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Ajay Chawla, MD, PhD

Address555 Mission Bay Blvd South
San Francisco CA 94158
Phone415-857-3709
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    Collapse Research 
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    Myeloid Cell Functions in Obesity and Diabetes.
    NIH/NIDDK R01DK101064Mar 1, 2015 - Feb 28, 2019
    Role: Principal Investigator
    Innate Immune Mechanisms of Thermogenesis
    NIH/NIDDK R01DK094641Sep 25, 2011 - Aug 31, 2020
    Role: Principal Investigator
    Immune Triggers of Tissue Regeneration
    NIH/NIAMS DP1AR064158Sep 30, 2009 - Jul 31, 2015
    Role: Principal Investigator
    Immune Triggers of Tissue Regeneration
    NIH DP1OD006415Sep 30, 2009 - Jul 31, 2014
    Role: Principal Investigator
    Nuclear receptor mechanisms controlling macrophage function in health and disease
    NIH/NIDDK R01DK081405May 20, 2009 - Mar 31, 2014
    Role: Principal Investigator
    Role of Cytokine Signaling Pathways and Macrophages in Type 2 Diabetes Mellitus
    NIH/NIDDK R01DK076760Jul 15, 2007 - Jun 30, 2012
    Role: Principal Investigator
    Transcriptional control of macrophage in atherogenesis
    NIH/NHLBI R01HL076746Apr 1, 2004 - May 31, 2015
    Role: Principal Investigator
    Role of PPARs in Atherosclerosis
    NIH/NIDDK K08DK062386Sep 15, 2002 - Jun 30, 2007
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Huo M, Huang Y, Qu D, Zhang H, Wong WT, Chawla A, Huang Y, Tian XY. Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis. FASEB J. 2017 Mar; 31(3):1097-1106. PMID: 27927724.
      View in: PubMed
    2. Man K, Loudon A, Chawla A. Immunity around the clock. Science. 2016 11 25; 354(6315):999-1003. PMID: 27885005.
      View in: PubMed
    3. Man K, Kutyavin VI, Chawla A. Tissue Immunometabolism: Development, Physiology, and Pathobiology. Cell Metab. 2017 Jan 10; 25(1):11-26. PMID: 27693378.
      View in: PubMed
    4. Odegaard JI, Lee MW, Sogawa Y, Bertholet AM, Locksley RM, Weinberg DE, Kirichok Y, Deo RC, Chawla A, et al. Perinatal Licensing of Thermogenesis by IL-33 and ST2. Cell. 2016 Aug 11; 166(4):841-854. PMID: 27453471; PMCID: PMC4985267 [Available on 08/11/17].
    5. Kutyavin VI, Chawla A. Insulin Signaling in a Bit of a Jam. Cell. 2016 Apr 07; 165(2):264-5. PMID: 27058657.
      View in: PubMed
    6. Tian XY, Ganeshan K, Hong C, Nguyen KD, Qiu Y, Kim J, Tangirala RK, Tonotonoz P, Chawla A. Thermoneutral Housing Accelerates Metabolic Inflammation to Potentiate Atherosclerosis but Not Insulin Resistance. Cell Metab. 2016 Jan 12; 23(1):165-78. PMID: 26549485; PMCID: PMC4715491 [Available on 01/12/17].
    7. Odegaard JI, Chawla A. Type 2 responses at the interface between immunity and fat metabolism. Curr Opin Immunol. 2015 Oct; 36:67-72. PMID: 26204571; PMCID: PMC4593747 [Available on 10/01/16].
    8. Xue J, Sharma V, Hsieh MH, Chawla A, Murali R, Pandol SJ, Habtezion A. Alternatively activated macrophages promote pancreatic fibrosis in chronic pancreatitis. Nat Commun. 2015 May 18; 6:7158. PMID: 25981357; PMCID: PMC4632846.
    9. Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, Yun K, Locksley RM, Chawla A. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell. 2015 Jan 15; 160(1-2):74-87. PMID: 25543153; PMCID: PMC4297518.
    10. Iqbal AJ, McNeill E, Kapellos TS, Regan-Komito D, Norman S, Burd S, Smart N, Machemer DE, Stylianou E, McShane H, Channon KM, Chawla A, Greaves DR. Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo. Blood. 2014 Oct 09; 124(15):e33-44. PMID: 25030063; PMCID: PMC4192756.
    11. Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell. 2014 Jun 05; 157(6):1292-308. PMID: 24906148; PMCID: PMC4129510.
    12. Carvalheira JB, Odegaard JI, Chawla A. A new role for the brain in metabolic control. Nat Med. 2014 May; 20(5):472-3. PMID: 24804753.
      View in: PubMed
    13. Mauer J, Chaurasia B, Goldau J, Vogt MC, Ruud J, Nguyen KD, Theurich S, Hausen AC, Schmitz J, Brönneke HS, Estevez E, Allen TL, Mesaros A, Partridge L, Febbraio MA, Chawla A, Wunderlich FT, Brüning JC. Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin. Nat Immunol. 2014 May; 15(5):423-30. PMID: 24681566; PMCID: PMC4161471.
    14. Odegaard JI, Chawla A. Old HDL learns a new (anti-inflammatory) trick. Nat Immunol. 2014 Feb; 15(2):138-9. PMID: 24448572.
      View in: PubMed
    15. Khalifeh-Soltani A, McKleroy W, Sakuma S, Cheung YY, Tharp K, Qiu Y, Turner SM, Chawla A, Stahl A, Atabai K. Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids. Nat Med. 2014 Feb; 20(2):175-83. PMID: 24441829; PMCID: PMC4273653.
    16. Ganeshan K, Chawla A. Metabolic regulation of immune responses. Annu Rev Immunol. 2014; 32:609-34. PMID: 24655299.
      View in: PubMed
    17. Odegaard JI, Ganeshan K, Chawla A. Adipose tissue macrophages: Amicus adipem? Cell Metab. 2013 Dec 03; 18(6):767-8. PMID: 24315364; PMCID: PMC3899686.
    18. Carvalheira JB, Qiu Y, Chawla A. Blood spotlight on leukocytes and obesity. Blood. 2013 Nov 07; 122(19):3263-7. PMID: 24065242; PMCID: PMC3821723.
    19. Nussbaum JC, Van Dyken SJ, von Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang HE, Locksley RM. Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. 2013 Oct 10; 502(7470):245-8. PMID: 24037376; PMCID: PMC3795960.
    20. Nguyen KD, Fentress SJ, Qiu Y, Yun K, Cox JS, Chawla A. Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science. 2013 Sep 27; 341(6153):1483-8. PMID: 23970558; PMCID: PMC3836670.
    21. Eisele NA, Ruby T, Jacobson A, Manzanillo PS, Cox JS, Lam L, Mukundan L, Chawla A, Monack DM. Salmonella require the fatty acid regulator PPARd for the establishment of a metabolic environment essential for long-term persistence. Cell Host Microbe. 2013 Aug 14; 14(2):171-182. PMID: 23954156; PMCID: PMC3785333.
    22. Goh YP, Henderson NC, Heredia JE, Red Eagle A, Odegaard JI, Lehwald N, Nguyen KD, Sheppard D, Mukundan L, Locksley RM, Chawla A. Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9914-9. PMID: 23716700; PMCID: PMC3683773.
    23. Wynn TA, Chawla A, Pollard JW. Macrophage biology in development, homeostasis and disease. Nature. 2013 Apr 25; 496(7446):445-55. PMID: 23619691; PMCID: PMC3725458.
    24. Odegaard JI, Chawla A. The immune system as a sensor of the metabolic state. Immunity. 2013 Apr 18; 38(4):644-54. PMID: 23601683; PMCID: PMC3663597.
    25. Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A. Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell. 2013 Apr 11; 153(2):376-88. PMID: 23582327; PMCID: PMC3663598.
    26. Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, Chawla A, Locksley RM. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med. 2013 Mar 11; 210(3):535-49. PMID: 23420878; PMCID: PMC3600903.
    27. Su X, Feng X, Terrando N, Yan Y, Chawla A, Koch LG, Britton SL, Matthay MA, Maze M. Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. Mol Med. 2013 Feb 08; 18:1481-90. PMID: 23296426; PMCID: PMC3576477.
    28. Odegaard JI, Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science. 2013 Jan 11; 339(6116):172-7. PMID: 23307735; PMCID: PMC3725457.
    29. Chao LC, Soto E, Hong C, Ito A, Pei L, Chawla A, Conneely OM, Tangirala RK, Evans RM, Tontonoz P. Bone marrow NR4A expression is not a dominant factor in the development of atherosclerosis or macrophage polarization in mice. J Lipid Res. 2013 Mar; 54(3):806-15. PMID: 23288947; PMCID: PMC3617954.
    30. Odegaard JI, Chawla A. Leukocyte set points in metabolic disease. F1000 Biol Rep. 2012; 4:13. PMID: 22802874; PMCID: PMC3388849.
    31. Odegaard JI, Chawla A. Connecting type 1 and type 2 diabetes through innate immunity. Cold Spring Harb Perspect Med. 2012 Mar; 2(3):a007724. PMID: 22393536; PMCID: PMC3282495.
    32. Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011 Nov 20; 480(7375):104-8. PMID: 22101429; PMCID: PMC3371761.
    33. Chawla A, Nguyen KD, Goh YP. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol. 2011 Oct 10; 11(11):738-49. PMID: 21984069; PMCID: PMC3383854.
    34. Köröskényi K, Duró E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fésüs L, Szondy Z. Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation. J Immunol. 2011 Jun 15; 186(12):7144-55. PMID: 21593381; PMCID: PMC3395167.
    35. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science. 2011 Apr 08; 332(6026):243-7. PMID: 21436399; PMCID: PMC3144160.
    36. Odegaard JI, Chawla A. Alternative macrophage activation and metabolism. Annu Rev Pathol. 2011; 6:275-97. PMID: 21034223; PMCID: PMC3381938.
    37. Ricardo-Gonzalez RR, Red Eagle A, Odegaard JI, Jouihan H, Morel CR, Heredia JE, Mukundan L, Wu D, Locksley RM, Chawla A. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22617-22. PMID: 21149710; PMCID: PMC3012500.
    38. Red Eagle A, Chawla A. In obesity and weight loss, all roads lead to the mighty macrophage. J Clin Invest. 2010 Oct; 120(10):3437-40. PMID: 20877005; PMCID: PMC2947244.
    39. Dunn SE, Bhat R, Straus DS, Sobel RA, Axtell R, Johnson A, Nguyen K, Mukundan L, Moshkova M, Dugas JC, Chawla A, Steinman L. Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity. J Exp Med. 2010 Aug 02; 207(8):1599-608. PMID: 20624891; PMCID: PMC2916127.
    40. Chawla A. Control of macrophage activation and function by PPARs. Circ Res. 2010 May 28; 106(10):1559-69. PMID: 20508200; PMCID: PMC2897247.
    41. Mukundan L, Odegaard JI, Morel CR, Heredia JE, Mwangi JW, Ricardo-Gonzalez RR, Goh YP, Eagle AR, Dunn SE, Awakuni JU, Nguyen KD, Steinman L, Michie SA, Chawla A. PPAR-delta senses and orchestrates clearance of apoptotic cells to promote tolerance. Nat Med. 2009 Nov; 15(11):1266-72. PMID: 19838202; PMCID: PMC2783696.
    42. Odegaard JI, Chawla A. Mechanisms of macrophage activation in obesity-induced insulin resistance. Nat Clin Pract Endocrinol Metab. 2008 Nov; 4(11):619-26. PMID: 18838972; PMCID: PMC3381907.
    43. Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, Goforth MH, Subramanian V, Mukundan L, Ferrante AW, Chawla A. Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab. 2008 Jun; 7(6):496-507. PMID: 18522831; PMCID: PMC2587370.
    44. Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, Red Eagle A, Vats D, Brombacher F, Ferrante AW, Chawla A. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature. 2007 Jun 28; 447(7148):1116-20. PMID: 17515919; PMCID: PMC2587297.
    45. Odegaard JI, Vats D, Zhang L, Ricardo-Gonzalez R, Smith KL, Sykes DB, Kamps MP, Chawla A. Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages. J Leukoc Biol. 2007 Mar; 81(3):711-9. PMID: 17158607; PMCID: PMC1904487.
    46. Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, Wagner RA, Greaves DR, Murray PJ, Chawla A. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006 Jul; 4(1):13-24. PMID: 16814729; PMCID: PMC1904486.
    47. Zhang L, Chawla A. Role of PPARgamma in macrophage biology and atherosclerosis. Trends Endocrinol Metab. 2004 Dec; 15(10):500-5. PMID: 15541649.
      View in: PubMed
    48. Lee CH, Chawla A, Urbiztondo N, Liao D, Boisvert WA, Evans RM, Curtiss LK. Transcriptional repression of atherogenic inflammation: modulation by PPARdelta. Science. 2003 Oct 17; 302(5644):453-7. PMID: 12970571.
      View in: PubMed
    49. Chawla A, Lee CH, Barak Y, He W, Rosenfeld J, Liao D, Han J, Kang H, Evans RM. PPARdelta is a very low-density lipoprotein sensor in macrophages. Proc Natl Acad Sci U S A. 2003 Feb 04; 100(3):1268-73. PMID: 12540828; PMCID: PMC298762.
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