Aleksandra Leligdowicz, MD, PhD

Title(s)Postdoctoral Scholar, Cardiovascular Research Inst
SchoolSchool of Medicine
Address513 Parnassus Ave, HSE
San Francisco CA 94143
ORCID ORCID Icon0000-0001-6055-4644 Additional info
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    Collapse Biography 
    Collapse Education and Training
    University of TorontoFellowship2015Interdepartmental Division of Critical Care Medicine
    University of British ColumbiaResidency2013Internal Medicine
    McGill UniversityMDCM2010Faculty of Medicine
    Oxford UniversityDPhil2008Weatherall Institute of Molecular Medicine
    University of ManitobaBSc distinction2002Faculty of Science

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis. Am J Physiol Lung Cell Mol Physiol. 2020 Dec 23. Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell CA, Matthay MA. PMID: 33355521.
      View in: PubMed   Mentions:    Fields:    
    2. Biological Mechanisms of COVID-19 Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2020 12 01; 202(11):1489-1491. Matthay MA, Leligdowicz A, Liu KD. PMID: 32997945.
      View in: PubMed   Mentions:    Fields:    Translation:HumansPHPublic Health
    3. Global Absence and Targeting of Protective Immune States in Severe COVID-19. bioRxiv. 2020 Oct 29. Combes AJ, Courau T, Kuhn NF, Hu KH, Ray A, Chen WS, Cleary SJ, Chew NW, Kushnoor D, Reeder GC, Shen A, Tsui J, Hiam-Galvez KJ, Muñoz-Sandoval P, Zhu WS, Lee DS, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik CR, Loudermilk RP, Wilson MR, Ye CJ, Fragiadakis GK, Looney MR, Chan V, Ward A, Carrillo S, Matthay M, Erle DJ, Woodruff PG, Langelier C, Kangelaris K, Hendrickson CM, Calfee C, Rao AA, Krummel MF. PMID: 33140050.
      View in: PubMed   Mentions:
    4. Global Absence and Targeting of Protective Immune States in Severe COVID-19. Res Sq. 2020 Oct 28. Krummel M, Combes A, Courau T, Kuhn N, Hu K, Ray A, Chen W, Cleary S, Chew N, Kushnoor D, Reeder G, Shen A, Tsui J, Hiam K, Sandoval PM, Zhu W, Lee D, Sun Y, You R, Magnen M, Rodriguez L, Leligdowicz A, Zamecnik C, Loudermilk R, Wilson M, Ye C, Fragiadakis G, Looney M, Chan V, Ward A, Carrillo S, Matthay M, Erle D, Woodruff P, Langelier C, Kangelaris K, Hendrickson C, Calfee C, Rao A. PMID: 33140041.
      View in: PubMed   Mentions:
    5. Using best subset regression to identify clinical characteristics and biomarkers associated with sepsis-associated acute kidney injury. Am J Physiol Renal Physiol. 2020 12 01; 319(6):F979-F987. Kwong YD, Mehta KM, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson C, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD. PMID: 33044866.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung. Intensive Care Med Exp. 2020 Sep 21; 8(1):56. Leligdowicz A, Ross JT, Nesseler N, Matthay MA. PMID: 32955627.
      View in: PubMed   Mentions:
    7. The ex vivo perfused human lung is resistant to injury by high-dose S. pneumoniae bacteremia. Am J Physiol Lung Cell Mol Physiol. 2020 08 01; 319(2):L218-L227. Ross JT, Nesseler N, Leligdowicz A, Zemans RL, Mahida RY, Minus E, Langelier C, Gotts JE, Matthay MA. PMID: 32519893.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    8. The Challenge and the Promise of Identifying More Homogeneous Subgroups in Acute Respiratory Distress Syndrome. Crit Care Med. 2019 12; 47(12):1806-1808. Leligdowicz A. PMID: 31738249.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Severe lactic acidosis due to excessive consumption of Cellucor C4 exercise supplement. Canadian Journal of Respiratory Critical Care and Sleep Medicine. 2019 Apr 19; 1-4. Jason Rajchgot, Mika Hamilton, David K. Wong, Sandra Fischer, Aleksandra Leligdowicz. .
      View in: Publisher Site   Mentions:
    10. Heterogeneity in sepsis: new biological evidence with clinical applications. Crit Care. 2019 Mar 09; 23(1):80. Leligdowicz A, Matthay MA. PMID: 30850013.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    11. AIMing Immunomodulation Therapy at Sepsis. Am J Respir Cell Mol Biol. 2019 Mar; 60(3):253-254. Leligdowicz A, Matthay MA. PMID: 30365342.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    12. Heterogeneity in Sepsis: New Biological Evidence with Clinical Applications. Annual Update in Intensive Care and Emergency Medicine 2019. 2019 Jan 1; 523-535. A. Leligdowicz, M. A. Matthay. .
      View in: Publisher Site   Mentions:
    13. Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness. Malar J. 2018 Oct 10; 17(1):353. McDonald CR, Weckman A, Richard-Greenblatt M, Leligdowicz A, Kain KC. PMID: 30305137.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. . 2018 11 01; 315(5):L638-L644. Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA. PMID: 30024307.
      View in: PubMed   Mentions:
    15. Erratum for Bansal et al., "Rectal and Naris Swabs: Practical and Informative Samples for Analyzing the Microbiota of Critically Ill Patients". mSphere. 2018 May-Jun; 3(3). Bansal S, Nguyen JP, Leligdowicz A, Zhang Y, Kain KC, Ricciuto DR, Coburn B. PMID: 31329809.
      View in: PubMed   Mentions:    Fields:    
    16. Rectal and Naris Swabs: Practical and Informative Samples for Analyzing the Microbiota of Critically Ill Patients. mSphere. 2018 06 13; 3(3). Bansal S, Nguyen JP, Leligdowicz A, Zhang Y, Kain KC, Ricciuto DR, Coburn B. PMID: 29898981.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. Endothelial Activation: The Ang/Tie Axis in Sepsis. Front Immunol. 2018; 9:838. Leligdowicz A, Richard-Greenblatt M, Wright J, Crowley VM, Kain KC. PMID: 29740443.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    18. HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS. 2018 03 27; 32(6):709-714. de Silva TI, Leligdowicz A, Carlson J, Garcia-Knight M, Onyango C, Miller N, Yindom LM, Hué S, Jaye A, Dong T, Cotten M, Rowland-Jones SL. PMID: 29369160.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    19. Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis. J Crit Care. 2018 10; 47:310-319. Mandelzweig K, Leligdowicz A, Murthy S, Lalitha R, Fowler RA, Adhikari NKJ. PMID: 29426584.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    20. Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. PLoS One. 2017; 12(4):e0175130. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC. PMID: 28419100.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. Development of an intensive care unit resource assessment survey for the care of critically ill patients in resource-limited settings. J Crit Care. 2017 04; 38:172-176. Leligdowicz A, Bhagwanjee S, Diaz JV, Xiong W, Marshall JC, Fowler RA, Adhikari NK. PMID: 27918902.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    22. Who Says There Is No "I" in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):911-912. Bartz RR, Gantner D, Gordon AC, Leligdowicz A, McNamee JJ, Murthy S, Nichol A, Webb S. PMID: 27689708.
      View in: PubMed   Mentions:    Fields:    
    23. Ebola virus disease and critical illness. Crit Care. 2016 Jul 29; 20(1):217. Leligdowicz A, Fischer WA, Uyeki TM, Fletcher TE, Adhikari NK, Portella G, Lamontagne F, Clement C, Jacob ST, Rubinson L, Vanderschuren A, Hajek J, Murthy S, Ferri M, Crozier I, Ibrahima E, Lamah MC, Schieffelin JS, Brett-Major D, Bausch DG, Shindo N, Chan AK, O'Dempsey T, Mishra S, Jacobs M, Dickson S, Lyon GM, Fowler RA. PMID: 27468829.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    24. Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. Eur J Immunol. 2015 Sep; 45(9):2701. Jallow S, Leligdowicz A, Kramer HB, Onyango C, Cotten M, Wright C, Whittle HC, McMichael A, Dong T, Kessler BM, Rowland-Jones SL. PMID: 26343564.
      View in: PubMed   Mentions:    Fields:    
    25. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. Eur J Immunol. 2015 Aug; 45(8):2232-42. Jallow S, Leligdowicz A, Kramer HB, Onyango C, Cotten M, Wright C, Whittle HC, McMichael A, Dong T, Kessler BM, Rowland-Jones SL. PMID: 26018465.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    26. Extracorporeal life support for severe acute respiratory distress syndrome. Curr Opin Crit Care. 2015 Feb; 21(1):13-9. Leligdowicz A, Fan E. PMID: 25517890.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    27. Intensive care unit capacity in low-income countries: a systematic review. PLoS One. 2015; 10(1):e0116949. Murthy S, Leligdowicz A, Adhikari NK. PMID: 25617837.
      View in: PubMed   Mentions: 49     Fields:    Translation:Humans
    28. 142. Critical Care Medicine. 2014 Dec 1; 42(12):a1394. Aleksandra Leligdowicz, Srinivas Murthy, Neill Adhikari. .
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    29. Is nosocomial infection really the major cause of death in sepsis? Crit Care. 2014 Oct 01; 18(5):540. Goldenberg NM, Leligdowicz A, Slutsky AS, Friedrich JO, Lee WL. PMID: 25672933.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    30. Altered innate immune development in HIV-exposed uninfected infants. . 2014 Jul 01; 66(3):245-255. Reikie BA, Adams RCM, Leligdowicz A, Ho K, Naidoo S, Rusk CE, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR. PMID: 24732876.
      View in: PubMed   Mentions:
    31. Association between source of infection and hospital mortality in patients who have septic shock. Am J Respir Crit Care Med. 2014 May 15; 189(10):1204-13. Leligdowicz A, Dodek PM, Norena M, Wong H, Kumar A, Kumar A. PMID: 24635548.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    32. The role of CD8+ T-cell responses in the pathogenesis of HIV-2, a naturally contained human retroviral infection. Journal of Infection. 2013 Oct 1; 67(4):344. Thushan de Silva, Yanchun Peng, Aleksandra Leligdowicz, Irfan Zaidi, Lucy Li, Harry Griffin, Marie-Eve Blais, Tim Vincent, Mavinga Saraiva, Louis-Marie Yindom, Carla van Tienen, Assan Jaye, Hilton Whittle, Tao Dong, Sarah Rowland-Jones. .
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    33. Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection. Blood. 2013 May 23; 121(21):4330-9. de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais ME, Vincent T, Saraiva M, Yindom LM, van Tienen C, Easterbrook P, Jaye A, Whittle H, Dong T, Rowland-Jones SL. PMID: 23558015.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    34. Effect of HIV-2 infection on HIV-1 disease progression. N Engl J Med. 2012 11 15; 367(20):1961-2; author reply 1962-3. de Silva T, Leligdowicz A, Rowland-Jones S. PMID: 23150974.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    35. Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS One. 2012; 7(9):e44763. Reikie BA, Adams RC, Ruck CE, Ho K, Leligdowicz A, Pillay S, Naidoo S, Fortuno ES, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR. PMID: 23028609.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    36. Multilayered defense in HLA-B51-associated HIV viral control. J Immunol. 2011 Jul 15; 187(2):684-91. Zhang Y, Peng Y, Yan H, Xu K, Saito M, Wu H, Chen X, Ranasinghe S, Kuse N, Powell T, Zhao Y, Li W, Zhang X, Feng X, Li N, Leligdowicz A, Xu X, John M, Takiguchi M, McMichael A, Rowland-Jones S, Dong T. PMID: 21670313.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    37. Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. Eur J Immunol. 2010 Jul; 40(7):1963-72. Leligdowicz A, Onyango C, Yindom LM, Peng Y, Cotten M, Jaye A, McMichael A, Whittle H, Dong T, Rowland-Jones S. PMID: 20411566.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    38. Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. J Virol. 2010 Aug; 84(16):8202-8. Yindom LM, Leligdowicz A, Martin MP, Gao X, Qi Y, Zaman SM, van der Loeff MS, van Tienen C, Jaye A, Aveika A, Worwui A, Diatta M, Vincent T, Whittle HC, Rowland-Jones SL, Walton R, Carrington M. PMID: 20519398.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    39. HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine. 2010 May 26; 28 Suppl 2:B60-7. Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H, Nakayama EE, Shioda T, de Silva T, Townend J, Jaye A, Whittle H, Rowland-Jones S, Cotten M. PMID: 20510746.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    40. Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village. Retrovirology. 2010 May 19; 7:46. van der Loeff MF, Larke N, Kaye S, Berry N, Ariyoshi K, Alabi A, van Tienen C, Leligdowicz A, Sarge-Njie R, da Silva Z, Jaye A, Ricard D, Vincent T, Jones SR, Aaby P, Jaffar S, Whittle H. PMID: 20482865.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    41. Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau. . 2010 Apr; 53(5):640-7. Tienen Cv, van der Loeff MS, Zaman SM, Vincent T, Sarge-Njie R, Peterson I, Leligdowicz A, Jaye A, Rowland-Jones S, Aaby P, Whittle H. PMID: 19841588.
      View in: PubMed   Mentions:
    42. Direct relationship between virus load and systemic immune activation in HIV-2 infection. J Infect Dis. 2010 Jan 01; 201(1):114-22. Leligdowicz A, Feldmann J, Jaye A, Cotten M, Dong T, McMichael A, Whittle H, Rowland-Jones S. PMID: 19938978.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    43. Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression. J Virol. 2009 Dec; 83(24):12968-72. Feldmann J, Leligdowicz A, Jaye A, Dong T, Whittle H, Rowland-Jones SL. PMID: 19812166.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    44. Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau. Clin Infect Dis. 2009 Jun 15; 48(12):1790-3. Jallow S, Vincent T, Leligdowicz A, De Silva T, Van Tienen C, Alabi A, Sarge-Njie R, Aaby P, Corrah T, Whittle H, Jaye A, Vanham G, Rowland-Jones S, Janssens W. PMID: 19438401.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    45. 139 HIV-2 Capsids Distinguishing High and Low Virus Load Patients in a West African Community Cohort. JAIDS Journal of Acquired Immune Deficiency Syndromes. 2009 Jun 1; 51:&na;. Clayton Onyango, Aleksandra Leligdowicz, Masaru Yokoyama, Hironori Sato, Haihan Song, Emi Nakayama, Tatsuo Shioda, Assan Jaye, Hilton Whittle, Sarah Rowland-Jones, Matthew Cotten. .
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    46. Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. J Clin Microbiol. 2008 Aug; 46(8):2723-30. Mendy ME, Kaye S, Le Roux E, Kirk GD, Jeng-Barry A, McConkey S, Cotten M, Kuniholm MH, Leligdowicz A, Hainaut P, Rowland-Jones S, Whittle H. PMID: 18508941.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    47. Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection. Expert Rev Vaccines. 2008 Apr; 7(3):319-31. Leligdowicz A, Rowland-Jones S. PMID: 18393602.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    48. Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. J Clin Invest. 2007 Oct; 117(10):3067-74. Leligdowicz A, Yindom LM, Onyango C, Sarge-Njie R, Alabi A, Cotten M, Vincent T, da Costa C, Aaby P, Jaye A, Dong T, McMichael A, Whittle H, Rowland-Jones S. PMID: 17823657.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    49. Vaccinia scars associated with improved survival among adults in rural Guinea-Bissau. PLoS One. 2006 Dec 20; 1:e101. Jensen ML, Dave S, Schim van der Loeff M, da Costa C, Vincent T, Leligdowicz A, Benn CS, Roth A, Ravn H, Lisse IM, Whittle H, Aaby P. PMID: 17183634.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    50. HIV-2 gene product-specific T cell responses and viraemia control. Retrovirology. 2006 Dec 1; 3(Suppl 1):s35. Aleksandra Leligdowicz, Louis-Marie Yindom, Assan Jaye, Tao Dong, Abraham Alabi, Ramu Sarge-N'jie, Harr Njai, Andrew McMichael, Hilton Whittle, Sarah Rowland-Jones. .
      View in: Publisher Site   Mentions:
    51. Identification of four novel HLA-A alleles from an East African population by high-resolution sequence-based typing. Hum Immunol. 2006 Oct; 67(10):833-8. Gill KK, Leligdowicz A, Luo M, Bielawny T, Brunham R, Plummer FA. PMID: 17055361.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    52. Challenges in diagnosis, treatment and follow-up of patients presenting with central nervous system infections in a resource-limited setting. Mcgill J Med. 2006 Jan; 9(1):39-48. Leligdowicz A, Katwere M, Piloya T, Ronald A, Kambugu A, Katabira E. PMID: 19529809.
      View in: PubMed   Mentions:
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