Alan Wolfe

Title(s)Recal Non-Faculty Academic, Bioengineering
SchoolSchool of Pharmacy
Address513 Parnassus Avenue, MSB, #822
San Francisco CA 94143
ORCID ORCID Icon0000-0002-0932-4146 Additional info
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    [The following career summary was generated by ChatGPT.] Throughout my career in the Bioengineering department at UCSF, I have been involved in impactful research projects focused on drug development and pharmacokinetics. My work on the schistosomicidal prodrug TPT sulfonate and the repurposing of auranofin for treating lymphatic filariasis and onchocerciasis has shown promise in addressing neglected tropical diseases. Additionally, I have contributed to the understanding of drug clearance and organ extraction ratio predictions, as well as the pharmacokinetics of nevirapine in HIV-infected adults. As a Coinvestigator on a project sponsored by the Sandler Center for Drug Discovery, I have played a vital role in identifying and optimizing bioactive principles for a new, single-dose, oral drug for schistosomiasis. My commitment to advancing research in pharmacology and drug development continues to drive my contributions to the field.

    Collapse Research 
    Collapse Research Activities and Funding
    A new, single-dose, oral drug for schistosomiasis: identifying and optimizing the bioactive principles
    Sandler Center for Drug Discovery (no number)Nov 1, 2011 - Oct 31, 2012
    Role: Coinvestigator
    Description: Carry out in vitro and rat pharmacokinetic (PK) work to identify path(s) of metabolism. Identify metabolites and analyze rat PK data generated by contract lab.

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. Int J Parasitol Drugs Drug Resist. 2018 12; 8(3):571-586. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. PMID: 30503203; PMCID: PMC6287543.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    2. Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Sci Rep. 2018 01 08; 8(1):92. Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. PMID: 29311658; PMCID: PMC5758798.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clin Pharmacol Ther. 2018 03; 103(3):521-525. Benet LZ, Liu S, Wolfe AR. PMID: 28762489; PMCID: PMC6364827.
      View in: PubMed   Mentions: 13     Fields:    Translation:Humans
    4. Effect of Moringa oleifera Lam. leaf powder on the pharmacokinetics of nevirapine in HIV-infected adults: a one sequence cross-over study. AIDS Res Ther. 2017 Mar 14; 14(1):12. Monera-Penduka TG, Maponga CC, Wolfe AR, Wiesner L, Morse GD, Nhachi CF. PMID: 28288665.
      View in: PubMed   Mentions:
    5. Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions. PLoS Negl Trop Dis. 2016 12; 10(12):e0005234. De Muylder G, Vanhollebeke B, Caljon G, Wolfe AR, McKerrow J, Dujardin JC. PMID: 28036391; PMCID: PMC5201425.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    6. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003534. Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. PMID: 25700363; PMCID: PMC4336141.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    7. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Transplantation. 2014 Mar 27; 97(6):702-7. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. PMID: 24389906; PMCID: PMC4018220.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    8. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Nature. 2014 Apr 03; 508(7494):93-7. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. PMID: 24572354; PMCID: PMC4161230.
      View in: PubMed   Mentions: 133     Fields:    Translation:HumansAnimalsCells
    9. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Biopharm Drug Dispos. 2013 Nov; 34(8):442-51. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. PMID: 24030928; PMCID: PMC4018225.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCellsCTClinical Trials
    10. OATP1B1-related drug-drug and drug-gene interactions as potential risk factors for cerivastatin-induced rhabdomyolysis. Pharmacogenet Genomics. 2013 Jul; 23(7):355-64. Tamraz B, Fukushima H, Wolfe AR, Kaspera R, Totah RA, Floyd JS, Ma B, Chu C, Marciante KD, Heckbert SR, Psaty BM, Kroetz DL, Kwok PY. PMID: 23652407; PMCID: PMC3894639.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
      View in: Publisher Site   Mentions:
    12. In vitro inhibitory effects of Hypoxis obtusa and Dicoma anomala on cyp450 enzymes and p-glycoprotein. Afr J Pharm Pharmacol. 2009; 3(11):539-546. Gwaza L, Wolfe AR, Benet LZ, Guglielmo BJ, Chagwedera TE, Maponga CC, Masimirembwa CM. View Publication.
    13. Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. J Acquir Immune Defic Syndr. 2009 Apr 15; 50(5):482-91. Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM, Women's Interagency HIV Study. PMID: 19408353; PMCID: PMC2700138.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    14. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. J Infect Dev Ctries. 2008 Oct 01; 2(5):379-83. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. PMID: 19745507; PMCID: PMC5385924.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    15. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Am J Transplant. 2007 Dec; 7(12):2816-20. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. PMID: 17949460.
      View in: PubMed   Mentions: 43     Fields:    Translation:HumansCellsCTClinical Trials
    16. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Antimicrob Agents Chemother. 2005 Dec; 49(12):5160-1. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. PMID: 16304193; PMCID: PMC1315979.
      View in: PubMed   Mentions: 57     Fields:    Translation:Animals
    17. Benzo[a]pyrene diol epoxide forms covalent adducts with deoxycytidylic acid by alkylation at both exocyclic amino N(4) and ring imino N-3 positions. Chem Res Toxicol. 2004 Apr; 17(4):476-91. Wolfe AR, Smith TJ, Meehan T. PMID: 15089090.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    18. Trans- and cis-DNA adduct concentration in epidermis from mouse and rat skin treated ex vivo with benzo[a]pyrene diol epoxide and its corresponding chlorohydrin. Mutat Res. 2001 Jul 01; 478(1-2):199-206. Vock EH, Wolfe AR, Meehan T. PMID: 11406185.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    19. Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes (Corrigendum). Hum Gene Ther. 1999; 10(13):322. Plank C, Tang MX, Wolfe AR, Szoka FC.
    20. Branched cationic peptides for gene delivery: role of type and number of cationic residues in formation and in vitro activity of DNA polyplexes. Hum Gene Ther. 1999 Jan 20; 10(2):319-32. Plank C, Tang MX, Wolfe AR, Szoka FC. PMID: 10022556.
      View in: PubMed   Mentions: 52     Fields:    Translation:HumansCells
    21. Synthesis and characterization of bay region halohydrins derived from Benzo[a]pyrene diol epoxide and their role as intermediates in halide-catalyzed cis adduct formation. Chem Res Toxicol. 1998 Sep; 11(9):1057-66. Song Q, Negrete GR, Wolfe AR, Wang K, Meehan T. PMID: 9760280.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    22. Benzo[a]pyrene diol epoxide-DNA cis adduct formation through a trans chlorohydrin intermediate. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1749-54. Meehan T, Wolfe AR, Negrete GR, Song Q. PMID: 9050850; PMCID: PMC19988.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    23. The effect of temperature on the stereochemistry of adducts and hydrolysis products derived from anti-benzo[a]pyrene diol epoxide in the presence and absence of halide ions. Polycyclic Aromatic Compounds. 1996; 10(1-4):203-210. Alan R Wolfe, Qi Song, Thomas Meehan. View Publication.
    24. The effect of sodium ion concentration on intrastrand base-pairing in single-stranded DNA. Nucleic Acids Res. 1994 Aug 11; 22(15):3147-50. Wolfe AR, Meehan T. PMID: 8065928; PMCID: PMC310288.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    25. Chloride ions catalyze the formation of cis adducts in the binding of anti-benzo[a]pyrene diol epoxide to nucleic acids. Proc Natl Acad Sci U S A. 1994 Feb 15; 91(4):1371-5. Wolfe AR, Yamamoto J, Meehan T. PMID: 8108418; PMCID: PMC43160.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    26. Halide-catalyzed cis product formation in the hydrolysis of anti-benzo[a]pyrene diol epoxide and its alkylation of poly(A). Chem Res Toxicol. 1994 Jan-Feb; 7(1):110-9. Wolfe AR, Meehan T. PMID: 8155819.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    27. Pyrene-modified oligodeoxynucleotides - enhanced duplex binding and stability towards exonuclease degradation in vitro. Journal of Cellular Biochemistry. 1993; 53(S17E):214. Shibata Y, Mann JS, Wolfe AR, Meehan T. View Publication.
    28. Use of binding site neighbor-effect parameters to evaluate the interactions between adjacent ligands on a linear lattice. Effects on ligand-lattice association. J Mol Biol. 1992 Feb 20; 223(4):1063-87. Wolfe AR, Meehan T. PMID: 1538390.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    29. The formation of covalent adducts between benzo[a]pyrenediol epoxide and RNA: structural analysis by mass spectrometry. Biochemistry. 1990 Apr 24; 29(16):3966-72. Yamamoto J, Subramaniam R, Wolfe AR, Meehan T. PMID: 2354168.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    30. Equilibrium binding of benzo[a]pyrene tetrol to synthetic polynucleotides: sequence selectivity, thermodynamic properties, and ionic strength dependence. Biochemistry. 1988 Oct 04; 27(20):7960-6. Shimer GH, Wolfe AR, Meehan T. PMID: 3207722.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    31. Polycyclic aromatic hydrocarbons physically intercalate into duplex regions of denatured DNA. Biochemistry. 1987 Oct 06; 26(20):6392-6. Wolfe A, Shimer GH, Meehan T. PMID: 3427013.
      View in: PubMed   Mentions: 145     Fields:    Translation:Cells
    32. Some Generally Unrecognized Properties of Purified Monoamine Oxidase B (Beef Liver). Journal of Pharmacy and Pharmacology. 1984; 36:4W. Von Korff RW, Wolfe AR. View Publication.
    33. Saturated amines and diamines as substrates which inhibit beef liver mitochondrial monoamine oxidase. J Bioenerg Biomembr. 1984 Dec; 16(5-6):597-609. Von Korff RW, Wolfe AR. PMID: 6537438.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    34. Reversible inactivation of monoamine oxidase by one-electron reduction of the flavin. 39th Fall Scientific Meeting, Midland (Michigan) Section of the American Chemical Society. 1983; 39:12. Von Korff RW, Wolfe AR. View Publication.
    35. The effect of superoxide dismutase on phenazine methosulfate inhibition of monoamine oxidase. Developments in Biochemistry. 1982; 21:222-227. Von Korff RW, Wolfe AR. View Publication.
    36. Function and Regulation of Monoamine Enzymes: Basic and Clinical Aspects (E. Usdin, N. Weiner, M. B. H. Youdim, Eds.). Anomalies in MAO assays using delta A249 and delta O measurements with benzylamine as substrate . 1981; 565-574. Von Korff RW, Wolfe AR. View Publication.
    Alan's Networks
    Concepts (223)
    Derived automatically from this person's publications.
    Co-Authors (23)
    People in Profiles who have published with this person.
    Similar People (60)
    People who share similar concepts with this person.
    Same Department
    Search Department