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Alessandro Didonna, PhD

Title(s)Assistant Professor, Neurology
SchoolSchool of Medicine
Phone415-476-1335
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    Collapse Biography 
    Collapse Education and Training
    University of Bari, ItalyB.Sc.2004Cell and Molecular Biology
    University of Bari, ItalyM.Sc.2006Cell and Molecular Biology
    International School for Advanced Studies, ItalyPh.D.2010Functional and Structural Genomics
    Northwestern UniversityPostdoctoral Fellow2011Neurology
    University of California, San FranciscoPostdoctoral Fellow2013Neurology
    Collapse Awards and Honors
    University of Bari2001  - 2006Graduation with honors (summa cum laude)
    Italian Multiple Sclerosis Foundation (FISM)2015  - 2017Senior Research Fellowship
    American Neurological Association2015Travel Grant
    American Society for Cell Biology2016Travel Grant
    Italian Multiple Sclerosis Foundation (FISM)2017Young Researcher Best Poster Award
    Conrad N. Hilton Foundation2017  - 2019Marilyn Hilton Award for Innovation in MS Research
    European Molecular Biology Organization 2017Travel Grant
    University of California San Francisco2018Pilot Award for Junior Investigators in Basic and Clinical/Translational Sciences
    Italian Multiple Sclerosis Foundation (FISM)2018  - 2020Senior Research Fellowship
    Queen's University Belfast2018Visiting Research Fellow

    Collapse Research 
    Collapse Research Activities and Funding
    MHC variation at high resolution in multiple sclerosis
    NIH/NINDS R01NS102153Aug 15, 2017 - Apr 30, 2022
    Role: Co-Investigator

    Collapse ORNG Applications 
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Frederick NM, Shah PV, Didonna A, Langley MR, Kanthasamy AG, Opal P. Loss of the dystonia gene Thap1 leads to transcriptional deficits that converge on common pathogenic pathways in dystonic syndromes. Hum Mol Genet. 2018 Dec 26. PMID: 30590536.
      View in: PubMed
    2. Edamakanti CR, Do J, Didonna A, Martina M, Opal P. Mutant ataxin1 disrupts cerebellar development in spinocerebellar ataxia type 1. J Clin Invest. 2018 Jun 01; 128(6):2252-2265. PMID: 29533923.
      View in: PubMed
    3. Canto E, Isobe N, Didonna A, Hauser SL, Oksenberg JR. Aberrant STAT phosphorylation signaling in peripheral blood mononuclear cells from multiple sclerosis patients. J Neuroinflammation. 2018 Mar 07; 15(1):72. PMID: 29514694.
      View in: PubMed
    4. Didonna A, Oksenberg JR.Multiple Sclerosis: Perspectives in Treatment and Pathogenesis. Ian S. Zagon and Patricia J. McLaughlin (Editors). The Genetics of Multiple Sclerosis. 2017; 3-16.
    5. Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):E6982-E6991. PMID: 28760957.
      View in: PubMed
    6. Didonna A, Opal P. Advances in Sequencing Technologies for Understanding Hereditary Ataxias: A Review. JAMA Neurol. 2016 Dec 01; 73(12):1485-1490. PMID: 27749953.
      View in: PubMed
    7. Didonna A, Cekanaviciute E, Oksenberg JR, Baranzini SE. Immune cell-specific transcriptional profiling highlights distinct molecular pathways controlled by Tob1 upon experimental autoimmune encephalomyelitis. Sci Rep. 2016 08 22; 6:31603. PMID: 27546286.
      View in: PubMed
    8. Didonna A, Benetti F.Post-translational modifications in neurodegeneration. AIMS Biophysics. 2016; 1(3):27-49.
    9. Didonna A. Preclinical Models of Multiple Sclerosis: Advantages and Limitations Towards Better Therapies. Curr Med Chem. 2016; 23(14):1442-59. PMID: 27048376.
      View in: PubMed
    10. Didonna A, Isobe N, Caillier SJ, Li KH, Burlingame AL, Hauser SL, Baranzini SE, Patsopoulos NA, Oksenberg JR. A non-synonymous single-nucleotide polymorphism associated with multiple sclerosis risk affects the EVI5 interactome. Hum Mol Genet. 2015 Dec 15; 24(24):7151-8. PMID: 26433934; PMCID: PMC5007634 [Available on 12/15/16].
      View in: PubMed, PubMed Central
    11. Didonna A, Venturini AC, Hartman K, Vranac T, Curin Šerbec V, Legname G. Characterization of four new monoclonal antibodies against the distal N-terminal region of PrP(c). PeerJ. 2015; 3:e811. PMID: 25802800; PMCID: PMC4369333.
      View in: PubMed, PubMed Central
    12. Didonna A, Oksenberg JR. Genetic determinants of risk and progression in multiple sclerosis. Clin Chim Acta. 2015 Sep 20; 449:16-22. PMID: 25661088; PMCID: PMC4524789 [Available on 09/20/16].
      View in: PubMed, PubMed Central
    13. Didonna A, Opal P. The promise and perils of HDAC inhibitors in neurodegeneration. Ann Clin Transl Neurol. 2015 Jan; 2(1):79-101. PMID: 25642438; PMCID: PMC4301678.
      View in: PubMed, PubMed Central
    14. Venkatraman A, Hu YS, Didonna A, Cvetanovic M, Krbanjevic A, Bilesimo P, Opal P. The histone deacetylase HDAC3 is essential for Purkinje cell function, potentially complicating the use of HDAC inhibitors in SCA1. Hum Mol Genet. 2014 Jul 15; 23(14):3733-45. PMID: 24594842; PMCID: PMC4065149.
      View in: PubMed, PubMed Central
    15. Mahammad S, Murthy SN, Didonna A, Grin B, Israeli E, Perrot R, Bomont P, Julien JP, Kuczmarski E, Opal P, Goldman RD. Giant axonal neuropathy-associated gigaxonin mutations impair intermediate filament protein degradation. J Clin Invest. 2013 May; 123(5):1964-75. PMID: 23585478; PMCID: PMC3635735.
      View in: PubMed, PubMed Central
    16. Didonna A. Prion protein and its role in signal transduction. Cell Mol Biol Lett. 2013 Jun; 18(2):209-30. PMID: 23479001.
      View in: PubMed
    17. Didonna A, Sussman J, Benetti F, Legname G. The role of Bax and caspase-3 in doppel-induced apoptosis of cerebellar granule cells. Prion. 2012 Jul 01; 6(3):309-16. PMID: 22561161; PMCID: PMC3399532.
      View in: PubMed, PubMed Central
    18. Didonna A, Vaccari L, Bek A, Legname G. Infrared microspectroscopy: a multiple-screening platform for investigating single-cell biochemical perturbations upon prion infection. ACS Chem Neurosci. 2011 Mar 16; 2(3):160-74. PMID: 22778865.
      View in: PubMed
    19. Didonna A, Legname G. Aberrant ERK 1/2 complex activation and localization in scrapie-infected GT1-1 cells. Mol Neurodegener. 2010 Aug 09; 5:29. PMID: 20696038; PMCID: PMC2928767.
      View in: PubMed, PubMed Central
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