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Aleksandra Leligdowicz, MD, PhD

Title(s)Postdoctoral Scholar, Cardiovascular Research Inst
SchoolSchool of Medicine
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    Collapse Biography 
    Collapse Education and Training
    University of TorontoFellowship2015Interdepartmental Division of Critical Care Medicine
    University of British ColumbiaResidency2013Internal Medicine
    McGill UniversityMDCM2010Faculty of Medicine
    Oxford UniversityDPhil2008Weatherall Institute of Molecular Medicine
    University of ManitobaBSc distinction2002Faculty of Science

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Leligdowicz A, Matthay MA. Heterogeneity in sepsis: new biological evidence with clinical applications. Crit Care. 2019 Mar 09; 23(1):80. PMID: 30850013.
      View in: PubMed
    2. Leligdowicz A, Matthay MA. AIMing Immunomodulation Therapy at Sepsis. Am J Respir Cell Mol Biol. 2018 Oct 26. PMID: 30365342.
      View in: PubMed
    3. McDonald CR, Weckman A, Richard-Greenblatt M, Leligdowicz A, Kain KC. Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness. Malar J. 2018 Oct 10; 17(1):353. PMID: 30305137.
      View in: PubMed
    4. Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA. Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 01; 315(5):L638-L644. PMID: 30024307.
      View in: PubMed
    5. Bansal S, Nguyen JP, Leligdowicz A, Zhang Y, Kain KC, Ricciuto DR, Coburn B. Rectal and Naris Swabs: Practical and Informative Samples for Analyzing the Microbiota of Critically Ill Patients. mSphere. 2018 06 13; 3(3). PMID: 29898981.
      View in: PubMed
    6. Leligdowicz A, Richard-Greenblatt M, Wright J, Crowley VM, Kain KC. Endothelial Activation: The Ang/Tie Axis in Sepsis. Front Immunol. 2018; 9:838. PMID: 29740443.
      View in: PubMed
    7. de Silva TI, Leligdowicz A, Carlson J, Garcia-Knight M, Onyango C, Miller N, Yindom LM, Hué S, Jaye A, Dong T, Cotten M, Rowland-Jones SL. HLA-associated polymorphisms in the HIV-2 capsid highlight key differences between HIV-1 and HIV-2 immune adaptation. AIDS. 2018 Mar 27; 32(6):709-714. PMID: 29369160.
      View in: PubMed
    8. Mandelzweig K, Leligdowicz A, Murthy S, Lalitha R, Fowler RA, Adhikari NKJ. Non-invasive ventilation in children and adults in low- and low-middle income countries: A systematic review and meta-analysis. J Crit Care. 2018 Oct; 47:310-319. PMID: 29426584.
      View in: PubMed
    9. Leligdowicz A, Conroy AL, Hawkes M, Zhong K, Lebovic G, Matthay MA, Kain KC. Validation of two multiplex platforms to quantify circulating markers of inflammation and endothelial injury in severe infection. PLoS One. 2017; 12(4):e0175130. PMID: 28419100.
      View in: PubMed
    10. Leligdowicz A, Bhagwanjee S, Diaz JV, Xiong W, Marshall JC, Fowler RA, Adhikari NK. Development of an intensive care unit resource assessment survey for the care of critically ill patients in resource-limited settings. J Crit Care. 2017 04; 38:172-176. PMID: 27918902.
      View in: PubMed
    11. Bartz RR, Gantner D, Gordon AC, Leligdowicz A, McNamee JJ, Murthy S, Nichol A, Webb S. Who Says There Is No "I" in Team? Achieving Individual Success in Collaborative Clinical Research in Critical Care. Am J Respir Crit Care Med. 2016 Oct 01; 194(7):911-912. PMID: 27689708.
      View in: PubMed
    12. Leligdowicz A, Fischer WA, Uyeki TM, Fletcher TE, Adhikari NK, Portella G, Lamontagne F, Clement C, Jacob ST, Rubinson L, Vanderschuren A, Hajek J, Murthy S, Ferri M, Crozier I, Ibrahima E, Lamah MC, Schieffelin JS, Brett-Major D, Bausch DG, Shindo N, Chan AK, O'Dempsey T, Mishra S, Jacobs M, Dickson S, Lyon GM, Fowler RA. Ebola virus disease and critical illness. Crit Care. 2016 Jul 29; 20(1):217. PMID: 27468829.
      View in: PubMed
    13. Jallow S, Leligdowicz A, Kramer HB, Onyango C, Cotten M, Wright C, Whittle HC, McMichael A, Dong T, Kessler BM, Rowland-Jones SL. Correction. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. Eur J Immunol. 2015 Sep; 45(9):2701. PMID: 26343564.
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    14. Jallow S, Leligdowicz A, Kramer HB, Onyango C, Cotten M, Wright C, Whittle HC, McMichael A, Dong T, Kessler BM, Rowland-Jones SL. The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of the epitope generated. Eur J Immunol. 2015 Aug; 45(8):2232-42. PMID: 26018465.
      View in: PubMed
    15. Leligdowicz A, Fan E. Extracorporeal life support for severe acute respiratory distress syndrome. Curr Opin Crit Care. 2015 Feb; 21(1):13-9. PMID: 25517890.
      View in: PubMed
    16. Murthy S, Leligdowicz A, Adhikari NK. Intensive care unit capacity in low-income countries: a systematic review. PLoS One. 2015; 10(1):e0116949. PMID: 25617837.
      View in: PubMed
    17. Goldenberg NM, Leligdowicz A, Slutsky AS, Friedrich JO, Lee WL. Is nosocomial infection really the major cause of death in sepsis? Crit Care. 2014 Oct 01; 18(5):540. PMID: 25672933; PMCID: PMC4331295.
      View in: PubMed, PubMed Central
    18. Reikie BA, Adams RCM, Leligdowicz A, Ho K, Naidoo S, Rusk CE, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR. Altered innate immune development in HIV-exposed uninfected infants. J Acquir Immune Defic Syndr. 2014 Jul 01; 66(3):245-255. PMID: 24732876.
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    19. Leligdowicz A, Dodek PM, Norena M, Wong H, Kumar A, Kumar A. Association between source of infection and hospital mortality in patients who have septic shock. Am J Respir Crit Care Med. 2014 May 15; 189(10):1204-13. PMID: 24635548.
      View in: PubMed
    20. de Silva TI, Peng Y, Leligdowicz A, Zaidi I, Li L, Griffin H, Blais ME, Vincent T, Saraiva M, Yindom LM, van Tienen C, Easterbrook P, Jaye A, Whittle H, Dong T, Rowland-Jones SL. Correlates of T-cell-mediated viral control and phenotype of CD8(+) T cells in HIV-2, a naturally contained human retroviral infection. Blood. 2013 May 23; 121(21):4330-9. PMID: 23558015.
      View in: PubMed
    21. de Silva T, Leligdowicz A, Rowland-Jones S. Effect of HIV-2 infection on HIV-1 disease progression. N Engl J Med. 2012 11 15; 367(20):1961-2; author reply 1962-3. PMID: 23150974.
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    22. Reikie BA, Adams RC, Ruck CE, Ho K, Leligdowicz A, Pillay S, Naidoo S, Fortuno ES, de Beer C, Preiser W, Cotton MF, Speert DP, Esser M, Kollmann TR. Ontogeny of Toll-like receptor mediated cytokine responses of South African infants throughout the first year of life. PLoS One. 2012; 7(9):e44763. PMID: 23028609; PMCID: PMC3441420.
      View in: PubMed, PubMed Central
    23. Zhang Y, Peng Y, Yan H, Xu K, Saito M, Wu H, Chen X, Ranasinghe S, Kuse N, Powell T, Zhao Y, Li W, Zhang X, Feng X, Li N, Leligdowicz A, Xu X, John M, Takiguchi M, McMichael A, Rowland-Jones S, Dong T. Multilayered defense in HLA-B51-associated HIV viral control. J Immunol. 2011 Jul 15; 187(2):684-91. PMID: 21670313; PMCID: PMC3166850.
      View in: PubMed, PubMed Central
    24. Leligdowicz A, Onyango C, Yindom LM, Peng Y, Cotten M, Jaye A, McMichael A, Whittle H, Dong T, Rowland-Jones S. Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection. Eur J Immunol. 2010 Jul; 40(7):1963-72. PMID: 20411566.
      View in: PubMed
    25. Yindom LM, Leligdowicz A, Martin MP, Gao X, Qi Y, Zaman SM, van der Loeff MS, van Tienen C, Jaye A, Aveika A, Worwui A, Diatta M, Vincent T, Whittle HC, Rowland-Jones SL, Walton R, Carrington M. Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa. J Virol. 2010 Aug; 84(16):8202-8. PMID: 20519398; PMCID: PMC2916551.
      View in: PubMed, PubMed Central
    26. Onyango CO, Leligdowicz A, Yokoyama M, Sato H, Song H, Nakayama EE, Shioda T, de Silva T, Townend J, Jaye A, Whittle H, Rowland-Jones S, Cotten M. HIV-2 capsids distinguish high and low virus load patients in a West African community cohort. Vaccine. 2010 May 26; 28 Suppl 2:B60-7. PMID: 20510746.
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    27. van der Loeff MF, Larke N, Kaye S, Berry N, Ariyoshi K, Alabi A, van Tienen C, Leligdowicz A, Sarge-Njie R, da Silva Z, Jaye A, Ricard D, Vincent T, Jones SR, Aaby P, Jaffar S, Whittle H. Undetectable plasma viral load predicts normal survival in HIV-2-infected people in a West African village. Retrovirology. 2010 May 19; 7:46. PMID: 20482865; PMCID: PMC2887382.
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    28. Tienen Cv, van der Loeff MS, Zaman SM, Vincent T, Sarge-Njie R, Peterson I, Leligdowicz A, Jaye A, Rowland-Jones S, Aaby P, Whittle H. Two distinct epidemics: the rise of HIV-1 and decline of HIV-2 infection between 1990 and 2007 in rural Guinea-Bissau. J Acquir Immune Defic Syndr. 2010 Apr; 53(5):640-7. PMID: 19841588.
      View in: PubMed
    29. Leligdowicz A, Feldmann J, Jaye A, Cotten M, Dong T, McMichael A, Whittle H, Rowland-Jones S. Direct relationship between virus load and systemic immune activation in HIV-2 infection. J Infect Dis. 2010 Jan 01; 201(1):114-22. PMID: 19938978.
      View in: PubMed
    30. Feldmann J, Leligdowicz A, Jaye A, Dong T, Whittle H, Rowland-Jones SL. Downregulation of the T-cell receptor by human immunodeficiency virus type 2 Nef does not protect against disease progression. J Virol. 2009 Dec; 83(24):12968-72. PMID: 19812166; PMCID: PMC2786859.
      View in: PubMed, PubMed Central
    31. Jallow S, Vincent T, Leligdowicz A, De Silva T, Van Tienen C, Alabi A, Sarge-Njie R, Aaby P, Corrah T, Whittle H, Jaye A, Vanham G, Rowland-Jones S, Janssens W. Presence of a multidrug-resistance mutation in an HIV-2 variant infecting a treatment-naive individual in Caio, Guinea Bissau. Clin Infect Dis. 2009 Jun 15; 48(12):1790-3. PMID: 19438401.
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    32. Mendy ME, Kaye S, Le Roux E, Kirk GD, Jeng-Barry A, McConkey S, Cotten M, Kuniholm MH, Leligdowicz A, Hainaut P, Rowland-Jones S, Whittle H. Application of a novel, rapid, and sensitive oligonucleotide ligation assay for detection of cancer-predicting mutations in the precore and basal core promoter of hepatitis B virus. J Clin Microbiol. 2008 Aug; 46(8):2723-30. PMID: 18508941; PMCID: PMC2519494.
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    33. Leligdowicz A, Rowland-Jones S. Tenets of protection from progression to AIDS: lessons from the immune responses to HIV-2 infection. Expert Rev Vaccines. 2008 Apr; 7(3):319-31. PMID: 18393602.
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    34. Leligdowicz A, Yindom LM, Onyango C, Sarge-Njie R, Alabi A, Cotten M, Vincent T, da Costa C, Aaby P, Jaye A, Dong T, McMichael A, Whittle H, Rowland-Jones S. Robust Gag-specific T cell responses characterize viremia control in HIV-2 infection. J Clin Invest. 2007 Oct; 117(10):3067-74. PMID: 17823657; PMCID: PMC1964515.
      View in: PubMed, PubMed Central
    35. Jensen ML, Dave S, Schim van der Loeff M, da Costa C, Vincent T, Leligdowicz A, Benn CS, Roth A, Ravn H, Lisse IM, Whittle H, Aaby P. Vaccinia scars associated with improved survival among adults in rural Guinea-Bissau. PLoS One. 2006 Dec 20; 1:e101. PMID: 17183634; PMCID: PMC1762358.
      View in: PubMed, PubMed Central
    36. Gill KK, Leligdowicz A, Luo M, Bielawny T, Brunham R, Plummer FA. Identification of four novel HLA-A alleles from an East African population by high-resolution sequence-based typing. Hum Immunol. 2006 Oct; 67(10):833-8. PMID: 17055361.
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    37. Leligdowicz A, Katwere M, Piloya T, Ronald A, Kambugu A, Katabira E. Challenges in diagnosis, treatment and follow-up of patients presenting with central nervous system infections in a resource-limited setting. Mcgill J Med. 2006 Jan; 9(1):39-48. PMID: 19529809; PMCID: PMC2687896.
      View in: PubMed, PubMed Central
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