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Aimee Kao, MD, PhD

Title(s)Associate Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of California, San FranciscoClinical Fellowship
    University of IowaM.D.2000College of Medicine

    Collapse Research 
    Collapse Research Activities and Funding
    Systematic profiling of lysosomes with age to improve proteostasis in Alzheimer's
    NIH/NIA R01AG057342Sep 30, 2018 - May 31, 2023
    Role: Principal Investigator
    Understanding the molecular functions of progranulin and granulin in FTLD
    NIH/NINDS R01NS095257Sep 1, 2018 - Aug 31, 2020
    Role: Principal Investigator
    Understanding cleaved granulin production, protease inhibition and effects on protein homeostasis
    NIH/NIA R01AG059052Apr 1, 2018 - Dec 31, 2022
    Role: Principal Investigator
    Systematic profiling of lysosomes with age to improve proteostasis in Alzheimer's
    NIH/NIA R56AG057342Sep 15, 2017 - Aug 31, 2018
    Role: Principal Investigator
    Genetic Approaches to Understanding Granulin Function
    NIH/NINDS R21NS082709Sep 1, 2013 - Aug 31, 2015
    Role: Principal Investigator
    Understanding Selective Neuronal Vulnerability in Parkinson's Disease
    NIH/NINDS K08NS059604Jul 1, 2007 - Jan 31, 2012
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons. Sci Rep. 2020 Jan 17; 10(1):569. Alquezar C, Felix JB, McCandlish E, Buckley BT, Caparros-Lefebvre D, Karch CM, Golbe LI, Kao AW. PMID: 31953414.
      View in: PubMed   Mentions:    Fields:    
    2. Protons in small spaces: Discrete simulations of vesicle acidification. PLoS Comput Biol. 2019 12; 15(12):e1007539. Singh A, Marcoline FV, Veshaguri S, Kao AW, Bruchez M, Mindell JA, Stamou D, Grabe M. PMID: 31869334.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    3. Association of Cognitive and Behavioral Features Between Adults With Tuberous Sclerosis and Frontotemporal Dementia. JAMA Neurol. 2019 Dec 20. Liu AJ, Staffaroni AM, Rojas-Martinez JC, Olney NT, Alquezar-Burillo C, Ljubenkov PA, La Joie R, Fong JC, Taylor J, Karydas A, Ramos EM, Coppola G, Boxer AL, Rabinovici GD, Miller BL, Kao AW. PMID: 31860018.
      View in: PubMed   Mentions:    Fields:    
    4. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. 2019 11 12; 13(5):939-955. Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S. PMID: 31631020.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy. NPJ Aging Mech Dis. 2019; 5:7. Tezil T, Chamoli M, Ng CP, Simon RP, Butler VJ, Jung M, Andersen J, Kao AW, Verdin E. PMID: 31602311.
      View in: PubMed   Mentions:
    6. Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. PLoS Genet. 2019 08; 15(8):e1008295. Butler VJ, Gao F, Corrales CI, Cortopassi WA, Caballero B, Vohra M, Ashrafi K, Cuervo AM, Jacobson MP, Coppola G, Kao AW. PMID: 31398187.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    7. Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro. Biochemistry. 2019 06 11; 58(23):2670-2674. Butler VJ, Cortopassi WA, Gururaj S, Wang AL, Pierce OM, Jacobson MP, Kao AW. PMID: 31099551.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    8. Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport. Hum Mol Genet. 2019 05 01; 28(9):1498-1514. Butler VJ, Salazar DA, Soriano-Castell D, Alves-Ferreira M, Dennissen FJA, Vohra M, Oses-Prieto JA, Li KH, Wang AL, Jing B, Li B, Groisman A, Gutierrez E, Mooney S, Burlingame AL, Ashrafi K, Mandelkow EM, Encalada SE, Kao AW. PMID: 30590647.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    9. Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH. J Mol Biol. 2019 03 01; 431(5):1038-1047. Butler VJ, Cortopassi WA, Argouarch AR, Ivry SL, Craik CS, Jacobson MP, Kao AW. PMID: 30690031.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress. Hum Mol Genet. 2018 11 15; 27(22):3951-3963. Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litvan I, Lin JH. PMID: 30137327.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    11. Regionally specific TSC1 and TSC2 gene expression in tuberous sclerosis complex. Sci Rep. 2018 09 06; 8(1):13373. Li Y, Barkovich MJ, Karch CM, Nillo RM, Fan CC, Broce IJ, Tan CH, Cuneo D, Hess CP, Dillon WP, Glenn OA, Glastonbury CM, Olney N, Yokoyama JS, Bonham LW, Miller B, Kao A, Schmansky N, Fischl B, Andreassen OA, Jernigan T, Dale A, Barkovich AJ, Desikan RS, Sugrue LP. PMID: 30190613.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    12. The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response. Methods Mol Biol. 2018; 1806:193-206. Hsu TY, Butler VJ, Kao AW. PMID: 29956278.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    13. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain. 2017 Dec 01; 140(12):3329-3345. Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. PMID: 29053860.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    14. Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia. Acta Neuropathol. 2017 11; 134(5):813-816. Olney NT, Alquezar C, Ramos EM, Nana AL, Fong JC, Karydas AM, Taylor JB, Stephens ML, Argouarch AR, Van Berlo VA, Dokuru DR, Sherr EH, Jicha GA, Dillon WP, Desikan RS, De May M, Seeley WW, Coppola G, Miller BL, Kao AW. PMID: 28828560.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    15. Progranulin, lysosomal regulation and neurodegenerative disease. Nat Rev Neurosci. 2017 06; 18(6):325-333. Kao AW, McKay A, Singh PP, Brunet A, Huang EJ. PMID: 28435163.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    16. Animal models of dementia. The Behavioral Neurology of Dementia. 2017 Jan 1; 77-93. Erik D. Roberson, Aimee W. Kao. .
      View in: Publisher Site   Mentions:
    17. MCP-1 and eotaxin-1 selectively and negatively associate with memory in MCI and Alzheimer's disease dementia phenotypes. Alzheimers Dement (Amst). 2016; 3:91-7. Bettcher BM, Fitch R, Wynn MJ, Lalli MA, Elofson J, Jastrzab L, Mitic L, Miller ZA, Rabinovici GD, Miller BL, Kao AW, Kosik KS, Kramer JH. PMID: 27453930.
      View in: PubMed   Mentions:
    18. The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels. J Neurosci. 2015 Jun 24; 35(25):9315-28. Salazar DA, Butler VJ, Argouarch AR, Hsu TY, Mason A, Nakamura A, McCurdy H, Cox D, Ng R, Pan G, Seeley WW, Miller BL, Kao AW. PMID: 26109656.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    19. A shift to organismal stress resistance in programmed cell death mutants. PLoS Genet. 2013; 9(9):e1003714. Judy ME, Nakamura A, Huang A, Grant H, McCurdy H, Weiberth KF, Gao F, Coppola G, Kenyon C, Kao AW. PMID: 24068943.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: the next therapeutic frontier). Alzheimers Dement. 2013 Mar; 9(2):189-98. Boxer AL, Gold M, Huey E, Hu WT, Rosen H, Kramer J, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Jackson G, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian ZS, Sutherland M, Abushakra S, Lewcock J, Farese R, Kenet RO, Laferla F, Perrin S, Whitaker S, Honig L, Mesulam MM, Boeve B, Grossman M, Miller BL, Cummings JL. PMID: 23062850.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimals
    21. Frontotemporal degeneration, the next therapeutic frontier: molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement. 2013 Mar; 9(2):176-88. Boxer AL, Gold M, Huey E, Gao FB, Burton EA, Chow T, Kao A, Leavitt BR, Lamb B, Grether M, Knopman D, Cairns NJ, Mackenzie IR, Mitic L, Roberson ED, Van Kammen D, Cantillon M, Zahs K, Salloway S, Morris J, Tong G, Feldman H, Fillit H, Dickinson S, Khachaturian Z, Sutherland M, Farese R, Miller BL, Cummings J. PMID: 23043900.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    22. A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4441-6. Kao AW, Eisenhut RJ, Martens LH, Nakamura A, Huang A, Bagley JA, Zhou P, de Luis A, Neukomm LJ, Cabello J, Farese RV, Kenyon C. PMID: 21368173.
      View in: PubMed   Mentions: 50     Fields:    Translation:AnimalsCells
    23. Cognitive and neuropsychiatric profile of the synucleinopathies: Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. Alzheimer Dis Assoc Disord. 2009 Oct-Dec; 23(4):365-70. Kao AW, Racine CA, Quitania LC, Kramer JH, Christine CW, Miller BL. PMID: 19935145.
      View in: PubMed   Mentions: 26     Fields:    Translation:Humans
    24. Animal models of dementia. The Behavioral Neurology of Dementia. 2009 Jan 1; 131-141. Erik D. Roberson, Aimee W. Kao. .
      View in: Publisher Site   Mentions:
    25. Chemokine receptors, neural progenitor cells, and the AIDS dementia complex. J Infect Dis. 2004 Jul 15; 190(2):211-5. Kao AW, Price RW. PMID: 15216453.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    26. Functional comparison of the role of dynamin 2 splice variants on GLUT-4 endocytosis in 3T3L1 adipocytes. Am J Physiol Endocrinol Metab. 2000 May; 278(5):E825-31. Kao AW, Yang C, Pessin JE. PMID: 10780938.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    27. Dynamin is required for recombinant adeno-associated virus type 2 infection. J Virol. 1999 Dec; 73(12):10371-6. Duan D, Li Q, Kao AW, Yue Y, Pessin JE, Engelhardt JF. PMID: 10559355.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
    28. The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. J Biol Chem. 1999 Jun 18; 274(25):17934-40. Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE, Birnbaum MJ. PMID: 10364240.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    29. Aldolase mediates the association of F-actin with the insulin-responsive glucose transporter GLUT4. J Biol Chem. 1999 Jun 18; 274(25):17742-7. Kao AW, Noda Y, Johnson JH, Pessin JE, Saltiel AR. PMID: 10364216.
      View in: PubMed   Mentions: 31     Fields:    Translation:AnimalsCells
    30. Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling. J Biol Chem. 1998 Sep 25; 273(39):25450-7. Kao AW, Ceresa BP, Santeler SR, Pessin JE. PMID: 9738014.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    31. Inhibition of clathrin-mediated endocytosis selectively attenuates specific insulin receptor signal transduction pathways. Mol Cell Biol. 1998 Jul; 18(7):3862-70. Ceresa BP, Kao AW, Santeler SR, Pessin JE. PMID: 9632770.
      View in: PubMed   Mentions: 53     Fields:    Translation:AnimalsCells
    32. The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway. J Biol Chem. 1997 Oct 31; 272(44):28042-9. Okada S, Kao AW, Ceresa BP, Blaikie P, Margolis B, Pessin JE. PMID: 9346957.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansAnimalsCells
    33. Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways. Endocrinology. 1997 Jun; 138(6):2474-80. Kao AW, Waters SB, Okada S, Pessin JE. PMID: 9165038.
      View in: PubMed   Mentions: 17     Fields:    Translation:AnimalsCells
    34. Insulin Stimulates the Phosphorylation of the 66- and 52-Kilodalton Shc Isoforms by Distinct Pathways 1. Endocrinology. 1997 Jun 1; 138(6):2474-2480. Aimee W. Kao, Steven B. Waters, Shuichi Okada, Jeffrey E. Pessin. .
      View in: Publisher Site   Mentions:
    35. Insulin and epidermal growth factor receptors regulate distinct pools of Grb2-SOS in the control of Ras activation. J Biol Chem. 1996 Jul 26; 271(30):18224-30. Waters SB, Chen D, Kao AW, Okada S, Holt KH, Pessin JE. PMID: 8663461.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    36. Evidence for myosin motors on organelles in squid axoplasm. Proc Natl Acad Sci U S A. 1993 Dec 01; 90(23):11252-6. Bearer EL, DeGiorgis JA, Bodner RA, Kao AW, Reese TS. PMID: 8248236.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
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