicting binding to p-glycoprotein by flexible receptor docking. PLoS Comput Biol. 2011 Jun; 7(6):e1002083. PMID: 21731480.
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    66. Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023. PMID: 21572521.
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    67. Burlingame MA, Tom CT, Renslo AR. Simple one-pot synthesis of disulfide fragments for use in disulfide-exchange screening. ACS Comb Sci. 2011 May 09; 13(3):205-8. PMID: 21500860.
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    68. Osorio Y, Travi BL, Renslo AR, Peniche AG, Melby PC. Identification of small molecule lead compounds for visceral leishmaniasis using a novel ex vivo splenic explant model system. PLoS Negl Trop Dis. 2011 Feb 15; 5(2):e962. PMID: 21358812.
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    69. Mahajan SS, Deu E, Lauterwasser EM, Leyva MJ, Ellman JA, Bogyo M, Renslo AR. A fragmenting hybrid approach for targeted delivery of multiple therapeutic agents to the malaria parasite. ChemMedChem. 2011 Mar 07; 6(3):415-9. PMID: 21360816.
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    70. Gallardo-Godoy A, Gever J, Fife KL, Silber BM, Prusiner SB, Renslo AR. 2-Aminothiazoles as therapeutic leads for prion diseases. J Med Chem. 2011 Feb 24; 54(4):1010-21. PMID: 21247166.
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    71. Renslo AR. Antibacterial oxazolidinones: emerging structure-toxicity relationships. Expert Rev Anti Infect Ther. 2010 May; 8(5):565-74. PMID: 20455685.
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    72. Thomas, RC, Poel, T-J, Barbachyn, MR, Gordeev, MF, Luehr, GW, Renslo, A, Singh, U, Joysula, VPVN.N-Aryl-2-oxazolidinone-5-carboxamides and Their Derivatives. US Patent 7,645,781. 2010.
    73. Diamond, M, Jones, J, Renslo, A.Small-Molecule Inhibitors of the Androgen Receptor US Patent 7,696,227. 2010.
    74. Ghaemmaghami S, May BC, Renslo AR, Prusiner SB. Discovery of 2-aminothiazoles as potent antiprion compounds. J Virol. 2010 Apr; 84(7):3408-12. PMID: 20032192.
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    75. Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6218-21. PMID: 19773167.
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    76. Ferreira RS, Bryant C, Ang KK, McKerrow JH, Shoichet BK, Renslo AR. Divergent modes of enzyme inhibition in a homologous structure-activity series. J Med Chem. 2009 Aug 27; 52(16):5005-8. PMID: 19637873.
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    77. Abdulla MH, Ruelas DS, Wolff B, Snedecor J, Lim KC, Xu F, Renslo AR, Williams J, McKerrow JH, Caffrey CR. Drug discovery for schistosomiasis: hit and lead compounds identified in a library of known drugs by medium-throughput phenotypic screening. PLoS Negl Trop Dis. 2009 Jul 14; 3(7):e478. PMID: 19597541.
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    78. Renslo, AR.When Medical Need is not Matched by Market Opportunity. Pharma Focus Asia. 2008; 9:24-26.
    79. Jaishankar P, Hansell E, Zhao DM, Doyle PS, McKerrow JH, Renslo AR. Potency and selectivity of P2/P3-modified inhibitors of cysteine proteases from trypanosomes. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):624-8. PMID: 18055204.
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    80. Gao H, Renslo AR. A practical synthesis of differentially protected 2-(hydroxymethyl)piperazines. J Org Chem. 2007 Oct 26; 72(22):8591-2. PMID: 17915928.
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    81. Renslo AR, Atuegbu A, Herradura P, Jaishankar P, Ji M, Leach KL, Huband MD, Dermyer MR, Wu L, Vara Prasad JV, Gordeev MF. A distal methyl substituent attenuates mitochondrial protein synthesis inhibition in oxazolidinone antibacterials. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5036-40. PMID: 17681758.
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    82. Renslo, AR.The Echinocandins: Total and Semi-Synthetic Approaches in Anti-fungal Drug Discovery. Anti-infective Agents in Medicinal Chemistry. 2007; 6:201-212.
    83. Renslo, AR, Gordeev, MF, Patel, DV, Gao, H, and Josyula, VPVN.Antimicrobial [3.1.0] bicyclohexylphenyl-oxazolidinone derivatives and analogues. US Patent 7,279,494. 2007.
    84. Renslo AR, McKerrow JH. Drug discovery and development for neglected parasitic diseases. Nat Chem Biol. 2006 Dec; 2(12):701-10. PMID: 17108988.
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    85. Renslo AR, Luehr GW, Lam S, Westlund NE, Gómez M, Hackbarth CJ, Patel DV, Gordeev MF. Synthesis and structure-activity studies of antibacterial oxazolidinones containing dihydrothiopyran or dihydrothiazine C-rings. Bioorg Med Chem Lett. 2006 Jul 01; 16(13):3475-8. PMID: 16644216.
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    86. Renslo AR, Luehr GW, Gordeev MF. Recent developments in the identification of novel oxazolidinone antibacterial agents. Bioorg Med Chem. 2006 Jun 15; 14(12):4227-40. PMID: 16527486.
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    87. Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gómez M, Blais J, Huband M, Vara Prasad JV, Gordeev MF. Conformational constraint in oxazolidinone antibacterials. Part 2: Synthesis and structure-activity studies of oxa-, aza-, and thiabicyclo[3.1.0]hexylphenyl oxazolidinones. Bioorg Med Chem Lett. 2006 Mar 01; 16(5):1126-9. PMID: 16387498.
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    88. Thomas, RC, Poel, T-J, Barbachyn, MR, Gordeev, MF, Luehr, GW, Renslo, A, Singh, U, Joysula, VPVN.N-Aryl-2-oxazolidinone-5-carboxamides and Their Derivatives. US Patent 7,141,588. 2006.
    89. Gordeev, MF, Renslo, A, Luehr, GW, Lam, S, Westlund, NE, and Patel, DV.Antimicrobial Dihydrothiazine and Dihydrothiopyran Oxazolidinones. US Patent 7,101,874. 2006.
    90. Renslo AR, Jaishankar P, Venkatachalam R, Hackbarth C, Lopez S, Patel DV, Gordeev MF. Conformational constraint in oxazolidinone antibacterials. Synthesis and structure-activity studies of (azabicyclo[3.1.0]hexylphenyl)oxazolidinones. J Med Chem. 2005 Jul 28; 48(15):5009-24. PMID: 16033280.
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    91. Renslo AR, Gao H, Jaishankar P, Venkatachalam R, Gordeev MF. Synthesis of aza-, oxa-, and thiabicyclo[3.1.0]hexane heterocycles from a common synthetic intermediate. Org Lett. 2005 Jun 23; 7(13):2627-30. PMID: 15957907.
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    92. Gordeev, MF, Renslo, A, and Patel, DV.Antimicrobial [3.1.0] Bicyclic Oxazolidinone Derivatives. US Patent 6,875,784. 2005.
    93. Gordeev, MF, Renslo, A, Luehr, GW, Lam, S, Westlund, NE, and Patel, DV.Antimicrobial Dihydrothiazine and Dihydrothiopyran Oxazolidinones. US Patent 6,884,813. 2005.
    94. Thomas, RC, Poel, T-J, Barbachyn, MR, Gordeev, MF, Luehr, GW, Renslo, A, and Singh, U.N-Aryl-2-oxazolidinone-5-carboxamides and Their Derivatives. US Patent 6,919,329. 2005.
    95. Amos DT, Renslo AR, Danheiser RL. Intramolecular [4 + 2] cycloadditions of iminoacetonitriles: a new class of azadienophiles for hetero Diels-Alder reactions. J Am Chem Soc. 2003 Apr 30; 125(17):4970-1. PMID: 12708834.
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    96. Danheiser, RL, Renslo, AR, Amos, DT, and Wright, GT.Preparation of Substituted Pyridines via Regiocontrolled [4+2] Cycloadditions of Oximinosulfonates: Methyl 5-Methylpyridine-2-Carboxylate. Org. Syn. 2003; 80:133-143.
    97. Wash PL, Renslo AR, Rebek J. Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We are pleased to acknowledge advice from Professors Stephen Craig and Dmitry Rudkevich. Angew Chem Int Ed Engl. 2001 04 01; 40(7):1221-1222. PMID: 11301430.
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    98. Wash, PL, Renslo, AR, and Rebek, J.Isolation of an Acid/Base Complex in Solution Puts the Brakes on Nitrogen Inversion. Angew. Chem. Int. Ed. 2001; 40:1221-1222.
    99. Renslo AR, Rebek J. Molecular Recognition with Introverted Functionality We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. We thank Prof. Dmitry Rudkevich and Dr. Paul Wash and Dr. Laura Pasternack for helpful advice and instrumental support. Angew Chem Int Ed Engl. 2000 09 15; 39(18):3281-3283. PMID: 11028077.
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    100. Tucci FC, Renslo AR, Rudkevich DM, Rebek Jr J. Nanoscale Container Structures and Their Host - Guest Properties We are grateful for financial support from the Skaggs Research Foundation and the National Institutes of Health. Dr. Laura Pasternack and Dr. Takeharu Haino are sincerely acknowledged for assistance with the 2D NMR experiments and experimental advise, respectively. Angew Chem Int Ed Engl. 2000 03; 39(6):1076-1079. PMID: 10760927.
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    101. Renslo, AR and Rebek, J.Molecular Recognition with Introverted Functionality. Angew. Chem. Int. Ed. 2000; 39:3281-3283.
    102. Renslo, AR, Tucci, FC, Rudkevich, DM, and Rebek, J.Synthesis and Assembly of Self-Complementary Cavitands. J. Am. Chem. Soc. 2000; 122:4573-4582.
    103. Tucci, FC, Renslo, AR, Rudkevich, DM, and Rebek, J.Nanoscale Container Structures and their Host¬–Guest Properties. Angew. Chem. Int. Ed. 2000; 39:1076-1079.
    104. Lützen, A, Renslo, AR, Schalley, CA, O’Leary, BM, and Rebek, J.Encapsulation of Ion-Molecule Complexes: Second-Sphere Supramolecular Chemistry. J. Am. Chem. Soc. 1999; 121:7455-7456.
    105. Weinstein, RD, Renslo, AR, Danheiser, RL, and Tester, JW.Silica-Promoted Diels–Alder Reactions in Carbon Dioxide from Gaseous to Supercritical Conditions. J. Phys. Chem. B. 1999; 103:2878-2887.
    106. Renslo, AR, Rudkevich, DM, and Rebek, J.Self-Complementary Cavitands. J. Am. Chem. Soc. 1999; 121:7459-7460.
    107. Renslo, AR and Danheiser, RL.Synthesis of Substituted Pyridines via Regiocontrolled [4+2] Cycloadditions of Oximinosulfonates. J. Org. Chem. 1998; 63:7840-7850.
    108. Renslo AR, Weinstein RD, Tester JW, Danheiser RL. Concerning the Regiochemical Course of the Diels-Alder Reaction in Supercritical Carbon Dioxide. J Org Chem. 1997 Jun 27; 62(13):4530-4533. PMID: 11671790.
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    109. Renslo, AR, Weinstein, RD, Tester, JW, and Danheiser, RL.Concerning the Regiochemical Course of the Diels–Alder Reaction in Supercritical Carbon Dioxide. J. Org. Chem. 1997; 62:4530-4533.
    110. Weinstein, RD, Renslo, AR, Danheiser, RL, Harris, JG, and Tester, JW.Kinetic Correlation of Diels–Alder Reactions in Supercritical Carbon Dioxide. J. Phys. Chem. 1996; 100:12337-12341.