Alexander Gupta, MD

Title(s)HS Clinical Instructor, Surgery
SchoolSchool of Medicine
Phone415-476-1239
PronounsHe/Him/His
ORCID ORCID Icon0000-0002-2813-6175 Additional info
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    Collapse Biography 
    Collapse education and training
    Southern Methodist University, Dallas, TXBSE5/2012Electrical Engineering with Biomedical Specialization
    University of Texas Medical Branch, Galveston, TXMD6/2016Doctor of Medicine
    University of California, San Francisco, San Francisco, CA6/2017Internship, General Surgery
    University of California, San Francisco, San Francisco, CA6/2024Residency, General Surgery
    University of California, San Francisco, San Francisco, CAPresentAbdominal Transplant Surgery Fellowship
    Collapse awards and honors
    Zuckerburg San Francisco General Hospital and Trauma Center2018Krevans Award for Clinical and Professional Excellence
    Zuckerburg San Francisco General Hospital and Trauma Center2019Emergency Department Consultant of the Year - Runner Up
    University of California, San Francisco2020Medical Student Teaching Award
    University of California, San Francisco2024Lawrence W. Way Critical Thinking Award
    University of California, San Francisco2024Haile T. Debas Resident Teaching Award

    Collapse Overview 
    Collapse overview
    Alexander (Alex) Gupta, MD is a Clinical Instructor and Fellow in Abdominal Transplant Surgery at the University of California, San Francisco Department of Surgery. He completed his undergraduate training at Southern Methodist University studying Electrical Engineering with a specialization in Biomedical Engineering in 2012. He attended medical school at the University of Texas Medical Branch in 2016. He completed his internship and residency in general surgery at the University of California, San Francisco in 2024.

    His research interests are based in mechanisms of immune tolerance. He continues to work with Dr. James Gardner, a UCSF transplant surgeon and basic immunologist, studying the fundamental biology of extrathymic Aire-expressing cells as they relate to peripheral tolerance induction.

    Collapse Research 
    Collapse research activities and funding
    Filling a Void of Research (FAVOR) Training for Transplant Surgeons
    NIH T32AI125222Aug 1, 2016 - Jul 31, 2026
    Role: Co-Investigator
    Description: Examining the role of extrathymic Aire-expressing cells in immune evasion by lung cancer.

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function. Nat Genet. 2024 Oct; 56(10):2078-2092. Loeb GB, Kathail P, Shuai RW, Chung R, Grona RJ, Peddada S, Sevim V, Federman S, Mader K, Chu AY, Davitte J, Du J, Gupta AR, Ye CJ, Shafer S, Przybyla L, Rapiteanu R, Ioannidis NM, Reiter JF. PMID: 39256582.
      View in: PubMed   Mentions: 2     Fields:    
    2. Real-time thermoconductive monitoring for early detection of kidney transplant rejection. Am J Transplant. 2024 Aug; 24(8):1332-1333. Gupta AR, Rickert CG, Gardner JM. PMID: 39111983.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Variants in tubule epithelial regulatory elements mediate most heritable differences in human kidney function. bioRxiv. 2024 Jun 22. Loeb GB, Kathail P, Shuai R, Chung R, Grona RJ, Peddada S, Sevim V, Federman S, Mader K, Chu A, Davitte J, Du J, Gupta AR, Ye CJ, Shafer S, Przybyla L, Rapiteanu R, Ioannidis N, Reiter JF. PMID: 38948875; PMCID: PMC11212968.
      View in: PubMed   Mentions:
    4. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024 Feb; 26(2):250-262. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 38321203; PMCID: PMC11654995.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimals
    5. Ikaros is a principal regulator of Aire+ mTEC homeostasis, thymic mimetic cell diversity, and central tolerance. Sci Immunol. 2023 10 27; 8(88):eabq3109. Sin JH, Sucharov J, Kashyap S, Wang Y, Proekt I, Liu X, Parent AV, Gupta A, Kastner P, Chan S, Gardner JM, Ntranos V, Miller CN, Anderson MS, Schjerven H, Waterfield MR. PMID: 37889983; PMCID: PMC11433069.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    6. Epithelial TNF controls cell differentiation and CFTR activity to maintain intestinal mucin homeostasis. J Clin Invest. 2023 10 16; 133(20). Reyes EA, Castillo-Azofeifa D, Rispal J, Wald T, Zwick RK, Palikuqi B, Mujukian A, Rabizadeh S, Gupta AR, Gardner JM, Boffelli D, Gartner ZJ, Klein OD. PMID: 37643009; PMCID: PMC10575728.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    7. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. bioRxiv. 2023 Sep 22. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. PMID: 37790430; PMCID: PMC10542170.
      View in: PubMed   Mentions:
    8. Early patient and liver allograft outcomes from donation after circulatory death donors using thoracoabdominal normothermic regional: a multi-center observational experience. Frontiers in Transplantation. 2023; 2. Brubaker AL, Taj R, Jackson B, Lee A, Tsai C, Berumen J, Parekh JR, Mekeel KL, Gupta AR, Gardner JM , Chaly T, Mathur AK, Jadlowiec C, Reddy S, Nunez R, Bellingham J, Thomas EM, Wellen JR, Pan JH, Kearns M, Pretorius V, Schnickel GT. View Publication.
    9. Early patient and liver allograft outcomes from donation after circulatory death donors using thoracoabdominal normothermic regional: a multi-center observational experience. Front Transplant. 2023; 2:1184620. Brubaker AL, Taj R, Jackson B, Lee A, Tsai C, Berumen J, Parekh JR, Mekeel KL, Gupta AR, Gardner JM, Chaly T, Mathur AK, Jadlowiec C, Reddy S, Nunez R, Bellingham J, Thomas EM, Wellen JR, Pan JH, Kearns M, Pretorius V, Schnickel GT. PMID: 38993873; PMCID: PMC11235322.
      View in: PubMed   Mentions:
    10. Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors. Elife. 2022 10 18; 11. Timón-Gómez A, Scharr AL, Wong NY, Ni E, Roy A, Liu M, Chau J, Lampert JL, Hireed H, Kim NS, Jan M, Gupta AR, Day RW, Gardner JM, Wilson RJA, Barrientos A, Chang AJ. PMID: 36255054; PMCID: PMC9635879.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    11. Internal hernia involving the transplant ureter after simultaneous pancreas and kidney transplant - and the atypical management of a consequent transplant ureteral injury. Clin Transplant. 2022 07; 36(7):e14675. Gupta AR, Kelly YM, Syed SM, Gardner JM. PMID: 35430751.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    12. Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium. Sci Immunol. 2021 Nov 12; 6(65):eabl5053. Wang J, Lareau CA, Bautista JL, Gupta AR, Sandor K, Germino J, Yin Y, Arvedson MP, Reeder GC, Cramer NT, Xie F, Ntranos V, Satpathy AT, Anderson MS, Gardner JM. PMID: 34767455; PMCID: PMC8855935.
      View in: PubMed   Mentions: 24     Fields:    Translation:Animals
    13. Improved outcomes and staging in non-small-cell lung cancer guided by a molecular assay. Future Oncol. 2021 Dec; 17(34):4785-4795. Gupta AR, Woodard GA, Jablons DM, Mann MJ, Kratz JR. PMID: 34435876; PMCID: PMC9039775.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    14. A human mutation in STAT3 promotes type 1 diabetes through a defect in CD8+ T cell tolerance. J Exp Med. 2021 08 02; 218(8). Warshauer JT, Belk JA, Chan AY, Wang J, Gupta AR, Shi Q, Skartsis N, Peng Y, Phipps JD, Acenas D, Smith JA, Tamaki SJ, Tang Q, Gardner JM, Satpathy AT, Anderson MS. PMID: 34115115; PMCID: PMC8203485.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    15. An Evidence-Based Model for the Successful Treatment of Flank and Lateral Abdominal Wall Hernias. Plast Reconstr Surg. 2015 Aug; 136(2):377-385. Pezeshk RA, Pulikkottil BJ, Bailey SH, Schaffer NE, Reece EM, Thornton NJ, Gupta AR, Hoxworth RE. PMID: 25946603.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
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