Alex Vecchio, PhD

InstitutionUniversity of California San Francisco
DepartmentBiochemistry and Biophysics
Address600 16th St
San Francisco CA 94158
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    Collapse Biography 
    Collapse Education and Training
    University at Buffalo, The State University of New YorkPh.D. Structural Biology2011Hauptman-Woodward Institute & Department of Structural Biology
    Rochester Institute of TechnologyB.S. Biology2000Thomas H. Gosnell School of Life Sciences
    Collapse Awards and Honors
    National Institutes of Health (NIGMS)2012  - 2015Ruth L. Kirschstein NRSA Postdoctoral Fellowship

    Collapse Overview 
    Collapse Overview
    Dr. Vecchio is a Postdoctoral Fellow at the University of California, San Francisco (USCF) in the laboratory of Professor Robert M. Stroud, Department of Biochemistry & Biophysics. Alex earned his Ph.D. in Structural Biology at the Hauptman-Woodward Medical Research Institute and the University at Buffalo, The State University of New York (SUNY), and obtained a B.S. in Biology from the Rochester Institute of Technology. His research interests currently focus on X-ray crystallographic determination of integral membrane proteins of epithelial tight junctions.

    Epithelia separate, protect, and shape the tissues of the human body, forming organs and glands. Integral membrane proteins found at tight junctions of adjacent epithelial cells are essential for these tissues ability to function as physical and chemical barriers, while still allowing for transport of molecules of various size and ionic charge to pass paracellularly, in-between cells. The goal of Alex's research is to determine the three-dimensional structures of these proteins to extend insight into their function; leading toward a better understanding of the tight junction multiprotein complex and the development of novel therapeutics aimed at ameliorating tight junction-related diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Structural and Functional Investigation of Tight Junction Membrane Proteins
    NIH/NIGMS F32GM103277Sep 1, 2012 - Aug 31, 2015
    Role: Principal Investigator

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    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG. Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry. Biochemistry. 2016 Mar 01; 55(8):1226-38. PMID: 26859324; PMCID: PMC4775376 [Available on 03/01/17].
    2. Vecchio AJ, Orlando BJ, Nandagiri R, Malkowski MG. Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. J Biol Chem. 2012 Jul 13; 287(29):24619-30. PMID: 22637474; PMCID: PMC3397890.
    3. Vecchio AJ, Malkowski MG. The structure of NS-398 bound to cyclooxygenase-2. J Struct Biol. 2011 Nov; 176(2):254-8. PMID: 21843643; PMCID: PMC3185125.
    4. Vecchio AJ, Malkowski MG. The structural basis of endocannabinoid oxygenation by cyclooxygenase-2. J Biol Chem. 2011 Jun 10; 286(23):20736-45. PMID: 21489986; PMCID: PMC3121521.
    5. Dong L, Vecchio AJ, Sharma NP, Jurban BJ, Malkowski MG, Smith WL. Human cyclooxygenase-2 is a sequence homodimer that functions as a conformational heterodimer. J Biol Chem. 2011 May 27; 286(21):19035-46. PMID: 21467029; PMCID: PMC3099718.
    6. Vecchio AJ, Simmons DM, Malkowski MG. Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16; 285(29):22152-63. PMID: 20463020; PMCID: PMC2903402.