Alan Wolfe

Title(s)	Recal Non-Faculty Academic, Bioengineering
School	School of Pharmacy
Address	513 Parnassus Avenue, MSB, #822 San Francisco CA 94117
Phone	415-476-2307
ORCID	0000-0002-0932-4146
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Overview

[The following career summary was generated by ChatGPT.] Throughout my career in the Bioengineering department at UCSF, I have been involved in impactful research projects focused on drug development and pharmacokinetics. My work on the schistosomicidal prodrug TPT sulfonate and the repurposing of auranofin for treating lymphatic filariasis and onchocerciasis has shown promise in addressing neglected tropical diseases. Additionally, I have contributed to the understanding of drug clearance and organ extraction ratio predictions, as well as the pharmacokinetics of nevirapine in HIV-infected adults. As a Coinvestigator on a project sponsored by the Sandler Center for Drug Discovery, I have played a vital role in identifying and optimizing bioactive principles for a new, single-dose, oral drug for schistosomiasis. My commitment to advancing research in pharmacology and drug development continues to drive my contributions to the field.

Websites

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In The News

	A liver divided (03/20/2014)
	iMPCs: Cell Reprogrammers Take Aim at Liver Disease (03/04/2014)
	Five studies you may have missed (02/28/2014)
	Groundbreaking New Study Transforms Skin Cells Into Healthy Liver Cells (02/26/2014)
	Human Skin Cells Transformed to Liver Cells, Used to Repopulate a Mouse Liver (02/24/2014)
	Repopulation of Damaged Livers With Skin-Derived Stem Cells (02/24/2014)
	Mature, functioning liver cells made from skin cells (02/24/2014)
	Un fegato nuovo dalle cellule della pelle (02/24/2014)
	Lively liver cells created, transplanted and functioning in mice (02/23/2014)
	Skin cells transformed into functioning liver cells in mouse study (02/23/2014)
	Skin-to-Liver Cell Shortcut (02/23/2014)
	Scientists Transform Skin Cells into Functioning Liver Cells (02/23/2014)

Research

Research Activities and Funding

A new, single-dose, oral drug for schistosomiasis: identifying and optimizing the bioactive principles
Sandler Center for Drug Discovery (no number)Nov 1, 2011 - Oct 31, 2012
Role: Coinvestigator
Description: Carry out in vitro and rat pharmacokinetic (PK) work to identify path(s) of metabolism. Identify metabolites and analyze rat PK data generated by contract lab.

ORNG Applications

Featured Publications

Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. PMID: 30503203; PMCID: PMC6287543.

View in: PubMed Mentions: 7 Fields:
Par Parasitology
Translation:Animals
Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Sci Rep. 2018 01 08; 8(1):92. Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. PMID: 29311658; PMCID: PMC5758798.

View in: PubMed Mentions: 2 Fields:
Sci Science
Translation:Humans Animals Cells
The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther. 2018 03; 103(3):521-525. Benet LZ, Liu S, Wolfe AR. PMID: 28762489; PMCID: PMC6364827.

View in: PubMed Mentions: 12 Fields:
Dru Drug Therapy Pha Pharmacology
Translation:Humans
Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS Res Ther. 2017 Mar 14; 14(1):12. Monera-Penduka TG, Maponga CC, Wolfe AR, Wiesner L, Morse GD, Nhachi CF. PMID: 28288665.

View in: PubMed Mentions:
Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 12; 10(12):e0005234. De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. PMID: 28036391; PMCID: PMC5201425.

View in: PubMed Mentions: 8 Fields:
Tro Tropical Medicine
Translation:Humans Animals Cells
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. PMID: 25700363; PMCID: PMC4336141.

View in: PubMed Mentions: 49 Fields:
Tro Tropical Medicine
Translation:Humans Animals Cells
Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. PMID: 24389906; PMCID: PMC4018220.

View in: PubMed Mentions: 6 Fields:
Tra Transplantation
Translation:Humans
Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. PMID: 24572354; PMCID: PMC4161230.

View in: PubMed Mentions: 132 Fields:
Sci Science
Translation:Humans Animals Cells
Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. PMID: 24030928; PMCID: PMC4018225.

View in: PubMed Mentions: 11 Fields:
Pha Pharmacology
Translation:Humans Cells CTClinical Trials
OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis. Pharmacogenet Genomics. 2013 Jul; 23(7):355-64. Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY. PMID: 23652407; PMCID: PMC3894639.

View in: PubMed Mentions: 22 Fields:
Gen Genetics Pha Pharmacology
Translation:Humans Cells
CYCLOSPORINE AND TACROLIMUS PHARMACOKINETICS IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED LIVER AND KIDNEY TRANSPLANT RECIPIENTS. Transplantation Journal. 2010 Jul 1; 90:252. TanTam TC, Frassetto FL, Barin BB, Browne BM, Wolfe WA, Stock SP, Roland RM, Benet BL. .

View in: Publisher Site Mentions:
In vitro inhibitory effects of Hypoxis obtusa and Dicoma anomala on cyp450 enzymes and p-glycoprotein. Afr J Pharm Pharmacol. 2009; 3(11):539-546. Gwaza L, Wolfe AR, Benet LZ, Guglielmo BJ, Chagwedera TE, Maponga CC, Masimirembwa CM. View Publication.
Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. J Acquir Immune Defic Syndr. 2009 Apr 15; 50(5):482-91. Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM, Women's Interagency HIV Study. PMID: 19408353; PMCID: PMC2700138.

View in: PubMed Mentions: 16 Fields:
Acq Acquired Immunodeficiency Synd
Translation:Humans
Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries. 2008 Oct 01; 2(5):379-83. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. PMID: 19745507; PMCID: PMC5385924.

View in: PubMed Mentions: 16 Fields:
Com Communicable Diseases
Translation:Humans Animals Cells
Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007 Dec; 7(12):2816-20. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. PMID: 17949460.

View in: PubMed Mentions: 45 Fields:
Tra Transplantation
Translation:Humans Cells CTClinical Trials
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. PMID: 16304193; PMCID: PMC1315979.

View in: PubMed Mentions: 54 Fields:
Ant Anti-Infective Agents
Translation:Animals
Benzo[a]pyrene diol epoxide forms covalent adducts with deoxycytidylic acid by alkylation at both exocyclic amino N(4) and ring imino N-3 positions. Chem Res Toxicol. 2004 Apr; 17(4):476-91. Wolfe AR, Smith TJ, Meehan T. PMID: 15089090.

View in: PubMed Mentions: 3 Fields:
Tox Toxicology
Translation:Cells
Trans- and cis-DNA adduct concentration in epidermis from mouse and rat skin treated ex vivo with benzo[a]pyrene diol epoxide and its corresponding chlorohydrin. Mutat Res. 2001 Jul 01; 478(1-2):199-206. Vock EH, Wolfe AR, Meehan T. PMID: 11406185.

View in: PubMed Mentions: 2 Fields:
Gen Genetics
Translation:Animals
Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes (Corrigendum). Hum Gene Ther. 1999; 10(13):322. Plank C, Tang MX, Wolfe AR, Szoka FC.
Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther. 1999 Jan 20; 10(2):319-32. Plank C, Tang MX, Wolfe AR, Szoka FC. PMID: 10022556.

View in: PubMed Mentions: 51 Fields:
Gen Genetics The Therapeutics
Translation:Humans Cells
Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol. 1998 Sep; 11(9):1057-66. Song Q, Negrete GR, Wolfe AR, Wang K, Meehan T. PMID: 9760280.

View in: PubMed Mentions: Fields:
Tox Toxicology
Translation:Cells
Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1749-54. Meehan T, Wolfe AR, Negrete GR, Song Q. PMID: 9050850; PMCID: PMC19988.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Cells
The effect of temperature on the stereochemistry of adducts and hydrolysis products derived from anti-benzo[a]pyrene diol epoxide in the presence and absence of halide ions. Polycyclic Aromatic Compounds. 1996; 10(1-4):203-210. Alan R Wolfe, Qi Song, Thomas Meehan. View Publication.
The effect of sodium ion concentration on intrastrand base-pairing in single-stranded DNA. Nucleic Acids Res. 1994 Aug 11; 22(15):3147-50. Wolfe AR, Meehan T. PMID: 8065928; PMCID: PMC310288.

View in: PubMed Mentions: 6 Fields:
Bio Biochemistry
Translation:Animals Cells
Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1371-5. Wolfe AR, Yamamoto J, Meehan T. PMID: 8108418; PMCID: PMC43160.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Cells
Halide-catalyzed cis product formation in the hydrolysis of anti-benzo[a]pyrene diol epoxide and its alkylation of poly(A). Chem Res Toxicol. 1994 Jan-Feb; 7(1):110-9. Wolfe AR, Meehan T. PMID: 8155819.

View in: PubMed Mentions: 1 Fields:
Tox Toxicology
Translation:Cells
Pyrene-modified oligodeoxynucleotides - enhanced duplex binding and stability towards exonuclease degradation in vitro. Journal of Cellular Biochemistry. 1993; 53(S17E):214. Shibata Y, Mann JS, Wolfe AR, Meehan T. View Publication.
Use of binding site neighbor-effect parameters to evaluate the interactions between adjacent ligands on a linear lattice. Effects on ligand-lattice association. J Mol Biol. 1992 Feb 20; 223(4):1063-87. Wolfe AR, Meehan T. PMID: 1538390.

View in: PubMed Mentions: 7 Fields:
Mol Molecular Biology
Translation:Cells
The formation of covalent adducts between benzo[a]pyrenediol epoxide and RNA: structural analysis by mass spectrometry. Biochemistry. 1990 Apr 24; 29(16):3966-72. Yamamoto J, Subramaniam R, Wolfe AR, Meehan T. PMID: 2354168.

View in: PubMed Mentions: 2 Fields:
Bio Biochemistry
Translation:Humans Animals Cells
Equilibrium binding of benzo[a]pyrene tetrol to synthetic polynucleotides: sequence selectivity, thermodynamic properties, and ionic strength dependence. Biochemistry. 1988 Oct 04; 27(20):7960-6. Shimer GH, Wolfe AR, Meehan T. PMID: 3207722.

View in: PubMed Mentions: 1 Fields:
Bio Biochemistry
Translation:Cells
Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA. Biochemistry. 1987 Oct 06; 26(20):6392-6. Wolfe A, Shimer GH, Meehan T. PMID: 3427013.

View in: PubMed Mentions: 140 Fields:
Bio Biochemistry
Translation:Cells
Saturated amines and diamines as substrates which inhibit beef liver mitochondrial monoamine oxidase. J Bioenerg Biomembr. 1984 Dec; 16(5-6):597-609. Von Korff RW, Wolfe AR. PMID: 6537438.

View in: PubMed Mentions: Fields:
Bio Biochemistry Met Metabolism
Translation:Animals Cells
Some Generally Unrecognized Properties of Purified Monoamine Oxidase B (Beef Liver). Journal of Pharmacy and Pharmacology. 1984; 36:4W. Von Korff RW, Wolfe AR. View Publication.
Reversible inactivation of monoamine oxidase by one-electron reduction of the flavin. 39th Fall Scientific Meeting, Midland (Michigan) Section of the American Chemical Society. 1983; 39:12. Von Korff RW, Wolfe AR. View Publication.
The effect of superoxide dismutase on phenazine methosulfate inhibition of monoamine oxidase. Developments in Biochemistry. 1982; 21:222-227. Von Korff RW, Wolfe AR. View Publication.
Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects (E. Usdin, N. Weiner, M. B. H. Youdim, Eds.). Anomalies in MAO assays using delta A249 and delta O measurements with benzylamine as substrate . 1981; 565-574. Von Korff RW, Wolfe AR. View Publication.