Alessandro Didonna, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Address675 Nelson Rising Lane
San Francisco CA 94158
Phone415-476-1335
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    Other Positions
    Title(s)UCSF Weill Institute for Neurosciences


    Collapse Biography 
    Collapse Education and Training
    University of Bari, ItalyB.Sc.2004Cell and Molecular Biology
    University of Bari, ItalyM.Sc.2006Cell and Molecular Biology
    International School for Advanced Studies, ItalyPh.D.2010Functional and Structural Genomics
    Northwestern UniversityPostdoctoral Fellow2011Neurology
    University of California, San FranciscoPostdoctoral Fellow2013Neurology
    Collapse Awards and Honors
    University of Bari2001  - 2006Graduation with honors (summa cum laude)
    Italian Multiple Sclerosis Foundation (FISM)2015  - 2017Senior Research Fellowship
    American Neurological Association2015Travel Grant
    American Society for Cell Biology2016Travel Grant
    Italian Multiple Sclerosis Foundation (FISM)2017Young Researcher Best Poster Award
    Conrad N. Hilton Foundation2017  - 2019Marilyn Hilton Award for Innovation in MS Research
    European Molecular Biology Organization 2017Travel Grant
    University of California San Francisco2018Pilot Award for Junior Investigators in Basic and Clinical/Translational Sciences
    Italian Multiple Sclerosis Foundation (FISM)2018  - 2020Senior Research Fellowship
    Queen's University Belfast2018Visiting Research Fellow
    American Society for Cell Biology2019Travel Grant
    National Institutes of Health (NIH)2021R56 Bridge Award
    International Progressive MS Alliance2021Research Challenge Award

    Collapse Overview 

    Collapse Research 
    Collapse Research Activities and Funding
    HLA genetics and Parkinson's disease
    NIH R56NS121112May 1, 2021 - Apr 30, 2022
    Role: Principal Investigator
    MHC variation at high resolution in multiple sclerosis
    NIH R01NS102153Aug 15, 2017 - Apr 30, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. The novel multiple sclerosis susceptibility gene ATXN1 regulates B cell receptor signaling in B-1a cells. Mol Brain. 2021 01 21; 14(1):19. Ma Q, Didonna A. PMID: 33478569.
      View in: PubMed   Mentions:    Fields:    
    2. A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain. Immunology. 2021 Feb; 162(2):194-207. Didonna A, Damotte V, Shams H, Matsunaga A, Caillier SJ, Dandekar R, Misra MK, Mofrad MRK, Oksenberg JR, Hollenbach JA. PMID: 32986852.
      View in: PubMed   Mentions:    Fields:    
    3. Oligodendrocyte-specific Argonaute profiling identifies microRNAs associated with experimental autoimmune encephalomyelitis. J Neuroinflammation. 2020 Oct 12; 17(1):297. Ma Q, Matsunaga A, Ho B, Oksenberg JR, Didonna A. PMID: 33046105.
      View in: PubMed   Mentions:    Fields:    
    4. Tau at the interface between neurodegeneration and neuroinflammation. Genes Immun. 2020 11; 21(5):288-300. Didonna A. PMID: 33011744.
      View in: PubMed   Mentions: 2     Fields:    
    5. Ataxin-1 regulates B cell function and the severity of autoimmune experimental encephalomyelitis. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23742-23750. Didonna A, Canto Puig E, Ma Q, Matsunaga A, Ho B, Caillier SJ, Shams H, Lee N, Hauser SL, Tan Q, Zamvil SS, Oksenberg JR. PMID: 32878998.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    6. TopoDB: a novel multifunctional management system for laboratory animal colonies. Database (Oxford). 2020 01 01; 2020. Renschen A, Matsunaga A, Oksenberg JR, Santaniello A, Didonna A. PMID: 33206961.
      View in: PubMed   Mentions:    Fields:    
    7. Mitoma H., Manto M. (eds) Neuroimmune Diseases. Contemporary Clinical Neuroscience. Genetic Factors in Neuroimmune Diseases. 2019; 357-386 . Didonna A, Cantó E. View Publication.
    8. The role of neurofilament aggregation in neurodegeneration: lessons from rare inherited neurological disorders. Mol Neurodegener. 2019 05 16; 14(1):19. Didonna A, Opal P. PMID: 31097008.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    9. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. J Autoimmun. 2019 07; 101:56-69. Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. PMID: 31010726.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Hum Mol Genet. 2019 04 15; 28(8):1343-1356. Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P. PMID: 30590536.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    11. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 06 01; 128(6):2252-2265. Edamakanti CR, Do J, Didonna A, Martina M, Opal P. PMID: 29533923.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    12. Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72. Canto E, Isobe N, Didonna A, MS-EPIC Study Group , Hauser SL, Oksenberg JR. PMID: 29514694.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    13. The Genetics of Multiple Sclerosis. Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. 2017 Nov 14; 3-16. ALESSANDRO DIDONNA, JORGE R. OKSENBERG. .
      View in: Publisher Site   Mentions:
    14. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):E6982-E6991. Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. PMID: 28760957.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    15. Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490. Didonna A, Opal P. PMID: 27749953.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    16. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603. Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. PMID: 27546286.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    17. Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59. Didonna A. PMID: 27048376.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    18. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. PMID: 26433934.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    19. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811. Didonna A, Venturini AC, Hartman K, Vranac T, Curin Šerbec V, Legname G. PMID: 25802800.
      View in: PubMed   Mentions:
    20. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22. Didonna A, Oksenberg JR. PMID: 25661088.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    21. Post-translational modifications in neurodegeneration. AIMS Biophysics. 2015 Jan 1; 3(1):27-49. Alessandro Didonna, Federico Benetti. .
      View in: Publisher Site   Mentions:
    22. The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101. Didonna A, Opal P. PMID: 25642438.
      View in: PubMed   Mentions: 41     Fields:    
    23. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45. Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. PMID: 24594842.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    24. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. PMID: 23585478.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansAnimalsCells
    25. Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30. Didonna A. PMID: 23479001.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    26. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16. Didonna A, Sussman J, Benetti F, Legname G. PMID: 22561161.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    27. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74. Didonna A, Vaccari L, Bek A, Legname G. PMID: 22778865.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    28. Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29. Didonna A, Legname G. PMID: 20696038.
      View in: PubMed   Mentions: 6     Fields:    
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